SG10201909596RA - Synthesis of Tyrosine Kinase Inhibitors - Google Patents

Synthesis of Tyrosine Kinase Inhibitors

Info

Publication number
SG10201909596RA
SG10201909596RA SG10201909596RA SG10201909596RA SG10201909596RA SG 10201909596R A SG10201909596R A SG 10201909596RA SG 10201909596R A SG10201909596R A SG 10201909596RA SG 10201909596R A SG10201909596R A SG 10201909596RA SG 10201909596R A SG10201909596R A SG 10201909596RA
Authority
SG
Singapore
Prior art keywords
synthesis
tyrosine kinase
kinase inhibitors
inhibitors
tyrosine
Prior art date
Application number
SG10201909596RA
Other languages
English (en)
Inventor
Abraham Rajkumar Gurubatham
Lin Xiangliang
Original Assignee
Esco Aster Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esco Aster Pte Ltd filed Critical Esco Aster Pte Ltd
Priority to SG10201909596RA priority Critical patent/SG10201909596RA/en
Priority to BR112022007107A priority patent/BR112022007107A2/pt
Priority to AU2020366118A priority patent/AU2020366118A1/en
Priority to US17/769,177 priority patent/US20230065387A1/en
Priority to JP2022547807A priority patent/JP2023503193A/ja
Priority to PCT/EP2020/078761 priority patent/WO2021074138A1/en
Priority to EP20792606.4A priority patent/EP4045494B1/en
Priority to TW109135376A priority patent/TWI832015B/zh
Priority to CN202080073377.3A priority patent/CN114585615A/zh
Priority to KR1020227014080A priority patent/KR20220124679A/ko
Publication of SG10201909596RA publication Critical patent/SG10201909596RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG10201909596RA 2019-10-14 2019-10-14 Synthesis of Tyrosine Kinase Inhibitors SG10201909596RA (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
SG10201909596RA SG10201909596RA (en) 2019-10-14 2019-10-14 Synthesis of Tyrosine Kinase Inhibitors
BR112022007107A BR112022007107A2 (pt) 2019-10-14 2020-10-13 Método para a síntese de um composto
AU2020366118A AU2020366118A1 (en) 2019-10-14 2020-10-13 Synthesis of 6-methyl-n1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
US17/769,177 US20230065387A1 (en) 2019-10-14 2020-10-13 Synthesis of tyrosine kinase inhibitors
JP2022547807A JP2023503193A (ja) 2019-10-14 2020-10-13 ６－メチル－ｎ１－（４－（ピリジン－３－イル）ピリミジン－２－イル）ベンゼン－１，３－ジアミンの合成
PCT/EP2020/078761 WO2021074138A1 (en) 2019-10-14 2020-10-13 Synthesis of 6-methyl-n1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
EP20792606.4A EP4045494B1 (en) 2019-10-14 2020-10-13 Synthesis of 6-methyl-n1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine
TW109135376A TWI832015B (zh) 2019-10-14 2020-10-13 酪胺酸激酶抑制物之合成
CN202080073377.3A CN114585615A (zh) 2019-10-14 2020-10-13 6-甲基-n1-(4-(吡啶-3-基)嘧啶-2-基)苯-1,3-二胺的合成
KR1020227014080A KR20220124679A (ko) 2019-10-14 2020-10-13 6-메틸-n1-(4-(피리딘-3-일)피리미딘-2-일)벤젠-1,3-디아민의 합성

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SG10201909596RA SG10201909596RA (en) 2019-10-14 2019-10-14 Synthesis of Tyrosine Kinase Inhibitors

Publications (1)

Publication Number Publication Date
SG10201909596RA true SG10201909596RA (en) 2021-05-28

Family

ID=72895951

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201909596RA SG10201909596RA (en) 2019-10-14 2019-10-14 Synthesis of Tyrosine Kinase Inhibitors

Country Status (10)

Country Link
US (1) US20230065387A1 (zh)
EP (1) EP4045494B1 (zh)
JP (1) JP2023503193A (zh)
KR (1) KR20220124679A (zh)
CN (1) CN114585615A (zh)
AU (1) AU2020366118A1 (zh)
BR (1) BR112022007107A2 (zh)
SG (1) SG10201909596RA (zh)
TW (1) TWI832015B (zh)
WO (1) WO2021074138A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113419004B (zh) * 2021-06-22 2023-04-18 海南鑫开源医药科技有限公司 3-氨基-4-甲基苯甲酸甲酯中杂质的检测方法
CN114853734A (zh) * 2022-06-14 2022-08-05 海南鑫开源医药科技有限公司 一种尼洛替尼游离碱的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GB2398565A (en) * 2003-02-18 2004-08-25 Cipla Ltd Imatinib preparation and salts
AR052900A1 (es) * 2005-02-11 2007-04-11 Astrazeneca Ab Derivados de tiazol, un metodo para su preparacion, composiciones farmaceuticas que los contienen y su uso en la elaboracion de medicamentos para el tratamiento de enfermedades mediadas por ece-1
CN100537563C (zh) * 2006-07-12 2009-09-09 浙江省医学科学院 N-苯基-2-嘧啶胺衍生物的制备方法
KR101286780B1 (ko) * 2011-02-01 2013-07-17 에스티팜 주식회사 비카보네이트 염 및 이를 이용한 이마티니브 또는 이의 염의 제조방법
WO2013035102A1 (en) * 2011-09-05 2013-03-14 Natco Pharma Limited Processes for the preparation of imatinib base and intermediates thereof
IN2013CH05653A (zh) * 2013-12-09 2016-06-24
CN105801559B (zh) * 2016-04-28 2019-03-01 北京化工大学 4-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]苯甲酸乙酯的制备方法
EP3404025B1 (en) * 2017-05-16 2019-12-04 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of pure nilotinib and its salt

Also Published As

Publication number Publication date
US20230065387A1 (en) 2023-03-02
EP4045494C0 (en) 2023-10-11
CN114585615A (zh) 2022-06-03
EP4045494B1 (en) 2023-10-11
KR20220124679A (ko) 2022-09-14
JP2023503193A (ja) 2023-01-26
TW202128641A (zh) 2021-08-01
AU2020366118A1 (en) 2022-05-12
BR112022007107A2 (pt) 2022-07-05
EP4045494A1 (en) 2022-08-24
WO2021074138A1 (en) 2021-04-22
TWI832015B (zh) 2024-02-11

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