PT2726510T - Direcionamento duplo - Google Patents
Direcionamento duploInfo
- Publication number
- PT2726510T PT2726510T PT127253110T PT12725311T PT2726510T PT 2726510 T PT2726510 T PT 2726510T PT 127253110 T PT127253110 T PT 127253110T PT 12725311 T PT12725311 T PT 12725311T PT 2726510 T PT2726510 T PT 2726510T
- Authority
- PT
- Portugal
- Prior art keywords
- dual targeting
- targeting
- dual
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11004373 | 2011-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2726510T true PT2726510T (pt) | 2023-05-03 |
Family
ID=46207961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT127253110T PT2726510T (pt) | 2011-05-27 | 2012-05-29 | Direcionamento duplo |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US20140206846A1 (pt) |
| EP (1) | EP2726510B1 (pt) |
| JP (2) | JP2014516542A (pt) |
| CN (2) | CN112661848A (pt) |
| AU (1) | AU2012265156B2 (pt) |
| CA (1) | CA2853383C (pt) |
| DK (1) | DK2726510T3 (pt) |
| ES (1) | ES2943577T3 (pt) |
| FI (1) | FI2726510T3 (pt) |
| HR (1) | HRP20230411T1 (pt) |
| HU (1) | HUE061692T2 (pt) |
| IL (1) | IL229649B (pt) |
| LT (1) | LT2726510T (pt) |
| PL (1) | PL2726510T3 (pt) |
| PT (1) | PT2726510T (pt) |
| RS (1) | RS64179B1 (pt) |
| SG (2) | SG10201604279TA (pt) |
| SI (1) | SI2726510T1 (pt) |
| WO (1) | WO2012163520A1 (pt) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2891566A1 (en) | 2012-12-05 | 2014-06-12 | Dutalys Gmbh | Dual targeting |
| CN105849124B (zh) * | 2013-12-20 | 2022-04-12 | 豪夫迈·罗氏有限公司 | 双重特异性抗体 |
| SG11201609707WA (en) | 2014-07-01 | 2017-01-27 | Pfizer | Bispecific heterodimeric diabodies and uses thereof |
| CN107108721B (zh) | 2014-09-29 | 2021-09-07 | 杜克大学 | 包含hiv-1包膜靶向臂的双特异性分子 |
| CA2979708A1 (en) | 2015-03-19 | 2016-09-22 | Duke University | Hiv-1 neutralizing antibodies and uses thereof |
| WO2016149695A1 (en) | 2015-03-19 | 2016-09-22 | Duke University | HIV-1 NEUTRALIZING ANTIBODIES AND USES THEREOF (CD4bs ANTIBODIES) |
| WO2016149698A2 (en) | 2015-03-19 | 2016-09-22 | Duke University | Hiv-1 neutralizing antibodies and uses thereof (v3 antibodies) |
| WO2016149710A2 (en) | 2015-03-19 | 2016-09-22 | Duke University | Hiv-1 neutralizing antibodies and uses thereof |
| WO2018060035A1 (en) | 2016-09-30 | 2018-04-05 | F. Hoffmann-La Roche Ag | Spr-based dual-binding assay for the functional analysis of multispecific molecules |
| EP3330289A1 (en) | 2016-12-02 | 2018-06-06 | Friedrich-Alexander-Universität Erlangen-Nürnberg | A cd33-, cd16- and cd123-specific single chain triplebody |
| GB201711208D0 (en) | 2017-07-12 | 2017-08-23 | Iontas Ltd | Ion channel inhibitors |
| US20190270806A1 (en) * | 2018-03-02 | 2019-09-05 | Kodiak Sciences Inc. | Il-6 antibodies and fusion constructs and conjugates thereof |
| AU2019406712A1 (en) | 2018-12-21 | 2021-06-17 | F. Hoffmann-La Roche Ag | Antibody that binds to VEGF and IL-1beta and methods of use |
| EP3903102B1 (en) | 2018-12-30 | 2023-04-12 | F. Hoffmann-La Roche AG | Ph-gradient spr-based binding assay |
| WO2020200944A1 (en) | 2019-03-29 | 2020-10-08 | F. Hoffmann-La Roche Ag | Method for generating avid-binding multispecific antibodies |
| WO2020200941A1 (en) | 2019-03-29 | 2020-10-08 | F. Hoffmann-La Roche Ag | Spr-based binding assay for the functional analysis of multivalent molecules |
