SE8501614L - Solubiliserbar, fibrinbaserad komposition och anvendning derav - Google Patents
Solubiliserbar, fibrinbaserad komposition och anvendning deravInfo
- Publication number
- SE8501614L SE8501614L SE8501614A SE8501614A SE8501614L SE 8501614 L SE8501614 L SE 8501614L SE 8501614 A SE8501614 A SE 8501614A SE 8501614 A SE8501614 A SE 8501614A SE 8501614 L SE8501614 L SE 8501614L
- Authority
- SE
- Sweden
- Prior art keywords
- fibrin
- composition
- pct
- desaa
- arginyl
- Prior art date
Links
- 108010073385 Fibrin Proteins 0.000 abstract 5
- 102000009123 Fibrin Human genes 0.000 abstract 5
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 5
- 229950003499 fibrin Drugs 0.000 abstract 5
- DSVOSLJAGTUKFB-SPAGYVKCSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]pentanedioic acid Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)CN DSVOSLJAGTUKFB-SPAGYVKCSA-N 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 2
- 230000003480 fibrinolytic effect Effects 0.000 abstract 2
- 108010053364 glycyl-prolyl-arginyl-valyl-valyl-glutamic acid Proteins 0.000 abstract 2
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 abstract 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000006862 enzymatic digestion Effects 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000011002 quantification Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/75—Fibrin; Fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/972—Plasminogen activators
- G01N2333/9726—Tissue plasminogen activator
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8501614A SE447579B (sv) | 1985-04-01 | 1985-04-01 | Solubiliserbar, fibrinbaserad komposition och anvendning av kompositionen vid bestemning av fibrinolysparametrar |
PCT/SE1986/000144 WO1986005814A1 (en) | 1985-04-01 | 1986-03-27 | A solubilizable, fibrin based composition and its use, in determinations of fibrinolysis parameters |
EP86902552A EP0216891B1 (en) | 1985-04-01 | 1986-03-27 | A solubilizable, fibrin based composition and its use |
AT86902552T ATE50002T1 (de) | 1985-04-01 | 1986-03-27 | Loesbare auf fibrin basierte zusammensetzung und deren verwendung. |
DE8686902552T DE3668643D1 (de) | 1985-04-01 | 1986-03-27 | Loesbare auf fibrin basierte zusammensetzung und deren verwendung. |
US06/936,347 US4957903A (en) | 1985-04-01 | 1986-03-27 | Pharmaceutical and clinical compositions of desAA fibrin monomers and the tetrapeptide gly-pro-arg-pro |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8501614A SE447579B (sv) | 1985-04-01 | 1985-04-01 | Solubiliserbar, fibrinbaserad komposition och anvendning av kompositionen vid bestemning av fibrinolysparametrar |
Publications (3)
Publication Number | Publication Date |
---|---|
SE8501614D0 SE8501614D0 (sv) | 1985-04-01 |
SE8501614L true SE8501614L (sv) | 1986-10-02 |
SE447579B SE447579B (sv) | 1986-11-24 |
Family
ID=20359734
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8501614A SE447579B (sv) | 1985-04-01 | 1985-04-01 | Solubiliserbar, fibrinbaserad komposition och anvendning av kompositionen vid bestemning av fibrinolysparametrar |
Country Status (5)
Country | Link |
---|---|
US (1) | US4957903A (sv) |
EP (1) | EP0216891B1 (sv) |
DE (1) | DE3668643D1 (sv) |
SE (1) | SE447579B (sv) |
WO (1) | WO1986005814A1 (sv) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2710376B2 (ja) * | 1987-07-06 | 1998-02-10 | サイトアールエックス バイオプール リミテッド | 組織プラズミノーゲン活性因子とプラズミノーゲン活性因子阻害因子の改良された評価方法 |
US5102787A (en) * | 1987-07-10 | 1992-04-07 | Miho Sasamata | Method, device and kit for measurement of tissue plasminogen activator activity |
US5320945A (en) * | 1989-07-14 | 1994-06-14 | Boehringer Mannheim Gmbh | Method and reagent for the determination of antithrombin III |
AU644205B2 (en) * | 1990-08-23 | 1993-12-02 | New York Blood Center, Inc., The | Assays using a soluble fibrin-like monomer |
EP0641222B1 (en) * | 1992-05-21 | 2000-09-06 | Diatide, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR THROMBUS IMAGING |
US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
CN1091315A (zh) * | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
AU6398596A (en) * | 1995-06-30 | 1997-02-05 | American Biogenetic Sciences, Inc. | Method of producing fibrin-specific antibodies using soluble fibrin polymers as an immunogen |
AU7353300A (en) | 1999-09-08 | 2001-04-10 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
FR2813395B1 (fr) * | 2000-08-28 | 2003-01-24 | Stago Diagnostica | Methode de dosage in vitro de la fibrine soluble par generation de produits de degradation specifiques |
MXPA03006666A (es) | 2001-01-25 | 2004-05-31 | Guilford Pharm Inc | Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso. |
US6593362B2 (en) | 2001-05-21 | 2003-07-15 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
RU2358754C2 (ru) | 2004-06-24 | 2009-06-20 | Тобиси Фармасьютикал Ко., Лтд. | Препарат, ингибирующий развитие злокачественных опухолей, содержащий дез-а-фибрин |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3966701A (en) * | 1973-11-07 | 1976-06-29 | The Dow Chemical Company | Fibrinogen peptide derivatives |
US4455290A (en) * | 1981-04-02 | 1984-06-19 | Research Corporation | Inhibition of fibrin polymerization by a peptide isolated from fibrin Fragment D1 |
-
1985
- 1985-04-01 SE SE8501614A patent/SE447579B/sv not_active IP Right Cessation
-
1986
- 1986-03-27 US US06/936,347 patent/US4957903A/en not_active Expired - Fee Related
- 1986-03-27 WO PCT/SE1986/000144 patent/WO1986005814A1/en not_active Application Discontinuation
- 1986-03-27 DE DE8686902552T patent/DE3668643D1/de not_active Expired - Lifetime
- 1986-03-27 EP EP86902552A patent/EP0216891B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1986005814A1 (en) | 1986-10-09 |
EP0216891A1 (en) | 1987-04-08 |
SE8501614D0 (sv) | 1985-04-01 |
DE3668643D1 (de) | 1990-03-08 |
US4957903A (en) | 1990-09-18 |
EP0216891B1 (en) | 1990-01-31 |
SE447579B (sv) | 1986-11-24 |
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