SG11201401587QA - Meldrum 's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as hno donors - Google Patents
Meldrum 's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as hno donorsInfo
- Publication number
- SG11201401587QA SG11201401587QA SG11201401587QA SG11201401587QA SG11201401587QA SG 11201401587Q A SG11201401587Q A SG 11201401587QA SG 11201401587Q A SG11201401587Q A SG 11201401587QA SG 11201401587Q A SG11201401587Q A SG 11201401587QA SG 11201401587Q A SG11201401587Q A SG 11201401587QA
- Authority
- SG
- Singapore
- Prior art keywords
- acid
- meldrum
- hydroxylamine
- derivatives substituted
- pyrazolone derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
- C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161548036P | 2011-10-17 | 2011-10-17 | |
| PCT/US2012/060425 WO2013059194A1 (fr) | 2011-10-17 | 2012-10-16 | Acide de meldrum, acide barbiturique et dérivés de la pyrazoline substitués par une hydroxylamine en tant que donneurs de hno |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201401587QA true SG11201401587QA (en) | 2014-07-30 |
Family
ID=47143299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201401587QA SG11201401587QA (en) | 2011-10-17 | 2012-10-16 | Meldrum 's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as hno donors |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9181213B2 (fr) |
| EP (1) | EP2776402B1 (fr) |
| JP (1) | JP6177246B2 (fr) |
| KR (1) | KR102061537B1 (fr) |
| CN (2) | CN108409662B (fr) |
| AU (2) | AU2013201929B2 (fr) |
| BR (1) | BR112014009282B1 (fr) |
| CA (1) | CA2852914C (fr) |
| HK (1) | HK1200168A1 (fr) |
| IL (1) | IL232101A (fr) |
| MX (1) | MX363306B (fr) |
| SG (1) | SG11201401587QA (fr) |
| WO (1) | WO2013059194A1 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013059194A1 (fr) | 2011-10-17 | 2013-04-25 | Johns Hopkins University | Acide de meldrum, acide barbiturique et dérivés de la pyrazoline substitués par une hydroxylamine en tant que donneurs de hno |
| HUE046722T2 (hu) | 2013-01-18 | 2020-03-30 | Cardioxyl Pharmaceuticals Inc | Javított terápiás indexû nitroxil donorok |
| EP3126329B1 (fr) | 2014-01-17 | 2019-05-29 | Cardioxyl Pharmaceuticals Inc. | Donneurs de nitroxyle n-hydroxymethanesulfonamide |
| WO2015183838A1 (fr) | 2014-05-27 | 2015-12-03 | The Johns Hopkins University | Dérivés d'acide n-hydroxylamino-barbiturique utilisés comme donneurs de nitroxyle |
| US9464061B2 (en) * | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
| ES2749682T3 (es) * | 2014-05-27 | 2020-03-23 | Cardioxyl Pharmaceuticals Inc | Derivados de pirazolona como donadores de nitroxilo |
| WO2016210392A1 (fr) * | 2015-06-26 | 2016-12-29 | The Johns Hopkins University | Acides hydroxamiques n-substitués comportant des groupes partants à base de carbone servant de donneurs de hno efficaces et utilisations de ceux-ci |
| KR20180070672A (ko) | 2015-10-19 | 2018-06-26 | 카르디옥실 파마슈티칼스 인코포레이티드 | 니트록실 공여자로서의 n-히드록실술폰아미드 유도체 |
| KR20180063326A (ko) * | 2015-10-19 | 2018-06-11 | 카르디옥실 파마슈티칼스 인코포레이티드 | 니트록실 공여자로서의 피라졸론 유도체 |
| ES2878060T3 (es) | 2016-07-28 | 2021-11-18 | Univ Johns Hopkins | Acidos hidroxámicos O-sustituidos |
| SG10202107533RA (en) | 2017-01-03 | 2021-08-30 | Cardioxyl Pharmaceuticals Inc | Method of administering nitroxyl donating compounds |
