SG10202109108UA - Chimeric antigen receptors (cars), compositions and methods thereof - Google Patents
Chimeric antigen receptors (cars), compositions and methods thereofInfo
- Publication number
- SG10202109108UA SG10202109108UA SG10202109108UA SG10202109108UA SG10202109108UA SG 10202109108U A SG10202109108U A SG 10202109108UA SG 10202109108U A SG10202109108U A SG 10202109108UA SG 10202109108U A SG10202109108U A SG 10202109108UA SG 10202109108U A SG10202109108U A SG 10202109108UA
- Authority
- SG
- Singapore
- Prior art keywords
- cars
- compositions
- methods
- chimeric antigen
- antigen receptors
- Prior art date
Links
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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US201762523147P | 2017-06-21 | 2017-06-21 | |
US15/538,620 US11820819B2 (en) | 2016-06-24 | 2017-06-21 | Chimeric antigen receptors (CARs), compositions and methods thereof |
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SG10202109108UA SG10202109108UA (en) | 2017-06-21 | 2018-06-20 | Chimeric antigen receptors (cars), compositions and methods thereof |
SG11202000555UA SG11202000555UA (en) | 2017-06-21 | 2018-06-20 | Chimeric antigen receptors (cars), compositions and methods thereof |
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SG11202000555UA SG11202000555UA (en) | 2017-06-21 | 2018-06-20 | Chimeric antigen receptors (cars), compositions and methods thereof |
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US (1) | US20200223918A1 (zh) |
EP (1) | EP3641768A4 (zh) |
JP (2) | JP2020524512A (zh) |
CN (1) | CN111247242A (zh) |
AU (1) | AU2018288814A1 (zh) |
CA (1) | CA3070578A1 (zh) |
SG (2) | SG10202109108UA (zh) |
WO (1) | WO2018237022A1 (zh) |
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Publication number | Priority date | Publication date | Assignee | Title |
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CA2990177A1 (en) * | 2015-06-25 | 2016-12-29 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars), compositions and methods thereof |
US11701384B2 (en) | 2016-09-02 | 2023-07-18 | The Regents Of The University Of California | Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments |
EP3675892A4 (en) | 2017-07-03 | 2021-10-06 | Torque Therapeutics, Inc. | IMMUNOSTIMULATORY FUSION MOLECULES AND THEIR USES |
CN112566643A (zh) * | 2018-06-12 | 2021-03-26 | 加利福尼亚大学董事会 | 用于治疗癌症的单链双特异性嵌合抗原受体 |
CN113874391A (zh) * | 2019-02-20 | 2021-12-31 | 希望之城公司 | 靶向baff-r/cd19的嵌合抗原受体修饰的t细胞及其用途 |
AU2020241428A1 (en) | 2019-03-15 | 2021-08-12 | Cartesian Therapeutics, Inc. | Anti-BCMA chimeric antigen receptors |
EP3952886A1 (en) | 2019-04-10 | 2022-02-16 | Elevatebio Technologies, Inc | Flt3-specific chimeric antigen receptors and methods of using the same |
CN114007642A (zh) | 2019-04-30 | 2022-02-01 | 森迪生物科学公司 | 嵌合受体及其使用方法 |
KR20220017914A (ko) | 2019-05-07 | 2022-02-14 | 그라셀 바이오테크놀로지스 (상하이) 컴퍼니, 리미티드 | Bcma를 표적으로 하는 조작된 면역 세포 및 그의 용도 |
US12023354B2 (en) | 2019-05-31 | 2024-07-02 | Case Western Reserve University | Targeting B cell activating factor receptor (BAFF-R) using ligand-based chimeric antigen receptor (CAR)-T cells |
CA3148072A1 (en) * | 2019-07-19 | 2021-01-28 | Memorial Sloan-Kettering Cancer Center | Fusion polypeptide for immunotherapy |
WO2021020559A1 (ja) * | 2019-08-01 | 2021-02-04 | 国立大学法人三重大学 | 抗原受容体 |
