SE9103397D0 - Nya substituerade salicylsyror - Google Patents
Nya substituerade salicylsyrorInfo
- Publication number
- SE9103397D0 SE9103397D0 SE9103397A SE9103397A SE9103397D0 SE 9103397 D0 SE9103397 D0 SE 9103397D0 SE 9103397 A SE9103397 A SE 9103397A SE 9103397 A SE9103397 A SE 9103397A SE 9103397 D0 SE9103397 D0 SE 9103397D0
- Authority
- SE
- Sweden
- Prior art keywords
- compound
- new substituted
- het
- acids
- substituted salicyl
- Prior art date
Links
- JZWFDVDETGFGFC-UHFFFAOYSA-N salacetamide Chemical class CC(=O)NC(=O)C1=CC=CC=C1O JZWFDVDETGFGFC-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (32)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9103397A SE9103397D0 (sv) | 1991-11-18 | 1991-11-18 | Nya substituerade salicylsyror |
| NZ244998A NZ244998A (en) | 1991-11-18 | 1992-11-03 | Heterocyclic substituted salicylic acid derivatives |
| AT92924067T ATE194597T1 (de) | 1991-11-18 | 1992-11-04 | Substituierte salizylsäure zur behandlung von autoimmunkrankheiten |
| PCT/SE1992/000758 WO1993010094A1 (en) | 1991-11-18 | 1992-11-04 | Novel substituted salicyclic acids |
| HU9401391A HU221476B (en) | 1991-11-18 | 1992-11-04 | Substituted salicylic acid derivatives, pharmaceutical compositions comprising thereof and process for producing them |
| AU29589/92A AU668528B2 (en) | 1991-11-18 | 1992-11-04 | Novel substituted salicyclic acids |
| CA002123697A CA2123697C (en) | 1991-11-18 | 1992-11-04 | Novel substituted salicylic acids |
| EP92924067A EP0613468B1 (en) | 1991-11-18 | 1992-11-04 | Substituted salicylic acids for the treatment of autoimmune diseases |
| RU94028109A RU2124501C1 (ru) | 1991-11-18 | 1992-11-04 | Производные салициловой кислоты, их алкиловые эфиры, содержащие от 1 до 6 атомов углерода в эфирной группе, соли и сольваты |
| UA94005499A UA42869C2 (uk) | 1991-11-18 | 1992-11-04 | Похідні саліцилової кислоти, спосіб одержання, фармацевтична композиція для лікування аутоімунного захворювання та спосіб лікування |
| DE69231252T DE69231252T2 (de) | 1991-11-18 | 1992-11-04 | Substituierte Salizylsäure zur Behandlung von Autoimmunkrankheiten |
| SK547-94A SK282080B6 (sk) | 1991-11-18 | 1992-11-04 | Substituované salicylové kyseliny a ich použitie |
| JP50919193A JP3259915B2 (ja) | 1991-11-18 | 1992-11-04 | 新規な置換されたサリチル酸 |
| ES92924067T ES2149780T3 (es) | 1991-11-18 | 1992-11-04 | Acidos salicilicos sustituidos para el tratamiento de enfermedades autoinmunes. |
| DK92924067T DK0613468T3 (da) | 1991-11-18 | 1992-11-04 | Substituerede salicylsyrer til behandling af autoimmune sygdomme |
| KR1019940701664A KR100253748B1 (ko) | 1991-11-18 | 1992-11-04 | 신규 치환된 살리실산 |
| IL10366592A IL103665A (en) | 1991-11-18 | 1992-11-06 | Analogues of sulfasalazine and their use in the preparation of a medicament having therapeutic effect against autoimmune diseases |
| US07/973,753 US5302718A (en) | 1991-11-18 | 1992-11-09 | Compounds containing an amino salicylic acid moiety linked to a sulphapyridine moiety via stable bridge |
| LVP-92-202A LV10246B (en) | 1991-11-18 | 1992-11-13 | Novel substituted salicylic acids |
| LTIP229A LT3182B (en) | 1991-11-18 | 1992-11-17 | Novel substituted salicylic acids |
| PT101068A PT101068B (pt) | 1991-11-18 | 1992-11-17 | Novos derivados do acido salicilico substituidos, seu processo de preparacao e composicoes farmaceuticas que os contem |
| ZA928864A ZA928864B (en) | 1991-11-18 | 1992-11-17 | Substituted salicylic acids. |
| MYPI92002100A MY130169A (en) | 1991-11-18 | 1992-11-17 | Novel substituted salicyclic acids |
| MX9206647A MX9206647A (es) | 1991-11-18 | 1992-11-18 | Nuevos acidos salicilicos sustituidos. |
