SG10201913507SA - Compositions and methods related to engineered fc constructs - Google Patents
Compositions and methods related to engineered fc constructsInfo
- Publication number
- SG10201913507SA SG10201913507SA SG10201913507SA SG10201913507SA SG10201913507SA SG 10201913507S A SG10201913507S A SG 10201913507SA SG 10201913507S A SG10201913507S A SG 10201913507SA SG 10201913507S A SG10201913507S A SG 10201913507SA SG 10201913507S A SG10201913507S A SG 10201913507SA
- Authority
- SG
- Singapore
- Prior art keywords
- engineered
- constructs
- compositions
- methods related
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Mycology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461987863P | 2014-05-02 | 2014-05-02 | |
| US201462081923P | 2014-11-19 | 2014-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201913507SA true SG10201913507SA (en) | 2020-02-27 |
Family
ID=54359511
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201607070VA SG11201607070VA (en) | 2014-05-02 | 2015-05-01 | Compositions and methods related to engineered fc constructs |
| SG10201913507SA SG10201913507SA (en) | 2014-05-02 | 2015-05-01 | Compositions and methods related to engineered fc constructs |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201607070VA SG11201607070VA (en) | 2014-05-02 | 2015-05-01 | Compositions and methods related to engineered fc constructs |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10239944B2 (fr) |
| EP (2) | EP3137506B1 (fr) |
| JP (3) | JP2017518965A (fr) |
| KR (1) | KR102546875B1 (fr) |
| CN (2) | CN113501880A (fr) |
| AU (2) | AU2015252866B2 (fr) |
| BR (1) | BR112016024780A2 (fr) |
| CA (1) | CA2941072A1 (fr) |
| DK (1) | DK3137506T3 (fr) |
| ES (1) | ES2962694T3 (fr) |
| IL (3) | IL286367B2 (fr) |
| PL (1) | PL3137506T3 (fr) |
| SG (2) | SG11201607070VA (fr) |
| WO (1) | WO2015168643A2 (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201606597QA (en) | 2014-03-05 | 2016-09-29 | Ucb Biopharma Sprl | Multimeric fc proteins |
| SG11201607070VA (en) | 2014-05-02 | 2016-11-29 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| WO2017059276A2 (fr) | 2015-10-02 | 2017-04-06 | Momenta Pharmaceuticals, Inc. | Procédés thérapeutiques et diagnostiques pour des maladies autoimmunes et/ou des inflammations |
| EP3423572B1 (fr) * | 2016-03-02 | 2023-11-29 | Momenta Pharmaceuticals, Inc. | Procédés se rapportant à des constructions fc génétiquement modifiées |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| JP7101621B2 (ja) | 2016-05-20 | 2022-07-15 | ハープーン セラピューティクス，インク． | 単一ドメイン血清アルブミン結合タンパク質 |
| CN109963869A (zh) | 2016-05-23 | 2019-07-02 | 动量制药公司 | 与经改造的Fc构建体相关的组合物和方法 |
| EP3464347B1 (fr) | 2016-06-07 | 2023-05-31 | Gliknik Inc. | Stradomères optimisés par la cystéine |
| CN109476763B (zh) * | 2016-07-19 | 2023-11-07 | 伊班绰斯有限责任公司 | 双特异性蛋白质及其制备方法 |
| CN109641048A (zh) | 2016-07-22 | 2019-04-16 | 格利克尼克股份有限公司 | 产生具有增强的Fc受体结合的经有序多聚化的免疫球蛋白Fc组合物的人蛋白片段的融合蛋白 |
| BR112019009495A2 (pt) * | 2016-12-09 | 2019-08-06 | Gliknik Inc | métodos de tratamento de distúrbios inflamatórios com compostos de fc multivalentes |
| CN110177802A (zh) | 2016-12-09 | 2019-08-27 | 格利克尼克股份有限公司 | 多聚化stradomer GL-2045的制造优化 |
