SG10201804868PA - Compounds for the inhibition of indoleamine-2,3-dioxygenase - Google Patents
Compounds for the inhibition of indoleamine-2,3-dioxygenaseInfo
- Publication number
- SG10201804868PA SG10201804868PA SG10201804868PA SG10201804868PA SG10201804868PA SG 10201804868P A SG10201804868P A SG 10201804868PA SG 10201804868P A SG10201804868P A SG 10201804868PA SG 10201804868P A SG10201804868P A SG 10201804868PA SG 10201804868P A SG10201804868P A SG 10201804868PA
- Authority
- SG
- Singapore
- Prior art keywords
- compounds
- dioxygenase
- ido
- indoleamine
- inhibition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462046242P | 2014-09-05 | 2014-09-05 | |
US201562151011P | 2015-04-22 | 2015-04-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201804868PA true SG10201804868PA (en) | 2018-07-30 |
Family
ID=54147306
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201700579XA SG11201700579XA (en) | 2014-09-05 | 2015-09-04 | Cyclohexyl-ethyl substituted diaza- and triaza-tricyclic compounds as indole-amine-2,3-dioxygenase (ido) antagonists for the treatment of cancer |
SG10201804868PA SG10201804868PA (en) | 2014-09-05 | 2015-09-04 | Compounds for the inhibition of indoleamine-2,3-dioxygenase |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201700579XA SG11201700579XA (en) | 2014-09-05 | 2015-09-04 | Cyclohexyl-ethyl substituted diaza- and triaza-tricyclic compounds as indole-amine-2,3-dioxygenase (ido) antagonists for the treatment of cancer |
Country Status (17)
Country | Link |
---|---|
US (2) | US9771370B2 (ru) |
EP (1) | EP3189054B1 (ru) |
JP (1) | JP6680766B2 (ru) |
KR (1) | KR20170044144A (ru) |
CN (1) | CN107074859B (ru) |
AU (1) | AU2015311826B2 (ru) |
BR (1) | BR112017003764A2 (ru) |
CA (1) | CA2956465A1 (ru) |
CL (1) | CL2017000420A1 (ru) |
ES (1) | ES2751602T3 (ru) |
IL (1) | IL250890B (ru) |
MX (1) | MX2017002365A (ru) |
PH (1) | PH12017500196A1 (ru) |
RU (1) | RU2017111200A (ru) |
SG (2) | SG11201700579XA (ru) |
WO (1) | WO2016037026A1 (ru) |
ZA (1) | ZA201700737B (ru) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
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GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
CA2956465A1 (en) * | 2014-09-05 | 2016-03-10 | Merck Patent Gmbh | Cyclohexyl-ethyl substituted diaza- and triaza-tricyclic compounds as indole-amine-2,3-dioxygenase (ido) antagonists for the treatment of cancer |
CN105884828A (zh) | 2015-02-16 | 2016-08-24 | 上海迪诺医药科技有限公司 | 多环化合物、其药物组合物及应用 |
JP2018511647A (ja) | 2015-04-12 | 2018-04-26 | ハンジョウ イノゲート ファーマ カンパニー リミテッドHangzhou Innogate Pharma Co.,Ltd. | Ido阻害剤とtdo阻害剤としての複素環化合物 |
GB201506872D0 (en) | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
WO2017075341A1 (en) * | 2015-10-29 | 2017-05-04 | Scifluor Life Sciences, Inc. | Fused imidazole derivatives as ido/tdo inhibitors |
EP3400226A1 (en) | 2016-02-02 | 2018-11-14 | Emcure Pharmaceuticals Limited | Derivatives of pyrroloimidazole or analogues thereof which are useful for the treatment of inter alia cancer |