| TW081109532A TW304944B (https=) | 1991-11-18 | 1992-11-27 | |
| US08/132,874 US5403930A (en) | 1991-11-18 | 1993-10-07 | Substituted salicylic acids |
| NO941799A NO300805B1 (no) | 1991-11-18 | 1994-05-13 | Nye substituerte salicylsyrer |
| FI942289A FI106857B (fi) | 1991-11-18 | 1994-05-17 | Menetelmä uusien farmakologisesti aktiivisten salisyylihappojohdannaisten valmistamiseksi |
| EE9400111A EE03026B1 (et) | 1991-11-18 | 1994-11-02 | Asendatud salitsüülhapped, meetod nende valmistamiseks ja nende kasutamine |
| US08/365,869 US5556855A (en) | 1991-11-18 | 1994-12-29 | N-heterocyclic substituted salicylic acids |
| HU95P/P00492P HU211163A9 (en) | 1991-11-18 | 1995-06-28 | Substituted salicylic acids |
| GR20000402274T GR3034585T3 (en) | 1991-11-18 | 2000-10-09 | Novel substituted salicyclic acids. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9103397A SE9103397D0 (sv) | 1991-11-18 | 1991-11-18 | Nya substituerade salicylsyror |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE9103397D0 true SE9103397D0 (sv) | 1991-11-18 |
Family
ID=20384352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9103397A SE9103397D0 (sv) | 1991-11-18 | 1991-11-18 | Nya substituerade salicylsyror |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US5302718A (https=) |
| EP (1) | EP0613468B1 (https=) |
| JP (1) | JP3259915B2 (https=) |
| KR (1) | KR100253748B1 (https=) |
| AT (1) | ATE194597T1 (https=) |
| AU (1) | AU668528B2 (https=) |
| CA (1) | CA2123697C (https=) |
| DE (1) | DE69231252T2 (https=) |
| DK (1) | DK0613468T3 (https=) |
| EE (1) | EE03026B1 (https=) |
| ES (1) | ES2149780T3 (https=) |
| FI (1) | FI106857B (https=) |
| GR (1) | GR3034585T3 (https=) |
| HU (2) | HU221476B (https=) |
| IL (1) | IL103665A (https=) |
| LT (1) | LT3182B (https=) |
| LV (1) | LV10246B (https=) |
| MX (1) | MX9206647A (https=) |
| MY (1) | MY130169A (https=) |
| NO (1) | NO300805B1 (https=) |
| NZ (1) | NZ244998A (https=) |
| PT (1) | PT101068B (https=) |
| RU (1) | RU2124501C1 (https=) |
| SE (1) | SE9103397D0 (https=) |
| SK (1) | SK282080B6 (https=) |
| TW (1) | TW304944B (https=) |
| UA (1) | UA42869C2 (https=) |
| WO (1) | WO1993010094A1 (https=) |
| ZA (1) | ZA928864B (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5514696A (en) * | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
| GB9310095D0 (en) * | 1993-05-17 | 1993-06-30 | Zeneca Ltd | Therapeutic compounds |
| US5965732A (en) * | 1993-08-30 | 1999-10-12 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
| US5405842A (en) * | 1994-01-28 | 1995-04-11 | Silverman; Bernard A. | Treatment of steroid dependent asthmatics |
| GB9504854D0 (en) * | 1994-03-31 | 1995-04-26 | Zeneca Ltd | Nitrogen derivatives |
| US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
| US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
| US6028052A (en) | 1995-09-18 | 2000-02-22 | Ligand Pharmaceuticals Incorporated | Treating NIDDM with RXR agonists |
| JPH09124620A (ja) | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | 置換ビフェニルスルホンアミドエンドセリン拮抗剤 |
| EP0904077A4 (en) | 1996-02-20 | 1999-12-22 | Bristol Myers Squibb Co | PROCESSES FOR THE PRODUCTION OF BIPHENYL ISOXAZOLE SULFAMIDES |
| US5856507A (en) * | 1997-01-21 | 1999-01-05 | Bristol-Myers Squibb Co. | Methods for the preparation of biphenyl isoxazole sulfonamides |
| US5939446A (en) * | 1996-04-09 | 1999-08-17 | Bristol-Myers Squibb Co. | Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists |
| JP3814742B2 (ja) * | 1996-10-18 | 2006-08-30 | イハラケミカル工業株式会社 | ４−フルオロサリチル酸類 |
