SG10201801188XA - Selective delivery of material to cells - Google Patents
Selective delivery of material to cellsInfo
- Publication number
- SG10201801188XA SG10201801188XA SG10201801188XA SG10201801188XA SG10201801188XA SG 10201801188X A SG10201801188X A SG 10201801188XA SG 10201801188X A SG10201801188X A SG 10201801188XA SG 10201801188X A SG10201801188X A SG 10201801188XA SG 10201801188X A SG10201801188X A SG 10201801188XA
- Authority
- SG
- Singapore
- Prior art keywords
- cells
- selective delivery
- selective
- delivery
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1028—Sorting particles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Fluid Mechanics (AREA)
- Hospice & Palliative Care (AREA)
- Clinical Laboratory Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Nanotechnology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Composite Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361866972P | 2013-08-16 | 2013-08-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201801188XA true SG10201801188XA (en) | 2018-03-28 |
Family
ID=52468732
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201801188XA SG10201801188XA (en) | 2013-08-16 | 2014-08-15 | Selective delivery of material to cells |
| SG11201601927SA SG11201601927SA (en) | 2013-08-16 | 2014-08-15 | Selective delivery of material to cells |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201601927SA SG11201601927SA (en) | 2013-08-16 | 2014-08-15 | Selective delivery of material to cells |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10124336B2 (en) |
| EP (2) | EP3848695A1 (en) |
| JP (1) | JP6502940B2 (en) |
| KR (4) | KR102243597B1 (en) |
| CN (1) | CN105848793B (en) |
| AU (2) | AU2014306423B2 (en) |
| CA (1) | CA2921579C (en) |
| ES (1) | ES2865107T3 (en) |
| IL (1) | IL244113B (en) |
| MX (2) | MX2016002058A (en) |
| PL (1) | PL3033184T3 (en) |
| SG (2) | SG10201801188XA (en) |
| WO (1) | WO2015023982A1 (en) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS59898B1 (en) | 2011-10-17 | 2020-03-31 | Massachusetts Inst Technology | Intracellular delivery |
| JP6502940B2 (en) | 2013-08-16 | 2019-04-17 | マサチューセッツ インスティテュート オブ テクノロジー | Selective delivery of substances to cells |
| SG10201903912XA (en) * | 2014-10-31 | 2019-05-30 | Massachusetts Inst Technology | Delivery of biomolecules to immune cells |
| CN107002089B (en) * | 2014-11-14 | 2021-09-07 | 麻省理工学院 | Disruption and field-effected delivery of compounds and compositions into cells |
| WO2016115179A1 (en) | 2015-01-12 | 2016-07-21 | Massachusetts Institute Of Technology | Gene editing through microfluidic delivery |
| AU2016289530B2 (en) | 2015-07-09 | 2021-05-06 | Massachusetts Institute Of Technology | Delivery of materials to anucleate cells |
| EP3344747B1 (en) | 2015-09-04 | 2022-11-09 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules mediated by a surface with pores |
| WO2017041051A1 (en) | 2015-09-04 | 2017-03-09 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| EP3365269A4 (en) * | 2015-10-19 | 2019-06-19 | The Methodist Hospital | Crispr-cas9 delivery to hard-to-transfect cells via membrane deformation |
| IL260257B2 (en) | 2015-12-28 | 2024-05-01 | Novartis Ag | Compositions and methods for the treatment of hemoglobinopathies |
| WO2017123663A1 (en) | 2016-01-12 | 2017-07-20 | Sqz Biotechnologies Company | Intracellular delivery of complexes |
| WO2017173373A1 (en) | 2016-03-31 | 2017-10-05 | Massachusetts Institute Of Technology | Flow-through microfluidic methods and devices featuring membrane-perturbing surface interactions for intracellular delivery |
