SG10202012205XA - Triterpene saponin analogues - Google Patents
Triterpene saponin analoguesInfo
- Publication number
- SG10202012205XA SG10202012205XA SG10202012205XA SG10202012205XA SG10202012205XA SG 10202012205X A SG10202012205X A SG 10202012205XA SG 10202012205X A SG10202012205X A SG 10202012205XA SG 10202012205X A SG10202012205X A SG 10202012205XA SG 10202012205X A SG10202012205X A SG 10202012205XA
- Authority
- SG
- Singapore
- Prior art keywords
- triterpene saponin
- saponin analogues
- analogues
- triterpene
- saponin
- Prior art date
Links
- 229930182493 triterpene saponin Natural products 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562252296P | 2015-11-06 | 2015-11-06 | |
| US201562268837P | 2015-12-17 | 2015-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10202012205XA true SG10202012205XA (en) | 2021-01-28 |
Family
ID=58662549
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202012205XA SG10202012205XA (en) | 2015-11-06 | 2016-11-04 | Triterpene saponin analogues |
| SG11201803594TA SG11201803594TA (en) | 2015-11-06 | 2016-11-04 | Triterpene saponin analogues |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201803594TA SG11201803594TA (en) | 2015-11-06 | 2016-11-04 | Triterpene saponin analogues |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US20180327436A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP4001290A1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6900385B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20180077180A (cg-RX-API-DMAC7.html) |
| CN (2) | CN112812143A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016349693B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3003483C (cg-RX-API-DMAC7.html) |
| CL (1) | CL2018001192A1 (cg-RX-API-DMAC7.html) |
| IL (3) | IL286493B (cg-RX-API-DMAC7.html) |
| SG (2) | SG10202012205XA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017079582A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201802891B (cg-RX-API-DMAC7.html) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2950750C (en) * | 2014-05-30 | 2023-01-10 | David Y. Gin | Minimal saponin analogues, synthesis and use thereof |
| EP4001290A1 (en) * | 2015-11-06 | 2022-05-25 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| US20210299237A1 (en) * | 2017-04-13 | 2021-09-30 | Adjuvance Technologies, Inc. | Triterpene saponin synthesis, intermediates and adjuvant combinations |
| WO2018200656A1 (en) * | 2017-04-25 | 2018-11-01 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| US20210283248A1 (en) * | 2017-04-25 | 2021-09-16 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| CN111212846B (zh) * | 2017-10-16 | 2023-05-26 | 佐剂技术公司 | 三萜皂苷类似物 |
| US20230128815A1 (en) * | 2020-03-23 | 2023-04-27 | Adjuvance Technologies, Inc. | Adjuvant compounds, salt forms, and formulations |
| CN115867304A (zh) | 2020-05-19 | 2023-03-28 | 欧萨尔普罗席纳有限公司 | 用于治疗阿兹海默症的多抗原决定基疫苗 |
| AU2021321549A1 (en) | 2020-08-07 | 2023-03-09 | Othair Prothena Limited | Multiepitope vaccine for the treatment of alzheimer's disease |
| WO2023056089A1 (en) | 2021-10-03 | 2023-04-06 | Eisai R&D Management Co., Ltd. | Immunological adjuvant formulations comprising tlr4 agonist e6020 |
| US20250025550A1 (en) * | 2021-11-08 | 2025-01-23 | Adjuvance Technologies, Inc. | Adjuvant compounds and formulations |
| EP4190359A1 (en) | 2021-12-03 | 2023-06-07 | Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE | Saponin-based adjuvants and vaccines |
| WO2023139145A1 (en) | 2022-01-19 | 2023-07-27 | Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune | Saponin-based adjuvants and vaccines |
| CN117106004A (zh) * | 2022-05-17 | 2023-11-24 | 北京科兴中维生物技术有限公司 | 三萜皂苷化合物及其制备方法及应用 |
| WO2024218268A1 (en) | 2023-04-20 | 2024-10-24 | Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune | Saponin derivatives as adjuvants and photoaffinity probes |
| WO2024261351A2 (en) | 2024-05-08 | 2024-12-26 | Vaccine Formulation Institute Ch Ltd. | Immunologically active saponin fractions and adjuvant formulations |