| WO1998033781A1 (en) * | 1997-01-30 | 1998-08-06 | Bristol-Myers Squibb Company | Method for preventing or treating low renin hypertension by administering an endothelin antagonist |
| TW536540B (en) * | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
| GB9804648D0 (en) | 1998-03-06 | 1998-04-29 | Zeneca Ltd | Chemical compounds |
| GB9805520D0 (en) * | 1998-03-17 | 1998-05-13 | Zeneca Ltd | Chemical compounds |
| GB9811427D0 (en) | 1998-05-29 | 1998-07-22 | Zeneca Ltd | Chemical compounds |
| CA2334545A1 (en) | 1998-06-12 | 1999-12-16 | Ligand Pharmaceuticals Incorporated | Treatment of anti-estrogen resistant breast cancer using rxr modulators |
| IL144708A0 (en) | 1999-03-19 | 2002-06-30 | Bristol Myers Squibb Co | Methods for the preparation of biphenyl isoxazole sulfonamide derivatives |
| MXPA02002319A (es) | 1999-09-04 | 2002-07-30 | Astrazeneca Ab | Derivados 2-hidroxi-2-metil-3,3,3-trifluoropropanamida con n-fenilo susbtituido que elevan la actividad de la deshidrogenasa de piruvato. |
| ES2273725T3 (es) | 1999-09-04 | 2007-05-16 | Astrazeneca Ab | Derivados de hidroxiacetamidobencenosulfonamida. |
| JP2003508509A (ja) | 1999-09-04 | 2003-03-04 | アストラゼネカ アクチボラグ | ピルビン酸デヒドロゲナーゼの阻害剤としてのアミド |
| CA2307278A1 (en) * | 2000-04-28 | 2001-10-28 | University Of British Columbia | Use of n-heterocyclic substituted salicylic acids for inhibition of cellular uptake of cystine |
| DE60115414D1 (de) * | 2000-04-28 | 2006-01-05 | Univ British Columbia | N-heterosubstituierten salicylaten zur behandlung von krebs |
| US6639082B2 (en) | 2000-10-17 | 2003-10-28 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
| KR100360342B1 (ko) * | 2002-04-19 | 2002-11-13 | 박계정 | 밸런스 머신의 언밸런스 수정위치 및 수정량의 자동 보상방법 |
| EP1661889A4 (en) * | 2003-09-05 | 2009-08-05 | Ono Pharmaceutical Co | ANTAGONIST OF THE CHEMOKINE RECEPTOR AND ITS USE FOR MEDICAL PURPOSES |
| AP2006003633A0 (en) * | 2003-12-19 | 2006-06-30 | Pfizer | Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-BETA-hydroxysteroid dehydrogenase type 1 (11-BETA-HSD-1) for the treatment of diabetes and obesity |
| BRPI0512915A (pt) * | 2004-06-29 | 2008-04-15 | Warner Lambert Co | terapias de combinação utilizando inibidores benzamida do receptor p2x7 |
| GB2421947A (en) * | 2005-01-07 | 2006-07-12 | Univ Southampton | Sulphonamide compounds for use as inhibitors of NF-kB |
| WO2007098169A1 (en) * | 2006-02-21 | 2007-08-30 | Amgen Inc. | Cinnoline derivatives as phosphodiesterase 10 inhibitors |
| JP5304785B2 (ja) * | 2008-06-23 | 2013-10-02 | アステラス製薬株式会社 | スルホンアミド化合物又はその塩 |
| EP2677865A4 (en) * | 2011-02-23 | 2015-04-22 | Icahn School Med Mount Sinai | BROMODOMAIN INHIBITORS AS MODULATORS OF GENE EXPRESSION |
| DK3300500T3 (da) | 2015-05-20 | 2020-05-18 | Amgen Inc | Triazolagonister af apj-receptoren |
| CN108602775B (zh) | 2016-01-14 | 2022-04-29 | 贝思以色列女会吏医学中心公司 | 肥大细胞调节剂及其用途 |
| WO2017192485A1 (en) | 2016-05-03 | 2017-11-09 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the apj receptor |
| WO2018093579A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Triazole phenyl compounds as agonists of the apj receptor |
| US11020395B2 (en) | 2016-11-16 | 2021-06-01 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the APJ receptor |
| EP3541792B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole furan compounds as agonists of the apj receptor |
| WO2018093576A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Alkyl substituted triazole compounds as agonists of the apj receptor |
| US11046680B1 (en) | 2016-11-16 | 2021-06-29 | Amgen Inc. | Heteroaryl-substituted triazoles as APJ receptor agonists |