| CA3023092A1 (en) * | 2016-05-03 | 2017-11-09 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
| AU2017259988B2 (en) | 2016-05-03 | 2023-04-27 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
| CN106378213B (en) * | 2016-05-05 | 2018-08-17 | 海南大学 | Deformable microparticle separating chips based on dielectrophoresis |
| EP3500662B1 (en) | 2016-08-20 | 2022-10-05 | The Regents Of The University Of California | High-throughput system and method for the temporary permeabilization of cells |
| WO2018089497A1 (en) * | 2016-11-08 | 2018-05-17 | Georgia Tech Research Corporation | Methods for convectively-driven intracellular delivery |
| TW201839136A (en) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | Compositions and methods for the treatment of hemoglobinopathies |
| US11383241B2 (en) * | 2017-10-11 | 2022-07-12 | The Regents Of The University Of California | Mechano-node pore sensing |
| WO2019089034A1 (en) * | 2017-11-02 | 2019-05-09 | The Methodist Hospital | Crispr-cas9 delivery to hard-to-transfect cells via membrane deformation |
| US20210317187A1 (en) | 2017-12-05 | 2021-10-14 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to modulate antibody production |
| US11365390B2 (en) | 2017-12-19 | 2022-06-21 | Xcell Biosciences, Inc. | Methods of modulating cell phenotype by way of regulating the gaseous environment |
| KR20200100707A (en) | 2017-12-20 | 2020-08-26 | 에스큐지 바이오테크놀로지스 컴퍼니 | Systems for delivering payloads into cells |
| JP2019154314A (en) * | 2018-03-13 | 2019-09-19 | 国立大学法人九州大学 | Capillary chip and device comprising the same and introduction method of foreign material to cell |
| EP3556845A1 (en) | 2018-04-20 | 2019-10-23 | Cellix Limited | A method and device for transfecting cells |
| CN109351370B (en) * | 2018-11-21 | 2020-05-05 | 晶准生物医学（深圳）有限公司 | Microfluidic chip and cell screening method |
| CN113614237A (en) | 2019-01-25 | 2021-11-05 | Sqz生物技术公司 | Vaccine of cell origin without nucleus |
| BR112021016903A2 (en) | 2019-02-28 | 2021-11-03 | Sqz Biotechnologies Co | Administration of biomolecules to pbmcs to modify an immune response |
| DE102019108155B3 (en) | 2019-03-29 | 2020-06-04 | Leibniz-Institut Für Photonische Technologien E.V. | Micro drop retention assembly |
| AU2020271040A1 (en) | 2019-04-08 | 2021-11-18 | Sqz Biotechnologies Company | Cartridge for use in a system for delivery of a payload into a cell |
| US20220168739A1 (en) * | 2019-04-11 | 2022-06-02 | The Chinese University Of Hong Kong | Systems and methods for controlled membrane disruption |
| WO2020232418A1 (en) * | 2019-05-15 | 2020-11-19 | Cellfe, Inc. | Intracellular delivery |
| JP2023506842A (en) | 2019-12-18 | 2023-02-20 | ノバルティス アーゲー | Compositions and methods for treating hemoglobinopathies |
| CN111413257B (en) * | 2020-01-21 | 2021-05-14 | 中国科学院电子学研究所 | Cell nucleus electrical property detection device and method |
| MX2022014134A (en) | 2020-05-11 | 2022-11-30 | Hoffmann La Roche | Combination therapy with modified pbmcs and an immunoconjugate. |
| US20210371881A1 (en) * | 2020-05-26 | 2021-12-02 | TransCytos, LLC | Devices and methods for transfection |
| EP4188428A1 (en) | 2020-07-29 | 2023-06-07 | SQZ Biotechnologies Company | Methods to stimulate immune responses to mutant ras using nucleated cells |
| JP2023535982A (en) | 2020-07-29 | 2023-08-22 | スクイーズ バイオテクノロジーズ カンパニー | Methods for stimulating an immune response against mutant Ras using anucleate-free cells |
| CN117015596B (en) | 2020-11-18 | 2024-02-09 | 塞尔菲公司 | Methods and systems for mechanically perforated payload delivery to biological cells |
