SG10201811365RA - Slow-release conjugates of sn-38 - Google Patents
Slow-release conjugates of sn-38Info
- Publication number
- SG10201811365RA SG10201811365RA SG10201811365RA SG10201811365RA SG10201811365RA SG 10201811365R A SG10201811365R A SG 10201811365RA SG 10201811365R A SG10201811365R A SG 10201811365RA SG 10201811365R A SG10201811365R A SG 10201811365RA SG 10201811365R A SG10201811365R A SG 10201811365RA
- Authority
- SG
- Singapore
- Prior art keywords
- slow
- conjugates
- release
- release conjugates
- glucuronate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33396—Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
- C08G65/48—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
- C08G83/002—Dendritic macromolecules
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361887111P | 2013-10-04 | 2013-10-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201811365RA true SG10201811365RA (en) | 2019-02-27 |
Family
ID=51871275
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201811365RA SG10201811365RA (en) | 2013-10-04 | 2014-10-03 | Slow-release conjugates of sn-38 |
SG11201602258WA SG11201602258WA (en) | 2013-10-04 | 2014-10-03 | Slow-release conjugates of sn-38 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201602258WA SG11201602258WA (en) | 2013-10-04 | 2014-10-03 | Slow-release conjugates of sn-38 |
Country Status (14)
Country | Link |
---|---|
US (2) | US10016411B2 (fr) |
EP (1) | EP3052101B1 (fr) |
JP (2) | JP6473145B2 (fr) |
KR (1) | KR102320753B1 (fr) |
CN (1) | CN106061483B (fr) |
AU (2) | AU2014331591B2 (fr) |
BR (1) | BR112016007410B1 (fr) |
CA (1) | CA2925132C (fr) |
DK (1) | DK3052101T3 (fr) |
ES (1) | ES2759905T3 (fr) |
MX (1) | MX371201B (fr) |
SG (2) | SG10201811365RA (fr) |
TW (1) | TWI716342B (fr) |
WO (1) | WO2015051307A1 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6473145B2 (ja) * | 2013-10-04 | 2019-02-20 | プロリンクス エルエルシー | Sn−38の徐放性コンジュゲート |
CN107375288B (zh) | 2016-05-16 | 2019-08-23 | 博瑞生物医药(苏州)股份有限公司 | 多臂的聚合靶向抗癌偶联物 |
KR102279429B1 (ko) | 2017-04-21 | 2021-07-20 | 브라이트제네 바이오-메디컬 테크놀로지 코., 엘티디. | 멀티 암 표적 항암 콘쥬게이트 |
MX2020007442A (es) | 2018-01-12 | 2020-09-14 | Prolynx Llc | Protocolo para minimizar la toxicidad de dosificaciones de combinacion y agente formador de imagen para verificacion. |
CA3134838A1 (fr) * | 2019-04-05 | 2020-10-08 | Prolynx Llc | Lieurs de conjugaison ameliores |
EP4021442A4 (fr) * | 2019-08-28 | 2023-09-20 | Prolynx LLC | Inhibiteurs conjugués de la réponse à l'endommagement de l'adn |
CA3193485A1 (fr) | 2020-09-28 | 2022-03-31 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Conjugues peptidiques de sn38 utiles dans le traitement du cancer |
WO2023186822A1 (fr) | 2022-03-28 | 2023-10-05 | Hospital Sant Joan De Deu | Système d'administration peptidique soluble dans l'eau de médicaments anticancéreux |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6011042A (en) * | 1997-10-10 | 2000-01-04 | Enzon, Inc. | Acyl polymeric derivatives of aromatic hydroxyl-containing compounds |
JP2005537266A (ja) * | 2002-07-12 | 2005-12-08 | バイオマリン ファーマシューティカル インコーポレイテッド | 加水分解性活性物質であるバイオポリマーコンジュゲートを作製するためのイソシアネートリンカーの使用 |
KR101057102B1 (ko) | 2002-10-31 | 2011-08-16 | 니폰 가야꾸 가부시끼가이샤 | 캄프토테신의 고분자량 유도체 |
US20040247624A1 (en) * | 2003-06-05 | 2004-12-09 | Unger Evan Charles | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
LT1675622T (lt) * | 2003-09-17 | 2017-09-11 | Nektar Therapeutics | Daugiašakio polimero provaistai |
US7462627B2 (en) | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
AU2007296056B2 (en) * | 2006-09-15 | 2012-09-13 | Enzon Pharmaceuticals, Inc. | Targeted polymeric prodrugs containing multifunctional linkers |
