SG10201913073YA - Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment - Google Patents
Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatmentInfo
- Publication number
- SG10201913073YA SG10201913073YA SG10201913073YA SG10201913073YA SG10201913073YA SG 10201913073Y A SG10201913073Y A SG 10201913073YA SG 10201913073Y A SG10201913073Y A SG 10201913073YA SG 10201913073Y A SG10201913073Y A SG 10201913073YA SG 10201913073Y A SG10201913073Y A SG 10201913073YA
- Authority
- SG
- Singapore
- Prior art keywords
- combination therapy
- cancer treatment
- parp inhibitor
- liposomal irinotecan
- irinotecan
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/04—Nitro compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562207760P | 2015-08-20 | 2015-08-20 | |
US201562207709P | 2015-08-20 | 2015-08-20 | |
US201562269756P | 2015-12-18 | 2015-12-18 | |
US201562269511P | 2015-12-18 | 2015-12-18 | |
US201662308924P | 2016-03-16 | 2016-03-16 | |
US201662323422P | 2016-04-15 | 2016-04-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201913073YA true SG10201913073YA (en) | 2020-03-30 |
Family
ID=56801880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201913073YA SG10201913073YA (en) | 2015-08-20 | 2016-08-19 | Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment |
Country Status (18)
Country | Link |
---|---|
US (4) | US9895365B2 (fr) |
EP (1) | EP3337467B1 (fr) |
JP (1) | JP7042739B2 (fr) |
KR (1) | KR20180037210A (fr) |
CN (1) | CN108348480A (fr) |
AU (1) | AU2016309002B2 (fr) |
CA (1) | CA2992789A1 (fr) |
ES (1) | ES2848118T3 (fr) |
HK (2) | HK1257216A1 (fr) |
IL (1) | IL257147B (fr) |
MX (1) | MX2018001659A (fr) |
PL (1) | PL3337467T3 (fr) |
PT (1) | PT3337467T (fr) |
RU (1) | RU2760185C2 (fr) |
SG (1) | SG10201913073YA (fr) |
SI (1) | SI3337467T1 (fr) |
TW (1) | TWI724018B (fr) |
WO (2) | WO2017031442A1 (fr) |
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Publication number | Priority date | Publication date | Assignee | Title |
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RU2424792C2 (ru) | 2004-05-03 | 2011-07-27 | Хермес Байесайенсиз, Инк. | Липосомы, используемые для доставки лекарственных средств |
AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
EP3229802A1 (fr) * | 2014-12-09 | 2017-10-18 | Ipsen Biopharm Ltd. | Traitement du cancer du sein à l'aide d'irinotécan liposomal |
US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
AU2016309002B2 (en) | 2015-08-20 | 2021-07-29 | Ipsen Biopharm Ltd. | Combination therapy using liposomal irinotecan and a PARP inhibitor for cancer treatment |
PT3337478T (pt) | 2015-08-21 | 2020-10-19 | Ipsen Biopharm Ltd | Combinação de fármacos compreendendo irinotecano lipossómico, oxaliplatina, 5-fluorouracilo e leucovorina para o tratamento do cancro do pâncreas metastático |
NZ741291A (en) | 2015-10-16 | 2022-10-28 | Ipsen Biopharm Ltd | Stabilizing camptothecin pharmaceutical compositions |
MY202377A (en) * | 2016-11-02 | 2024-04-24 | Ipsen Biopharm Ltd | Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluorouracil (and leucovorin) |
KR20200018436A (ko) * | 2017-05-09 | 2020-02-19 | 테사로, 인코포레이티드 | 암 치료를 위한 조합 요법 |
EP3624850A1 (fr) | 2017-05-18 | 2020-03-25 | Tesaro, Inc. | Polythérapies pour le traitement du cancer |
GB201709076D0 (en) * | 2017-06-07 | 2017-07-19 | Inst Of Cancer Research: Royal Cancer Hospital | Parp inhibitors for use in methods of treating cancer |
CN111372607A (zh) | 2017-09-30 | 2020-07-03 | 特沙诺有限公司 | 用于治疗癌症的联合疗法 |
CN111182923A (zh) | 2017-10-06 | 2020-05-19 | 特沙诺有限公司 | 组合疗法及其用途 |
WO2019090227A1 (fr) * | 2017-11-04 | 2019-05-09 | Aravive Biologics, Inc. | Méthodes de traitement de cancers métastatiques à l'aide de récepteurs-leurres axl |
WO2019140266A1 (fr) * | 2018-01-12 | 2019-07-18 | Prolynx Llc | Protocole pour réduire au minimum la toxicité d'associations posologiques et agent d'imagerie pour vérification |