| US20220296691A1 (en) | 2020-12-29 | 2022-09-22 | Sqz Biotechnologies Company | Methods for treating cancer with activating antigen carriers |
| US20220203368A1 (en) | 2020-12-29 | 2022-06-30 | Sqz Biotechnologies Company | Microfluidic chip having increased throughput for use in a system for delivery of a payload into a cell |
| US20220233676A1 (en) | 2020-12-29 | 2022-07-28 | Sqz Biotechnologies Company | Formulations of activating antigen carriers |
| WO2022147017A1 (en) | 2020-12-29 | 2022-07-07 | Sqz Biotechnologies Company | Formulations for cryopreservation of pbmcs |
| JP2024502791A (en) | 2020-12-29 | 2024-01-23 | スクイーズ バイオテクノロジーズ カンパニー | High-throughput microfluidic chip with parallelized constrictions for perturbing cell membranes |
| EP4271711A1 (en) | 2020-12-29 | 2023-11-08 | SQZ Biotechnologies Company | Methods for treating cancers with modified pbmcs |
| WO2022269518A2 (en) | 2021-06-23 | 2022-12-29 | Novartis Ag | Compositions and methods for the treatment of hemoglobinopathies |
| WO2023010090A1 (en) | 2021-07-29 | 2023-02-02 | Sqz Biotechnologies Company | Methods to generate enhanced tumor infiltrating lymphocytes through microfluidic delivery |
| WO2023087009A1 (en) | 2021-11-11 | 2023-05-19 | Sqz Biotechnologies Company | Methods to generate enhanced tumor infiltrating lymphocytes through microfluidic delivery |
| WO2023230253A1 (en) | 2022-05-27 | 2023-11-30 | Sqz Biotechnologies Company | Cartridges and devices for use in a system for delivery of a payload into a cell |
| WO2024026492A1 (en) | 2022-07-28 | 2024-02-01 | Sqz Biotechnologies Company | Methods for treating cancer with enhanced antigen presenting cells |
| WO2024026491A2 (en) | 2022-07-28 | 2024-02-01 | Sqz Biotechnologies Company | Enhanced antigen presenting cell formulations |
Family Cites Families (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2502621C3 (en) | 1975-01-23 | 1978-09-14 | Kernforschungsanlage Juelich Gmbh, 5170 Juelich | Measurement of elastic and dielectric properties of the membrane of living cells |
| US4376634A (en) | 1980-05-30 | 1983-03-15 | Mallinckrodt, Inc. | Assay kit having syringe, dilution device and reagents within sealed container |
| US4478824A (en) | 1983-08-08 | 1984-10-23 | Franco Robert S | Method for altering red blood cell function and survival |
| FR2569477B1 (en) | 1984-08-24 | 1987-01-02 | Descartes Universite Rene | APPARATUS AND METHOD FOR DETERMINING THE DEFORMABILITY OF RED BLOOD CELLS |
| JP2720161B2 (en) | 1988-02-01 | 1998-02-25 | 株式会社アドバンス | Cell deformability measuring device |
| JP2685544B2 (en) | 1988-11-11 | 1997-12-03 | 株式会社日立製作所 | Blood filter, blood test method, and blood test apparatus |
| JP2532707B2 (en) | 1990-03-08 | 1996-09-11 | 佑二 菊池 | Blood circuit, blood measuring apparatus and blood measuring method using the same |
| US5643577A (en) | 1990-04-24 | 1997-07-01 | The University Of Newcastle Research Associates Limited | Oral vaccine comprising antigen surface-associated with red blood cells |
| US5658892A (en) | 1993-01-15 | 1997-08-19 | The General Hospital Corporation | Compound delivery using high-pressure impulse transients |
| US6218166B1 (en) | 1994-12-09 | 2001-04-17 | John Wayne Cancer Institute | Adjuvant incorporation into antigen carrying cells: compositions and methods |
| DK0814838T3 (en) | 1995-03-08 | 2003-09-15 | Scripps Research Inst | Antigen presenting system and activation of T cells |
| US6051409A (en) | 1995-09-25 | 2000-04-18 | Novartis Finance Corporation | Method for achieving integration of exogenous DNA delivered by non-biological means to plant cells |
