SE8204238L - Forfarande for framstellning av nya derivat av vinkristin och leurosidin - Google Patents

Forfarande for framstellning av nya derivat av vinkristin och leurosidin

Info

Publication number
SE8204238L
SE8204238L SE8204238A SE8204238A SE8204238L SE 8204238 L SE8204238 L SE 8204238L SE 8204238 A SE8204238 A SE 8204238A SE 8204238 A SE8204238 A SE 8204238A SE 8204238 L SE8204238 L SE 8204238L
Authority
SE
Sweden
Prior art keywords
denotes
group
leurosidine
christine
vine
Prior art date
Application number
SE8204238A
Other languages
English (en)
Other versions
SE444684B (sv
SE8204238D0 (sv
Inventor
G L Thompson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/853,979 external-priority patent/US4143041A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SE8204238D0 publication Critical patent/SE8204238D0/sv
Publication of SE8204238L publication Critical patent/SE8204238L/sv
Publication of SE444684B publication Critical patent/SE444684B/sv

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04Dimeric indole alkaloids, e.g. vincaleucoblastine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (1)

1. Patentkrav Ftrfarande for framstAllning av ett 4-desacetylderiva av diner indol-dihydroindol med den allmanna formeln: 5' R3 7:.21/Nit R4 I24C \\II°fl. ,72' I, 13 \3-6 vrC-0-CH3 0 234. R och R bar de oven anglvna betydelserna, hydrolyseras under aura eller basiska betingelser i en reaktionsblandning, varefter den bildade produkten utvinnes sAsom fri bas eller sAsom ett farmaceutiskt godtagbart salt darav. dgr R2 betecknar CH3 eller CHO, och dal"' en av symbolerna R3 och R4 betecknar H och den andra betecknar C2H, samt farmaceutiskt godtagbara salter ddrav,kAnnetecknat av att ett 4-acetoxiderivat av dimes- indol-dihydroindol med den allmanna formeln: 7'4 4 ir 2' 13c AJ\N/8' (V) 16,117, H3 3
SE8204238A 1977-01-19 1982-07-08 Forfarande for framstellning av 4-desacetylderivat av vinkristin och leurosidin SE444684B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76059577A 1977-01-19 1977-01-19
US05/853,979 US4143041A (en) 1977-01-19 1977-11-25 4'-Deoxyvincristine and related compounds

Publications (3)

Publication Number Publication Date
SE8204238D0 SE8204238D0 (sv) 1982-07-08
SE8204238L true SE8204238L (sv) 1982-07-08
SE444684B SE444684B (sv) 1986-04-28

Family

ID=27116837

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7800555A SE425852B (sv) 1977-01-19 1978-01-17 Analogiforfarande for framstellning av derivat av vinkristin och leurosidin
SE8204238A SE444684B (sv) 1977-01-19 1982-07-08 Forfarande for framstellning av 4-desacetylderivat av vinkristin och leurosidin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7800555A SE425852B (sv) 1977-01-19 1978-01-17 Analogiforfarande for framstellning av derivat av vinkristin och leurosidin

Country Status (24)

Country Link
JP (1) JPS5390299A (sv)
AR (1) AR217459A1 (sv)
AT (1) AT363620B (sv)
BG (2) BG33293A3 (sv)
CA (2) CA1088526A (sv)
CH (1) CH635106A5 (sv)
CS (2) CS194832B2 (sv)
DD (1) DD134527A5 (sv)
DE (1) DE2801748A1 (sv)
DK (1) DK144420C (sv)
FR (1) FR2378032A1 (sv)
GB (1) GB1593231A (sv)
GR (1) GR68940B (sv)
IE (1) IE46308B1 (sv)
IL (1) IL53813A (sv)
IT (1) IT1174356B (sv)
MX (1) MX5112E (sv)
NL (1) NL7800667A (sv)
NZ (1) NZ186232A (sv)
PL (1) PL109695B1 (sv)
PT (1) PT67535B (sv)
RO (2) RO78290A (sv)
SE (2) SE425852B (sv)
YU (1) YU7278A (sv)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0649314U (ja) * 1992-12-11 1994-07-05 ヒノマル株式会社 食品包装容器

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2296418B1 (sv) * 1974-12-30 1978-07-21 Anvar
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine

Also Published As

Publication number Publication date
SE7800555L (sv) 1978-07-20
CS194850B2 (en) 1979-12-31
CA1088526A (en) 1980-10-28
PL204091A1 (pl) 1978-12-04
FR2378032B1 (sv) 1981-06-19
AU3246978A (en) 1979-07-26
IE46308B1 (en) 1983-05-04
IL53813A (en) 1982-07-30
CH635106A5 (en) 1983-03-15
IE780106L (en) 1978-07-19
DE2801748A1 (de) 1978-07-20
IL53813A0 (en) 1978-04-30
IT7819388A0 (it) 1978-01-18
CS194832B2 (en) 1979-12-31
RO73126A (ro) 1981-09-24
GB1593231A (en) 1981-07-15
DK144420C (da) 1982-08-09
BG33158A3 (en) 1982-12-15
PL109695B1 (en) 1980-06-30
JPS6153360B2 (sv) 1986-11-17
ATA35478A (de) 1981-01-15
DK144420B (da) 1982-03-08
SE444684B (sv) 1986-04-28
MX5112E (es) 1983-03-22
RO78290A (ro) 1982-02-01
FR2378032A1 (fr) 1978-08-18
JPS5390299A (en) 1978-08-08
YU7278A (en) 1983-01-21
CA1088527A (en) 1980-10-28
PT67535A (en) 1978-02-01
NL7800667A (nl) 1978-07-21
SE8204238D0 (sv) 1982-07-08
DD134527A5 (de) 1979-03-07
AT363620B (de) 1981-08-25
IT1174356B (it) 1987-07-01
SE425852B (sv) 1982-11-15
AR217459A1 (es) 1980-03-31
GR68940B (sv) 1982-03-29
BG33293A3 (en) 1983-01-14
PT67535B (en) 1979-06-15
NZ186232A (en) 1980-04-28
DK22478A (da) 1978-07-20

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