| AU2018205272A1 (en) * | 2017-01-06 | 2019-07-25 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered Fc-antigen binding domain constructs |
| BR112019013955A2 (pt) | 2017-01-06 | 2020-02-11 | Momenta Pharmaceuticals, Inc. | Composições e métodos relacionados a construtos de fc manipulados |
| EP3589662A4 (fr) * | 2017-02-28 | 2020-12-30 | Harpoon Therapeutics, Inc. | Protéine monovalente inductible de fixation d' antigène |
| AU2018265856B2 (en) | 2017-05-12 | 2023-04-27 | Harpoon Therapeutics, Inc. | Mesothelin binding proteins |
| MX2019014480A (es) | 2017-06-02 | 2020-01-23 | Pfizer | Proteinas recombinantes robo2, composiciones, metodos y usos de las mismas. |
| AU2018302343B2 (en) * | 2017-07-21 | 2020-11-26 | Trianni, Inc. | Single chain vh and heavy chain antibodies |
| EP3665202A1 (fr) | 2017-08-09 | 2020-06-17 | Massachusetts Institute Of Technology | Conjugués peptidiques de liaison à l'albumine et leurs procédés |
| SG11202003341UA (en) | 2017-10-13 | 2020-05-28 | Harpoon Therapeutics Inc | B cell maturation antigen binding proteins |
| EP3715377A4 (fr) * | 2017-11-20 | 2021-06-02 | Taizhou Mabtech Pharmaceutical Co., Ltd | Protéine de fusion bifonctionnelle ciblant cd47 et pd-l1 |
| US20210147549A1 (en) * | 2018-07-11 | 2021-05-20 | Momenta Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS RELATED TO ENGINEERED Fc-ANTIGEN BINDING DOMAIN CONSTRUCTS TARGETED TO PD-L1 |
| WO2020014542A2 (fr) * | 2018-07-11 | 2020-01-16 | Momenta Pharmaceuticals, Inc. | Compositions et procédés associés à des constructions de domaine de liaison à un antigène fc technologique |
| WO2020014505A2 (fr) * | 2018-07-11 | 2020-01-16 | Momenta Pharmaceuticals, Inc. | Compositions et procédés associés à des constructions de domaine de liaison à un antigène fc technologique |
| CN113164591A (zh) * | 2018-07-11 | 2021-07-23 | 动量制药公司 | 与工程化Fc-抗原结合结构域构建体有关的组合物和方法 |
| US10815311B2 (en) | 2018-09-25 | 2020-10-27 | Harpoon Therapeutics, Inc. | DLL3 binding proteins and methods of use |
| BR112021025426A2 (pt) * | 2019-06-19 | 2022-06-21 | Bioverativ Therapeutics Inc | Fator recombinante viii-fc para tratamento de hemofilia e baixa densidade mineral óssea |
| US20220332847A1 (en) | 2019-09-13 | 2022-10-20 | CSL Behring Lengnau AG | RECOMBINANT IgG Fc MULTIMERS FOR THE TREATMENT OF IMMUNE COMPLEX-MEDIATED KIDNEY DISORDERS |
| AU2020394844A1 (en) | 2019-12-06 | 2022-06-30 | CSL Behring Lengnau AG | Stable compositions of Fc multimers |
| US20240132624A1 (en) | 2022-07-27 | 2024-04-25 | Ablynx N.V. | Polypeptides binding to a specific epitope of the neonatal fc receptor |
| WO2024094119A1 (fr) * | 2022-11-02 | 2024-05-10 | 北京昌平实验室 | Protéine de fusion et son utilisation |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2556219B1 (fr) | 1983-12-07 | 1987-06-26 | Merieux Inst | Nouveau medicament immunomodulateur, a base de fragments fc d'igg humaines |
| US5426641A (en) | 1994-01-28 | 1995-06-20 | Bell Communications Research, Inc. | Adaptive class AB amplifier for TDMA wireless communications systems |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| AU3804397A (en) | 1996-06-14 | 1998-01-07 | Smithkline Beecham Corporation | Hexameric fusion proteins and uses therefor |