| PT3762368T (pt) | 2018-03-08 | 2022-05-06 | Incyte Corp | Compostos de aminopirazina diol como inibidores de pi3k-y |
| WO2020010003A1 (fr) | 2018-07-02 | 2020-01-09 | Incyte Corporation | DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ |
| US11912647B2 (en) | 2020-05-22 | 2024-02-27 | University Of Georgia Research Foundation, Inc. | Diversity-oriented synthesis of N,N,O-trisubstituted hydroxylamines from alcohols and amines by N—O bond formation |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3751255A (en) | 1972-03-24 | 1973-08-07 | Eastman Kodak Co | Photosensitive and thermosensitive element, composition and process |
| JPS567710A (en) | 1979-06-28 | 1981-01-27 | Sansho Seiyaku Kk | Whitening cosmetic |
| US4539321A (en) | 1981-10-26 | 1985-09-03 | William H. Rorer, Inc. | 5-Diaza-aryl-3-substituted pyridone compounds |
| DE3583799D1 (de) | 1985-01-11 | 1991-09-19 | Abbott Lab Ltd | Feste zubereitung mit langsamer freisetzung. |
| US4663351A (en) | 1985-08-23 | 1987-05-05 | Berlex Laboratories, Inc. | Dobutamine tri-isobutyric acid ester and the use thereof as a cardiotonic agent |
| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| JP2773959B2 (ja) | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
| AU741180B2 (en) | 1997-10-24 | 2001-11-22 | Shionogi & Co., Ltd. | Antirheumatic |
| UA73092C2 (uk) | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| EP1101490B1 (fr) | 1998-07-28 | 2005-04-13 | Tanabe Seiyaku Co., Ltd. | Preparation capable de liberer un medicament au niveau d'un site cible dans l'intestin |
| GB9918684D0 (en) | 1999-08-09 | 1999-10-13 | Novartis Ag | Organic compounds |
| GB0114223D0 (en) | 2001-06-12 | 2001-08-01 | Ici Plc | Catalytic oxidation process |
| US20040038947A1 (en) * | 2002-06-14 | 2004-02-26 | The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services | Method of treating ischemia/reperfusion injury with nitroxyl donors |
| US6936639B2 (en) | 2002-08-21 | 2005-08-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxyl progenitors in the treatment of heart failure |
| EP1694686A1 (fr) | 2003-12-19 | 2006-08-30 | Takeda San Diego, Inc. | Inhibiteurs de kinase |
| CA2554771A1 (fr) | 2004-01-30 | 2005-08-18 | Johns Hopkins University | Composes precurseurs de nitroxyle et methodes d'utilisation |
| EP1846439A2 (fr) | 2005-01-31 | 2007-10-24 | The Johns Hopkins University | Utilisation de sequences consensus en tant qu'antigene de vaccin dans le but d'ameliorer la reconnaissance de variants viraux virulents |
| WO2007002444A1 (fr) | 2005-06-23 | 2007-01-04 | Johns Hopkins University | Inotropes positifs sensibles au thiol |
| MX368352B (es) | 2006-03-17 | 2019-09-30 | Univ Johns Hopkins | Derivados de n-hidroxilsulfonamida como nuevos donantes de nitroxilo fisiologicamente utiles. |
| US7696373B2 (en) | 2006-04-13 | 2010-04-13 | Wake Forest University Health Sciences | C-nitroso-derived nitroxyl donors |
| CA2699567C (fr) | 2007-09-26 | 2018-01-09 | Cardioxyl Pharmaceuticals, Inc. | Derives de n-hydroxylsulfonamide utilises comme nouveaux donneurs de nitroxyle physiologiquement utiles |
| JP5654450B2 (ja) * | 2008-05-07 | 2015-01-14 | カルディオキシル ファーマシューティカルズ，インク． | ニトロキシル供与体としての新規ニトロソ化合物およびその使用方法 |
| US20110160200A1 (en) | 2009-11-23 | 2011-06-30 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension |
