SG10201911860VA - Duocarmycin adcs showing improved in vivo antitumor activity - Google Patents
Duocarmycin adcs showing improved in vivo antitumor activityInfo
- Publication number
- SG10201911860VA SG10201911860VA SG10201911860VA SG10201911860VA SG10201911860VA SG 10201911860V A SG10201911860V A SG 10201911860VA SG 10201911860V A SG10201911860V A SG 10201911860VA SG 10201911860V A SG10201911860V A SG 10201911860VA SG 10201911860V A SG10201911860V A SG 10201911860VA
- Authority
- SG
- Singapore
- Prior art keywords
- antitumor activity
- vivo antitumor
- showing improved
- duocarmycin
- duocarmycin adcs
- Prior art date
Links
- VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 title 1
- 229960005501 duocarmycin Drugs 0.000 title 1
- 229930184221 duocarmycin Natural products 0.000 title 1
- 230000005917 in vivo anti-tumor Effects 0.000 title 1
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR (2) | KR102344354B1 (fr) |
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AU (2) | AU2015205509B2 (fr) |
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DK (2) | DK2948184T3 (fr) |
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SG (2) | SG10201911860VA (fr) |
WO (1) | WO2015104385A2 (fr) |
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KR101901555B1 (ko) | 2010-04-21 | 2018-09-21 | 신타가 비.브이. | Cc―1065 유사체와 2작용성 링커의 신규한 콘쥬게이트 |
SG11201504887TA (en) | 2012-12-21 | 2015-07-30 | Bioalliance Cv | Hydrophilic self-immolative linkers and conjugates thereof |
EP3069735B1 (fr) | 2014-01-10 | 2018-03-14 | Synthon Biopharmaceuticals B.V. | Adc de duocarmycine pour le traitement du cancer de la vessie |
MY177390A (en) | 2014-01-10 | 2020-09-14 | Byondis Bv | Method for purifying cys-linked antibody-drug conjugates |
MY189713A (en) * | 2014-01-10 | 2022-02-28 | Univ Yale | Duocarmycin adcs for use in treatment of endometrial cancer |
DK3151865T3 (da) | 2014-05-22 | 2021-10-25 | Byondis Bv | Stedsspecifik konjugation af linker medicin til antistof og resulterende adcs |
WO2015195925A1 (fr) | 2014-06-18 | 2015-12-23 | Mersana Therapeutics, Inc. | Conjugués médicament-protéine-polymère et leurs procédés d'utilisation |
TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗her2表位之單株抗體及其使用之方法 |
JP2017525755A (ja) * | 2014-06-20 | 2017-09-07 | アブジェノミクス インターナショナル インコーポレイテッド.Abgenomics International Inc. | Her2抗体−薬物抱合体 |
MX2016016490A (es) | 2014-06-20 | 2017-07-28 | Bioalliance Cv | Conjugados de farmaco-anticuerpo anti-receptor de folato alfa (fra) y metodos de uso de los mismos. |
EP3319597B1 (fr) | 2015-07-10 | 2021-02-17 | Byondis B.V. | Compositions comprenant des conjugués de médicaments anticorps-duocarmycine |
DK3352857T3 (da) * | 2015-09-22 | 2021-03-01 | Byondis Bv | Syd985 behandling af t-dm1 refraktære kræftpatienter |
CN106729743B (zh) * | 2015-11-23 | 2021-09-21 | 四川科伦博泰生物医药股份有限公司 | 抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用 |
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TWI753875B (zh) | 2016-01-08 | 2022-02-01 | 美商美國全心醫藥生技股份有限公司 | 四價抗psgl-1抗體及其用途 |
KR102514317B1 (ko) | 2016-04-15 | 2023-03-27 | 마크로제닉스, 인크. | 신규 b7-h3-결합 분자, 그것의 항체 약물 콘쥬게이트 및 그것의 사용 방법 |
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JP2023517477A (ja) * | 2020-02-06 | 2023-04-26 | ビョンディス・ビー.ブイ. | デュオカルマイシン誘導体含有抗体薬物複合体及びチオ硫酸類を含む組合せ |
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