| US6133503A (en) | 1995-10-31 | 2000-10-17 | The Regents Of The University Of California | Mammalian artificial chromosomes and methods of using same |
| AU725669B2 (en) | 1995-12-04 | 2000-10-19 | Puget Sound Blood Center | Non-immunogenic and toleragenic platelet and red blood cell compositions |
| BR9708387A (en) | 1996-03-28 | 2000-01-04 | Genitrix Llc | Process for vaccination of a mammal to a selected antigen, host and pathogenic cells, vaccine composition, nucleic acid, and engineered opsonin. |
| US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
| EP0882448B1 (en) | 1997-05-05 | 2005-01-12 | DIDECO S.r.l. | Method of encapsulating biologically active agents within erythrocytes and apparatus therefor |
| US5842787A (en) | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
| SE9704076D0 (en) | 1997-11-06 | 1997-11-06 | Holdingbolaget Vid Goeteborgs | Method for permeabilization of cell structures and use thereof |
| WO2003046171A1 (en) | 2001-11-27 | 2003-06-05 | Cellectricon Ab | A method for combined sequential agent delivery and electroporation for cell structures and use thereof |
| GB9816583D0 (en) | 1998-07-31 | 1998-09-30 | Univ Ulster | Nucleic acid carrier |
| WO2000078920A1 (en) | 1999-06-21 | 2000-12-28 | The General Hospital Corporation | Methods and devices for cell culturing and organ assist systems |
| JP2002325572A (en) | 2000-12-25 | 2002-11-12 | Univ Osaka | Method for introducing exogenous substance |
| WO2002067863A2 (en) | 2001-02-22 | 2002-09-06 | The Scepens Eye Research Institute, Inc. | Tolerogenic antigen presenting cells and in treating immune-inflammatory conditions |
| WO2003020039A1 (en) | 2001-08-28 | 2003-03-13 | Rush-Presbyterian-St. Luke's Medical Center | Immune tolerance to predetermined antigens |
| US20030133922A1 (en) | 2002-01-15 | 2003-07-17 | Kasha John R. | Oral tolerance using allogeneic platelets in ITP |
| CN100487456C (en) | 2002-06-05 | 2009-05-13 | 松下电器产业株式会社 | Extracellular electric potential measuring device and its manufacturing method |
| GB0214528D0 (en) | 2002-06-24 | 2002-08-07 | Univ Aberdeen | Materials and methods for induction of immune tolerance |
| JP2006517790A (en) | 2003-01-09 | 2006-08-03 | インヴィトロジェン コーポレーション | Cellular delivery and activation of polypeptide-nucleic acid complexes |
| US20060134067A1 (en) | 2003-02-18 | 2006-06-22 | Maxcyte, Inc. | Loading of cells with antigens by electroporation |
| US7968335B2 (en) | 2004-06-17 | 2011-06-28 | Ken Nakata | Cell culturing method using biomechanical stimulation loading and system therefor |
| JP4669876B2 (en) | 2004-07-27 | 2011-04-13 | ディーエスエム アイピー アセッツ ビー．ブイ． | Method for producing carbon nanotube / ultra high molecular weight polyethylene composite fiber |
| FR2873925B1 (en) | 2004-08-05 | 2006-10-13 | Erytech Pharma Soc Par Actions | METHOD AND DEVICE FOR LYSE-RESCALING FOR THE INCORPORATION OF ACTIVE PRINCIPLE, IN PARTICULAR ASPARAGINASE OR INOSITOL HEXAPHOSPHATE, IN ERYTHROCYTES |
| ES2350895T3 (en) | 2004-08-19 | 2011-01-28 | University College Cardiff Consultants Limited | PREPARATION OF T GAMMA DELTA HUMAN CELLS PRESENTING ANTIGENS AND ITS USE IN IMMUNOTHERAPY. |
| US20060134772A1 (en) | 2004-11-18 | 2006-06-22 | The Regents Of The University Of California | System for locating cells and for cellular analysis |
| US8420078B2 (en) | 2005-03-10 | 2013-04-16 | Yeda Research And Development Co. Ltd. | Methods and immunogenic cell preparations for treating antigen-associated diseases |
| US7704743B2 (en) | 2005-03-30 | 2010-04-27 | Georgia Tech Research Corporation | Electrosonic cell manipulation device and method of use thereof |
| KR100760309B1 (en) | 2005-07-06 | 2007-10-05 | 한국과학기술원 | Micro particle deformability sensor using micro filter |
