SG10201604279TA - Dual targeting - Google Patents
Dual targetingInfo
- Publication number
- SG10201604279TA SG10201604279TA SG10201604279TA SG10201604279TA SG10201604279TA SG 10201604279T A SG10201604279T A SG 10201604279TA SG 10201604279T A SG10201604279T A SG 10201604279TA SG 10201604279T A SG10201604279T A SG 10201604279TA SG 10201604279T A SG10201604279T A SG 10201604279TA
- Authority
- SG
- Singapore
- Prior art keywords
- dual targeting
- targeting
- dual
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Ecology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11004373 | 2011-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201604279TA true SG10201604279TA (en) | 2016-07-28 |
Family
ID=46207961
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201604279TA SG10201604279TA (en) | 2011-05-27 | 2012-05-29 | Dual targeting |
| SG2013087945A SG195196A1 (en) | 2011-05-27 | 2012-05-29 | Dual targeting |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013087945A SG195196A1 (en) | 2011-05-27 | 2012-05-29 | Dual targeting |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US20140206846A1 (de) |
| EP (1) | EP2726510B1 (de) |
| JP (2) | JP2014516542A (de) |
| CN (2) | CN103930445B (de) |
| AU (1) | AU2012265156B2 (de) |
| CA (1) | CA2853383C (de) |
| DK (1) | DK2726510T3 (de) |
| ES (1) | ES2943577T3 (de) |
| FI (1) | FI2726510T3 (de) |
| HR (1) | HRP20230411T1 (de) |
| HU (1) | HUE061692T2 (de) |
| IL (1) | IL229649B (de) |
| LT (1) | LT2726510T (de) |
| PL (1) | PL2726510T3 (de) |
| PT (1) | PT2726510T (de) |
| RS (1) | RS64179B1 (de) |
| SG (2) | SG10201604279TA (de) |
| SI (1) | SI2726510T1 (de) |
| WO (1) | WO2012163520A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2928920A1 (de) * | 2012-12-05 | 2015-10-14 | Dutalys GmbH | Zweifaches targeting |
| RU2020129339A (ru) * | 2013-12-20 | 2020-10-02 | Дженентек, Инк. | Антитела с двойной специфичностью |
| CN106661119A (zh) | 2014-07-01 | 2017-05-10 | 辉瑞公司 | 双特异性异二聚化双抗体及其用途 |
| MX2017004076A (es) | 2014-09-29 | 2017-07-04 | Univ Duke | Moleculas biespecificas que comprenden un brazo orientado a la envoltura vih-1. |
| US11071783B2 (en) | 2015-03-19 | 2021-07-27 | Duke University | HIV-1 neutralizing antibodies and uses thereof |
| WO2016149698A2 (en) | 2015-03-19 | 2016-09-22 | Duke University | Hiv-1 neutralizing antibodies and uses thereof (v3 antibodies) |
| WO2016149695A1 (en) | 2015-03-19 | 2016-09-22 | Duke University | HIV-1 NEUTRALIZING ANTIBODIES AND USES THEREOF (CD4bs ANTIBODIES) |
| CA2979708A1 (en) | 2015-03-19 | 2016-09-22 | Duke University | Hiv-1 neutralizing antibodies and uses thereof |
| WO2018060035A1 (en) | 2016-09-30 | 2018-04-05 | F. Hoffmann-La Roche Ag | Spr-based dual-binding assay for the functional analysis of multispecific molecules |
| EP3330289A1 (de) | 2016-12-02 | 2018-06-06 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Cd33-, cd16- und cd123-spezifischer einkettiger tribody |
| GB201711208D0 (en) | 2017-07-12 | 2017-08-23 | Iontas Ltd | Ion channel inhibitors |
| MX2020009152A (es) * | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| SG11202106198YA (en) * | 2018-12-21 | 2021-07-29 | Hoffmann La Roche | Antibody that binds to vegf and il-1beta and methods of use |
| JP7241888B2 (ja) | 2018-12-30 | 2023-03-17 | エフ． ホフマン－ラ ロシュ アーゲー | ｐＨ勾配ＳＰＲに基づく結合アッセイ |
