BE898856A - MITOMYCIN ANALOGS - Google Patents

MITOMYCIN ANALOGS

Info

Publication number
BE898856A
BE898856A BE0/212351A BE212351A BE898856A BE 898856 A BE898856 A BE 898856A BE 0/212351 A BE0/212351 A BE 0/212351A BE 212351 A BE212351 A BE 212351A BE 898856 A BE898856 A BE 898856A
Authority
BE
Belgium
Prior art keywords
mitomycin analogs
mitomycin
analogs
azirino
pyrrolo
Prior art date
Application number
BE0/212351A
Other languages
French (fr)
Inventor
W A Remers
Original Assignee
University Patents Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Patents Inc filed Critical University Patents Inc
Publication of BE898856A publication Critical patent/BE898856A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Traitement d'affections néoplasiques au moyen de carbamate de 1, 1a, 2,8,8a,8b-hexahydro-8-(hydroxyméthyl)-8a-méthoxy-5-méthyl-6-(3-hydroxy-1-pyrrolidinyl)-azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione.Treatment of neoplastic conditions using carbamate of 1, 1a, 2,8,8a, 8b-hexahydro-8- (hydroxymethyl) -8a-methoxy-5-methyl-6- (3-hydroxy-1-pyrrolidinyl) - azirino (2 ', 3': 3,4) pyrrolo (1,2-a) indole-4,7-dione.

BE0/212351A 1983-02-07 1984-02-07 MITOMYCIN ANALOGS BE898856A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46461283A 1983-02-07 1983-02-07

Publications (1)

Publication Number Publication Date
BE898856A true BE898856A (en) 1984-05-30

Family

ID=23844605

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/212351A BE898856A (en) 1983-02-07 1984-02-07 MITOMYCIN ANALOGS

Country Status (29)

Country Link
JP (1) JPS59152384A (en)
KR (1) KR900006854B1 (en)
AT (1) AT385509B (en)
AU (1) AU571193B2 (en)
BE (1) BE898856A (en)
CA (1) CA1252789A (en)
CH (1) CH658658A5 (en)
DD (1) DD233844A5 (en)
DE (1) DE3403922A1 (en)
DK (1) DK161890C (en)
ES (1) ES8607305A1 (en)
FI (1) FI80698C (en)
FR (1) FR2540500B1 (en)
GB (1) GB2134514B (en)
GR (1) GR81455B (en)
HU (1) HU190236B (en)
IE (1) IE56814B1 (en)
IL (1) IL70897A (en)
IT (1) IT1178855B (en)
LU (1) LU85199A1 (en)
NL (1) NL8400338A (en)
NO (1) NO161374C (en)
NZ (1) NZ206932A (en)
OA (1) OA07654A (en)
PH (1) PH20249A (en)
PT (1) PT78067B (en)
SE (1) SE461982B (en)
YU (1) YU44984B (en)
ZA (1) ZA84788B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
CA1282069C (en) * 1985-09-12 1991-03-26 Damon L. Meyer Antibody complexes of hapten-modified diagnostic or therapeutic agents
JPS63150282A (en) * 1986-12-13 1988-06-22 Kyowa Hakko Kogyo Co Ltd Mitomycin derivative
JPS63246379A (en) * 1987-03-31 1988-10-13 Kyowa Hakko Kogyo Co Ltd 7-n,8-n-ethylenemitomycin 8-imines
EP0485904B1 (en) * 1990-11-13 1997-08-20 Kyowa Hakko Kogyo Co., Ltd. Mitomycin derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332944A (en) * 1964-11-02 1967-07-25 American Cyanamid Co Antibiotic derivatives of mitomycins a, b, c and porfiromycin
JPS5439098A (en) * 1977-08-31 1979-03-24 Kyowa Hakko Kogyo Co Ltd Mitomycin c derivatives
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
JPS5686184A (en) * 1979-12-17 1981-07-13 Kyowa Hakko Kogyo Co Ltd Novel mitomycin c derivative
NZ199617A (en) * 1981-05-15 1985-08-30 University Patents Inc Azirino(2',3',:3,4)pyrrolo(1,2-a)indole-4,7-dione derivatives and pharmaceutical compositions
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes

Also Published As

Publication number Publication date
DK161890B (en) 1991-08-26
SE8400628D0 (en) 1984-02-07
DK52484D0 (en) 1984-02-06
IE840272L (en) 1984-08-07
AT385509B (en) 1988-04-11
FR2540500B1 (en) 1987-07-17
HU190236B (en) 1986-08-28
GB2134514A (en) 1984-08-15
FI840502A (en) 1984-08-08
DK161890C (en) 1992-02-03
PT78067B (en) 1986-03-20
AU571193B2 (en) 1988-04-14
SE461982B (en) 1990-04-23
IT1178855B (en) 1987-09-16
KR900006854B1 (en) 1990-09-22
LU85199A1 (en) 1984-05-30
YU21784A (en) 1986-10-31
IT8467113A0 (en) 1984-02-07
ATA37684A (en) 1987-09-15
NO161374B (en) 1989-05-02
ES529478A0 (en) 1986-05-16
IL70897A0 (en) 1984-05-31
JPS59152384A (en) 1984-08-31
OA07654A (en) 1985-05-23
ZA84788B (en) 1984-09-26
GB2134514B (en) 1987-04-01
FI80698C (en) 1990-07-10
IL70897A (en) 1989-01-31
YU44984B (en) 1991-06-30
KR840007726A (en) 1984-12-10
AU2407384A (en) 1984-08-16
DD233844A5 (en) 1986-03-12
PT78067A (en) 1984-03-01
DE3403922A1 (en) 1984-08-09
ES8607305A1 (en) 1986-05-16
GB8402233D0 (en) 1984-02-29
NO840433L (en) 1984-08-08
DK52484A (en) 1984-08-08
NO161374C (en) 1989-08-09
CH658658A5 (en) 1986-11-28
FR2540500A1 (en) 1984-08-10
GR81455B (en) 1984-12-11
PH20249A (en) 1986-11-10
FI840502A0 (en) 1984-02-07
IE56814B1 (en) 1991-12-18
CA1252789A (en) 1989-04-18
FI80698B (en) 1990-03-30
NL8400338A (en) 1984-09-03
SE8400628L (en) 1984-08-08
NZ206932A (en) 1987-08-31

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: UNIVERSITY PATENTS INC.

Effective date: 19930228