US20220275104A1 (en) * | 2019-08-01 | 2022-09-01 | Mie University | Gd2 binding molecule |
WO2021064718A1 (en) * | 2019-10-01 | 2021-04-08 | Case Western Reserve University | Targeting b cell activating factor receptor (baff-r) using ligand-based chimeric antigen receptor (car)-t cells |
TWI717880B (zh) * | 2019-10-24 | 2021-02-01 | 中國醫藥大學附設醫院 | Hla-g特異性嵌合抗原受體、核酸、hla-g特異性嵌合抗原受體表達質體、表達hla-g特異性嵌合抗原受體細胞、其用途以及用於治療癌症之醫藥組合物 |
BR112022010206A2 (pt) * | 2019-11-26 | 2022-11-29 | Novartis Ag | Receptores de antígeno quiméricos e usos dos mesmos |
CN116568812A (zh) * | 2020-09-08 | 2023-08-08 | 亘喜生物科技(上海)有限公司 | 用于t细胞工程化的组合物和方法 |
CN112710843B (zh) * | 2020-12-16 | 2022-11-04 | 江苏伟禾生物科技有限公司 | 一种测定群体反应性抗体检测的板式免疫荧光试剂盒及其制备方法 |
CN112778427B (zh) * | 2021-01-29 | 2022-03-15 | 武汉思安医疗技术有限公司 | 双特异性cs1-bcma car-t细胞及其应用 |
WO2022180586A1 (en) * | 2021-02-25 | 2022-09-01 | Senthil Natesan | Car t-cell product and method of preparation thereof |
WO2023168436A1 (en) * | 2022-03-03 | 2023-09-07 | Board Of Regents, The University Of Texas System | Anti-cd19 and anti-cd79b chimeric antigen receptors and methods of use thereof |
WO2024026407A1 (en) * | 2022-07-28 | 2024-02-01 | The Board Of Regents Of The University Of Oklahoma | Biomarkers, diagnostic methods, treatments, and therapeutics for autoimmune disorders and diseases |
WO2024037627A1 (zh) * | 2022-08-19 | 2024-02-22 | 盛禾(中国)生物制药有限公司 | 一种双特异性抗体及其应用 |
CN116355079B (zh) * | 2022-08-19 | 2023-12-26 | 上海迈科康生物科技有限公司 | 检测重组人轮状病毒vp8抗原(vp8 p[8])的单克隆抗体及其应用 |
CN116179495A (zh) * | 2022-11-28 | 2023-05-30 | 上海恩凯细胞技术有限公司 | 转基因免疫细胞及其应用 |
CN115947869B (zh) * | 2022-11-28 | 2023-12-12 | 广州佰芮慷生物科技有限公司 | 一种靶向人巨细胞病毒的嵌合抗原受体、car-nk细胞及用途 |
CN115838439B (zh) * | 2022-12-06 | 2023-10-31 | 上海恩凯细胞技术有限公司 | 嵌合转换受体基因修饰的nk细胞制备方法及应用 |
CN116949099B (zh) * | 2023-07-12 | 2024-04-02 | 山东大学第二医院 | 一种靶向cd38和cs1抗原的并联嵌合抗原受体t细胞及其制备方法和应用 |
CN117143193B (zh) * | 2023-11-01 | 2024-02-13 | 北京大学第一医院 | 血小板聚集抑制肽、其制备方法及应用 |
CN117143194B (zh) * | 2023-11-01 | 2024-02-06 | 北京大学第一医院 | 抗血小板聚集多肽、其制备方法及应用 |
CN117756918A (zh) * | 2023-12-13 | 2024-03-26 | 宁夏回族自治区人民医院(宁夏眼科医院) | 一种baff重组截短蛋白及应用其的试剂盒 |
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EP1777294A1 (en) * | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
US20170145108A1 (en) * | 2014-02-05 | 2017-05-25 | The University Of Chicago | Chimeric antigen receptors recognizing cancer-specific tn glycopeptide variants |
DK3105317T3 (en) * | 2014-02-14 | 2019-01-14 | Cellectis | Immunotherapy cells that are genetically engineered to target antigen on both immune cells and pathological cells |
MY181834A (en) * | 2014-07-21 | 2021-01-08 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
CA2990177A1 (en) * | 2015-06-25 | 2016-12-29 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars), compositions and methods thereof |
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2018
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JP2020524512A (ja) | 2020-08-20 |
EP3641768A4 (en) | 2021-07-07 |
SG11202000555UA (en) | 2020-02-27 |
CA3070578A1 (en) | 2018-12-27 |
WO2018237022A1 (en) | 2018-12-27 |
US20200223918A1 (en) | 2020-07-16 |
CN111247242A (zh) | 2020-06-05 |
AU2018288814A1 (en) | 2020-02-06 |
EP3641768A1 (en) | 2020-04-29 |
JP2023029373A (ja) | 2023-03-03 |
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