SE8204238L - PROCEDURE FOR PREPARING NEW DERIVATIVES OF VINE CHRISTINE AND LEUROSIDINE - Google Patents

PROCEDURE FOR PREPARING NEW DERIVATIVES OF VINE CHRISTINE AND LEUROSIDINE

Info

Publication number
SE8204238L
SE8204238L SE8204238A SE8204238A SE8204238L SE 8204238 L SE8204238 L SE 8204238L SE 8204238 A SE8204238 A SE 8204238A SE 8204238 A SE8204238 A SE 8204238A SE 8204238 L SE8204238 L SE 8204238L
Authority
SE
Sweden
Prior art keywords
denotes
group
leurosidine
christine
vine
Prior art date
Application number
SE8204238A
Other languages
Swedish (sv)
Other versions
SE8204238D0 (en
SE444684B (en
Inventor
G L Thompson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/853,979 external-priority patent/US4143041A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SE8204238L publication Critical patent/SE8204238L/en
Publication of SE8204238D0 publication Critical patent/SE8204238D0/en
Publication of SE444684B publication Critical patent/SE444684B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Dimeric indolodihydroindoles have the following formula In this formula: R<1> denotes the group OH or , R<2> denotes the group CHO or, if R<1> denotes the group OH, the group CH3, one of the radicals R<3> and R<4> denotes hydrogen and the other of these radicals denotes the group C2H5 and R<5> denotes hydrogen. As active compound, antitumour medicaments contain a compound of the formula I or a pharmaceutically acceptable salt thereof. Two processes for the preparation of the novel compounds are described.

Claims (1)

1. Patentkrav Ftrfarande for framstAllning av ett 4-desacetylderiva av diner indol-dihydroindol med den allmanna formeln: 5' R3 7:.21/Nit R4 I24C \\II°fl. ,72' I, 13 \3-6 vrC-0-CH3 0 234. R och R bar de oven anglvna betydelserna, hydrolyseras under aura eller basiska betingelser i en reaktionsblandning, varefter den bildade produkten utvinnes sAsom fri bas eller sAsom ett farmaceutiskt godtagbart salt darav. dgr R2 betecknar CH3 eller CHO, och dal"' en av symbolerna R3 och R4 betecknar H och den andra betecknar C2H, samt farmaceutiskt godtagbara salter ddrav,kAnnetecknat av att ett 4-acetoxiderivat av dimes- indol-dihydroindol med den allmanna formeln: 7'4 4 ir 2' 13c AJ\N/8' (V) 16,117, H3 3A process for the preparation of a 4-desacetyl derivative of diner indole-dihydroindole having the general formula: 5 'R3 7: .21 / Nit R4 I24C \\ II ° fl. R 3 and R 3 have the above meanings, are hydrolyzed under aura or basic conditions in a reaction mixture, after which the product formed is recovered as a free base or as a pharmaceutically acceptable salt darav. d2 R2 represents CH3 or CHO, and one of the symbols R3 and R4 represents H and the other denotes C2H, and pharmaceutically acceptable salts ddrav, characterized in that a 4-acetoxide derivative of dimesedol-dihydroindole of the general formula: 7 '4 4 ir 2' 13c AJ \ N / 8 '(V) 16,117, H3 3
SE8204238A 1977-01-19 1982-07-08 PROCEDURE FOR PREPARING 4-DESACETYL DERIVATIVES OF VINE CHRISTINE AND LEUROSIDINE SE444684B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76059577A 1977-01-19 1977-01-19
US05/853,979 US4143041A (en) 1977-01-19 1977-11-25 4'-Deoxyvincristine and related compounds

Publications (3)

Publication Number Publication Date
SE8204238L true SE8204238L (en) 1982-07-08
SE8204238D0 SE8204238D0 (en) 1982-07-08
SE444684B SE444684B (en) 1986-04-28

Family

ID=27116837

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7800555A SE425852B (en) 1977-01-19 1978-01-17 ANALOGY PROCEDURE FOR PREPARING DERIVATIVES OF VINE CHRISTINE AND LEUROSIDINE
SE8204238A SE444684B (en) 1977-01-19 1982-07-08 PROCEDURE FOR PREPARING 4-DESACETYL DERIVATIVES OF VINE CHRISTINE AND LEUROSIDINE

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7800555A SE425852B (en) 1977-01-19 1978-01-17 ANALOGY PROCEDURE FOR PREPARING DERIVATIVES OF VINE CHRISTINE AND LEUROSIDINE

Country Status (24)

Country Link
JP (1) JPS5390299A (en)
AR (1) AR217459A1 (en)
AT (1) AT363620B (en)
BG (2) BG33158A3 (en)
CA (2) CA1088526A (en)
CH (1) CH635106A5 (en)
CS (2) CS194850B2 (en)
DD (1) DD134527A5 (en)
DE (1) DE2801748A1 (en)
DK (1) DK144420C (en)
FR (1) FR2378032A1 (en)
GB (1) GB1593231A (en)
GR (1) GR68940B (en)
IE (1) IE46308B1 (en)
IL (1) IL53813A (en)
IT (1) IT1174356B (en)
MX (1) MX5112E (en)
NL (1) NL7800667A (en)
NZ (1) NZ186232A (en)
PL (1) PL109695B1 (en)
PT (1) PT67535B (en)
RO (2) RO78290A (en)
SE (2) SE425852B (en)
YU (1) YU7278A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0649314U (en) * 1992-12-11 1994-07-05 ヒノマル株式会社 Food packaging container

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2296418B1 (en) * 1974-12-30 1978-07-21 Anvar
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine

Also Published As

Publication number Publication date
AR217459A1 (en) 1980-03-31
PT67535B (en) 1979-06-15
YU7278A (en) 1983-01-21
DE2801748A1 (en) 1978-07-20
AT363620B (en) 1981-08-25
ATA35478A (en) 1981-01-15
CA1088527A (en) 1980-10-28
FR2378032A1 (en) 1978-08-18
BG33293A3 (en) 1983-01-14
SE7800555L (en) 1978-07-20
CA1088526A (en) 1980-10-28
NL7800667A (en) 1978-07-21
CS194832B2 (en) 1979-12-31
IL53813A0 (en) 1978-04-30
NZ186232A (en) 1980-04-28
GR68940B (en) 1982-03-29
PT67535A (en) 1978-02-01
CS194850B2 (en) 1979-12-31
SE425852B (en) 1982-11-15
FR2378032B1 (en) 1981-06-19
CH635106A5 (en) 1983-03-15
DK144420C (en) 1982-08-09
IE46308B1 (en) 1983-05-04
PL204091A1 (en) 1978-12-04
IT7819388A0 (en) 1978-01-18
MX5112E (en) 1983-03-22
RO73126A (en) 1981-09-24
SE8204238D0 (en) 1982-07-08
JPS6153360B2 (en) 1986-11-17
RO78290A (en) 1982-02-01
DK144420B (en) 1982-03-08
DK22478A (en) 1978-07-20
BG33158A3 (en) 1982-12-15
IL53813A (en) 1982-07-30
AU3246978A (en) 1979-07-26
JPS5390299A (en) 1978-08-08
PL109695B1 (en) 1980-06-30
GB1593231A (en) 1981-07-15
SE444684B (en) 1986-04-28
DD134527A5 (en) 1979-03-07
IT1174356B (en) 1987-07-01
IE780106L (en) 1978-07-19

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