WO2017149469A1 (en) | 2016-03-03 | 2017-09-08 | Emcure Pharmaceuticals Limited | Heterocyclic compounds useful as ido and/or tdo modulators |
CN105732643A (zh) * | 2016-04-18 | 2016-07-06 | 苏州大学 | 一种偶联物、其制备方法及在制备ido酶抑制剂和非甾体抗炎药物中的应用 |
CN107312005B (zh) * | 2016-04-27 | 2021-12-17 | 上海翰森生物医药科技有限公司 | 具有ido/tdo抑制活性的稠合咪唑衍生物及其制备方法和应用 |
CN105902542A (zh) * | 2016-05-16 | 2016-08-31 | 张阳 | 一种偶联物在制备治疗心血管疾病药物中的应用 |
CN107556316B (zh) * | 2016-06-30 | 2021-11-12 | 鲁南制药集团股份有限公司 | 含桥环的咪唑衍生物 |
CN107383012B (zh) * | 2016-05-16 | 2021-09-28 | 鲁南制药集团股份有限公司 | 含二环的咪唑醇衍生物 |
WO2017198159A1 (zh) * | 2016-05-16 | 2017-11-23 | 鲁南制药集团股份有限公司 | 含桥环的咪唑衍生物 |
CN107488179B (zh) * | 2016-06-11 | 2024-06-07 | 鲁南制药集团股份有限公司 | 含桥环的咪唑醇衍生物 |
CN107698594A (zh) * | 2016-08-09 | 2018-02-16 | 苏州国匡医药科技有限公司 | 吲哚胺2,3‑双加氧酶抑制剂及其在药学中的用途 |
US11046682B2 (en) | 2016-08-23 | 2021-06-29 | Beijing Innocare Pharma Tech Co., Ltd. | Fused heterocyclic derivatives, their preparation methods thereof and medical uses thereof |
CN107383024B (zh) * | 2016-09-12 | 2018-06-08 | 广州必贝特医药技术有限公司 | 含咪唑稠合三环类化合物及其应用 |
CN109952300B (zh) | 2016-09-24 | 2022-01-18 | 百济神州有限公司 | 5或8-取代的咪唑并[1,5-a]吡啶 |
EP3560928B1 (en) * | 2016-12-20 | 2021-10-20 | Shenzhen Chipscreen Biosciences Co., Ltd. | Fused imidazole compound having indoleamine 2,3-dioxygenase inhibitory activity |
NZ754364A (en) | 2016-12-22 | 2023-04-28 | Calithera Biosciences Inc | Compositions and methods for inhibiting arginase activity |
JP2020506895A (ja) | 2017-01-17 | 2020-03-05 | ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | インドールアミン2,3−ジオキシゲナーゼおよび/またはトリプトファンジオキシゲナーゼの阻害剤として有用な化合物 |
WO2018175954A1 (en) * | 2017-03-23 | 2018-09-27 | F. Hoffmann-La Roche Ag | Synthesis of imidazo[5,1-a]isoindole derivative useful as ido inhibitors |
EA201992359A1 (ru) | 2017-04-05 | 2020-03-12 | Дзе Брод Инститьют Инк. | Трициклические соединения в качестве ингибиторов киназы гликогенсинтазы-3 (gsk3) и их применение |
US11603373B2 (en) | 2017-06-28 | 2023-03-14 | Genentech, Inc. | TDO2 and IDO1 inhibitors |
CN109384791B (zh) * | 2017-08-09 | 2020-09-11 | 江苏恒瑞医药股份有限公司 | 一种咪唑并异吲哚类衍生物游离碱的晶型及其制备方法 |
CN107501272B (zh) * | 2017-09-05 | 2020-03-31 | 中国药科大学 | 咪唑并异吲哚类ido1抑制剂、其制备方法及应用 |
CN108424414A (zh) * | 2017-12-08 | 2018-08-21 | 苏州国匡医药科技有限公司 | 一类含杂环的吲哚胺2,3-双加氧酶调节化合物及其在药学中的用途 |
EP3727374A4 (en) * | 2017-12-21 | 2021-11-10 | Merck Patent GmbH | COMBINATION OF AN ANTI-PD-L1 ANTIBODY AND AN IDO1 INHIBITOR FOR THE TREATMENT OF CANCER |
CA3084829A1 (en) | 2018-01-05 | 2019-07-11 | Dicerna Pharmaceuticals, Inc. | Reducing beta-catenin and ido expression to potentiate immunotherapy |
EP3823604A4 (en) | 2018-07-17 | 2022-03-16 | Board of Regents, The University of Texas System | COMPOUNDS USEFUL AS INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHANE DIOXYGENASE INHIBITORS |
EP4052705A1 (en) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions for the treatment of ebv associated diseases or conditions |
BR112023017582A2 (pt) | 2021-03-05 | 2023-12-05 | Univ Basel | Composições para o tratamento de doenças ou condições associadas ao ebv |