| US7993821B2 (en) | 2005-08-11 | 2011-08-09 | University Of Washington | Methods and apparatus for the isolation and enrichment of circulating tumor cells |
| WO2007067032A1 (en) | 2005-12-09 | 2007-06-14 | Academisch Medisch Cemtrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
| WO2007097934A2 (en) | 2006-02-17 | 2007-08-30 | Elusys Therapeutics, Inc. | Methods and compositions for using erythrocytes as carriers for delivery of drugs |
| US8293524B2 (en) | 2006-03-31 | 2012-10-23 | Fluxion Biosciences Inc. | Methods and apparatus for the manipulation of particle suspensions and testing thereof |
| US20070249038A1 (en) | 2006-04-21 | 2007-10-25 | Andrea Adamo | Microfluidic device for single cell targeted operations |
| CA2662826A1 (en) | 2006-08-17 | 2008-02-21 | Massachusetts Institute Of Technology | Method and apparatus for microfluidic injection |
| WO2008098094A1 (en) | 2007-02-06 | 2008-08-14 | Network Biosystems, Inc. | Devices and methods for the performance of miniaturized in vitro assays |
| US20080311140A1 (en) | 2007-05-29 | 2008-12-18 | Baylor College Of Medicine | Antigen specific immunosuppression by dendritic cell therapy |
| US8841135B2 (en) | 2007-06-20 | 2014-09-23 | University Of Washington | Biochip for high-throughput screening of circulating tumor cells |
| CN101688218B (en) | 2007-06-21 | 2012-10-31 | 国立大学法人名古屋大学 | Method for introducing foreign substance into cell having cell wall |
| FR2919804B1 (en) | 2007-08-08 | 2010-08-27 | Erytech Pharma | COMPOSITION AND ANTI-TUMOR THERAPEUTIC VACCINE |
| GB0718160D0 (en) | 2007-09-18 | 2007-10-24 | Medical Res Council | Methods |
| EP2057998A1 (en) | 2007-10-31 | 2009-05-13 | Universitätsklinikum Hamburg-Eppendorf | Use of modified cells for the treatment of multiple sclerosis |
| KR100891487B1 (en) | 2007-11-01 | 2009-04-01 | 한국과학기술원 | Enucleation system of oocyte or ovum which based on microfluid mechanics |
| WO2009069418A1 (en) | 2007-11-28 | 2009-06-04 | Konica Minolta Opto, Inc. | Blood fluidity measurement apparatus and blood fluidity measurement method |
| US20090280518A1 (en) | 2008-05-12 | 2009-11-12 | Massachusetts Institute Of Technology | System for high throughput measurement of mechanical properties of cells |
| JP5137129B2 (en) | 2008-07-23 | 2013-02-06 | 国立大学法人山口大学 | Measuring device for mechanical properties of blood cells |
| US9115340B2 (en) | 2008-08-08 | 2015-08-25 | Agency For Science Technology & Research | Microfluidic continuous flow device |
| US8211656B2 (en) | 2008-08-13 | 2012-07-03 | The Invention Science Fund I, Llc | Biological targeting compositions and methods of using the same |
| US20110091973A1 (en) | 2008-12-09 | 2011-04-21 | Glaser Larry F | Modified and fusion enhanced erythrocytes, cells and uses thereof |
| US9157550B2 (en) | 2009-01-05 | 2015-10-13 | The Board Of Trustees Of The University Of Illinois | Microfluidic systems and methods |
| US9017991B2 (en) | 2009-03-13 | 2015-04-28 | Tufts University | Methods tip assemblies and kits for introducing material into cells |
| EP2405959A4 (en) | 2009-03-13 | 2013-10-16 | Univ Tufts | Methods, apparatuses, and kits for introducing genetic material into living cells |
| WO2010107399A1 (en) | 2009-03-20 | 2010-09-23 | Agency For Science, Technology And Research | Devices for separating cells and methods of using them |
| JP4849278B2 (en) | 2009-03-27 | 2012-01-11 | セイコーエプソン株式会社 | Cell treatment device, cell treatment cartridge, and body fluid treatment system |
| WO2010129671A2 (en) | 2009-05-08 | 2010-11-11 | Chauncey Sayre | Method of and apparatus for changing one type of cell into another type of cell |
