SG10202002593SA - Activated bifidobacteria and methods of use thereof - Google Patents

Activated bifidobacteria and methods of use thereof

Info

Publication number
SG10202002593SA
SG10202002593SA SG10202002593SA SG10202002593SA SG10202002593SA SG 10202002593S A SG10202002593S A SG 10202002593SA SG 10202002593S A SG10202002593S A SG 10202002593SA SG 10202002593S A SG10202002593S A SG 10202002593SA SG 10202002593S A SG10202002593S A SG 10202002593SA
Authority
SG
Singapore
Prior art keywords
methods
activated bifidobacteria
bifidobacteria
activated
Prior art date
Application number
SG10202002593SA
Other languages
English (en)
Inventor
David Kyle
David Mills
Samara Freeman-Sharkey
Original Assignee
Evolve Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55761664&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10202002593S(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Evolve Biosystems Inc filed Critical Evolve Biosystems Inc
Publication of SG10202002593SA publication Critical patent/SG10202002593SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/51—Bifidobacterium
    • A23V2400/529—Infantis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG10202002593SA 2014-10-24 2015-10-23 Activated bifidobacteria and methods of use thereof SG10202002593SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462068553P 2014-10-24 2014-10-24
US201562133243P 2015-03-13 2015-03-13

Publications (1)

Publication Number Publication Date
SG10202002593SA true SG10202002593SA (en) 2020-05-28

Family

ID=55761664

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202002593SA SG10202002593SA (en) 2014-10-24 2015-10-23 Activated bifidobacteria and methods of use thereof
SG11201703298SA SG11201703298SA (en) 2014-10-24 2015-10-23 Activated bifidobacteria and methods of use thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201703298SA SG11201703298SA (en) 2014-10-24 2015-10-23 Activated bifidobacteria and methods of use thereof

Country Status (10)

