CL2017000420A1 - Compuestos diaza-y triaza-triciclicos sustituidos con ciclohexil-etilo como antagonistas de indol-amina-2,3-dioxigenasa (ido) para el tratamiento de cáncer. - Google Patents

Compuestos diaza-y triaza-triciclicos sustituidos con ciclohexil-etilo como antagonistas de indol-amina-2,3-dioxigenasa (ido) para el tratamiento de cáncer.

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Publication number
CL2017000420A1
CL2017000420A1 CL2017000420A CL2017000420A CL2017000420A1 CL 2017000420 A1 CL2017000420 A1 CL 2017000420A1 CL 2017000420 A CL2017000420 A CL 2017000420A CL 2017000420 A CL2017000420 A CL 2017000420A CL 2017000420 A1 CL2017000420 A1 CL 2017000420A1
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CL
Chile
Prior art keywords
triaza
dioxygenase
diaza
antagonists
cancer
Prior art date
Application number
CL2017000420A
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English (en)
Inventor
Brian A Sherer
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Merck Patent Gmbh
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Publication date
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Publication of CL2017000420A1 publication Critical patent/CL2017000420A1/es

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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    • C07D487/14—Ortho-condensed systems

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Abstract

<p>LA PRESENTE INVENCIÓN SE RELACIONA CON COMPUESTOS DIAZA-Y TRIAZA-TRICÍCLICOS SUSTITUIDOS CON CICLOHEXILETILO, TALES COMO, POR EJEMPLO, DERIVADOS DE 5-(2-CICLOHEXIL)ETIL)-5H-IMIDAZO[5,1-A]ISOINDOL, 1-CICLOHEXIL-2-[4,6,10-TRIAZATRICICLO[6.4.0.0^[2,6]]DODECA-1(8),2,4,9,11-PENTAEN-7-IL]ETAN-1-OL Y DERIVADOS DE 1-CICLOHEXIL-2-[4,6,9,11-TETRAAZATRICICLO[6.4.0.0^ [2,6] ]DODECA-1(8),2,4,9,1 1-PENTAEN-7-IL]ETAN-1-OL COMO ANTAGONISTAS DE INDOL-AMINA-2,3-DIOXIGENASA (IDO) PARA EL TRATAMIENTO DE, POR EJEMPLO, CÁNCER, TRASTORNO PROLIFERATIVO, ENFERMEDAD VIRAL, SEPSIS, NEUMONÍA, BACTERIEMIA, TRAUMA, TUBERCULOSIS, ENFERMEDAD PARASITARIA, NEUROINFLAMACIÓN, ESQUIZOFRENIA, DEPRESIÓN, ENFERMEDAD NEURODEGENERATIVA Y DOLOR.</p>
CL2017000420A 2014-09-05 2017-02-21 Compuestos diaza-y triaza-triciclicos sustituidos con ciclohexil-etilo como antagonistas de indol-amina-2,3-dioxigenasa (ido) para el tratamiento de cáncer. CL2017000420A1 (es)

Applications Claiming Priority (2)

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US201462046242P 2014-09-05 2014-09-05
US201562151011P 2015-04-22 2015-04-22

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CL2017000420A1 true CL2017000420A1 (es) 2017-10-06

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US (2) US9771370B2 (es)
EP (1) EP3189054B1 (es)
JP (1) JP6680766B2 (es)
KR (1) KR20170044144A (es)
CN (1) CN107074859B (es)
AU (1) AU2015311826B2 (es)
BR (1) BR112017003764A2 (es)
CA (1) CA2956465A1 (es)
CL (1) CL2017000420A1 (es)
ES (1) ES2751602T3 (es)
IL (1) IL250890B (es)
MX (1) MX2017002365A (es)
PH (1) PH12017500196A1 (es)
RU (1) RU2017111200A (es)
SG (2) SG10201804868PA (es)
WO (1) WO2016037026A1 (es)
ZA (1) ZA201700737B (es)

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