SE8400628D0 - MITOMYCIN ANALOGS - Google Patents
MITOMYCIN ANALOGSInfo
- Publication number
- SE8400628D0 SE8400628D0 SE8400628A SE8400628A SE8400628D0 SE 8400628 D0 SE8400628 D0 SE 8400628D0 SE 8400628 A SE8400628 A SE 8400628A SE 8400628 A SE8400628 A SE 8400628A SE 8400628 D0 SE8400628 D0 SE 8400628D0
- Authority
- SE
- Sweden
- Prior art keywords
- lower alkyl
- substituted
- radical
- nitro
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Mitomycin derivatives useful for treatment of neoplastic disease states in animals have the formula IIIa, <IMAGE> wherein: Y is hydrogen or lower alkyl; and Z is an hydroxy substituted 1-pyrrolidinyl radical, or a lower alkyl substituted piperidyl radical, or a 1-piperazinyl radical or an acetamino, acetyl, carbamido, cyano, carboxy lower alkylamino, di-lower alkoxy, nitro, sulfamyl, or lower alkyl substituted anilino radical, or a radical of the formula, <IMAGE> wherein R is hydrogen or lower alkyl and R<1> is a nitrogen containing heterocyclic radial selected from amino substituted triazolyl, lower alkyl substituted isothiazolyl, benzothiazolyl, and nitro and halo substituted derivatives of benzothiazolyl, or R<1> is a substituted lower alkyl radical selected from amino lower alkyl, lower alkylamino lower alkyl, hydroxy lower alkylamino lower alkyl, hydroxy lower alkoxy lower alkyl, imidazolyl lower alkyl, nitro substituted imidazolyl lower alkyl, mono- and di-hydroxy phenyl lower alkyl, nitro substituted pyridylamino lower alkyl, piperazinyl lower alkyl, and pyridyl ethyl.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46461283A | 1983-02-07 | 1983-02-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8400628D0 true SE8400628D0 (en) | 1984-02-07 |
| SE8400628L SE8400628L (en) | 1984-08-08 |
| SE461982B SE461982B (en) | 1990-04-23 |
Family
ID=23844605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8400628A SE461982B (en) | 1983-02-07 | 1984-02-07 | MITOMYCIN ANALOGUES AND PHARMACEUTICAL COMPOSITION THEREOF, WITH ANTINEOPLASTIC EFFECT |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPS59152384A (en) |
| KR (1) | KR900006854B1 (en) |
| AT (1) | AT385509B (en) |
| AU (1) | AU571193B2 (en) |
| BE (1) | BE898856A (en) |
| CA (1) | CA1252789A (en) |
| CH (1) | CH658658A5 (en) |
| DD (1) | DD233844A5 (en) |
| DE (1) | DE3403922A1 (en) |
| DK (1) | DK161890C (en) |
| ES (1) | ES8607305A1 (en) |
| FI (1) | FI80698C (en) |
| FR (1) | FR2540500B1 (en) |
| GB (1) | GB2134514B (en) |
| GR (1) | GR81455B (en) |
| HU (1) | HU190236B (en) |
| IE (1) | IE56814B1 (en) |
| IL (1) | IL70897A (en) |
| IT (1) | IT1178855B (en) |
| LU (1) | LU85199A1 (en) |
| NL (1) | NL8400338A (en) |
| NO (1) | NO161374C (en) |
| NZ (1) | NZ206932A (en) |
| OA (1) | OA07654A (en) |
| PH (1) | PH20249A (en) |
| PT (1) | PT78067B (en) |
| SE (1) | SE461982B (en) |
| YU (1) | YU44984B (en) |
| ZA (1) | ZA84788B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4487769A (en) * | 1982-06-04 | 1984-12-11 | Bristol-Myers Company | Amidines |
| CA1282069C (en) * | 1985-09-12 | 1991-03-26 | Damon L. Meyer | Antibody complexes of hapten-modified diagnostic or therapeutic agents |