Country Link
US (2) US10716816B2 (fr)
EP (1) EP3209308B1 (fr)
CN (2) CN107249611A (fr)
AU (2) AU2015335601A1 (fr)
BR (1) BR112017008284A8 (fr)
CA (1) CA2965663C (fr)
DK (1) DK3209308T3 (fr)
MX (1) MX2017005260A (fr)
SG (2) SG10202002593SA (fr)
WO (1) WO2016065324A1 (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201112091D0 (en) 2011-07-14 2011-08-31 Gt Biolog Ltd Bacterial strains isolated from pigs
GB201117313D0 (en) 2011-10-07 2011-11-16 Gt Biolog Ltd Bacterium for use in medicine
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
CN107249611A (zh) 2014-10-24 2017-10-13 进化生物系统股份有限公司 活化的双歧杆菌及其应用方法
SG10201903823QA (en) 2014-10-31 2019-05-30 Whole Biome Inc Methods and compositions relating to microbial treatment and diagnosis of disorders
EP3400953A1 (fr) 2014-12-23 2018-11-14 4D Pharma Research Limited Polypeptide pirin et modulation immunitaire
KR102523805B1 (ko) 2014-12-23 2023-04-20 4디 파마 리서치 리미티드 면역 조정
RU2731154C2 (ru) * 2015-03-05 2020-08-31 Сосьете Де Продюи Нестле С.А. Композиция для применения в улучшении консистенции или частоты стула у младенцев или детей младшего возраста
BR112017019468A2 (pt) * 2015-03-13 2018-05-15 Evolve Biosystems Inc composições que metabolizam ou sequestram monômeros de açúcar livres e seus usos
MA41010B1 (fr) 2015-06-15 2020-01-31 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
MA41060B1 (fr) 2015-06-15 2019-11-29 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
DK3206700T3 (da) 2015-06-15 2019-08-05 4D Pharma Res Ltd Sammensætninger omfattende bakteriestammer
PT3240554T (pt) 2015-06-15 2019-11-04 4D Pharma Res Ltd Blautia stercosis e wexlerae para uso no tratamento de doenças inflamatórias e autoimunes
PT3307288T (pt) 2015-06-15 2019-10-17 4D Pharma Res Ltd Composições compreendendo estirpes bacterianas
GB201520497D0 (en) 2015-11-20 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
KR101914245B1 (ko) 2015-11-20 2018-11-02 4디 파마 리서치 리미티드 박테리아성 균주를 함유한 조성물
GB201520638D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520631D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201612191D0 (en) 2016-07-13 2016-08-24 4D Pharma Plc Compositions comprising bacterial strains
MA42560B1 (fr) 2016-03-04 2019-07-31 4D Pharma Plc Compositions comprenant des souches bactériennes de blautia pour le traitement de l'hypersensibilité viscérale
WO2017156550A1 (fr) * 2016-03-11 2017-09-14 Evolve Biosystems Inc. Un microorganisme commensal transitoire pour améliorer la santé intestinale
AU2017290900A1 (en) 2016-07-01 2019-01-17 Infinant Health, Inc Method for facilitating maturation of the mammalian immune system
TW201821093A (zh) 2016-07-13 2018-06-16 英商４Ｄ製藥有限公司 包含細菌菌株之組合物
GB201621123D0 (en) 2016-12-12 2017-01-25 4D Pharma Plc Compositions comprising bacterial strains
TW201907928A (zh) 2017-05-22 2019-03-01 英商4D製藥研究有限公司 包含細菌品系之組成物
MA41708A (fr) 2017-05-24 2020-04-08 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
ES2841902T3 (es) 2017-06-14 2021-07-12 4D Pharma Res Ltd Composiciones que comprenden cepas bacterianas
MA49425A (fr) 2017-06-14 2020-04-22 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
CN107365705B (zh) * 2017-07-14 2021-01-12 江苏微康生物科技有限公司 一种油溶性益生菌冻干菌粉的冻干保护剂及其应用
WO2019046646A1 (fr) 2017-08-30 2019-03-07 Whole Biome Inc. Methodes et compositions pour le traitement de troubles associés au microbiome
CN111587376A (zh) * 2017-09-13 2020-08-25 进化生物系统股份有限公司 哺乳动物婴儿的代谢组学修正
WO2019143871A1 (fr) 2018-01-17 2019-07-25 Evolve Biosystems, Inc. Activation de voies d'oligosaccharides exprimées de manière conditionnelle pendant la fermentation de souches probiotiques
CN113164532A (zh) * 2018-05-30 2021-07-23 进化生物系统股份有限公司 H5功能性长双歧杆菌婴儿亚种的组合物和使用方法
US20210308196A1 (en) * 2018-06-01 2021-10-07 Evolve Biosystems, Inc. Compositions and methods to promote host defense and stimulate, expand, and/or reset t cell repertoires
WO2019246316A1 (fr) * 2018-06-19 2019-12-26 Evolve Biosystems, Inc. Oligosides innovants utilisables dans des applications prébiotiques
US20230133446A1 (en) * 2020-03-20 2023-05-04 Glycom A/S Methods for providing a solid hmo product, and solid hmo products obtained thereby
CN111826324A (zh) * 2020-08-05 2020-10-27 厦门惠盈动物科技有限公司 一种鼠李糖乳杆菌菌粉的制备方法
CN114568516A (zh) * 2020-11-30 2022-06-03 内蒙古伊利实业集团股份有限公司 包含长双歧杆菌婴儿亚种与母乳低聚糖的组合物及其应用
CN114568520A (zh) * 2020-11-30 2022-06-03 内蒙古伊利实业集团股份有限公司 包含长双歧杆菌婴儿亚种的婴幼儿配方粉及其应用
CN116615203A (zh) 2020-12-11 2023-08-18 帝斯曼知识产权资产管理有限公司 改进的益生元制剂
IT202100024911A1 (it) * 2021-09-29 2023-03-29 Univ Degli Studi Di Napoli Federico Ii Dipartimento Di Fisica Ettore Pancini Prebiotico a base di "scotta" delattosata per la prevenzione e gestione della disbiosi intestinale