| ES2719101T3 (es) | 2009-12-07 | 2019-07-08 | Univ Johns Hopkins | Derivados de hidroxilamina N-acilados y derivados de hidroxilamina o-acilados |
| AU2010328230B2 (en) | 2009-12-07 | 2016-06-02 | Cardioxyl Pharmaceuticals, Inc. | Bis-acylated hydroxylamine derivatives |
| WO2013059194A1 (fr) | 2011-10-17 | 2013-04-25 | Johns Hopkins University | Acide de meldrum, acide barbiturique et dérivés de la pyrazoline substitués par une hydroxylamine en tant que donneurs de hno |
| HUE046722T2 (hu) | 2013-01-18 | 2020-03-30 | Cardioxyl Pharmaceuticals Inc | Javított terápiás indexû nitroxil donorok |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
| WO2015183838A1 (fr) | 2014-05-27 | 2015-12-03 | The Johns Hopkins University | Dérivés d'acide n-hydroxylamino-barbiturique utilisés comme donneurs de nitroxyle |
| ES2749682T3 (es) | 2014-05-27 | 2020-03-23 | Cardioxyl Pharmaceuticals Inc | Derivados de pirazolona como donadores de nitroxilo |
-
2012
- 2012-10-16 WO PCT/US2012/060425 patent/WO2013059194A1/fr active Application Filing
- 2012-10-16 CN CN201810435608.5A patent/CN108409662B/zh active Active
- 2012-10-16 US US14/352,399 patent/US9181213B2/en active Active
- 2012-10-16 SG SG11201401587QA patent/SG11201401587QA/en unknown
- 2012-10-16 CN CN201280051009.4A patent/CN104053647B/zh active Active
- 2012-10-16 AU AU2013201929A patent/AU2013201929B2/en active Active
- 2012-10-16 EP EP12781538.9A patent/EP2776402B1/fr active Active
- 2012-10-16 JP JP2014537151A patent/JP6177246B2/ja active Active
- 2012-10-16 MX MX2014004596A patent/MX363306B/es unknown
- 2012-10-16 CA CA2852914A patent/CA2852914C/fr active Active
- 2012-10-16 KR KR1020147013269A patent/KR102061537B1/ko active IP Right Grant
- 2012-10-16 BR BR112014009282-6A patent/BR112014009282B1/pt active IP Right Grant
-
2014
- 2014-04-13 IL IL232101A patent/IL232101A/en active IP Right Grant
-
2015
- 2015-01-19 HK HK15100597.0A patent/HK1200168A1/xx unknown
- 2015-10-21 AU AU2015246114A patent/AU2015246114A1/en not_active Abandoned
- 2015-10-29 US US14/927,039 patent/US9499511B2/en active Active
-
2016
- 2016-10-11 US US15/290,872 patent/US9862699B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9499511B2 (en) | 2016-11-22 |
| BR112014009282A8 (pt) | 2020-04-22 |
| US9181213B2 (en) | 2015-11-10 |
| IL232101A (en) | 2017-04-30 |
| KR102061537B1 (ko) | 2020-01-03 |
| JP2015501308A (ja) | 2015-01-15 |
| US9862699B2 (en) | 2018-01-09 |
| EP2776402A1 (fr) | 2014-09-17 |
| EP2776402B1 (fr) | 2017-07-26 |
| CN104053647B (zh) | 2018-06-01 |
| IL232101A0 (en) | 2014-05-28 |
| MX363306B (es) | 2019-03-20 |
| MX2014004596A (es) | 2014-09-04 |
| BR112014009282B1 (pt) | 2021-12-14 |
| HK1200168A1 (en) | 2015-07-31 |
| WO2013059194A1 (fr) | 2013-04-25 |
| CA2852914A1 (fr) | 2013-04-25 |
| CN108409662B (zh) | 2021-10-26 |
| JP6177246B2 (ja) | 2017-08-09 |
| KR20140107197A (ko) | 2014-09-04 |
| US20170050947A1 (en) | 2017-02-23 |
| AU2013201929B2 (en) | 2015-07-23 |
| BR112014009282A2 (pt) | 2017-06-13 |
| US20160115148A1 (en) | 2016-04-28 |
| CN108409662A (zh) | 2018-08-17 |
| CA2852914C (fr) | 2019-11-26 |
| US20140275134A1 (en) | 2014-09-18 |
| CN104053647A (zh) | 2014-09-17 |
| AU2015246114A1 (en) | 2015-11-12 |
| AU2013201929A1 (en) | 2013-05-02 |
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