SG10202107055SA - Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue - Google Patents
Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissueInfo
- Publication number
- SG10202107055SA SG10202107055SA SG10202107055SA SG10202107055SA SG10202107055SA SG 10202107055S A SG10202107055S A SG 10202107055SA SG 10202107055S A SG10202107055S A SG 10202107055SA SG 10202107055S A SG10202107055S A SG 10202107055SA SG 10202107055S A SG10202107055S A SG 10202107055SA
- Authority
- SG
- Singapore
- Prior art keywords
- proteins
- user
- cross
- defined region
- simultaneous quantification
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6832—Enhancement of hybridisation reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6841—In situ hybridisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/30—Characterised by physical treatment
- C12Q2523/319—Photocleavage, photolysis, photoactivation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/161—Modifications characterised by incorporating target specific and non-target specific sites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2543/00—Reactions characterised by the reaction site, e.g. cell or chromosome
- C12Q2543/10—Reactions characterised by the reaction site, e.g. cell or chromosome the purpose being "in situ" analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Bioinformatics & Computational Biology (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562193819P | 2015-07-17 | 2015-07-17 | |
US201562261654P | 2015-12-01 | 2015-12-01 | |
US201662277283P | 2016-01-11 | 2016-01-11 | |
US201662323018P | 2016-04-15 | 2016-04-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10202107055SA true SG10202107055SA (en) | 2021-08-30 |
Family
ID=56550406
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202107055SA SG10202107055SA (en) | 2015-07-17 | 2016-07-15 | Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue |
Country Status (9)
Country | Link |
---|---|
US (2) | US10501777B2 (ja) |
EP (2) | EP3325649B1 (ja) |
JP (2) | JP6971219B2 (ja) |
KR (1) | KR102545430B1 (ja) |
CN (1) | CN108350483A (ja) |
AU (2) | AU2016297513B2 (ja) |
CA (1) | CA2992480A1 (ja) |
SG (1) | SG10202107055SA (ja) |
WO (1) | WO2017015097A1 (ja) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI2556171T1 (sl) | 2010-04-05 | 2016-03-31 | Prognosys Biosciences, Inc. | Prostorsko kodirane biološke analize |
US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US11021737B2 (en) | 2011-12-22 | 2021-06-01 | President And Fellows Of Harvard College | Compositions and methods for analyte detection |
DK3013983T3 (da) | 2013-06-25 | 2023-03-06 | Prognosys Biosciences Inc | Spatialt kodede biologiske assays ved brug af en mikrofluidisk anordning |
CN107532207B (zh) | 2015-04-10 | 2021-05-07 | 空间转录公司 | 生物样本的空间区别、多重核酸分析 |
AU2016295158B2 (en) | 2015-07-17 | 2021-02-25 | Nanostring Technologies, Inc. | Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue |
CN109415761B (zh) | 2016-04-25 | 2022-09-20 | 哈佛学院董事及会员团体 | 用于原位分子检测的杂交链反应方法 |
EP4050112A1 (en) | 2016-06-21 | 2022-08-31 | 10X Genomics, Inc. | Nucleic acid sequencing |
CN111263819A (zh) | 2017-10-06 | 2020-06-09 | 卡特阿纳公司 | Rna模板化连接 |
US20190249248A1 (en) | 2018-02-12 | 2019-08-15 | Nanostring Technologies, Inc. | Biomolecular probes and methods of detecting gene and protein expression |
AT521238B1 (de) | 2018-05-09 | 2020-02-15 | Lifetaq Analytics Gmbh | In-situ zellanalyse im zellkultursystem |
US20210395805A1 (en) * | 2018-12-04 | 2021-12-23 | Roche Sequencing Solutions, Inc. | Spatially oriented quantum barcoding of cellular targets |
WO2020123319A2 (en) | 2018-12-10 | 2020-06-18 | 10X Genomics, Inc. | Methods of using master / copy arrays for spatial detection |
KR20210121016A (ko) | 2018-12-21 | 2021-10-07 | 나노스트링 테크놀로지스, 인크. | 병리학적 표본의 모바일 디지털 공간 프로파일링을 위한 방법, 장치, 시스템 및 디바이스 |
US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
AU2020282024A1 (en) | 2019-05-31 | 2021-11-11 | 10X Genomics, Inc. | Method of detecting target nucleic acid molecules |
WO2021092433A2 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