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716615A (en) 1992-02-10 1998-02-10 Renata Maria Anna Cavaliere Vesely Dietary and pharmaceutical compositions containing lyophilized lactic bacteria, their preparation and use
RU2180915C1 (ru) 2001-04-28 2002-03-27 Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского Консорциум бифидобактерий и лактобацилл, используемый для приготовления бактериальных препаратов, заквасок для кисломолочных продуктов, ферментированных и неферментированных пищевых продуктов, биологически активных добавок, предназначенных для коррекции микрофлоры детей в возрасте до 3-х лет
PL1675481T3 (pl) * 2003-10-24 2009-03-31 Nutricia Nv Kompozycja synbiotyczna dla niemowląt
US20070082087A1 (en) * 2005-10-06 2007-04-12 Schweitzer Biotech Company Ltd. Fermented milk products containing bifidobacterium longum and isomalto oligosaccharide and the process for producing the same
EP1776877A1 (fr) * 2005-10-21 2007-04-25 N.V. Nutricia Méthode de stimulation de la flore intestinale
CA2690058A1 (fr) 2006-06-09 2007-12-13 9205-5961 Quebec Inc. Compositions probiotiques derivees de produits laitiers et leurs utilisations
US8361756B2 (en) * 2006-09-15 2013-01-29 The Regents Of The University Of California Bifidobacterial gene sequences and their use
US8197872B2 (en) 2007-05-17 2012-06-12 The Regents Of The University Of California Human milk oligosaccharides to promote growth of beneficial gut bacteria
WO2008153377A1 (fr) * 2007-06-15 2008-12-18 N.V. Nutricia Nutrition avec une bifidobactérie non viable et un oligosaccharide non digestible
EP2072052A1 (fr) * 2007-12-17 2009-06-24 Nestec S.A. Prévention d'infections opportunistes dans des sujets dont l'immunité est fragilisée
UA32462U (uk) 2008-02-14 2008-05-12 Харьковский Национальный Медицинский Университет Спосіб оцінки ефективності корекції порушень мікробіоценозу кишечнику у дітей молодшого віку з атопічним дерматитом
CA2658440C (fr) * 2008-04-04 2016-08-23 Kraft Foods Global Brands Llc Composition laitiere comprenant des probiotiques et un agent antimicrobien
US20110064707A1 (en) 2008-05-27 2011-03-17 Nestec S.A. Probiotics to improve gut microbiota
EP2143341A1 (fr) * 2008-07-08 2010-01-13 Nestec S.A. Composition nutritionnelle contenant un mélange d'oligosaccharides
RU2570557C2 (ru) 2008-11-11 2015-12-10 Алиментари Хелс Лимитед ПРОБИОТИЧЕСКАЯ БИФИДОБАКТЕРИЯ Bifidobacterium Longum
US8927027B2 (en) 2008-12-02 2015-01-06 Prolacta Bioscience Human milk permeate compositions and methods of making and using same
US9649380B2 (en) 2009-01-12 2017-05-16 Pfizer Italia S.R.L. Compositions comprising probiotic and prebiotic components and mineral salts, with lactoferrin
US8198872B2 (en) 2009-03-10 2012-06-12 Honeywell International, Inc. Starter-generator with improved excitation
US7888062B1 (en) * 2010-02-01 2011-02-15 Microbios, Inc. Process and composition for the manufacture of a microbial-based product
MX2012009306A (es) 2010-02-19 2012-09-12 Glycom As Produccion de 6'-o-sialil-lactosa y compuestos intermedios.
EP3369739A1 (fr) 2010-07-12 2018-09-05 The Regents of The University of California Oligosaccharides du lait de vache
EP2465507A1 (fr) * 2010-11-23 2012-06-20 Nestec S.A. Composition comportant des oligosaccharides pour le traitement des maladies de la peau
EP2465509A1 (fr) 2010-11-23 2012-06-20 Nestec S.A. Composition comprenant des oligosaccharides pour le traitement des infections des voies respiratoires aiguës
EP2454948A1 (fr) * 2010-11-23 2012-05-23 Nestec S.A. Mélange oligosaccharide et produit alimentaire comportant ce mélange, spécialement une formule pour enfants
SG191798A1 (en) * 2010-12-31 2013-08-30 Abbott Lab Synbiotic combination of probiotic and human milk oligosaccharides to promote growth of beneficial microbiota
CN104126749A (zh) * 2011-02-10 2014-11-05 雀巢产品技术援助有限公司 使用人乳中发现的特定量的寡糖的组合调节双歧杆菌属的生长
US9579353B2 (en) 2011-06-10 2017-02-28 Prothera, Inc. Pharmaceutical compositions containing pediococcus and methods for reducing the symptoms of gastroenterological syndromes
EP3502123B1 (fr) * 2012-02-14 2021-10-13 The Regents Of The University Of California Une composition comprenant des n-glycans libres ou des protéines déglycosylées
US10165788B2 (en) 2013-06-17 2019-01-01 The Regents Of The University Of California Methods and compositions for improved digestion of milk oligosaccharides
CN107249611A (zh) 2014-10-24 2017-10-13 进化生物系统股份有限公司 活化的双歧杆菌及其应用方法
ES2862176T3 (es) 2014-12-12 2021-10-07 Univ California Reducción de los glucanos de la leche y sus productos de degradación en el intestino del recién nacido

Also Published As

Publication number Publication date
EP3209308A1 (fr) 2017-08-30
MX2017005260A (es) 2018-01-30
BR112017008284A8 (pt) 2023-04-11
SG11201703298SA (en) 2017-05-30
AU2021204822A1 (en) 2021-08-05
CA2965663A1 (fr) 2016-04-28
CN114376234A (zh) 2022-04-22
WO2016065324A1 (fr) 2016-04-28
AU2015335601A1 (en) 2017-06-01
EP3209308A4 (fr) 2018-06-27
BR112017008284A2 (pt) 2017-12-19
US10716816B2 (en) 2020-07-21
US20170304375A1 (en) 2017-10-26
US20200397837A1 (en) 2020-12-24
CA2965663C (fr) 2023-04-04
DK3209308T3 (da) 2022-10-03
CN107249611A (zh) 2017-10-13
EP3209308B1 (fr) 2022-08-03

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