SE8203913L - PROCESS FOR THE PREPARATION OF 2,4-DIAMINO-5-(3ს៟,4ს៟,5ს-TRIMETHOXYBENZYL)-PYRIMIDINE - Google Patents

PROCESS FOR THE PREPARATION OF 2,4-DIAMINO-5-(3ს៟,4ს៟,5ს-TRIMETHOXYBENZYL)-PYRIMIDINE

Info

Publication number
SE8203913L
SE8203913L SE8203913A SE8203913A SE8203913L SE 8203913 L SE8203913 L SE 8203913L SE 8203913 A SE8203913 A SE 8203913A SE 8203913 A SE8203913 A SE 8203913A SE 8203913 L SE8203913 L SE 8203913L
Authority
SE
Sweden
Prior art keywords
trimethoxybenzyl
diamino
pyrimidine
preparation
formula
Prior art date
Application number
SE8203913A
Other languages
Swedish (sv)
Other versions
SE451134B (en
SE8203913D0 (en
Inventor
I Beck
I Biro
A Dietz
E Jakfalvi
L Ladanyi
I Simonyi
Z Takacs
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of SE8203913D0 publication Critical patent/SE8203913D0/en
Publication of SE8203913L publication Critical patent/SE8203913L/en
Publication of SE451134B publication Critical patent/SE451134B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

2,4-Diamino-5-/3',4',5'-trimethoxybenzyl/pyrimidine is prepared by reacting alpha-/3,4,5-trimethoxy-benzal/-beta-methoxypropionitrile with a diethylene glycol monalkyl ether of the formula HO-CH2-CH2-O-CH2-CH2-OR (wherein R is an alkyl group having 1 to 4 carbon atoms) at 60 to 90 DEG C in the presence of an alkali metal alkoxide, and reacting the obtained benzyl isomer of the formula <IMAGE> (optionally without separation) with guanidine in the presence of an alkanol having 4 to 8 carbon atoms.
SE8203913A 1981-06-26 1982-06-23 PROCESS FOR THE PREPARATION OF 2,4-DIAMINO-5-(3ს៟,4ს៟,5ს-TRIMETHOXYBENZYL)-PYRIMIDINE SE451134B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU811868A HU186413B (en) 1981-06-26 1981-06-26 Process for producing 2,4-diamino-5-bracket-3-comma above,4-comma above,5-comma above-trimethoxy-benzyl-bracket closed-pyrimidine

Publications (3)

Publication Number Publication Date
SE8203913D0 SE8203913D0 (en) 1982-06-23
SE8203913L true SE8203913L (en) 1982-12-27
SE451134B SE451134B (en) 1987-09-07

Family

ID=10956590

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8203913A SE451134B (en) 1981-06-26 1982-06-23 PROCESS FOR THE PREPARATION OF 2,4-DIAMINO-5-(3ს៟,4ს៟,5ს-TRIMETHOXYBENZYL)-PYRIMIDINE

Country Status (22)

Country Link
JP (1) JPS5838265A (en)
AT (1) AT385033B (en)
AU (1) AU547822B2 (en)
BE (1) BE893609A (en)
CA (1) CA1164458A (en)
CH (1) CH651828A5 (en)
CS (1) CS244907B2 (en)
DD (1) DD202702A5 (en)
DK (1) DK155668C (en)
ES (1) ES8304948A1 (en)
FI (1) FI76789C (en)
FR (1) FR2508449B1 (en)
GB (1) GB2106098B (en)
GR (1) GR76158B (en)
HU (1) HU186413B (en)
IE (1) IE53347B1 (en)
IL (1) IL66131A (en)
IT (1) IT1190888B (en)
RO (1) RO85316B (en)
SE (1) SE451134B (en)
SU (1) SU1147252A3 (en)
YU (1) YU42264B (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1303727B (en) * 1959-09-03 1976-02-05 Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London Alpha-arylidene-substituted propioni-iriles
NL122146C (en) * 1960-09-02
DE2635765C3 (en) * 1976-08-09 1979-02-08 Ludwig Heumann & Co Gmbh, 8500 Nuernberg Process for the preparation of 2,4-EMamino-5- (3 ', 4'r5'-trimethoxybenzyl) -pyrimidine
US4115650A (en) * 1976-11-17 1978-09-19 Hoffmann-La Roche Inc. Process for preparing 2,4-diamino-5-(substituted benzyl)-pyrimidines
DE2730467A1 (en) * 1977-07-06 1979-01-18 Basf Ag BENZYLPYRIMIDINE, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THE SAME

Also Published As

Publication number Publication date
GR76158B (en) 1984-08-03
SE451134B (en) 1987-09-07
RO85316B (en) 1984-10-30
SE8203913D0 (en) 1982-06-23
CA1164458A (en) 1984-03-27
JPS5838265A (en) 1983-03-05
ES513481A0 (en) 1983-04-01
HU186413B (en) 1985-07-29
AU8534582A (en) 1983-01-06
RO85316A (en) 1984-09-29
AT385033B (en) 1988-02-10
YU42264B (en) 1988-06-30
FI822267A0 (en) 1982-06-24
FR2508449B1 (en) 1986-01-10
CH651828A5 (en) 1985-10-15
SU1147252A3 (en) 1985-03-23
IE821521L (en) 1982-12-20
GB2106098A (en) 1983-04-07
IL66131A (en) 1985-03-31
GB2106098B (en) 1984-12-19
FI822267L (en) 1982-12-27
ES8304948A1 (en) 1983-04-01
FI76789B (en) 1988-08-31
CS244907B2 (en) 1986-08-14
IE53347B1 (en) 1988-10-26
ATA244882A (en) 1987-07-15
IL66131A0 (en) 1982-09-30
AU547822B2 (en) 1985-11-07
FI76789C (en) 1988-12-12
FR2508449A1 (en) 1982-12-31
IT1190888B (en) 1988-02-24
IT8222034A0 (en) 1982-06-24
DD202702A5 (en) 1983-09-28
DK155668C (en) 1989-09-18
DK275682A (en) 1982-12-27
DK155668B (en) 1989-05-01
BE893609A (en) 1982-12-23
CS471682A2 (en) 1985-09-17
YU138482A (en) 1984-10-31

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