| US20090074839A1 (en) | 1997-01-22 | 2009-03-19 | Marton Milankovits | Pharmaceutical Compositions Primarily for the Treatment and Prevention of Genitourinary Infections and their Extragenital Complications |
| US20020062010A1 (en) * | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US7951917B1 (en) | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US7608681B2 (en) * | 1999-12-24 | 2009-10-27 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| US20050089932A1 (en) | 2001-04-26 | 2005-04-28 | Avidia Research Institute | Novel proteins with targeted binding |
| EP1697520A2 (fr) | 2003-12-22 | 2006-09-06 | Xencor, Inc. | Polypeptides fc a nouveaux sites de liaison de ligands fc |
| WO2006031994A2 (fr) * | 2004-09-14 | 2006-03-23 | Xencor, Inc. | Domaines fc monomeres des immunoglobulines |
| ES2592271T3 (es) | 2005-03-31 | 2016-11-29 | Chugai Seiyaku Kabushiki Kaisha | Métodos de producción de polipéptidos mediante la regulación de la asociación de los polipéptidos |
| US8354109B2 (en) * | 2005-12-13 | 2013-01-15 | Suppremol Gmbh | Multimeric Fc receptor polypeptides |
| GB0614780D0 (en) | 2006-07-25 | 2006-09-06 | Ucb Sa | Biological products |
| CA2667678A1 (fr) | 2006-10-25 | 2008-07-24 | Amgen Inc. | Agents therapeutiques a base de peptides toxiques |
| BRPI0620639A2 (pt) | 2006-12-21 | 2011-11-22 | Micromet Ag | anticorpos de cadeia simples biespecìficos e composição farmacêutica compreendendo os mesmos |
| US20080260738A1 (en) | 2007-04-18 | 2008-10-23 | Moore Margaret D | Single chain fc, methods of making and methods of treatment |
| CN101802197A (zh) | 2007-05-14 | 2010-08-11 | 比奥根艾迪克Ma公司 | 单链FC（ScFc）区、包含其的结合多肽及与其相关的方法 |
| CN107011445B (zh) | 2007-06-01 | 2021-06-29 | 马里兰大学巴尔的摩分校 | 免疫球蛋白恒定区Fc受体结合剂 |
| EP2235064B1 (fr) * | 2008-01-07 | 2015-11-25 | Amgen Inc. | Méthode de fabrication de molécules hétérodimères fc d'anticorps utilisant les effets de conduite électrostatique |
| CN102333540B (zh) | 2008-10-06 | 2015-04-22 | 芝加哥大学 | 与细菌eap、emp和/或adsa蛋白相关的组合物和方法 |
| WO2010065578A2 (fr) | 2008-12-04 | 2010-06-10 | Leukosight Inc. | Polypeptides comprenant des fragments fc de l'immunoglobuline g (igg) et leurs procédés d'utilisation |
| ES2550384T3 (es) | 2008-12-18 | 2015-11-06 | Dana-Farber Cancer Institute, Inc. | NKG2D-Fc para la inmunoterapia |
| MX2011007833A (es) | 2009-01-23 | 2011-10-06 | Biogen Idec Inc | Polipeptidos fc estabilizados con funcion efectora reducida y metodos de uso. |
| EP2432451A2 (fr) | 2009-05-20 | 2012-03-28 | Children's Medical Center Corporation | Compositions pour le traitement du cancer metastatique et leurs procedes d'utilisation |
| US8858948B2 (en) | 2009-05-20 | 2014-10-14 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| WO2011034605A2 (fr) | 2009-09-16 | 2011-03-24 | Genentech, Inc. | Complexes protéiques contenant une super-hélice et/ou une attache et leurs utilisations |
| WO2011044368A1 (fr) | 2009-10-07 | 2011-04-14 | Macrogenics, Inc. | Polypeptides contenant une région fc qui présentent une fonction d'effecteur améliorée due à des modifications de l'étendue de la fucosylation, et leurs méthodes d'utilisation |