WO2019200382A1 (fr) * | 2018-04-13 | 2019-10-17 | The Board Of Regents Of University Of Texas System | Compositions de nanoparticules et procédés d'utilisation d'inhibiteur de parp pour le traitement du cancer |
TW202002985A (zh) * | 2018-06-01 | 2020-01-16 | 英屬開曼群島商百濟神州有限公司 | 在胃癌治療中的parp抑制劑維持療法 |
AU2019395284A1 (en) * | 2018-12-14 | 2021-06-24 | Athenex HK Innovative Limited | Therapeutic combinations of orally administered irinotecan and a P-gp Inhibitor for the treatment of cancer |
CN114053415B (zh) * | 2020-07-30 | 2024-06-18 | 江苏天士力帝益药业有限公司 | Tsl-1502复方药物组合 |
CN114053271B (zh) * | 2020-07-30 | 2024-05-07 | 江苏天士力帝益药业有限公司 | 一种含有tsl-1502m的药物组合物及其应用 |
CA3216716A1 (fr) * | 2021-05-03 | 2022-11-10 | Tim BERGBREDE | Composition comprenant un inhibiteur de la transcription mitochondriale |
RU2769543C2 (ru) * | 2021-07-21 | 2022-04-01 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Способ оценки первичного ответа на проводимую комбинированную химиотерапию спорадического рака яичников III и IV стадий |
CN114259569B (zh) * | 2021-12-30 | 2024-02-27 | 中山大学附属第八医院(深圳福田) | 基于伊立替康和尼拉帕利的超分子纳米药物的制备方法和应用 |
EP4209217A1 (fr) * | 2022-01-11 | 2023-07-12 | Fundación Profesor Novoa Santos | Procédé de traitement d'un cancer à brca1/2 muté |
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2016
- 2016-08-19 AU AU2016309002A patent/AU2016309002B2/en active Active
- 2016-08-19 PT PT167574987T patent/PT3337467T/pt unknown
- 2016-08-19 KR KR1020187004965A patent/KR20180037210A/ko not_active Application Discontinuation
- 2016-08-19 CA CA2992789A patent/CA2992789A1/fr active Pending
- 2016-08-19 RU RU2018105655A patent/RU2760185C2/ru active
- 2016-08-19 EP EP16757498.7A patent/EP3337467B1/fr not_active Revoked
- 2016-08-19 WO PCT/US2016/047814 patent/WO2017031442A1/fr active Application Filing
- 2016-08-19 SG SG10201913073YA patent/SG10201913073YA/en unknown
- 2016-08-19 CN CN201680046591.3A patent/CN108348480A/zh active Pending
- 2016-08-19 ES ES16757498T patent/ES2848118T3/es active Active
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- 2016-08-19 WO PCT/US2016/047827 patent/WO2017031445A1/fr active Application Filing
- 2016-08-19 SI SI201631023T patent/SI3337467T1/sl unknown
- 2016-08-19 TW TW105126680A patent/TWI724018B/zh active
- 2016-08-19 PL PL16757498T patent/PL3337467T3/pl unknown
- 2016-10-28 US US15/337,274 patent/US9895365B2/en active Active
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2017
- 2017-12-22 US US15/852,551 patent/US10478428B2/en active Active
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- 2018-01-25 IL IL257147A patent/IL257147B/en unknown
- 2018-12-18 HK HK18116219.1A patent/HK1257216A1/zh unknown
- 2018-12-19 HK HK18116309.2A patent/HK1257249A1/zh unknown
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2019
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CN108348480A (zh) | 2018-07-31 |
US10478428B2 (en) | 2019-11-19 |
JP2018528184A (ja) | 2018-09-27 |
AU2016309002A1 (en) | 2018-02-08 |
ES2848118T3 (es) | 2021-08-05 |
RU2760185C2 (ru) | 2021-11-22 |
US20230074866A1 (en) | 2023-03-09 |
WO2017031442A1 (fr) | 2017-02-23 |
US20200268742A1 (en) | 2020-08-27 |
CA2992789A1 (fr) | 2017-02-23 |
TWI724018B (zh) | 2021-04-11 |
WO2017031445A1 (fr) | 2017-02-23 |
RU2018105655A (ru) | 2019-09-23 |
HK1257249A1 (zh) | 2019-10-18 |
PT3337467T (pt) | 2021-01-25 |
US11844795B2 (en) | 2023-12-19 |
TW201713312A (zh) | 2017-04-16 |
IL257147A (en) | 2018-03-29 |
US20170049767A1 (en) | 2017-02-23 |
AU2016309002B2 (en) | 2021-07-29 |
KR20180037210A (ko) | 2018-04-11 |
SI3337467T1 (sl) | 2021-03-31 |
RU2018105655A3 (fr) | 2020-02-21 |
JP7042739B2 (ja) | 2022-03-28 |
IL257147B (en) | 2021-07-29 |
US20180117034A1 (en) | 2018-05-03 |
MX2018001659A (es) | 2018-05-28 |
EP3337467B1 (fr) | 2020-12-09 |
HK1257216A1 (zh) | 2019-10-18 |
US9895365B2 (en) | 2018-02-20 |
PL3337467T3 (pl) | 2021-06-14 |
EP3337467A1 (fr) | 2018-06-27 |
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