| GB0909754D0 (en) | 2009-06-05 | 2009-07-22 | Magnani Mauro | Drug delivery systems |
| AU2010266705B2 (en) | 2009-06-30 | 2014-06-05 | Sangamo Therapeutics, Inc. | Rapid screening of biologically active nucleases and isolation of nuclease-modified cells |
| WO2011005799A2 (en) | 2009-07-06 | 2011-01-13 | Novartis Ag | Self replicating rna molecules and uses thereof |
| KR101125060B1 (en) * | 2009-07-22 | 2012-03-21 | 한국과학기술원 | Microfluidic device of capturing particles and method of capturing particles using it |
| US9364831B2 (en) | 2009-08-08 | 2016-06-14 | The Regents Of The University Of California | Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting |
| HUE029150T2 (en) | 2009-10-27 | 2017-02-28 | Erytech Pharma | Composition to induce specific immune tolerance |
| AU2010335107B2 (en) | 2009-12-21 | 2014-07-03 | Keygene N.V. | Improved techniques for transfecting protoplasts |
| WO2011079217A1 (en) | 2009-12-23 | 2011-06-30 | Cytovera, Inc. | A system and method for particle filtration |
| US9005579B2 (en) | 2010-01-05 | 2015-04-14 | Contrafect Corporation | Methods and compositions for enhanced immunological therapy and targeting of gram-positive bacteria |
| US8844570B2 (en) | 2010-02-01 | 2014-09-30 | California Institute Of Technology | Generating binary states using a microfluidic channel |
| JP5704590B2 (en) * | 2010-02-05 | 2015-04-22 | 国立大学法人東京農工大学 | Detection of circulating tumor cells using size-selective microcavity array |
| US9458489B2 (en) | 2010-03-04 | 2016-10-04 | Massachusetts Institute Of Technology | Microfluidics sorter for cell detection and isolation |
| WO2011119492A2 (en) | 2010-03-22 | 2011-09-29 | Massachusetts Institute Of Technology | Methods and compositions related to the measurement of material properties |
| CA2812063A1 (en) | 2010-08-30 | 2012-06-07 | President And Fellows Of Harvard College | Shear controlled release for stenotic lesions and thrombolytic therapies |
| RU2615460C2 (en) | 2010-11-25 | 2017-04-04 | Имнейт Сарл | Immunogenic peptides for application for prevention and/or treatment of infectious diseases, autoimmune diseases, the immune responses to allogeneic factors, allergic diseases, tumour, transplant rejection and immune responses against viral vectors used for genetic therapy or genetic vaccination |
| AU2012208926A1 (en) * | 2011-01-19 | 2013-07-25 | The University Of British Columbia | Apparatus and method for particle separation |
| BR112013021785A8 (en) | 2011-02-25 | 2018-07-03 | Recombinetics Inc | genetically modified animals and methods for doing the same |
| CN103502426B (en) | 2011-02-28 | 2018-03-13 | 哈佛大学校长及研究员协会 | Cell culture system |
| CN108531360A (en) | 2011-05-27 | 2018-09-14 | 不列颠哥伦比亚大学 | Micro-current controlled cell capture for high throughput analysis and analytical equipment |
| MX2013013243A (en) | 2011-07-05 | 2014-05-30 | Sotio As | Means and methods for active cellular immunotherapy of cancer by using tumor cells killed by high hydrostatic pressure and dendritic cells. |
| US20130065314A1 (en) | 2011-08-25 | 2013-03-14 | Phytocentric Biotech Inc. | Algal transformation systems, compositions and methods |
| RS59898B1 (en) | 2011-10-17 | 2020-03-31 | Massachusetts Inst Technology | Intracellular delivery |
| WO2013185032A1 (en) | 2012-06-07 | 2013-12-12 | President And Fellows Of Harvard College | Nanotherapeutics for drug targeting |
| US9255245B2 (en) | 2012-07-03 | 2016-02-09 | Agilent Technologies, Inc. | Sample probes and methods for sampling intracellular material |