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| WO2016096968A1 (en) | 2014-12-18 | 2016-06-23 | Glaxosmithkline Biologicals S.A. | Vaccination |
| EP4001290A1 (en) | 2015-11-06 | 2022-05-25 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| ES2944947T3 (es) | 2015-12-17 | 2023-06-27 | Memorial Sloan Kettering Cancer Center | Variantes de triterpeno-saponina, métodos de síntesis y uso de las mismas |
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| US20210299237A1 (en) | 2017-04-13 | 2021-09-30 | Adjuvance Technologies, Inc. | Triterpene saponin synthesis, intermediates and adjuvant combinations |
| US20210283248A1 (en) | 2017-04-25 | 2021-09-16 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| WO2018200656A1 (en) | 2017-04-25 | 2018-11-01 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| US20200276299A1 (en) | 2017-09-08 | 2020-09-03 | Infectious Disease Research Institute | Liposomal formulations comprising saponin and methods of use |
| CN111212846B (zh) | 2017-10-16 | 2023-05-26 | 佐剂技术公司 | 三萜皂苷类似物 |
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-
2016
- 2016-11-04 EP EP21210191.9A patent/EP4001290A1/en active Pending
- 2016-11-04 KR KR1020187012783A patent/KR20180077180A/ko not_active Ceased
- 2016-11-04 CN CN202011417416.5A patent/CN112812143A/zh active Pending
- 2016-11-04 SG SG10202012205XA patent/SG10202012205XA/en unknown
- 2016-11-04 IL IL286493A patent/IL286493B/en unknown
- 2016-11-04 CA CA3003483A patent/CA3003483C/en active Active
- 2016-11-04 JP JP2018543061A patent/JP6900385B2/ja active Active
- 2016-11-04 US US15/774,081 patent/US20180327436A1/en not_active Abandoned
- 2016-11-04 WO PCT/US2016/060564 patent/WO2017079582A1/en not_active Ceased
- 2016-11-04 AU AU2016349693A patent/AU2016349693B2/en active Active
- 2016-11-04 EP EP16863057.2A patent/EP3370730A4/en not_active Withdrawn
- 2016-11-04 IL IL293848A patent/IL293848B2/en unknown
- 2016-11-04 CN CN201680078068.9A patent/CN108778289B/zh active Active
- 2016-11-04 SG SG11201803594TA patent/SG11201803594TA/en unknown
-
2018
- 2018-05-03 CL CL2018001192A patent/CL2018001192A1/es unknown
- 2018-05-03 IL IL259145A patent/IL259145B/en unknown
- 2018-05-03 ZA ZA2018/02891A patent/ZA201802891B/en unknown
-
2020
- 2020-03-23 US US16/827,220 patent/US10906926B2/en active Active
- 2020-08-27 US US17/005,110 patent/US20210002316A1/en not_active Abandoned
-
2021
- 2021-06-16 JP JP2021099839A patent/JP2021152043A/ja active Pending
-
2022
- 2022-11-02 JP JP2022176130A patent/JP2023012519A/ja active Pending
-
2023
- 2023-03-08 US US18/180,421 patent/US12037355B2/en active Active
-
2024
- 2024-06-04 US US18/733,207 patent/US20240327443A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016349693B2 (en) | 2022-08-11 |
| US20240327443A1 (en) | 2024-10-03 |
| US20180327436A1 (en) | 2018-11-15 |
| SG11201803594TA (en) | 2018-05-30 |
| JP2021152043A (ja) | 2021-09-30 |
| AU2016349693A1 (en) | 2018-05-17 |
| US10906926B2 (en) | 2021-02-02 |
| CN108778289A (zh) | 2018-11-09 |
| US20210002316A1 (en) | 2021-01-07 |
| ZA201802891B (en) | 2020-01-29 |
| WO2017079582A1 (en) | 2017-05-11 |
| IL259145B (en) | 2021-09-30 |
| IL286493B (en) | 2022-07-01 |
| IL293848A (en) | 2022-08-01 |
| CA3003483C (en) | 2022-09-13 |
| CN108778289B (zh) | 2020-11-17 |
| CL2018001192A1 (es) | 2018-11-23 |
| JP2018537527A (ja) | 2018-12-20 |
| JP6900385B2 (ja) | 2021-07-07 |
| KR20180077180A (ko) | 2018-07-06 |
| IL293848B2 (en) | 2025-02-01 |
| EP3370730A1 (en) | 2018-09-12 |
| IL259145A (en) | 2018-06-28 |
| IL293848B1 (en) | 2024-10-01 |
| US20230219991A1 (en) | 2023-07-13 |
| JP2023012519A (ja) | 2023-01-25 |
| US20200239509A1 (en) | 2020-07-30 |
| IL286493A (en) | 2021-10-31 |
| CN112812143A (zh) | 2021-05-18 |
| CA3003483A1 (en) | 2017-05-11 |
| US12037355B2 (en) | 2024-07-16 |
| EP4001290A1 (en) | 2022-05-25 |
| EP3370730A4 (en) | 2019-07-31 |
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