BRPI0919842A8 (pt) * | 2008-10-21 | 2015-09-22 | Enzon Pharmaceuticals Inc | tratamento de neuroblastioma com conjugados poliméricos de múltiplos braços de 7-etil-10-hidroxicamptotecina |
AU2009316749A1 (en) | 2008-11-18 | 2011-06-30 | Baxter Healthcare S.A. | Methods of determining polydispersity and/or molecular weight distribution of a polyethylene glycol sample |
JP2012528240A (ja) | 2009-05-28 | 2012-11-12 | メルサナ セラピューティックス, インコーポレイテッド | 可変速度放出リンカーを含むポリアル−薬物コンジュゲート |
DK2501413T3 (da) * | 2009-11-18 | 2019-06-11 | Nektar Therapeutics | Syre-saltformer af polymermedikamentkonjugater |
ES2584381T3 (es) | 2010-05-05 | 2016-09-27 | Prolynx Llc | Liberación controlada de compuestos activos desde conjugados macromoleculares |
WO2011140376A1 (fr) * | 2010-05-05 | 2011-11-10 | Prolynx Llc | Libération contrôlée de médicament à partir de dendrimères |
JP2012000072A (ja) * | 2010-06-18 | 2012-01-05 | Japan Health Science Foundation | 新規な抗フィブリン抗体 |
AR082806A1 (es) * | 2010-08-30 | 2013-01-09 | Sun Pharma Advanced Res Co Ltd | Composicion farmaceutica estable |
EP2654795B1 (fr) * | 2010-12-21 | 2018-03-07 | Nektar Therapeutics | Conjugués de prodrogue et polymères à bras multiples à base de pemetrexed |
WO2013036857A1 (fr) * | 2011-09-07 | 2013-03-14 | Prolynx Llc | Coupleurs au sulfone |
JP6473145B2 (ja) * | 2013-10-04 | 2019-02-20 | プロリンクス エルエルシー | Sn−38の徐放性コンジュゲート |
-
2014
- 2014-10-03 JP JP2016520004A patent/JP6473145B2/ja active Active
- 2014-10-03 CA CA2925132A patent/CA2925132C/fr active Active
- 2014-10-03 ES ES14796322T patent/ES2759905T3/es active Active
- 2014-10-03 KR KR1020167011936A patent/KR102320753B1/ko active IP Right Grant
- 2014-10-03 WO PCT/US2014/059146 patent/WO2015051307A1/fr active Application Filing
- 2014-10-03 TW TW103134678A patent/TWI716342B/zh active
- 2014-10-03 SG SG10201811365RA patent/SG10201811365RA/en unknown
- 2014-10-03 DK DK14796322.7T patent/DK3052101T3/da active
- 2014-10-03 AU AU2014331591A patent/AU2014331591B2/en active Active
- 2014-10-03 US US15/026,579 patent/US10016411B2/en active Active
- 2014-10-03 MX MX2016004299A patent/MX371201B/es active IP Right Grant
- 2014-10-03 CN CN201480062543.4A patent/CN106061483B/zh active Active
- 2014-10-03 SG SG11201602258WA patent/SG11201602258WA/en unknown
- 2014-10-03 EP EP14796322.7A patent/EP3052101B1/fr active Active
- 2014-10-03 BR BR112016007410-6A patent/BR112016007410B1/pt active IP Right Grant
-
2018
- 2018-06-14 US US16/009,078 patent/US10342792B2/en active Active
- 2018-11-01 AU AU2018256608A patent/AU2018256608A1/en not_active Abandoned
-
2019
- 2019-01-24 JP JP2019010029A patent/JP6842479B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
TW201601759A (zh) | 2016-01-16 |
DK3052101T3 (da) | 2019-12-16 |
US20180289695A1 (en) | 2018-10-11 |
BR112016007410B1 (pt) | 2022-07-19 |
MX371201B (es) | 2020-01-22 |
EP3052101A1 (fr) | 2016-08-10 |
AU2014331591A1 (en) | 2016-05-19 |
AU2014331591B2 (en) | 2018-08-16 |
TWI716342B (zh) | 2021-01-21 |
US10342792B2 (en) | 2019-07-09 |
MX2016004299A (es) | 2016-10-04 |
US10016411B2 (en) | 2018-07-10 |
KR20160065203A (ko) | 2016-06-08 |
JP2019104739A (ja) | 2019-06-27 |
WO2015051307A1 (fr) | 2015-04-09 |
BR112016007410A8 (pt) | 2020-02-27 |
CA2925132C (fr) | 2021-11-30 |
JP2016531895A (ja) | 2016-10-13 |
CA2925132A1 (fr) | 2015-04-09 |
KR102320753B1 (ko) | 2021-11-02 |
JP6842479B2 (ja) | 2021-03-17 |
BR112016007410A2 (pt) | 2017-08-01 |
CN106061483A (zh) | 2016-10-26 |
CN106061483B (zh) | 2021-01-08 |
ES2759905T3 (es) | 2020-05-12 |
EP3052101B1 (fr) | 2019-11-20 |
US20160243106A1 (en) | 2016-08-25 |
AU2018256608A1 (en) | 2018-11-22 |
JP6473145B2 (ja) | 2019-02-20 |
SG11201602258WA (en) | 2016-04-28 |
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