| EP3372679A1 (en) | 2012-10-23 | 2018-09-12 | Toolgen Incorporated | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof |
| CN102925337B (en) | 2012-11-08 | 2014-06-18 | 武汉友芝友生物制药有限公司 | Microfluid cell capturing chip and manufacture method thereof |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| GB201300049D0 (en) | 2013-01-03 | 2013-02-20 | Transimmune Ag | Method for obtaining immuno-stimulatory dendritic cells |
| GB201300052D0 (en) | 2013-01-03 | 2013-02-20 | Transimmune Ag | Method for obtaining immuno-suppressive dendritic cells |
| US20140295490A1 (en) | 2013-01-30 | 2014-10-02 | Asta Fluidic Technologies, Inc. | Fetal red blood cell detection |
| US9725709B2 (en) | 2013-03-12 | 2017-08-08 | OpenCell Technologies, Inc. | Intracellular delivery and transfection methods and devices |
| KR102202742B1 (en) | 2013-03-15 | 2021-01-12 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | High-throughput cargo delivery into live cells using photothermal platforms |
| KR20140115560A (en) | 2013-03-21 | 2014-10-01 | 인하대학교 산학협력단 | Method of modifying characteristics of cells by mechanical stress and device for the same |
| PT2981607T (en) | 2013-04-03 | 2020-11-20 | Memorial Sloan Kettering Cancer Center | Effective generation of tumor-targeted t-cells derived from pluripotent stem cells |
| KR101508974B1 (en) * | 2013-05-14 | 2015-04-07 | 한국과학기술연구원 | Device for detection of tumor cells and detecting method thereof |
| JP6502940B2 (en) | 2013-08-16 | 2019-04-17 | マサチューセッツ インスティテュート オブ テクノロジー | Selective delivery of substances to cells |
| CA2927947A1 (en) | 2013-10-22 | 2015-04-30 | Cellanyx Diagnostics, Llc | Systems, devices and methods for microfluidic culturing, manipulation and analysis of tissues and cells |
| US10137673B2 (en) | 2013-12-31 | 2018-11-27 | Canon U.S. Life Sciences, Inc. | Methods and systems for continuous flow cell lysis in a microfluidic device |
| AU2015241422B2 (en) | 2014-04-01 | 2020-12-03 | Rubius Therapeutics, Inc. | Methods and compositions for immunomodulation |
| AU2015247323B2 (en) | 2014-04-18 | 2021-07-01 | Editas Medicine, Inc. | CRISPR-Cas-related methods, compositions and components for cancer immunotherapy |
| US10947526B2 (en) | 2014-07-03 | 2021-03-16 | Massachusetts Institute Of Technology | Microfluidic assay for rapid optimization of cell electroporation |
| SG10201903912XA (en) | 2014-10-31 | 2019-05-30 | Massachusetts Inst Technology | Delivery of biomolecules to immune cells |
| CN107002089B (en) | 2014-11-14 | 2021-09-07 | 麻省理工学院 | Disruption and field-effected delivery of compounds and compositions into cells |
| US9744533B2 (en) | 2014-12-10 | 2017-08-29 | Berkeley Lights, Inc. | Movement and selection of micro-objects in a microfluidic apparatus |
| JP6367493B2 (en) | 2015-01-07 | 2018-08-01 | インディー．インコーポレイテッド | Method of mechanical and hydrodynamic microfluidic transfection and apparatus therefor |
| WO2016115179A1 (en) | 2015-01-12 | 2016-07-21 | Massachusetts Institute Of Technology | Gene editing through microfluidic delivery |
| US20180135012A1 (en) | 2015-05-13 | 2018-05-17 | Rubius Therapeutics, Inc. | Membrane-receiver complex therapeutics |
| GB201513278D0 (en) | 2015-07-03 | 2015-09-09 | Transimmune Ag And Yale University | Device and method for obtaining immunostimulatory antigen-presenting cells |
| AU2016289530B2 (en) | 2015-07-09 | 2021-05-06 | Massachusetts Institute Of Technology | Delivery of materials to anucleate cells |
| WO2017041051A1 (en) | 2015-09-04 | 2017-03-09 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| EP3344747B1 (en) | 2015-09-04 | 2022-11-09 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules mediated by a surface with pores |