| MX2021015540A (es) | 2019-06-19 | 2022-02-10 | Hoffmann La Roche | Metodo para la generacion de una celula que expresa un anticuerpo trivalente mediante la integracion dirigida de multiples casetes de expresion en una organizacion definida. |
| JP2022537338A (ja) | 2019-06-19 | 2022-08-25 | エフ．ホフマン－ラ ロシュ アーゲー | 所定の構成の複数の発現カセットの標的指向性組込みによって二価二重特異性抗体発現細胞を作製するための方法 |
| EP3986924A1 (en) | 2019-06-19 | 2022-04-27 | F. Hoffmann-La Roche AG | Method for the generation of a multivalent, multispecific antibody expressing cell by targeted integration of multiple expression cassettes in a defined organization |
| MX2021015536A (es) | 2019-06-19 | 2022-02-10 | Hoffmann La Roche | Metodo para la generacion de una celula que expresa proteina mediante integracion dirigida usando acido ribonucleico mensajero (arnm) de cre. |
| MX2021015537A (es) | 2019-06-19 | 2022-02-10 | Hoffmann La Roche | Metodo para la generacion de una celula que expresa anticuerpo biespecifico multivalente mediante la integracion diana de casetes de expresion multiples en una organizacion definida. |
| KR20220016957A (ko) | 2019-06-26 | 2022-02-10 | 에프. 호프만-라 로슈 아게 | Sirt-1 유전자 녹아웃을 갖는 포유류 세포주 |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| WO2021084104A1 (en) | 2019-10-30 | 2021-05-06 | Bioinvent International Ab | Tetravalent antibody molecules |
| JP2023509435A (ja) | 2020-01-02 | 2023-03-08 | エフ． ホフマン－ラ ロシュ アーゲー | Ａｄａ応答特定アッセイ |
| CN115397850A (zh) | 2020-03-30 | 2022-11-25 | 豪夫迈·罗氏有限公司 | 与vegf和pdgf-b结合的抗体及其使用方法 |
| KR20230061458A (ko) | 2020-09-04 | 2023-05-08 | 에프. 호프만-라 로슈 아게 | Vegf-a 및 ang2에 결합하는 항체 및 사용 방법 |
| AU2021347580A1 (en) | 2020-09-24 | 2023-04-06 | F. Hoffmann-La Roche Ag | Mammalian cell lines with gene knockout |
| EP4267734A1 (en) | 2020-12-22 | 2023-11-01 | F. Hoffmann-La Roche AG | Oligonucleotides targeting xbp1 |
| WO2022175217A1 (en) | 2021-02-18 | 2022-08-25 | F. Hoffmann-La Roche Ag | Method for resolving complex, multistep antibody interactions |
| EP4320444A1 (en) | 2021-04-09 | 2024-02-14 | F. Hoffmann-La Roche AG | Process for selecting cell clones expressing a heterologous polypeptide |
| WO2023117325A1 (en) | 2021-12-21 | 2023-06-29 | F. Hoffmann-La Roche Ag | Method for the determination of hydrolytic activity |
| WO2023202967A1 (en) | 2022-04-19 | 2023-10-26 | F. Hoffmann-La Roche Ag | Improved production cells |
| WO2023217933A1 (en) | 2022-05-11 | 2023-11-16 | F. Hoffmann-La Roche Ag | Antibody that binds to vegf-a and il6 and methods of use |
| WO2023232961A1 (en) | 2022-06-03 | 2023-12-07 | F. Hoffmann-La Roche Ag | Improved production cells |
| WO2024079069A1 (en) | 2022-10-12 | 2024-04-18 | F. Hoffmann-La Roche Ag | Method for classifying cells |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| EP0859841B1 (en) | 1995-08-18 | 2002-06-19 | MorphoSys AG | Protein/(poly)peptide libraries |
| US7883704B2 (en) * | 1999-03-25 | 2011-02-08 | Abbott Gmbh & Co. Kg | Methods for inhibiting the activity of the P40 subunit of human IL-12 |
| DE60137421D1 (de) | 2000-06-29 | 2009-03-05 | Abbott Lab | Antikörper mit zwei spezifizitäten und verfahren zur deren herstellung und verwendung |
| DE60237282D1 (de) * | 2001-06-28 | 2010-09-23 | Domantis Ltd | Doppelspezifischer ligand und dessen verwendung |
