SE8201649L - Forfarande for framstellning av prostacyklinderivat - Google Patents
Forfarande for framstellning av prostacyklinderivatInfo
- Publication number
- SE8201649L SE8201649L SE8201649A SE8201649A SE8201649L SE 8201649 L SE8201649 L SE 8201649L SE 8201649 A SE8201649 A SE 8201649A SE 8201649 A SE8201649 A SE 8201649A SE 8201649 L SE8201649 L SE 8201649L
- Authority
- SE
- Sweden
- Prior art keywords
- denotes
- ddr
- formula
- alkyl
- carbon atoms
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 2
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical class O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- -1 1-ethoxyethyl Chemical group 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000004187 tetrahydropyran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000007795 chemical reaction product Substances 0.000 abstract 2
- RJADQDXZYFCVHV-JQMWNLLFSA-N 5-[(2s,4r,5r,6ar)-5-hydroxy-4-[(e,3s)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydro-2h-cyclopenta[b]furan-2-yl]pentanoic acid Chemical class O1[C@@H](CCCCC(O)=O)CC2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@H]21 RJADQDXZYFCVHV-JQMWNLLFSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052753 mercury Inorganic materials 0.000 abstract 1
- 229940100892 mercury compound Drugs 0.000 abstract 1
- 150000002731 mercury compounds Chemical class 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/10—Mercury compounds
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (1)
1. FOrfarande fdr framsttllning as en fdrening med formeln dLr R2 betecknar (1) R -C-CgH2I 16 fluoro, kloro, trifluorometyl eller -0R7- dPr R7 betecknar alkyl med 1 - 6 kolatomer, och ddr s betecknar 0, 1, 2 eller 3, varvid hOgst tva T bar annan betydelse On alkyl och ddr ndr s betecknar 2 eller 3 T antingen Pr lika eller olika orb dEr betecknar /••■ H , 63094eller 63014 ddr R3 betecknar vdte eller alkyl med 1 - 4 kolatomer, ddr R4 betecknar vdte, tetrahydropyran-2-yl, tetrahydrofuranyl, 1-etoxietyl eller en grupp med formeln ii 10 0-C R,Rio dal, 16 beteeknar alkyl med 1 - 18 kolatomer, cyklcalkyl mod 3 - kolatomer, aralkyl med 7 - 12 kolatomer, fenyl eller fenyl substituerad med 1, 2 eller 3 alkyl med 1 - 4 kolatomer, dAr 69 och R dr like eller olika, cab betecknar state, alkyl med 1 - 4 kolatomer, fenyl eller fenyl substituerad med 1, 2 eller 3 all, 1 - 4 Ro/r eller ddr 69 ooh Rio tillsag- mans beteckn-(CH2)a- elle_CH2)b-0-(CH2)c- ddr a heteck- nar 3, 4 eller 5, b betecknar 1, 2 eller 3, c betecknar 1, 2 Rd oweller 3 och b plus c betecknar 2, 3 eller 4 och clar Ri, beteck-dar 23 tidigare definierats och dirR har samma betydelse nar 'crate eller fenyl; ddrbetecknarsom R4 med det undantaget att det inte innefattar cite, omvandlas till ett tosylat med formeln ai2 OR ' 4 024 ryCH2CH2-0Ts CH, ddr 01, R,,°oh,/ tidigare definierats och dar Ts betecknar p-to usulfonylgruppen; och eventuellt aylagsnande av den blockerande gruppen R fir bildning an en forening med formeln dar 2, R2, a ach.,, tidigare definierats. , eller ddr R4 tidigare definierats; dar Ts betecknar p-toluensulfonyl- gruppen ochbetecknar anslutning i alfa- eller beta- -kOnfiguration,kannetecknatay att en fire- fling med formeln ddr 22,och,,., tidigare definierats och ddr Qi beteck- oar V's■ HH , 230242 , ei.23OR /0-CH ryCH2C1-12-0H —CH2 C-R, 01
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69139976A | 1976-06-01 | 1976-06-01 | |
| US69140076A | 1976-06-01 | 1976-06-01 | |
| US78814677A | 1977-04-19 | 1977-04-19 | |
| US78814777A | 1977-04-19 | 1977-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE8201649L true SE8201649L (sv) | 1982-03-16 |
Family
ID=27505431
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7706245A SE436744B (sv) | 1976-06-01 | 1977-05-27 | Forfarande for framstellning av prostacyklinderivat |