| EP3948281A1 (de) | 2019-03-29 | 2022-02-09 | F. Hoffmann-La Roche AG | Spr-basierter bindungstest zur funktionellen analyse mehrwertiger moleküle |
| EP3947440A1 (de) | 2019-03-29 | 2022-02-09 | F. Hoffmann-La Roche AG | Verfahren zur erzeugung von avid-bindenden multispezifischen antikörpern |
| CN114008081A (zh) | 2019-06-19 | 2022-02-01 | 豪夫迈·罗氏有限公司 | 通过以限定的组织形式靶向整合多个表达盒来产生二价双特异性抗体表达细胞的方法 |
| BR112021025425A2 (pt) | 2019-06-19 | 2022-02-01 | Hoffmann La Roche | Método para produzir uma célula de mamífero recombinante e uso de mrna de recombinase cre |
| AU2020297940A1 (en) | 2019-06-19 | 2021-12-16 | F. Hoffmann-La Roche Ag | Method for the generation of a multivalent, bispecific antibody expressing cell by targeted integration of multiple expression cassettes in a defined organization |
| MX2021015648A (es) | 2019-06-19 | 2022-02-03 | Hoffmann La Roche | Metodo para la generacion de una celula que expresa un anticuerpo multiespecifico multivalente mediante integracion dirigida de multiples casetes de expresion en una organizacion definida. |
| CN114008212A (zh) | 2019-06-19 | 2022-02-01 | 豪夫迈·罗氏有限公司 | 通过以限定的组织形式靶向整合多个表达盒来产生三价抗体表达细胞的方法 |
| JP7450647B2 (ja) | 2019-06-26 | 2024-03-15 | エフ． ホフマン－ラ ロシュ アーゲー | Ｓｉｒｔ－１遺伝子ノックアウトを有する哺乳類細胞株 |
| JP2022553640A (ja) | 2019-10-10 | 2022-12-26 | コディアック サイエンシーズ インコーポレイテッド | 眼障害を処置する方法 |
| WO2021084104A1 (en) | 2019-10-30 | 2021-05-06 | Bioinvent International Ab | Tetravalent antibody molecules |
| EP4085254B1 (de) | 2020-01-02 | 2024-06-05 | F. Hoffmann-La Roche AG | Ada-reaktionsspezifikationsassay |
| EP4126940A1 (de) | 2020-03-30 | 2023-02-08 | F. Hoffmann-La Roche AG | An vegf und pdgf-b bindender antikörper und verfahren zur verwendung |
| KR20230061458A (ko) | 2020-09-04 | 2023-05-08 | 에프. 호프만-라 로슈 아게 | Vegf-a 및 ang2에 결합하는 항체 및 사용 방법 |
| IL301366A (en) | 2020-09-24 | 2023-05-01 | Hoffmann La Roche | Mammalian cell lines with genetic knockout |
| CN116670282A (zh) | 2020-12-22 | 2023-08-29 | 豪夫迈·罗氏有限公司 | 靶向xbp1的寡核苷酸 |
| WO2022175217A1 (en) | 2021-02-18 | 2022-08-25 | F. Hoffmann-La Roche Ag | Method for resolving complex, multistep antibody interactions |
| EP4320444A1 (de) | 2021-04-09 | 2024-02-14 | F. Hoffmann-La Roche AG | Verfahren zur selektion von zellklonen, die ein heterologes polypeptid exprimieren |
| WO2023117325A1 (en) | 2021-12-21 | 2023-06-29 | F. Hoffmann-La Roche Ag | Method for the determination of hydrolytic activity |
| WO2023202967A1 (en) | 2022-04-19 | 2023-10-26 | F. Hoffmann-La Roche Ag | Improved production cells |
| WO2023217933A1 (en) | 2022-05-11 | 2023-11-16 | F. Hoffmann-La Roche Ag | Antibody that binds to vegf-a and il6 and methods of use |
| WO2023232961A1 (en) | 2022-06-03 | 2023-12-07 | F. Hoffmann-La Roche Ag | Improved production cells |
| WO2024079069A1 (en) | 2022-10-12 | 2024-04-18 | F. Hoffmann-La Roche Ag | Method for classifying cells |
| WO2024110426A1 (en) | 2022-11-23 | 2024-05-30 | F. Hoffmann-La Roche Ag | Method for increasing recombinant protein expression |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| EP0859841B1 (de) | 1995-08-18 | 2002-06-19 | MorphoSys AG | Protein-/(poly)peptidbibliotheken |
| US7883704B2 (en) * | 1999-03-25 | 2011-02-08 | Abbott Gmbh & Co. Kg | Methods for inhibiting the activity of the P40 subunit of human IL-12 |
| PE20020132A1 (es) | 2000-06-29 | 2002-03-04 | Abbott Lab | Anticuerpos de especificidad doble y metodos para la elaboracion y el uso de los mismos |