EP4219754B1 (en) | 2019-12-23 | 2024-05-15 | 10X Genomics, Inc. | Methods for spatial analysis using rna-templated ligation |
US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
ES2965354T3 (es) | 2020-04-22 | 2024-04-12 | 10X Genomics Inc | Métodos para análisis espacial que usan eliminación de ARN elegido como diana |
WO2021237087A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
WO2021236929A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
EP4162074B1 (en) | 2020-06-08 | 2024-04-24 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
AU2021294334A1 (en) | 2020-06-25 | 2023-02-02 | 10X Genomics, Inc. | Spatial analysis of DNA methylation |
US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
AU2021409136A1 (en) | 2020-12-21 | 2023-06-29 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
EP4092414A1 (en) * | 2021-05-19 | 2022-11-23 | Leica Microsystems CMS GmbH | Connector, marker and method for analysing biological samples |
EP4341671A1 (en) * | 2021-05-19 | 2024-03-27 | Leica Microsystems CMS GmbH | Method for analyzing a biological sample or a chemical compound or a chemical element |
WO2023034489A1 (en) | 2021-09-01 | 2023-03-09 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
EP4220162A3 (en) * | 2022-02-01 | 2023-10-18 | Leica Microsystems CMS GmbH | Connector, connector-label conjugate and marker for analysing biological samples |
EP4328175A1 (en) * | 2022-08-23 | 2024-02-28 | Leica Microsystems CMS GmbH | Method for sequencing |
Family Cites Families (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5320814A (en) | 1991-01-25 | 1994-06-14 | Trustees Of Tufts College | Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample |
US5543838A (en) | 1993-08-31 | 1996-08-06 | Xerox Corporation | Signal multiplexing system for an image sensor array |
US5681697A (en) | 1993-12-08 | 1997-10-28 | Chiron Corporation | Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor |
WO1997007245A1 (en) | 1995-08-14 | 1997-02-27 | Ely Michael Rabani | Methods and devices for parallel multiplex polynucleotide sequencing |
AU7398996A (en) | 1995-10-11 | 1997-04-30 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and method |
US7144119B2 (en) | 1996-04-25 | 2006-12-05 | Bioarray Solutions Ltd. | System and method for programmable illumination pattern generation |
US6387707B1 (en) | 1996-04-25 | 2002-05-14 | Bioarray Solutions | Array Cytometry |
US6416960B1 (en) | 1996-08-08 | 2002-07-09 | Prolume, Ltd. | Detection and visualization of neoplastic tissues and other tissues |
AU5794498A (en) | 1996-12-10 | 1998-07-03 | Genetrace Systems, Inc. | Releasable nonvolatile mass-label molecules |
US20020034737A1 (en) | 1997-03-04 | 2002-03-21 | Hyseq, Inc. | Methods and compositions for detection or quantification of nucleic acid species |
DE69836734D1 (de) | 1997-02-20 | 2007-02-08 | Univ California | Plasmon-schwingteilchen, methode und vorrichtung |
US7115884B1 (en) | 1997-10-06 | 2006-10-03 | Trustees Of Tufts College | Self-encoding fiber optic sensor |
US7348181B2 (en) | 1997-10-06 | 2008-03-25 | Trustees Of Tufts College | Self-encoding sensor with microspheres |
US6632526B1 (en) | 1997-10-14 | 2003-10-14 | Luminex Corporation | Precision fluorescently dyed particles and methods of making and using same |
US6207392B1 (en) | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
JP3662850B2 (ja) | 1998-06-24 | 2005-06-22 | イルミナ インコーポレイテッド | 微小球を有するアレイセンサーのデコード |
GB2342651B (en) | 1998-09-18 | 2001-10-17 | Massachusetts Inst Technology | Biological applications of semiconductor nanocrystals |
AU2206800A (en) | 1998-12-11 | 2000-06-26 | Regents Of The University Of California, The | Targeted molecular bar codes and methods for using the same |
US6429027B1 (en) | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
US6908737B2 (en) | 1999-04-15 | 2005-06-21 | Vitra Bioscience, Inc. | Systems and methods of conducting multiplexed experiments |
US6355431B1 (en) | 1999-04-20 | 2002-03-12 | Illumina, Inc. | Detection of nucleic acid amplification reactions using bead arrays |
WO2000068692A1 (en) | 1999-05-07 | 2000-11-16 | Quantum Dot Corporation | A method of detecting an analyte using semiconductor nanocrystals |
