ES8304948A1 - Preparation of 2,4-diamino-5-/3',4',5'- trimethoxybenzyl/pyrimidine - Google Patents

Preparation of 2,4-diamino-5-/3',4',5'- trimethoxybenzyl/pyrimidine

Info

Publication number
ES8304948A1
ES8304948A1 ES513481A ES513481A ES8304948A1 ES 8304948 A1 ES8304948 A1 ES 8304948A1 ES 513481 A ES513481 A ES 513481A ES 513481 A ES513481 A ES 513481A ES 8304948 A1 ES8304948 A1 ES 8304948A1
Authority
ES
Spain
Prior art keywords
trimethoxybenzyl
diamino
pyrimidine
preparation
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513481A
Other languages
Spanish (es)
Other versions
ES513481A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ES513481A0 publication Critical patent/ES513481A0/en
Publication of ES8304948A1 publication Critical patent/ES8304948A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

2,4-Diamino-5-/3',4',5'-trimethoxybenzyl/pyrimidine is prepared by reacting alpha-/3,4,5-trimethoxy-benzal/-beta-methoxypropionitrile with a diethylene glycol monalkyl ether of the formula HO-CH2-CH2-O-CH2-CH2-OR (wherein R is an alkyl group having 1 to 4 carbon atoms) at 60 to 90 DEG C in the presence of an alkali metal alkoxide, and reacting the obtained benzyl isomer of the formula < IMAGE > (optionally without separation) with guanidine in the presence of an alkanol having 4 to 8 carbon atoms.
ES513481A 1981-06-26 1982-06-25 Preparation of 2,4-diamino-5-/3',4',5'- trimethoxybenzyl/pyrimidine Expired ES8304948A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU811868A HU186413B (en) 1981-06-26 1981-06-26 Process for producing 2,4-diamino-5-bracket-3-comma above,4-comma above,5-comma above-trimethoxy-benzyl-bracket closed-pyrimidine

Publications (2)

Publication Number Publication Date
ES513481A0 ES513481A0 (en) 1983-04-01
ES8304948A1 true ES8304948A1 (en) 1983-04-01

Family

ID=10956590

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513481A Expired ES8304948A1 (en) 1981-06-26 1982-06-25 Preparation of 2,4-diamino-5-/3',4',5'- trimethoxybenzyl/pyrimidine

Country Status (22)

Country Link
JP (1) JPS5838265A (en)
AT (1) AT385033B (en)
AU (1) AU547822B2 (en)
BE (1) BE893609A (en)
CA (1) CA1164458A (en)
CH (1) CH651828A5 (en)
CS (1) CS244907B2 (en)
DD (1) DD202702A5 (en)
DK (1) DK155668C (en)
ES (1) ES8304948A1 (en)
FI (1) FI76789C (en)
FR (1) FR2508449B1 (en)
GB (1) GB2106098B (en)
GR (1) GR76158B (en)
HU (1) HU186413B (en)
IE (1) IE53347B1 (en)
IL (1) IL66131A (en)
IT (1) IT1190888B (en)
RO (1) RO85316B (en)
SE (1) SE451134B (en)
SU (1) SU1147252A3 (en)
YU (1) YU42264B (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1303727B (en) * 1959-09-03 1976-02-05 Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London Alpha-arylidene-substituted propioni-iriles
NL122146C (en) * 1960-09-02
DE2635765C3 (en) * 1976-08-09 1979-02-08 Ludwig Heumann & Co Gmbh, 8500 Nuernberg Process for the preparation of 2,4-EMamino-5- (3 ', 4'r5'-trimethoxybenzyl) -pyrimidine
US4115650A (en) * 1976-11-17 1978-09-19 Hoffmann-La Roche Inc. Process for preparing 2,4-diamino-5-(substituted benzyl)-pyrimidines
DE2730467A1 (en) * 1977-07-06 1979-01-18 Basf Ag BENZYLPYRIMIDINE, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THE SAME

Also Published As

Publication number Publication date
GR76158B (en) 1984-08-03
SE451134B (en) 1987-09-07
RO85316B (en) 1984-10-30
SE8203913D0 (en) 1982-06-23
CA1164458A (en) 1984-03-27
JPS5838265A (en) 1983-03-05
ES513481A0 (en) 1983-04-01
HU186413B (en) 1985-07-29
AU8534582A (en) 1983-01-06
RO85316A (en) 1984-09-29
AT385033B (en) 1988-02-10
YU42264B (en) 1988-06-30
FI822267A0 (en) 1982-06-24
FR2508449B1 (en) 1986-01-10
CH651828A5 (en) 1985-10-15
SU1147252A3 (en) 1985-03-23
IE821521L (en) 1982-12-20
GB2106098A (en) 1983-04-07
IL66131A (en) 1985-03-31
GB2106098B (en) 1984-12-19
FI822267L (en) 1982-12-27
FI76789B (en) 1988-08-31
CS244907B2 (en) 1986-08-14
IE53347B1 (en) 1988-10-26
ATA244882A (en) 1987-07-15
IL66131A0 (en) 1982-09-30
AU547822B2 (en) 1985-11-07
FI76789C (en) 1988-12-12
FR2508449A1 (en) 1982-12-31
IT1190888B (en) 1988-02-24
IT8222034A0 (en) 1982-06-24
DD202702A5 (en) 1983-09-28
DK155668C (en) 1989-09-18
DK275682A (en) 1982-12-27
DK155668B (en) 1989-05-01
BE893609A (en) 1982-12-23
CS471682A2 (en) 1985-09-17
SE8203913L (en) 1982-12-27
YU138482A (en) 1984-10-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603