CN113816965B (zh) * | 2021-11-23 | 2022-03-08 | 北京鑫开元医药科技有限公司 | 一种具有ido抑制活性的化合物及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1307193A1 (en) | 2000-07-27 | 2003-05-07 | Affymax Research Institute | Agonists of follicle stimulating hormone activity |
EP2365748A4 (en) * | 2008-11-13 | 2012-05-02 | Merck Sharp & Dohme | IMIDAZOISOINDOLA ANTAGONISTS OF NEUROPEPTIDE S RECEPTORS |
NO2694640T3 (ru) * | 2011-04-15 | 2018-03-17 | ||
US9617272B2 (en) | 2013-03-14 | 2017-04-11 | Newlink Genetics Corporation | Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization |
CA2956465A1 (en) * | 2014-09-05 | 2016-03-10 | Merck Patent Gmbh | Cyclohexyl-ethyl substituted diaza- and triaza-tricyclic compounds as indole-amine-2,3-dioxygenase (ido) antagonists for the treatment of cancer |
GB201418300D0 (en) * | 2014-10-15 | 2014-11-26 | Redx Pharma Ltd | Compounds |
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2015
- 2015-09-04 CA CA2956465A patent/CA2956465A1/en active Pending
- 2015-09-04 ES ES15766320T patent/ES2751602T3/es active Active
- 2015-09-04 US US14/845,428 patent/US9771370B2/en active Active
- 2015-09-04 RU RU2017111200A patent/RU2017111200A/ru not_active Application Discontinuation
- 2015-09-04 SG SG11201700579XA patent/SG11201700579XA/en unknown
- 2015-09-04 BR BR112017003764A patent/BR112017003764A2/pt not_active IP Right Cessation
- 2015-09-04 CN CN201580059548.6A patent/CN107074859B/zh active Active
- 2015-09-04 AU AU2015311826A patent/AU2015311826B2/en not_active Ceased
- 2015-09-04 SG SG10201804868PA patent/SG10201804868PA/en unknown
- 2015-09-04 JP JP2017512706A patent/JP6680766B2/ja active Active
- 2015-09-04 EP EP15766320.4A patent/EP3189054B1/en active Active
- 2015-09-04 WO PCT/US2015/048474 patent/WO2016037026A1/en active Application Filing
- 2015-09-04 MX MX2017002365A patent/MX2017002365A/es unknown
- 2015-09-04 KR KR1020177007060A patent/KR20170044144A/ko unknown
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- 2017-02-01 PH PH12017500196A patent/PH12017500196A1/en unknown
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- 2017-08-18 US US15/680,683 patent/US10329297B2/en active Active
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KR20170044144A (ko) | 2017-04-24 |
RU2017111200A3 (ru) | 2019-03-12 |
US10329297B2 (en) | 2019-06-25 |
WO2016037026A1 (en) | 2016-03-10 |
CN107074859A (zh) | 2017-08-18 |
CL2017000420A1 (es) | 2017-10-06 |
MX2017002365A (es) | 2017-05-17 |
BR112017003764A2 (pt) | 2017-12-05 |
EP3189054A1 (en) | 2017-07-12 |
JP2017525742A (ja) | 2017-09-07 |
RU2017111200A (ru) | 2018-10-05 |
IL250890A0 (en) | 2017-04-30 |
AU2015311826A1 (en) | 2017-02-16 |
ZA201700737B (en) | 2019-04-24 |
PH12017500196A1 (en) | 2017-07-10 |
EP3189054B1 (en) | 2019-07-24 |
SG11201700579XA (en) | 2017-02-27 |
ES2751602T3 (es) | 2020-04-01 |
AU2015311826B2 (en) | 2019-05-23 |
US20170355703A1 (en) | 2017-12-14 |
IL250890B (en) | 2019-12-31 |
JP6680766B2 (ja) | 2020-04-15 |
CA2956465A1 (en) | 2016-03-10 |
US20160075711A1 (en) | 2016-03-17 |
CN107074859B (zh) | 2021-08-06 |
US9771370B2 (en) | 2017-09-26 |
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