US20020051971A1 (en) | 1999-05-21 | 2002-05-02 | John R. Stuelpnagel | Use of microfluidic systems in the detection of target analytes using microsphere arrays |
WO2001000875A2 (en) | 1999-06-25 | 2001-01-04 | Motorola, Inc. | Novel methods and products for arrayed microsphere analysis |
AU771499B2 (en) | 1999-07-26 | 2004-03-25 | Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The | Layered device with capture regions for cellular analysis |
US7214477B1 (en) | 1999-07-26 | 2007-05-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Layered device with capture regions for cellular analysis |
EP1212599A2 (en) | 1999-08-30 | 2002-06-12 | Illumina, Inc. | Methods for improving signal detection from an array |
US7585632B2 (en) | 1999-10-29 | 2009-09-08 | Hologic, Inc. | Compositions and methods for the detection of a nucleic acid using a cleavage reaction |
AU2922701A (en) | 1999-11-04 | 2001-05-14 | Arcturus Engineering, Inc. | Automated laser capture microdissection |
JP4954415B2 (ja) | 2000-02-10 | 2012-06-13 | イルミナ インコーポレイテッド | 試料のビーズをベースとした同時プロセシングのための基材としての個々のアレイのアレイおよびその製造法 |
US20020028457A1 (en) | 2000-02-16 | 2002-03-07 | Quantum Dot Corporation | Single target counting assays using semiconductor nanocrystals |
JP2004502923A (ja) | 2000-02-22 | 2004-01-29 | ジェノスペクトラ,インコーポレイティド | マイクロアレイの製造方法と製造装置 |
US20030186426A1 (en) | 2000-03-15 | 2003-10-02 | The Regents Of The University Of California | Multichannel flow cell for interacting single optically trapped, DNA molecules with different chemical species |
US6759235B2 (en) | 2000-04-06 | 2004-07-06 | Quantum Dot Corporation | Two-dimensional spectral imaging system |
US20020034827A1 (en) | 2000-08-01 | 2002-03-21 | Rajendra Singh | Methods for solid phase nanoextraction and desorption |
US6777244B2 (en) | 2000-12-06 | 2004-08-17 | Hrl Laboratories, Llc | Compact sensor using microcavity structures |
US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
US20040229294A1 (en) | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB surface receptor complexes as biomarkers |
US20040000519A1 (en) | 2002-06-28 | 2004-01-01 | Postnova Analytics, Inc. | Field-flow fractionation method and apparatus |
US20050048498A1 (en) | 2003-08-29 | 2005-03-03 | Applera Corporation | Compositions, methods, and kits for assembling probes |
US7402399B2 (en) | 2003-10-14 | 2008-07-22 | Monogram Biosciences, Inc. | Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy |
US8637650B2 (en) | 2003-11-05 | 2014-01-28 | Genovoxx Gmbh | Macromolecular nucleotide compounds and methods for using the same |
US7569392B2 (en) | 2004-01-08 | 2009-08-04 | Vanderbilt University | Multiplex spatial profiling of gene expression |
US7295026B2 (en) * | 2005-06-03 | 2007-11-13 | Ut-Battelle, Llc | Automated position control of a surface array relative to a liquid microjunction surface sampler |
ATE520022T1 (de) * | 2005-06-07 | 2011-08-15 | Centre Nat Rech Scient | Verwendung von konjugaten mit mittels photodissoziation oder fragmentation spaltbaren bindern für die massenspektrometrieanalyse von gewebeschnitten |
CN101495650B (zh) | 2005-06-20 | 2015-02-04 | 领先细胞医疗诊断有限公司 | 检测单个细胞中的核酸和鉴定异质大细胞群中罕见细胞的方法 |
GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
WO2007076129A2 (en) | 2005-12-23 | 2007-07-05 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
CA2635215C (en) | 2005-12-23 | 2016-08-30 | Nanostring Technologies, Inc. | Compositions comprising oriented, immobilized macromolecules and methods for their preparation |
WO2007139766A2 (en) | 2006-05-22 | 2007-12-06 | Nanostring Technologies, Inc. | Systems and methods for analyzing nanoreporters |
US8797644B2 (en) * | 2006-08-11 | 2014-08-05 | The Regents Of The University Of California | Capillary-based cell and tissue acquisition system (CTAS) |
US8003312B2 (en) | 2007-02-16 | 2011-08-23 | The Board Of Trustees Of The Leland Stanford Junior University | Multiplex cellular assays using detectable cell barcodes |
US7728287B2 (en) | 2007-03-01 | 2010-06-01 | Lawrence Livermore National Security, Llc | Imaging mass spectrometer with mass tags |
