SG10201701649YA - 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors - Google Patents

1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors

Info

Publication number
SG10201701649YA
SG10201701649YA SG10201701649YA SG10201701649YA SG10201701649YA SG 10201701649Y A SG10201701649Y A SG 10201701649YA SG 10201701649Y A SG10201701649Y A SG 10201701649YA SG 10201701649Y A SG10201701649Y A SG 10201701649YA SG 10201701649Y A SG10201701649Y A SG 10201701649YA
Authority
SG
Singapore
Prior art keywords
indazole
glycogen synthase
synthase kinase
carboxamide compounds
beta inhibitors
Prior art date
Application number
SG10201701649YA
Other languages
English (en)
Inventor
Maria Alessandra Alisi
Nicola Cazzolla
Patrizia Dragone
Guido Furlotti
Caterina Maugeri
Rosella Ombrato
Francesca Mancini
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of SG10201701649YA publication Critical patent/SG10201701649YA/en

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    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P13/00Drugs for disorders of the urinary system
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    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
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    • AHUMAN NECESSITIES
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
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    • AHUMAN NECESSITIES
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG10201701649YA 2012-02-21 2013-02-07 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors SG10201701649YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12156292 2012-02-21

Publications (1)

Publication Number Publication Date
SG10201701649YA true SG10201701649YA (en) 2017-04-27

Family

ID=47739223

Family Applications (2)

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SG11201403602WA SG11201403602WA (en) 2012-02-21 2013-02-07 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
SG10201701649YA SG10201701649YA (en) 2012-02-21 2013-02-07 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201403602WA SG11201403602WA (en) 2012-02-21 2013-02-07 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors

Country Status (27)

Country Link
US (3) US9611249B2 (es)
EP (1) EP2817302B1 (es)
JP (1) JP6141331B2 (es)
KR (1) KR20140130124A (es)
CN (1) CN104093712B (es)
AR (1) AR090086A1 (es)
AU (1) AU2013224302B2 (es)
BR (1) BR112014018655B1 (es)
CA (1) CA2860250C (es)
CY (1) CY1117469T1 (es)
DK (1) DK2817302T3 (es)
EA (1) EA024939B1 (es)
ES (1) ES2564961T3 (es)
GE (1) GEP20166489B (es)
HK (1) HK1203930A1 (es)
HR (1) HRP20160125T1 (es)
HU (1) HUE026893T2 (es)
IL (1) IL233824A (es)
ME (1) ME02353B (es)
MX (1) MX351287B (es)
PL (1) PL2817302T3 (es)
RS (1) RS54567B1 (es)
SG (2) SG11201403602WA (es)
SI (1) SI2817302T1 (es)
SM (1) SMT201600053B (es)
UA (1) UA112564C2 (es)
WO (1) WO2013124158A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2817301T1 (sl) * 2012-02-21 2016-03-31 Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A Uporaba 1H-indazol-3-karboksamidnih spojin kot inhibitorjev glikogen sintaza-kinaze-3beta
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk
SG10201914111XA (en) 2014-03-20 2020-03-30 Samumed Llc 5-substituted indazole-3-carboxamides and preparation and use thereof
JP2019521111A (ja) * 2016-06-08 2019-07-25 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited Atf4経路阻害剤としての化学化合物
MX2020008852A (es) * 2018-02-23 2020-10-14 Samumed Llc Indazol-3-carboxamidas sustituidas con 5-heteroarilo y preparacion y uso de las mismas.
PL3790873T3 (pl) * 2018-05-07 2022-06-27 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Związki 1h-indazolo-3-karboksyamidowe jako inhibitory kinazy syntazy glikogenu 3 beta
JP2021527039A (ja) * 2018-06-05 2021-10-11 アクチュエイト セラピューティクス、インク. 悪性リンパ腫性障害の治療法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR950704328A (ko) 1992-11-05 1995-11-17 데이비드 로버츠 5-HT₄ 수용체 길항제로서의 피페리딘 유도체(Piperidine Derivatives as 5-HT₄ Receptor Antagonists)
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
JP2006502133A (ja) * 2002-08-10 2006-01-19 アステックス、セラピューティックス、リミテッド サイクリン依存キナーゼ(cdk)インヒビターとしての3−(カルボニル)1h−インダゾール化合物
GB0218625D0 (en) * 2002-08-10 2002-09-18 Astex Technology Ltd Pharmaceutical compounds
ITMI20030287A1 (it) * 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20030972A1 (it) 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
WO2005014554A1 (en) * 2003-08-08 2005-02-17 Astex Therapeutics Limited 1h-indazole-3-carboxamide compounds as mapkap kinase modulators
GB0414438D0 (en) * 2004-06-28 2004-07-28 Syngenta Participations Ag Chemical compounds
AR052559A1 (es) * 2005-01-21 2007-03-21 Astex Therapeutics Ltd Derivados de pirazol para inhibir cdk's y gsk's
EP1692939A1 (en) * 2005-02-19 2006-08-23 Bayer CropScience S.A. Pesticidal substituted piperidines
CN101790526A (zh) * 2007-06-08 2010-07-28 雅培制药有限公司 用作激酶抑制剂的5-杂芳基取代的吲唑化合物
UA99927C2 (uk) 2007-11-12 2012-10-25 Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. Медикамент, який є активним при невропатичному болі
US8377968B2 (en) * 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
TW201040191A (en) 2009-03-27 2010-11-16 Abbott Gmbh & Co Kg Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
US7947728B1 (en) * 2009-11-11 2011-05-24 Hoffmann-La Roche Inc. Indole and indazole analogs as glycogen synthase activators

Also Published As

Publication number Publication date
HRP20160125T1 (hr) 2016-03-11
KR20140130124A (ko) 2014-11-07
DK2817302T3 (en) 2016-03-21
MX2014009297A (es) 2014-08-27
AU2013224302B2 (en) 2017-03-30
GEP20166489B (en) 2016-06-10
EP2817302B1 (en) 2015-12-30
EP2817302A1 (en) 2014-12-31
IL233824A (en) 2016-09-29
BR112014018655B1 (pt) 2022-02-08
PL2817302T3 (pl) 2016-06-30
HUE026893T2 (en) 2016-07-28
JP6141331B2 (ja) 2017-06-07
US10160746B2 (en) 2018-12-25
BR112014018655A8 (pt) 2017-07-11
SI2817302T1 (sl) 2016-03-31
AR090086A1 (es) 2014-10-15
SMT201600053B (it) 2016-04-29
US20150057294A1 (en) 2015-02-26
CY1117469T1 (el) 2017-04-26
BR112014018655A2 (es) 2017-06-20
EA024939B1 (ru) 2016-11-30
CA2860250A1 (en) 2013-08-29
US20170157121A1 (en) 2017-06-08
JP2015506993A (ja) 2015-03-05
AU2013224302A1 (en) 2014-07-17
ME02353B (me) 2016-06-20
WO2013124158A1 (en) 2013-08-29
CN104093712B (zh) 2016-11-09
MX351287B (es) 2017-10-09
UA112564C2 (uk) 2016-09-26
EA201491449A1 (ru) 2014-11-28
US9611249B2 (en) 2017-04-04
RS54567B1 (en) 2016-06-30
CA2860250C (en) 2020-11-10
HK1203930A1 (zh) 2015-11-06
IL233824A0 (en) 2014-09-30
SG11201403602WA (en) 2014-07-30
ES2564961T3 (es) 2016-03-30
US20170174657A1 (en) 2017-06-22
CN104093712A (zh) 2014-10-08

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