| WO2011063348A1 (fr) | 2009-11-23 | 2011-05-26 | Amgen Inc. | Anticorps monomère fc |
| GB0922209D0 (en) | 2009-12-18 | 2010-02-03 | Univ Nottingham | Proteins, nucleic acid molecules and compositions |
| US8691771B2 (en) | 2010-05-21 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Bi-specific fusion proteins for tissue repair |
| PL2591006T3 (pl) | 2010-07-09 | 2019-10-31 | Bioverativ Therapeutics Inc | Przetwarzalne cząsteczki jednołańcuchowe i polipeptydy wytworzone przy ich zastosowaniu |
| DK2598533T3 (en) * | 2010-07-28 | 2019-04-23 | Gliknik Inc | Fusion proteins of natural human protein fragments to create in an orderly fashion multimerized immunoglobulin FC compositions |
| EP2603526A1 (fr) | 2010-08-13 | 2013-06-19 | Medimmune Limited | Polypeptides monomères comprenant des régions du variant fc et procédés d'utilisation de ceux-ci |
| BR112013011811A2 (pt) | 2010-11-05 | 2023-02-23 | Zymeworks Inc | Modelo de anticorpo heterodimérico estável com mutações no domínio fc |
| US9624291B2 (en) | 2011-03-17 | 2017-04-18 | Ramot At Tel-Aviv University Ltd. | Bi- and monospecific, asymmetric antibodies and methods of generating the same |
| EP2688909A2 (fr) | 2011-03-25 | 2014-01-29 | Glenmark Pharmaceuticals S.A. | Immunoglobulines hétéro-dimériques |
| CA2899433A1 (fr) * | 2012-01-27 | 2013-08-01 | Gliknik Inc. | Proteines de fusion comprenant des domaines charnieres igg2 |
| CA2875246A1 (fr) | 2012-06-08 | 2013-12-12 | Biogen Idec Ma Inc. | Composes pro-coagulants |
| EP2863954A1 (fr) | 2012-06-21 | 2015-04-29 | Indiana University Research and Technology Corporation | Polypeptides de fusion de région fc de polypeptide ligand du récepteur d'incrétine et conjugués à fonction effectrice fc modifiée |
| BR112015003459A2 (pt) * | 2012-08-20 | 2017-09-26 | Gliknik Inc | moléculas com atividade de ligação ao antígeno e de ligação ao receptor fc gama polivalente |
| CN104870055A (zh) * | 2012-10-17 | 2015-08-26 | 利物浦热带医学院 | 免疫调节蛋白 |
| CN104558194B (zh) | 2013-10-17 | 2018-04-27 | 泰州迈博太科药业有限公司 | 一类抗CD20-Flex双功能融合蛋白、其制备方法及用途 |
| EP3082847A1 (fr) | 2013-12-20 | 2016-10-26 | Indiana University Research and Technology Corporation | Polypeptides de fusion ligand lipidé du récepteur de l'incrétine - région fc d'immunoglobuline humaine |
| MX2016008539A (es) | 2014-01-15 | 2016-09-26 | Hoffmann La Roche | Variantes de region fc con propiedades de union a receptor fc neonatal (fcrn) modificadas y de union a proteina a mantenidas. |
| BR112016016411A2 (pt) | 2014-01-15 | 2017-10-03 | Hoffmann La Roche | VARIANTES DE REGIÕES-"Fc" COM PROPRIEDADES DE LIGAÇÃO DE "FcRn" MODIFICADAS |
| SG11201606597QA (en) | 2014-03-05 | 2016-09-29 | Ucb Biopharma Sprl | Multimeric fc proteins |
| WO2015132365A1 (fr) | 2014-03-05 | 2015-09-11 | Ucb Biopharma Sprl | Protéines fc multimères |
| SG11201607070VA (en) * | 2014-05-02 | 2016-11-29 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| SG10201913324PA (en) | 2014-05-29 | 2020-03-30 | Macrogenics Inc | Tri-specific binding molecules and methods of use thereof |
| EP3423572B1 (fr) | 2016-03-02 | 2023-11-29 | Momenta Pharmaceuticals, Inc. | Procédés se rapportant à des constructions fc génétiquement modifiées |
