SG10201605397PA - Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides - Google Patents

Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides

Info

Publication number
SG10201605397PA
SG10201605397PA SG10201605397PA SG10201605397PA SG10201605397PA SG 10201605397P A SG10201605397P A SG 10201605397PA SG 10201605397P A SG10201605397P A SG 10201605397PA SG 10201605397P A SG10201605397P A SG 10201605397PA SG 10201605397P A SG10201605397P A SG 10201605397PA
Authority
SG
Singapore
Prior art keywords
polypeptides
separation
aggregated
monomeric
monomeric polypeptides
Prior art date
Application number
SG10201605397PA
Other languages
English (en)
Inventor
Monika Baehner
Adelbert Grossmann
Stefan Hepbildikler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG10201605397PA publication Critical patent/SG10201605397PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
SG10201605397PA 2011-07-01 2012-06-28 Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides SG10201605397PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11172348 2011-07-01

Publications (1)

Publication Number Publication Date
SG10201605397PA true SG10201605397PA (en) 2016-08-30

Family

ID=46466477

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201605397PA SG10201605397PA (en) 2011-07-01 2012-06-28 Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides

Country Status (5)

Country Link
US (3) US9783570B2 (fr)
EP (1) EP2726496B1 (fr)
JP (1) JP6292718B2 (fr)
SG (1) SG10201605397PA (fr)
WO (1) WO2013004587A1 (fr)

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KR101226353B1 (ko) 2007-06-01 2013-01-24 에프. 호프만-라 로슈 아게 면역글로불린 정제
JP5814951B2 (ja) 2010-03-10 2015-11-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 免疫グロブリン溶液を精製するための方法
SG10201605397PA (en) * 2011-07-01 2016-08-30 Hoffmann La Roche Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides
MY178616A (en) 2012-09-17 2020-10-19 Grace W R & Co Chromatography media and devices
JP6853670B2 (ja) 2014-01-16 2021-04-07 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ 親和性クロマトグラフィー媒体及びクロマトグラフィーデバイス
SG11201607341SA (en) * 2014-03-04 2016-10-28 Merck Patent Gmbh Robust antibody purification
CN107847907A (zh) 2014-05-02 2018-03-27 格雷斯公司 官能化载体材料以及制备和使用官能化载体材料的方法
SI3215528T1 (sl) 2014-11-06 2019-11-29 Hoffmann La Roche Variante regije Fc s spremenjeno vezavo FcRn in postopki uporabe
EP3302784B1 (fr) 2015-06-05 2021-10-06 W.R. Grace & Co.-Conn. Agents de clarification adsorbants pour le biotraitement et procédés de production et d'utilisation desdits agents
JP6621176B2 (ja) * 2016-01-22 2019-12-18 旭化成メディカル株式会社 タンパク質の精製方法
EA202092335A1 (ru) 2018-04-02 2021-01-22 Эмджен Инк. Композиции на основе эренумаба и пути их применения

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US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
WO1997041232A1 (fr) 1996-04-26 1997-11-06 Beth Israel Deaconess Medical Center Antagonistes de l'interleukine-15
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ITBO20010426A1 (it) * 2001-07-06 2003-01-06 Alfa Wassermann Spa Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico
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US20100069617A1 (en) 2008-09-12 2010-03-18 Ge Healthcare Bio-Sciences Ab Enhanced protein aggregate removal by mixed mode chromatography on hydrophobic interaction media in the presence of protein-excluded zwitterions
JP2010158624A (ja) 2009-01-08 2010-07-22 Asahi Kasei Chemicals Corp 多孔質吸着膜、及び当該多孔質吸着膜を用いたたんぱく質の精製方法
WO2011001963A1 (fr) 2009-07-03 2011-01-06 旭化成ケミカルズ株式会社 Procédé de purification d'un anticorps à l'aide d'une membrane poreuse ayant une groupe amino et un groupe alkyle tous deux liés à une chaîne greffée immobilisée sur une matière de base poreuse
JP5814951B2 (ja) 2010-03-10 2015-11-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 免疫グロブリン溶液を精製するための方法
RU2591523C2 (ru) * 2010-11-05 2016-07-20 Ф. Хоффманн-Ля Рош Аг Оптимизированный метод захвата антител хроматографией смешанного типа
SG10201605397PA (en) * 2011-07-01 2016-08-30 Hoffmann La Roche Method For Separation Of Monomeric Polypeptides From Aggregated Polypeptides
CA3159061A1 (fr) 2012-02-15 2013-08-22 F. Hoffmann-La Roche Ag Chromatographie d'affinite faisant appel a des recepteurs fc

Also Published As

Publication number Publication date
US9783570B2 (en) 2017-10-10
EP2726496A1 (fr) 2014-05-07
JP2014520775A (ja) 2014-08-25
US20180094023A1 (en) 2018-04-05
US10654886B2 (en) 2020-05-19
JP6292718B2 (ja) 2018-03-14
EP2726496B1 (fr) 2018-04-04
US11168110B2 (en) 2021-11-09
WO2013004587A1 (fr) 2013-01-10
US20140142283A1 (en) 2014-05-22
US20200291063A1 (en) 2020-09-17

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