| SE7811142A SE432101B (sv) | 1976-06-01 | 1978-10-26 | Prostacyklinderivat for anvendning att reglera reproduktionscykeln hos menstruerande hondeggdjur |
| SE8201649A SE8201649L (sv) | 1976-06-01 | 1982-03-16 | Forfarande for framstellning av prostacyklinderivat |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7706245A SE436744B (sv) | 1976-06-01 | 1977-05-27 | Forfarande for framstellning av prostacyklinderivat |
| SE7811142A SE432101B (sv) | 1976-06-01 | 1978-10-26 | Prostacyklinderivat for anvendning att reglera reproduktionscykeln hos menstruerande hondeggdjur |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5936912B2 (sv) |
| AU (1) | AU508891B2 (sv) |
| BE (1) | BE855224A (sv) |
| CA (1) | CA1196632A (sv) |
| CH (1) | CH640847A5 (sv) |
| DE (1) | DE2724555A1 (sv) |
| FR (1) | FR2353543B1 (sv) |
| GB (1) | GB1554048A (sv) |
| IE (1) | IE45604B1 (sv) |
| IL (1) | IL52099A (sv) |
| MX (1) | MX4813E (sv) |
| NL (1) | NL7705991A (sv) |
| SE (3) | SE436744B (sv) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL51189A (en) * | 1976-02-04 | 1985-08-30 | Upjohn Co | Prostaglandin analogs |
| FI71138C (fi) | 1976-12-31 | 1986-11-24 | Erba Farmitalia | Foerfarande foer framstaellning av terapeutiskt aktiva bisykliska prostaglandiner |
| AU524786B2 (en) * | 1977-03-07 | 1982-10-07 | The Upjohn Company | Prostacyclins |
| DE2743283A1 (de) * | 1977-09-27 | 1979-04-05 | Hoechst Ag | Neue prostacyclin-analoga |
| DE2811950A1 (de) * | 1978-03-18 | 1979-12-13 | Hoechst Ag | Neue analoga von prostacyclin |
| US4237060A (en) | 1979-03-23 | 1980-12-02 | Hoffmann-La Roche Inc. | Prostacyclin analogs |
| CN1377263A (zh) * | 1999-08-05 | 2002-10-30 | 帝人株式会社 | 含有含氮化合物作为活性成分的神经损伤治疗剂 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1079025B (it) * | 1976-05-11 | 1985-05-08 | Wellcome Found | Perfezionamento nella preparazione di eteri |
-
1977
- 1977-04-10 MX MX77100668U patent/MX4813E/es unknown
- 1977-05-11 AU AU25086/77A patent/AU508891B2/en not_active Ceased
- 1977-05-16 IL IL52099A patent/IL52099A/xx unknown
- 1977-05-20 GB GB21363/77A patent/GB1554048A/en not_active Expired
- 1977-05-25 CA CA000279106A patent/CA1196632A/en not_active Expired
- 1977-05-27 SE SE7706245A patent/SE436744B/sv not_active IP Right Cessation
- 1977-05-27 CH CH660877A patent/CH640847A5/de not_active IP Right Cessation
- 1977-05-31 FR FR7716615A patent/FR2353543B1/fr not_active Expired
- 1977-05-31 DE DE19772724555 patent/DE2724555A1/de not_active Withdrawn
- 1977-05-31 BE BE178059A patent/BE855224A/xx not_active IP Right Cessation
- 1977-06-01 IE IE1133/77A patent/IE45604B1/en unknown
- 1977-06-01 NL NL7705991A patent/NL7705991A/xx not_active Application Discontinuation
- 1977-06-01 JP JP52063395A patent/JPS5936912B2/ja not_active Expired
-
1978
- 1978-10-26 SE SE7811142A patent/SE432101B/sv unknown
-
1982
- 1982-03-16 SE SE8201649A patent/SE8201649L/sv not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1196632A (en) | 1985-11-12 |
| FR2353543B1 (fr) | 1986-02-21 |
| IL52099A (en) | 1985-03-31 |
| SE436744B (sv) | 1985-01-21 |
| AU508891B2 (en) | 1980-04-03 |
| IE45604B1 (en) | 1982-10-06 |
| DE2724555A1 (de) | 1977-12-15 |
| JPS52156854A (en) | 1977-12-27 |
| JPS5936912B2 (ja) | 1984-09-06 |
| SE7811142L (sv) | 1978-11-28 |
| FR2353543A1 (fr) | 1977-12-30 |
| BE855224A (fr) | 1977-11-30 |
| AU2508677A (en) | 1978-11-16 |
| IL52099A0 (en) | 1977-07-31 |
| SE7706245L (sv) | 1977-12-16 |
| CH640847A5 (en) | 1984-01-31 |
| GB1554048A (en) | 1979-10-17 |
| SE432101B (sv) | 1984-03-19 |
| MX4813E (es) | 1982-10-19 |
| IE45604L (en) | 1977-12-01 |
| NL7705991A (nl) | 1977-12-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
Ref document number: 8201649-4 |