FR2432516A1 - 4-Phenyl-piperazino-ethanol derivs. - having CNS activity, useful for treating anxiety and depression - Google Patents

4-Phenyl-piperazino-ethanol derivs. - having CNS activity, useful for treating anxiety and depression

Info

Publication number
FR2432516A1
FR2432516A1 FR7822673A FR7822673A FR2432516A1 FR 2432516 A1 FR2432516 A1 FR 2432516A1 FR 7822673 A FR7822673 A FR 7822673A FR 7822673 A FR7822673 A FR 7822673A FR 2432516 A1 FR2432516 A1 FR 2432516A1
Authority
FR
France
Prior art keywords
derivs
depression
ethanol
useful
piperazino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7822673A
Other languages
French (fr)
Other versions
FR2432516B1 (en
Inventor
Henry Najer
Philippe Michel Jacque Manoury
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7822673A priority Critical patent/FR2432516A1/en
Publication of FR2432516A1 publication Critical patent/FR2432516A1/en
Application granted granted Critical
Publication of FR2432516B1 publication Critical patent/FR2432516B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

4-Phenyl piperazino ethanol derivs. of formula (I) and their salts are new. In (I) R is H, COR3, -CONHR3 or (II) R1-2 are alkoxy, alkylthio, haloalkyl, haloalkylthio or haloalkoxy R3 is alkyl; R4 is H, halogen, amino, nitro, R3 or OR3; the alkyl gps. having 1-4C atoms. (I) are active on the CNS and are useful in the treatment of anxiety and depression.
FR7822673A 1978-08-01 1978-08-01 4-Phenyl-piperazino-ethanol derivs. - having CNS activity, useful for treating anxiety and depression Granted FR2432516A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7822673A FR2432516A1 (en) 1978-08-01 1978-08-01 4-Phenyl-piperazino-ethanol derivs. - having CNS activity, useful for treating anxiety and depression

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7822673A FR2432516A1 (en) 1978-08-01 1978-08-01 4-Phenyl-piperazino-ethanol derivs. - having CNS activity, useful for treating anxiety and depression

Publications (2)

Publication Number Publication Date
FR2432516A1 true FR2432516A1 (en) 1980-02-29
FR2432516B1 FR2432516B1 (en) 1981-04-17

Family

ID=9211435

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7822673A Granted FR2432516A1 (en) 1978-08-01 1978-08-01 4-Phenyl-piperazino-ethanol derivs. - having CNS activity, useful for treating anxiety and depression

Country Status (1)

Country Link
FR (1) FR2432516A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2532304A1 (en) * 1982-08-27 1984-03-02 Pharmaton Sa BASIC ESTERS OF BENZOIC ACIDS AND THIOPHENECARBOXYLIC ACIDS-2, PROCESSES FOR THE PREPARATION THEREOF AND MEDICAMENTS CONTAINING THE SAME
GB2230780A (en) * 1989-04-22 1990-10-31 American Home Prod Tertiary alkyl functionalised piperazine derivatives
US4988814A (en) * 1989-04-22 1991-01-29 American Home Products Corp. Tertiary alkyl functionalized piperazine derivatives

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE179973T1 (en) 1989-04-22 1999-05-15 Wyeth John & Brother Ltd PIPERAZINE DERIVATIVES

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE682342A (en) * 1965-06-10 1966-12-09

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE682342A (en) * 1965-06-10 1966-12-09

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2532304A1 (en) * 1982-08-27 1984-03-02 Pharmaton Sa BASIC ESTERS OF BENZOIC ACIDS AND THIOPHENECARBOXYLIC ACIDS-2, PROCESSES FOR THE PREPARATION THEREOF AND MEDICAMENTS CONTAINING THE SAME
GB2230780A (en) * 1989-04-22 1990-10-31 American Home Prod Tertiary alkyl functionalised piperazine derivatives
US4988814A (en) * 1989-04-22 1991-01-29 American Home Products Corp. Tertiary alkyl functionalized piperazine derivatives
GB2230780B (en) * 1989-04-22 1992-10-21 American Home Prod Tertiary alkyl functionalized piperazine derivatives

Also Published As

Publication number Publication date
FR2432516B1 (en) 1981-04-17

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