| EP3541803B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole pyridyl compounds as agonists of the apj receptor |
| US11149040B2 (en) | 2017-11-03 | 2021-10-19 | Amgen Inc. | Fused triazole agonists of the APJ receptor |
| WO2019213006A1 (en) | 2018-05-01 | 2019-11-07 | Amgen Inc. | Substituted pyrimidinones as agonists of the apj receptor |
| CN111056978B (zh) * | 2019-12-13 | 2021-01-19 | 西安交通大学 | 一种磺酰胺类化合物及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2396145A (en) | 1940-12-14 | 1946-03-05 | Pharmscia Ab | Heterocyclic sulphonamido azo compounds |
| BE791889A (fr) * | 1971-11-26 | 1973-05-24 | Pharmacia Ab | Nouveaux derives de la pyridine |
| AU567140B2 (en) * | 1984-01-06 | 1987-11-12 | Shionogi & Co., Ltd. | Sulphonamido-benzamide derivatives |
| US4663334A (en) * | 1985-12-11 | 1987-05-05 | Mcneilab, Inc. | Heteroaromatic acetylenes useful as antihypertensive agents |
| US4897397A (en) * | 1988-12-16 | 1990-01-30 | Schering Corporation | Aryl-alkynoic, alkenoic or alkanoic compounds and compositions useful as antiallergy and anti-inflammatory agents |
-
1991
- 1991-11-18 SE SE9103397A patent/SE9103397D0/xx unknown
-
1992
- 1992-11-03 NZ NZ244998A patent/NZ244998A/en not_active IP Right Cessation
- 1992-11-04 EP EP92924067A patent/EP0613468B1/en not_active Expired - Lifetime
- 1992-11-04 WO PCT/SE1992/000758 patent/WO1993010094A1/en not_active Ceased
- 1992-11-04 JP JP50919193A patent/JP3259915B2/ja not_active Expired - Fee Related
- 1992-11-04 UA UA94005499A patent/UA42869C2/uk unknown
- 1992-11-04 ES ES92924067T patent/ES2149780T3/es not_active Expired - Lifetime
- 1992-11-04 KR KR1019940701664A patent/KR100253748B1/ko not_active Expired - Fee Related
- 1992-11-04 SK SK547-94A patent/SK282080B6/sk unknown
- 1992-11-04 CA CA002123697A patent/CA2123697C/en not_active Expired - Fee Related
- 1992-11-04 HU HU9401391A patent/HU221476B/hu not_active IP Right Cessation
- 1992-11-04 RU RU94028109A patent/RU2124501C1/ru not_active IP Right Cessation
- 1992-11-04 DK DK92924067T patent/DK0613468T3/da active
- 1992-11-04 DE DE69231252T patent/DE69231252T2/de not_active Expired - Fee Related
- 1992-11-04 AU AU29589/92A patent/AU668528B2/en not_active Ceased
- 1992-11-04 AT AT92924067T patent/ATE194597T1/de not_active IP Right Cessation
- 1992-11-06 IL IL10366592A patent/IL103665A/xx not_active IP Right Cessation
- 1992-11-09 US US07/973,753 patent/US5302718A/en not_active Expired - Lifetime
- 1992-11-13 LV LVP-92-202A patent/LV10246B/xx unknown
- 1992-11-17 PT PT101068A patent/PT101068B/pt not_active IP Right Cessation
- 1992-11-17 MY MYPI92002100A patent/MY130169A/en unknown
- 1992-11-17 ZA ZA928864A patent/ZA928864B/xx unknown
- 1992-11-17 LT LTIP229A patent/LT3182B/lt not_active IP Right Cessation
- 1992-11-18 MX MX9206647A patent/MX9206647A/es not_active IP Right Cessation
- 1992-11-27 TW TW081109532A patent/TW304944B/zh active
-
1993
- 1993-10-07 US US08/132,874 patent/US5403930A/en not_active Expired - Fee Related
-
1994
- 1994-05-13 NO NO941799A patent/NO300805B1/no unknown
- 1994-05-17 FI FI942289A patent/FI106857B/fi not_active IP Right Cessation
- 1994-11-02 EE EE9400111A patent/EE03026B1/xx not_active IP Right Cessation
- 1994-12-29 US US08/365,869 patent/US5556855A/en not_active Expired - Fee Related
-
1995
- 1995-06-28 HU HU95P/P00492P patent/HU211163A9/hu unknown
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2000
- 2000-10-09 GR GR20000402274T patent/GR3034585T3/el not_active IP Right Cessation
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