| JPS63150282A (en) * | 1986-12-13 | 1988-06-22 | Kyowa Hakko Kogyo Co Ltd | Mitomycin derivative |
| JPS63246379A (en) * | 1987-03-31 | 1988-10-13 | Kyowa Hakko Kogyo Co Ltd | 7-n,8-n-ethylenemitomycin 8-imines |
| DE69127345D1 (en) * | 1990-11-13 | 1997-09-25 | Kyowa Hakko Kogyo Kk | Mitomycin derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3332944A (en) * | 1964-11-02 | 1967-07-25 | American Cyanamid Co | Antibiotic derivatives of mitomycins a, b, c and porfiromycin |
| JPS5439098A (en) * | 1977-08-31 | 1979-03-24 | Kyowa Hakko Kogyo Co Ltd | Mitomycin c derivatives |
| US4268676A (en) * | 1979-12-05 | 1981-05-19 | University Patents, Inc. | Mitomycin analogs |
| JPS5686184A (en) * | 1979-12-17 | 1981-07-13 | Kyowa Hakko Kogyo Co Ltd | Novel mitomycin c derivative |
| NZ199617A (en) * | 1981-05-15 | 1985-08-30 | University Patents Inc | Azirino(2',3',:3,4)pyrrolo(1,2-a)indole-4,7-dione derivatives and pharmaceutical compositions |
| US4487769A (en) * | 1982-06-04 | 1984-12-11 | Bristol-Myers Company | Amidines |
| US4642352A (en) * | 1983-12-23 | 1987-02-10 | Bristol-Myers Company | Acylamino mitosanes |
-
1984
- 1984-01-25 NZ NZ206932A patent/NZ206932A/en unknown
- 1984-01-27 GB GB08402233A patent/GB2134514B/en not_active Expired
- 1984-02-02 ZA ZA84788A patent/ZA84788B/en unknown
- 1984-02-03 NL NL8400338A patent/NL8400338A/en not_active Application Discontinuation
- 1984-02-03 AU AU24073/84A patent/AU571193B2/en not_active Ceased
- 1984-02-04 DE DE19843403922 patent/DE3403922A1/en not_active Withdrawn
- 1984-02-06 DD DD84259885A patent/DD233844A5/en not_active IP Right Cessation
- 1984-02-06 AT AT0037684A patent/AT385509B/en not_active IP Right Cessation
- 1984-02-06 HU HU84483A patent/HU190236B/en not_active IP Right Cessation
- 1984-02-06 CA CA000446811A patent/CA1252789A/en not_active Expired
- 1984-02-06 NO NO840433A patent/NO161374C/en unknown
- 1984-02-06 GR GR73720A patent/GR81455B/el unknown
- 1984-02-06 ES ES529478A patent/ES8607305A1/en not_active Expired
- 1984-02-06 PT PT78067A patent/PT78067B/en not_active IP Right Cessation
- 1984-02-06 CH CH550/84A patent/CH658658A5/en not_active IP Right Cessation
- 1984-02-06 IE IE272/84A patent/IE56814B1/en not_active IP Right Cessation
- 1984-02-06 DK DK052484A patent/DK161890C/en active
- 1984-02-06 PH PH30204A patent/PH20249A/en unknown
- 1984-02-07 IL IL70897A patent/IL70897A/en unknown
- 1984-02-07 FR FR8401845A patent/FR2540500B1/en not_active Expired
- 1984-02-07 LU LU85199A patent/LU85199A1/en unknown
- 1984-02-07 KR KR1019840000574A patent/KR900006854B1/en not_active IP Right Cessation
- 1984-02-07 SE SE8400628A patent/SE461982B/en not_active IP Right Cessation
- 1984-02-07 FI FI840502A patent/FI80698C/en not_active IP Right Cessation
- 1984-02-07 IT IT67113/84A patent/IT1178855B/en active
- 1984-02-07 OA OA58227A patent/OA07654A/en unknown
- 1984-02-07 YU YU217/84A patent/YU44984B/en unknown
- 1984-02-07 JP JP59021505A patent/JPS59152384A/en active Pending
- 1984-02-07 BE BE0/212351A patent/BE898856A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 8400628-7 Effective date: 19930912 Format of ref document f/p: F |