SG10201603931TA - Purification Of Biological Products By Constrained Cohydration Chromatography - Google Patents

Purification Of Biological Products By Constrained Cohydration Chromatography

Info

Publication number
SG10201603931TA
SG10201603931TA SG10201603931TA SG10201603931TA SG10201603931TA SG 10201603931T A SG10201603931T A SG 10201603931TA SG 10201603931T A SG10201603931T A SG 10201603931TA SG 10201603931T A SG10201603931T A SG 10201603931TA SG 10201603931T A SG10201603931T A SG 10201603931TA
Authority
SG
Singapore
Prior art keywords
chromatography
purification
biological products
cohydration
constrained
Prior art date
Application number
SG10201603931TA
Other languages
English (en)
Inventor
Peter Stanley Gagnon
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Priority to SG10201603931TA priority Critical patent/SG10201603931TA/en
Publication of SG10201603931TA publication Critical patent/SG10201603931TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/166—Fluid composition conditioning, e.g. gradient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1807—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using counter-currents, e.g. fluidised beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3861—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36 using an external stimulus
    • B01D15/3885—Using electrical or magnetic means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/14011—Details ssDNA Bacteriophages
    • C12N2795/14111—Inoviridae
    • C12N2795/14151—Methods of production or purification of viral material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicinal Preparation (AREA)
SG10201603931TA 2011-06-08 2012-06-01 Purification Of Biological Products By Constrained Cohydration Chromatography SG10201603931TA (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SG10201603931TA SG10201603931TA (en) 2011-06-08 2012-06-01 Purification Of Biological Products By Constrained Cohydration Chromatography

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161494687P 2011-06-08 2011-06-08
US201161494669P 2011-06-08 2011-06-08
US201113201108A 2011-11-14 2011-11-14
SG2011083979 2011-11-14
SG10201603931TA SG10201603931TA (en) 2011-06-08 2012-06-01 Purification Of Biological Products By Constrained Cohydration Chromatography

Publications (1)

Publication Number Publication Date
SG10201603931TA true SG10201603931TA (en) 2016-07-28

Family

ID=47296298

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201603931TA SG10201603931TA (en) 2011-06-08 2012-06-01 Purification Of Biological Products By Constrained Cohydration Chromatography
SG2013089933A SG195306A1 (en) 2011-06-08 2012-06-01 Purification of biological products by constrained cohydration chromatography

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG2013089933A SG195306A1 (en) 2011-06-08 2012-06-01 Purification of biological products by constrained cohydration chromatography

Country Status (6)

Country Link
US (2) US9809639B2 (zh)
EP (2) EP3210662A1 (zh)
KR (1) KR101901830B1 (zh)
CN (1) CN103717284B (zh)
SG (2) SG10201603931TA (zh)
WO (1) WO2012169970A1 (zh)

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WO2013180657A1 (en) * 2012-05-31 2013-12-05 Agency For Science, Technology And Research Rapid high-sensitivity affinity ligand-based constrained cohydration chromatography assays
CN105026418B (zh) * 2013-02-06 2019-01-11 新加坡科技研究局 蛋白质纯化方法
KR20150113027A (ko) * 2013-02-06 2015-10-07 에이전시 포 사이언스, 테크놀로지 앤드 리서치 티오-헤테로시클릭 양이온들로 처리에 의한 단백질 제제 내의 응집체 레벨 감소를 위한 방법
WO2014133458A1 (en) * 2013-02-26 2014-09-04 Agency For Science, Technology And Research Protein purification in the presence of nonionic organic polymers and electropositive surfaces
KR20150123796A (ko) * 2013-02-28 2015-11-04 에이전시 포 사이언스, 테크놀로지 앤드 리서치 크로마틴 결핍 세포 배양 수확물로부터의 항체들의 크로마토그래프 정제
EP2961761B1 (en) * 2013-02-28 2018-09-12 Agency For Science, Technology And Research Protein purification in the presence of nonionic organic polymers at elevated conductivity
US10500231B2 (en) 2013-03-13 2019-12-10 University Of Miami Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids
EP3052616A4 (en) * 2013-10-02 2017-03-29 Paradigm Biopharmaceuticals Limited A method of producing exosomes
JP6510508B2 (ja) * 2013-10-24 2019-05-08 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 低分子量の有機双性イオンを用いたエキソソーム回収方法
EP3116892A4 (en) * 2014-02-27 2017-11-22 Agency For Science, Technology And Research Methods for reducing aggregate content of protein preparations by treatment with aryl anions
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CN106399250A (zh) * 2015-07-31 2017-02-15 广州市锐博生物科技有限公司 一种分离外泌体的方法及其试剂盒
WO2017076553A1 (en) * 2015-11-05 2017-05-11 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method for the separation of virus compositions including depletion and purification thereof
EP3165604A1 (en) 2015-11-05 2017-05-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for the purification of virus compositions and virus compositions obtained
EP3427060A4 (en) 2016-03-07 2019-12-18 CFGenome, LLC NON-INVASIVE MOLECULAR WITNESSES
DE102016010601B4 (de) 2016-09-01 2018-11-08 Sartorius Stedim Biotech Gmbh Verfahren zur Aufreinigung von Viren oder virusähnlichen Partikeln unter Verwendung einer vernetzten Cellulosehydrat-Membran
CN108225873A (zh) * 2016-12-14 2018-06-29 成都中医药大学 一种提取尿液外泌体的组合物及其制备方法和用途
CN108865978A (zh) * 2018-07-25 2018-11-23 辽宁润基生物科技有限公司 一种分离和纯化外泌体的方法
TW202122569A (zh) * 2019-08-09 2021-06-16 日商宇部興產股份有限公司 應用小片多孔膜的細胞培養法
EP3871690A1 (en) * 2020-02-27 2021-09-01 Technische Hochschule Mittelhessen Method for virus production
US11821000B2 (en) * 2020-11-10 2023-11-21 Dionex Corporation Method of separating viral vectors
EP4316623A1 (en) * 2022-08-04 2024-02-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Chromatography method for nanoparticle purification and/or separation
CN115505578A (zh) * 2022-09-20 2022-12-23 苏州博腾生物制药有限公司 可放大的用于纯化重组病毒的方法
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Also Published As

Publication number Publication date
CN103717284B (zh) 2016-02-24
EP2720768B1 (en) 2017-04-12
US20140227766A1 (en) 2014-08-14
SG195306A1 (en) 2013-12-30
US20170218011A1 (en) 2017-08-03
EP3210662A1 (en) 2017-08-30
EP2720768A1 (en) 2014-04-23
CN103717284A (zh) 2014-04-09
WO2012169970A1 (en) 2012-12-13
US9809639B2 (en) 2017-11-07
KR101901830B1 (ko) 2018-09-27
KR20140145955A (ko) 2014-12-24

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