SG10202112528QA - Nsg mice lacking mhc class i and class ii - Google Patents

Nsg mice lacking mhc class i and class ii

Info

Publication number
SG10202112528QA
SG10202112528QA SG10202112528QA SG10202112528QA SG10202112528QA SG 10202112528Q A SG10202112528Q A SG 10202112528QA SG 10202112528Q A SG10202112528Q A SG 10202112528QA SG 10202112528Q A SG10202112528Q A SG 10202112528QA SG 10202112528Q A SG10202112528Q A SG 10202112528QA
Authority
SG
Singapore
Prior art keywords
class
nsg mice
mice lacking
lacking mhc
mhc class
Prior art date
Application number
SG10202112528QA
Other languages
English (en)
Inventor
Michael Brehm
Michael Wiles
Dale Greiner
Leonard Shultz
Original Assignee
Jackson Lab
Univ Massachusetts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jackson Lab, Univ Massachusetts filed Critical Jackson Lab
Publication of SG10202112528QA publication Critical patent/SG10202112528QA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knockout animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
SG10202112528QA 2017-05-12 2018-05-14 Nsg mice lacking mhc class i and class ii SG10202112528QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762505264P 2017-05-12 2017-05-12
US201862649099P 2018-03-28 2018-03-28

Publications (1)

Publication Number Publication Date
SG10202112528QA true SG10202112528QA (en) 2021-12-30

Family

ID=62598038

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10202112528QA SG10202112528QA (en) 2017-05-12 2018-05-14 Nsg mice lacking mhc class i and class ii

Country Status (10)

Country Link
US (1) US11778994B2 (ja)
EP (2) EP3621433B1 (ja)
JP (2) JP7129426B2 (ja)
KR (1) KR102652838B1 (ja)
CN (2) CN115851834A (ja)
AU (1) AU2018265887B2 (ja)
CA (1) CA3063368A1 (ja)
RU (1) RU2019140867A (ja)
SG (1) SG10202112528QA (ja)
WO (1) WO2018209344A1 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11712026B2 (en) * 2017-10-18 2023-08-01 The Jackson Laboratory Murine-MHC-deficient HLA-transgenic nod-mouse models for T1D therapy development
CN112094869A (zh) * 2020-08-06 2020-12-18 郑州大学 基于基因敲除叙利亚仓鼠的胰腺癌动物模型制备方法及其应用
KR20230074758A (ko) * 2020-09-24 2023-05-31 더 잭슨 래보라토리 면역 세포 요법을 평가하기 위한 인간화 마우스 모델
WO2024054904A1 (en) * 2022-09-08 2024-03-14 The Jackson Laboratory Humanized immunodeficient mouse models

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9100481D0 (en) * 1991-01-10 1991-02-20 Inst Nat Sante Rech Med Genetically engineered mice
US5436150A (en) 1992-04-03 1995-07-25 The Johns Hopkins University Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease
US5356802A (en) 1992-04-03 1994-10-18 The Johns Hopkins University Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease
US5487994A (en) 1992-04-03 1996-01-30 The Johns Hopkins University Insertion and deletion mutants of FokI restriction endonuclease
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6830910B1 (en) 1999-07-21 2004-12-14 Albert Einstein College Of Medicine Of Yeshiva University Drosophila recombination-associated protein and methods for use
WO2001007627A1 (en) 1999-07-21 2001-02-01 Albert Einstein College Of Medicine Of Yeshiva University Drosophila recombination-associated protein and methods for use
FR2827302B1 (fr) 2001-07-13 2003-10-10 Genoway Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
US8409861B2 (en) 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
JP2008505104A (ja) 2004-07-01 2008-02-21 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション 免疫抑制性エキソソーム
WO2006044962A1 (en) 2004-10-19 2006-04-27 Regeneron Pharmaceuticals, Inc. Method for generating an animal homozygous for a genetic modification
KR101419729B1 (ko) 2005-07-26 2014-07-17 상가모 바이오사이언스 인코포레이티드 외래 핵산 서열의 표적화된 통합 및 발현
JP2007244268A (ja) * 2006-03-15 2007-09-27 Osaka Prefecture Univ イヌの造血前駆細胞を認識するモノクローナル抗体の製造方法
WO2007139898A2 (en) 2006-05-25 2007-12-06 Sangamo Biosciences, Inc. Variant foki cleavage half-domains
EP1878342A1 (en) * 2006-07-13 2008-01-16 Institut Pasteur Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses
JP2010525794A (ja) * 2007-04-06 2010-07-29 インターナショナル ステム セル コーポレイション ヒト単為生殖性胚盤胞に由来する患者特異的幹細胞株
EP2206723A1 (en) 2009-01-12 2010-07-14 Bonas, Ulla Modular DNA-binding domains
SG181601A1 (en) 2009-12-10 2012-07-30 Univ Minnesota Tal effector-mediated dna modification
US9018441B2 (en) * 2010-04-14 2015-04-28 Harlan Laboratories, Inc. Hairless NOD scid mouse
BR112013018311A2 (pt) 2011-01-18 2017-03-21 Univ Pennsylvania sequência de ácido nucleico isolada, receptor de antígeno quimérico isolado, célula t geneticamente modificada, vetor, e, uso de uma célula t geneticamente modificada.
US8450107B1 (en) 2011-11-30 2013-05-28 The Broad Institute Inc. Nucleotide-specific recognition sequences for designer TAL effectors
BR112015001459B1 (pt) 2012-07-25 2023-02-14 Celldex Therapeutics, Inc Anticorpo isolado ou fragmento do mesmo, conjugado, usos dos mesmos, composição farmacêutica, polinucleotídeo, vetor, célula hospedeira, célula isolada, kit, método in vitro para inibir atividade da kit, método para produzir um anticorpo
SG10201707449TA (en) 2012-11-05 2017-10-30 Regeneron Pharma Genetically modified non-human animals and methods of use thereof
JP7458185B2 (ja) 2016-11-30 2024-03-29 ザ ジャクソン ラボラトリー 改善されたヒト自然免疫細胞の発生を有するヒト化マウスモデル
US11712026B2 (en) 2017-10-18 2023-08-01 The Jackson Laboratory Murine-MHC-deficient HLA-transgenic nod-mouse models for T1D therapy development