| AU2016374643B2 (en) | 2015-12-22 | 2023-12-14 | Sangui Bio Pty. Ltd | Therapeutic methods using erythrocytes |
| KR20180095098A (en) | 2016-01-11 | 2018-08-24 | 루비우스 테라퓨틱스, 아이엔씨. | Compositions and methods related to multimodal therapeutic cell systems for cancer indications |
| WO2017123663A1 (en) | 2016-01-12 | 2017-07-20 | Sqz Biotechnologies Company | Intracellular delivery of complexes |
| AU2017259988B2 (en) | 2016-05-03 | 2023-04-27 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
| CA3023092A1 (en) | 2016-05-03 | 2017-11-09 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
| US20170326213A1 (en) | 2016-05-16 | 2017-11-16 | Augusta University Research Institute, Inc. | Protein-Coupled Red Blood Cell Compositions and Methods of Their Use |
| CN106244543A (en) | 2016-07-29 | 2016-12-21 | 北京时合生物科技有限公司 | A kind of method that PBMC Differentiation Induction in vitro becomes dendritic cell |
| WO2018089497A1 (en) | 2016-11-08 | 2018-05-17 | Georgia Tech Research Corporation | Methods for convectively-driven intracellular delivery |
-
2014
- 2014-08-15 JP JP2016534877A patent/JP6502940B2/en active Active
- 2014-08-15 EP EP21158382.8A patent/EP3848695A1/en active Pending
- 2014-08-15 CA CA2921579A patent/CA2921579C/en active Active
- 2014-08-15 PL PL14836593T patent/PL3033184T3/en unknown
- 2014-08-15 US US14/912,001 patent/US10124336B2/en active Active
- 2014-08-15 WO PCT/US2014/051343 patent/WO2015023982A1/en active Application Filing
- 2014-08-15 CN CN201480056295.2A patent/CN105848793B/en active Active
- 2014-08-15 AU AU2014306423A patent/AU2014306423B2/en active Active
- 2014-08-15 SG SG10201801188XA patent/SG10201801188XA/en unknown
- 2014-08-15 ES ES14836593T patent/ES2865107T3/en active Active
- 2014-08-15 KR KR1020167006938A patent/KR102243597B1/en active IP Right Grant
- 2014-08-15 SG SG11201601927SA patent/SG11201601927SA/en unknown
- 2014-08-15 KR KR1020227011724A patent/KR102530914B1/en active IP Right Grant
- 2014-08-15 EP EP14836593.5A patent/EP3033184B1/en active Active
- 2014-08-15 KR KR1020217010816A patent/KR102304167B1/en active IP Right Grant
- 2014-08-15 MX MX2016002058A patent/MX2016002058A/en unknown
- 2014-08-15 KR KR1020217028921A patent/KR102386122B1/en active IP Right Grant
-
2016
- 2016-02-14 IL IL244113A patent/IL244113B/en unknown
- 2016-02-16 MX MX2021005777A patent/MX2021005777A/en unknown
-
2018
- 2018-09-28 US US16/145,865 patent/US10870112B2/en active Active
-
2019
- 2019-06-25 AU AU2019204480A patent/AU2019204480A1/en not_active Withdrawn
-
2020
- 2020-10-20 US US17/075,116 patent/US11806714B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL244113A0 (en) | Selective delivery of material to cells | |
| HK1223553A1 (en) | Cell | |
| HK1222338A1 (en) | Cell receptors | |
| ZA201507790B (en) | Enhanced adoptive cell therapy | |
| HK1221724A1 (en) | Cell receptors | |
| EP2968549A4 (en) | Methods of cell culture | |
| EP2971014A4 (en) | Methods of cell culture | |
| IL245524A0 (en) | New methods to produce active tert | |
| GB201310031D0 (en) | Cell | |
| GB201322430D0 (en) | T cell receptors | |
| HK1208400A1 (en) | Apparatus to reduce size of material | |
| GB201300324D0 (en) | Improvements to letter-plates | |
| GB201304514D0 (en) | Cell delivery | |
| GB201411724D0 (en) | Improvements to packaging means and manufacture thereof | |
| GB201317589D0 (en) | Cell | |
| GB201319932D0 (en) | Electrochemical materials and their manufacture | |
| GB201308905D0 (en) | Cell culture | |
| GB201306488D0 (en) | Cell culture | |
| GB201310215D0 (en) | Construction material |