SE8304457D0 - BASIC ESTERS OF BENZOIC ACIDS AND 2-THIOPHENCARBONIC ACIDS, PROCEDURES FOR THEIR PRODUCTION AND MEDICINAL CONTAINING THESE ESTERS - Google Patents

BASIC ESTERS OF BENZOIC ACIDS AND 2-THIOPHENCARBONIC ACIDS, PROCEDURES FOR THEIR PRODUCTION AND MEDICINAL CONTAINING THESE ESTERS

Info

Publication number
SE8304457D0
SE8304457D0 SE8304457A SE8304457A SE8304457D0 SE 8304457 D0 SE8304457 D0 SE 8304457D0 SE 8304457 A SE8304457 A SE 8304457A SE 8304457 A SE8304457 A SE 8304457A SE 8304457 D0 SE8304457 D0 SE 8304457D0
Authority
SE
Sweden
Prior art keywords
group
esters
optionally substituted
acids
basic
Prior art date
Application number
SE8304457A
Other languages
Swedish (sv)
Other versions
SE8304457L (en
Inventor
E Rudinger
X Perlia
Original Assignee
Pharmaton Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmaton Sa filed Critical Pharmaton Sa
Publication of SE8304457D0 publication Critical patent/SE8304457D0/en
Publication of SE8304457L publication Critical patent/SE8304457L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

A compound for use as e.g. a local anaesthetic is a basic ester of the formula I <IMAGE> wherein R is a group of the formula <IMAGE> or <IMAGE> wherein each R1 independently is hydrogen or optionally substituted alkyl, and R2 is an optionally substituted alkyl group, an acyl group, halogen, an optionally substituted alkoxy group, an optionally substituted alkylthio group, nitro, amino or an optionally substituted alkylamino group, whereby R and R2 are the same or different, and R3 is a basic group, on a pharmacologically useful salt thereof. Preferably, R1 is hydrogen or methyl, R2 is methyl, fluorine, bromine, iodine, ethoxy, ethylthio, nitro, amino, ethylamine, or butylamine, and R3 is diethylamino, piperidine or morpholino.
SE8304457A 1982-08-27 1983-08-17 BASIC ESTERS OF BENZOIC ACIDS AND 2-THIOPHENCARBONIC ACIDS, PROCEDURES FOR THEIR PRODUCTION AND MEDICINAL CONTAINING THESE ESTERS SE8304457L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH5115/82A CH651014A5 (en) 1982-08-27 1982-08-27 BASIC ESTERS OF BENZOESIC ACIDS AND OF 2-THIOPHENIC CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE ESTERS.

Publications (2)

Publication Number Publication Date
SE8304457D0 true SE8304457D0 (en) 1983-08-17
SE8304457L SE8304457L (en) 1984-02-28

Family

ID=4288176

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8304457A SE8304457L (en) 1982-08-27 1983-08-17 BASIC ESTERS OF BENZOIC ACIDS AND 2-THIOPHENCARBONIC ACIDS, PROCEDURES FOR THEIR PRODUCTION AND MEDICINAL CONTAINING THESE ESTERS

Country Status (8)

Country Link
JP (1) JPS5998044A (en)
CA (1) CA1244020A (en)
CH (1) CH651014A5 (en)
DE (1) DE3328494A1 (en)
FR (1) FR2532304B1 (en)
GB (1) GB2126219B (en)
IT (1) IT1168211B (en)
SE (1) SE8304457L (en)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL19578C (en) * 1925-01-15
US2173827A (en) * 1936-10-26 1939-09-26 Pitman Moore Company Alkyl thio-substituted benzoic acid alkamine ester salts, intermediate and process of preparing same
GB525199A (en) * 1939-02-15 1940-08-23 Novocol Chemical M F G Co Inc Improvements in or relating to local anaesthetic bases and process of preparing same
US2372116A (en) * 1942-03-24 1945-03-20 Pierce Amino alcohol esters
US2383074A (en) * 1942-04-16 1945-08-21 American Cyanamid Co Alkamine derivatives of o-alkoxymethyl benzoic acid
US2404691A (en) * 1944-08-30 1946-07-23 Squibb & Sons Inc Chemical compounds
US2831016A (en) * 1954-05-27 1958-04-15 Univ Missouri beta-substituted aminoalkyl 2,6-dialkylsubstituted benzoates and method of making the same
US3047574A (en) * 1960-03-28 1962-07-31 Searle & Co 2-cyclohexyl-4-(2-hydroxyethyl)-3-methylmorpholine esters of substituted benzoic acids
FR2432516A1 (en) * 1978-08-01 1980-02-29 Synthelabo 4-Phenyl-piperazino-ethanol derivs. - having CNS activity, useful for treating anxiety and depression

Also Published As

Publication number Publication date
CH651014A5 (en) 1985-08-30
IT8348885A0 (en) 1983-08-26
FR2532304A1 (en) 1984-03-02
CA1244020A (en) 1988-11-01
FR2532304B1 (en) 1989-05-19
SE8304457L (en) 1984-02-28
JPS5998044A (en) 1984-06-06
GB2126219B (en) 1987-05-28
IT1168211B (en) 1987-05-20
DE3328494A1 (en) 1984-03-01
GB2126219A (en) 1984-03-21
GB8321954D0 (en) 1983-09-14

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Effective date: 19880624