Also Published As

Publication number Publication date
EP4144213A1 (en) 2023-03-08
CN115851834A (zh) 2023-03-28
KR102652838B1 (ko) 2024-04-01
AU2018265887B2 (en) 2024-05-09
EP3621433A1 (en) 2020-03-18
RU2019140867A (ru) 2021-06-15
AU2018265887A1 (en) 2019-11-28
JP2022159551A (ja) 2022-10-17
US20200060245A1 (en) 2020-02-27
EP3621433B1 (en) 2022-07-27
CA3063368A1 (en) 2018-11-15
CN110868850B (zh) 2023-07-14
WO2018209344A8 (en) 2019-12-05
KR20200006109A (ko) 2020-01-17
JP2020519282A (ja) 2020-07-02
CN110868850A (zh) 2020-03-06
JP7129426B2 (ja) 2022-09-01
US11778994B2 (en) 2023-10-10
WO2018209344A1 (en) 2018-11-15

Similar Documents

Publication Publication Date Title
ZA202003833B (en) Conjugates and preparation and use thereof
IL290457A (en) Antibodies and their conjugates
SG10201912906RA (en) Affinity-oligonucleotide conjugates and uses thereof
IL249647B (en) Intended conjugates and particles and their formulations
MA49715A (fr) Oligomères et conjugués d'oligomères
BR112016021717A2 (pt) anticorpos anti-egfr e conjugados anticorpo-fármaco
EP3164420A4 (en) Targeted conjugates and particles and formulations thereof
GB201507908D0 (en) IL2 and TNF immunoconjugates
HK1248538A1 (zh) Cd48抗體和其綴合物
HK1250634A1 (zh) 多配體藥物偶聯體及其用途
HK1259311A1 (zh) Sstr靶向綴合物及其顆粒和製劑
IL265471A (en) Pulling-oligonucleotide conjugates and their uses
EP3386986A4 (en) OR-PEG PORPHYRIN CONJUGATES AND METHODS OF USE
SG10202112528QA (en) Nsg mice lacking mhc class i and class ii
IL275208A (en) Hsp90-targeting conjugates and formulations thereof
FI20146023A (fi) Hammas- ja kielituki
ZA201608327B (en) Curcumin-peptide conjugates and formulations thereof
IL265770A (en) Conjugates are intended for sstr and particles and their formulations
DK3525826T3 (da) Ikke-lineære selvofrende linkere og konjugater deraf
HK1256368A1 (zh) 加利車黴素-抗體-藥物綴合物和使用方法
MA49905A (fr) Polyesteramines et polyesterquats
IL258759A (en) Anti-cd3-folate conjugates and their uses
IL255993A (en) Targeted conjugates and particles and formulations thereof
PT3544637T (pt) Conjugados omv-antigénio nativos e sua utilização
GB201818562D0 (en) Pyrrolobenzodiazephones and conjugates thereof