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US7749724B2 (en) | 2005-07-05 | 2010-07-06 | Washington State University | Fluorogenic selective and differential medium for isolation of Enterobacter sakazakii |
| WO2007112940A2 (en) | 2006-03-31 | 2007-10-11 | Ablynx N.V. | Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same |
| EP2471816A1 (en) * | 2006-08-30 | 2012-07-04 | Genentech, Inc. | Multispecific antibodies |
-
2012
- 2012-05-29 EP EP12725311.0A patent/EP2726510B1/en active Active
- 2012-05-29 ES ES12725311T patent/ES2943577T3/es active Active
- 2012-05-29 US US14/122,758 patent/US20140206846A1/en not_active Abandoned
- 2012-05-29 PT PT127253110T patent/PT2726510T/pt unknown
- 2012-05-29 CA CA2853383A patent/CA2853383C/en active Active
- 2012-05-29 FI FIEP12725311.0T patent/FI2726510T3/fi active
- 2012-05-29 CN CN202011214419.9A patent/CN112661848A/zh active Pending
- 2012-05-29 HR HRP20230411TT patent/HRP20230411T1/hr unknown
- 2012-05-29 PL PL12725311.0T patent/PL2726510T3/pl unknown
- 2012-05-29 SI SI201232028T patent/SI2726510T1/sl unknown
- 2012-05-29 AU AU2012265156A patent/AU2012265156B2/en active Active
- 2012-05-29 WO PCT/EP2012/002279 patent/WO2012163520A1/en active Application Filing
- 2012-05-29 SG SG10201604279TA patent/SG10201604279TA/en unknown
- 2012-05-29 RS RS20230337A patent/RS64179B1/sr unknown
- 2012-05-29 CN CN201280037640.9A patent/CN103930445B/zh active Active
- 2012-05-29 JP JP2014513080A patent/JP2014516542A/ja not_active Withdrawn
- 2012-05-29 HU HUE12725311A patent/HUE061692T2/hu unknown
- 2012-05-29 DK DK12725311.0T patent/DK2726510T3/da active
- 2012-05-29 SG SG2013087945A patent/SG195196A1/en unknown
- 2012-05-29 LT LTEPPCT/EP2012/002279T patent/LT2726510T/lt unknown
-
2013
- 2013-11-27 IL IL229649A patent/IL229649B/en active IP Right Grant
-
2017
- 2017-06-09 US US15/618,724 patent/US20180094078A1/en not_active Abandoned
- 2017-07-06 JP JP2017132795A patent/JP6659626B2/ja active Active
-
2020
- 2020-04-28 US US16/860,418 patent/US20210079119A1/en not_active Abandoned
-
2023
- 2023-05-15 US US18/317,385 patent/US20230279155A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PL2726510T3 (pl) | 2023-05-29 |
| AU2012265156B2 (en) | 2017-01-19 |
| FI2726510T3 (fi) | 2023-05-04 |
| IL229649A0 (en) | 2014-01-30 |
| JP6659626B2 (ja) | 2020-03-04 |
| HUE061692T2 (hu) | 2023-08-28 |
| CN112661848A (zh) | 2021-04-16 |
| JP2017221200A (ja) | 2017-12-21 |
| US20180094078A1 (en) | 2018-04-05 |
| CA2853383C (en) | 2021-04-06 |
| SG195196A1 (en) | 2013-12-30 |
| CN103930445A (zh) | 2014-07-16 |
| WO2012163520A1 (en) | 2012-12-06 |
| SG10201604279TA (en) | 2016-07-28 |
| US20230279155A1 (en) | 2023-09-07 |
| NZ619409A (en) | 2016-05-27 |
| WO2012163520A4 (en) | 2013-01-24 |
| AU2012265156A1 (en) | 2014-01-16 |
| EP2726510B1 (en) | 2023-03-08 |
| US20140206846A1 (en) | 2014-07-24 |
| RS64179B1 (sr) | 2023-05-31 |
| DK2726510T3 (da) | 2023-05-15 |
| CN103930445B (zh) | 2021-03-09 |
| SI2726510T1 (sl) | 2023-06-30 |
| ES2943577T3 (es) | 2023-06-14 |
| HRP20230411T1 (hr) | 2023-07-07 |
| US20210079119A1 (en) | 2021-03-18 |
| CA2853383A1 (en) | 2012-12-06 |
| EP2726510A1 (en) | 2014-05-07 |
| IL229649B (en) | 2019-08-29 |
| LT2726510T (lt) | 2023-05-10 |
| JP2014516542A (ja) | 2014-07-17 |
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