| CN109963869A (zh) | 2016-05-23 | 2019-07-02 | 动量制药公司 | 与经改造的Fc构建体相关的组合物和方法 |
| BR112019013955A2 (pt) | 2017-01-06 | 2020-02-11 | Momenta Pharmaceuticals, Inc. | Composições e métodos relacionados a construtos de fc manipulados |
-
2015
- 2015-05-01 SG SG11201607070VA patent/SG11201607070VA/en unknown
- 2015-05-01 SG SG10201913507SA patent/SG10201913507SA/en unknown
- 2015-05-01 EP EP15785583.4A patent/EP3137506B1/fr active Active
- 2015-05-01 CN CN202110761899.9A patent/CN113501880A/zh active Pending
- 2015-05-01 BR BR112016024780A patent/BR112016024780A2/pt active Search and Examination
- 2015-05-01 IL IL286367A patent/IL286367B2/en unknown
- 2015-05-01 JP JP2016564612A patent/JP2017518965A/ja active Pending
- 2015-05-01 CA CA2941072A patent/CA2941072A1/fr active Pending
- 2015-05-01 KR KR1020167029772A patent/KR102546875B1/ko active IP Right Grant
- 2015-05-01 PL PL15785583.4T patent/PL3137506T3/pl unknown
- 2015-05-01 WO PCT/US2015/028926 patent/WO2015168643A2/fr active Application Filing
- 2015-05-01 ES ES15785583T patent/ES2962694T3/es active Active
- 2015-05-01 EP EP23193565.1A patent/EP4299595A3/fr active Pending
- 2015-05-01 AU AU2015252866A patent/AU2015252866B2/en active Active
- 2015-05-01 CN CN201580020385.0A patent/CN106661125B/zh active Active
- 2015-05-01 DK DK15785583.4T patent/DK3137506T3/da active
-
2016
- 2016-04-28 US US15/141,413 patent/US10239944B2/en active Active
- 2016-08-23 IL IL247442A patent/IL247442B/en active IP Right Grant
-
2019
- 2019-03-25 US US16/363,846 patent/US11124573B2/en active Active
-
2020
- 2020-05-14 JP JP2020084900A patent/JP2020128415A/ja active Pending
- 2020-05-18 IL IL274735A patent/IL274735B/en unknown
-
2021
- 2021-04-27 AU AU2021202578A patent/AU2021202578A1/en active Pending
- 2021-08-20 US US17/407,814 patent/US20220033499A1/en active Pending
-
2022
- 2022-04-14 JP JP2022066669A patent/JP2022095892A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL286367A (en) | Compositions and methods relating to engineered fc constructs | |
| IL263213A (en) | Compositions and methods relating to engineered fc constructs | |
| HK1247238B (zh) | 改造的crispr-cas9組合物和使用方法 | |
| GB2535253B (en) | Compositions and methods | |
| ZA201702794B (en) | Cellulose-containing compositions and methods of making same | |
| IL250568A0 (en) | Anti-methanogenic preparations and their uses | |
| EP3423572A4 (fr) | Procédés se rapportant à des constructions fc génétiquement modifiées | |
| ZA201701909B (en) | Trichoderma compositions and methods of use | |
| GB201417828D0 (en) | New methods and compositions | |
| IL246879B (en) | Preparations of Epilimod and methods of using them | |
| SG10202107391YA (en) | Compositions and methods related to engineered fc constructs | |
| SG11201607736UA (en) | Engineered chimeric pegylated adi and methods of use | |
| IL234929B (en) | Preparations containing liposomes and their use to prevent infections | |
| HK1243404A1 (zh) | 色酰胺組合物和使用方法 | |
| GB201421430D0 (en) | Antibodies to Adam17 and uses thereof | |
| GB201402915D0 (en) | Compositions and methods | |
| GB201403212D0 (en) | Compositions and methods |