| JP4303105B2 (ja) * | 2001-06-28 | 2009-07-29 | ドマンティス リミテッド | 二重特異性リガンドとその利用 |
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US7749724B2 (en) | 2005-07-05 | 2010-07-06 | Washington State University | Fluorogenic selective and differential medium for isolation of Enterobacter sakazakii |
| WO2007112940A2 (en) | 2006-03-31 | 2007-10-11 | Ablynx N.V. | Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same |
| DK2059533T3 (da) | 2006-08-30 | 2013-02-25 | Genentech Inc | Multispecifikke antistoffer |
-
2012
- 2012-05-29 US US14/122,758 patent/US20140206846A1/en not_active Abandoned
- 2012-05-29 SG SG10201604279TA patent/SG10201604279TA/en unknown
- 2012-05-29 DK DK12725311.0T patent/DK2726510T3/da active
- 2012-05-29 ES ES12725311T patent/ES2943577T3/es active Active
- 2012-05-29 RS RS20230337A patent/RS64179B1/sr unknown
- 2012-05-29 AU AU2012265156A patent/AU2012265156B2/en active Active
- 2012-05-29 HR HRP20230411TT patent/HRP20230411T1/hr unknown
- 2012-05-29 HU HUE12725311A patent/HUE061692T2/hu unknown
- 2012-05-29 EP EP12725311.0A patent/EP2726510B1/de active Active
- 2012-05-29 CA CA2853383A patent/CA2853383C/en active Active
- 2012-05-29 SI SI201232028T patent/SI2726510T1/sl unknown
- 2012-05-29 LT LTEPPCT/EP2012/002279T patent/LT2726510T/lt unknown
- 2012-05-29 PL PL12725311.0T patent/PL2726510T3/pl unknown
- 2012-05-29 JP JP2014513080A patent/JP2014516542A/ja not_active Withdrawn
- 2012-05-29 WO PCT/EP2012/002279 patent/WO2012163520A1/en active Application Filing
- 2012-05-29 FI FIEP12725311.0T patent/FI2726510T3/fi active
- 2012-05-29 CN CN201280037640.9A patent/CN103930445B/zh active Active
- 2012-05-29 SG SG2013087945A patent/SG195196A1/en unknown
- 2012-05-29 PT PT127253110T patent/PT2726510T/pt unknown
- 2012-05-29 CN CN202011214419.9A patent/CN112661848A/zh active Pending
-
2013
- 2013-11-27 IL IL229649A patent/IL229649B/en active IP Right Grant
-
2017
- 2017-06-09 US US15/618,724 patent/US20180094078A1/en not_active Abandoned
- 2017-07-06 JP JP2017132795A patent/JP6659626B2/ja active Active
-
2020
- 2020-04-28 US US16/860,418 patent/US20210079119A1/en not_active Abandoned
-
2023
- 2023-05-15 US US18/317,385 patent/US20230279155A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL229649B (en) | 2019-08-29 |
| ES2943577T3 (es) | 2023-06-14 |
| JP2017221200A (ja) | 2017-12-21 |
| CA2853383C (en) | 2021-04-06 |
| US20180094078A1 (en) | 2018-04-05 |
| CN103930445B (zh) | 2021-03-09 |
| JP2014516542A (ja) | 2014-07-17 |
| SI2726510T1 (sl) | 2023-06-30 |
| US20140206846A1 (en) | 2014-07-24 |
| US20230279155A1 (en) | 2023-09-07 |
| AU2012265156B2 (en) | 2017-01-19 |
| CN103930445A (zh) | 2014-07-16 |
| EP2726510A1 (de) | 2014-05-07 |
| DK2726510T3 (da) | 2023-05-15 |
| WO2012163520A4 (en) | 2013-01-24 |
| US20210079119A1 (en) | 2021-03-18 |
| PL2726510T3 (pl) | 2023-05-29 |
| SG195196A1 (en) | 2013-12-30 |
| WO2012163520A1 (en) | 2012-12-06 |
| AU2012265156A1 (en) | 2014-01-16 |
| IL229649A0 (en) | 2014-01-30 |
| EP2726510B1 (de) | 2023-03-08 |
| JP6659626B2 (ja) | 2020-03-04 |
| HUE061692T2 (hu) | 2023-08-28 |
| FI2726510T3 (fi) | 2023-05-04 |
| LT2726510T (lt) | 2023-05-10 |
| CA2853383A1 (en) | 2012-12-06 |
| RS64179B1 (sr) | 2023-05-31 |
| NZ619409A (en) | 2016-05-27 |
| CN112661848A (zh) | 2021-04-16 |
| HRP20230411T1 (hr) | 2023-07-07 |
| PT2726510T (pt) | 2023-05-03 |
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