AU2008237018B2 (en) * | 2007-04-10 | 2014-04-03 | Nanostring Technologies, Inc. | Methods and computer systems for identifying target-specific sequences for use in nanoreporters |
US8906700B2 (en) | 2007-11-06 | 2014-12-09 | Ambergen, Inc. | Methods and compositions for phototransfer |
AU2009274115A1 (en) * | 2008-07-21 | 2010-01-28 | Neodiagnostix, Inc. | Methods for the cytological analysis of cervical cells |
EP3162900B1 (en) | 2008-08-14 | 2018-07-18 | Nanostring Technologies, Inc | Stable nanoreporters |
EP2163900A1 (en) | 2008-09-04 | 2010-03-17 | Commissariat A L'energie Atomique | New method of imaging by mass spectrometry and new mass tag associated trityl derivatives |
US8309306B2 (en) | 2008-11-12 | 2012-11-13 | Nodality, Inc. | Detection composition |
DE102008062372B3 (de) | 2008-12-17 | 2010-06-17 | Medizinische Hochschule Hannover | Nachweiskonjugat und Verfahren zur Analyse |
SG172983A1 (en) | 2009-01-15 | 2011-08-29 | Lab Corp America Holdings | Methods of determining patient response by measurement of her-3 |
WO2010115089A2 (en) | 2009-04-03 | 2010-10-07 | University Of Virginia Patent Foundation | Serial multiple antigen colocalization in paraffin-embedded tissue |
WO2011038403A1 (en) * | 2009-09-28 | 2011-03-31 | Yuling Luo | Methods of detecting nucleic acid sequences with high specificity |
JP5954876B2 (ja) * | 2009-10-13 | 2016-07-20 | ナノストリング テクノロジーズ, インコーポレイテッド | ナノレポーターによるタンパク質の検出 |
SI2556171T1 (sl) | 2010-04-05 | 2016-03-31 | Prognosys Biosciences, Inc. | Prostorsko kodirane biološke analize |
ES2687761T3 (es) | 2011-01-31 | 2018-10-29 | F. Hoffmann-La Roche Ag | Métodos de identificación de múltiples epítopos en células |
AU2012255121B2 (en) | 2011-05-17 | 2017-03-09 | Dxterity Diagnostics Incorporated | Methods and compositions for detecting target nucleic acids |
US9637781B2 (en) | 2012-02-14 | 2017-05-02 | The Johns Hopkins University | MiRNA analysis methods |
CN105264088B (zh) | 2012-08-08 | 2018-12-28 | 豪夫迈·罗氏有限公司 | 提高鉴定细胞中的多个表位的动态范围 |
EP4075478A1 (en) | 2012-10-26 | 2022-10-19 | Fluidigm Canada Inc. | Sample and method of sample preparation |
CN104854447B (zh) | 2012-10-26 | 2017-04-26 | 富鲁达加拿大公司 | 通过质谱流式细胞术的样品分析 |
KR101969847B1 (ko) | 2012-10-30 | 2019-04-17 | 삼성전자주식회사 | 동일 검체에서 여러 항원을 검출하기 위한 순차적 다중 면역염색법 |
EP3008201B1 (en) | 2013-06-12 | 2019-08-07 | The General Hospital Corporation | Methods for multiplexed detection of target molecules and uses thereof |
EP3434784A1 (en) | 2013-06-14 | 2019-01-30 | Nanostring Technologies, Inc | Multiplexable tag-based reporter system |
JP6546177B2 (ja) | 2013-09-13 | 2019-07-17 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 質量タグ及び二次イオン質量分析計を用いた組織の多重化イメージング |
US9322051B2 (en) | 2013-10-07 | 2016-04-26 | General Electric Company | Probing of biological samples |
EP3068883B1 (en) | 2013-11-13 | 2020-04-29 | Nugen Technologies, Inc. | Compositions and methods for identification of a duplicate sequencing read |
EP3126512B1 (en) * | 2014-02-26 | 2019-04-17 | Ventana Medical Systems, Inc. | Photo-selective method for biological sample analysis field |
WO2015153464A1 (en) | 2014-04-02 | 2015-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | An apparatus and method for sub-micrometer elemental image analysis by mass spectrometry |
US9909167B2 (en) | 2014-06-23 | 2018-03-06 | The Board Of Trustees Of The Leland Stanford Junior University | On-slide staining by primer extension |
WO2016081740A1 (en) | 2014-11-21 | 2016-05-26 | Nanostring Technologies, Inc. | Enzyme- and amplification-free sequencing |
AU2016295158B2 (en) | 2015-07-17 | 2021-02-25 | Nanostring Technologies, Inc. | Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue |
US10415080B2 (en) | 2016-11-21 | 2019-09-17 | Nanostring Technologies, Inc. | Chemical compositions and methods of using same |
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WO2017015097A1 (en) | 2017-01-26 |
CA2992480A1 (en) | 2017-01-26 |
AU2016297513A1 (en) | 2018-02-15 |
EP3325649B1 (en) | 2024-01-03 |
KR102545430B1 (ko) | 2023-06-19 |
JP6971219B2 (ja) | 2021-11-24 |
CN108350483A (zh) | 2018-07-31 |
US20200040382A1 (en) | 2020-02-06 |
AU2021203155A1 (en) | 2021-06-10 |
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