SE516272C2 - Metoder och kit för analytdetektion mha proximitets-probning - Google Patents

Metoder och kit för analytdetektion mha proximitets-probning

Info

Publication number
SE516272C2
SE516272C2 SE0000538A SE0000538A SE516272C2 SE 516272 C2 SE516272 C2 SE 516272C2 SE 0000538 A SE0000538 A SE 0000538A SE 0000538 A SE0000538 A SE 0000538A SE 516272 C2 SE516272 C2 SE 516272C2
Authority
SE
Sweden
Prior art keywords
analyte
binding
proximity
nucleic acid
ligation
Prior art date
Application number
SE0000538A
Other languages
English (en)
Swedish (sv)
Other versions
SE0000538D0 (sv
SE0000538L (sv
Inventor
Ulf Landegren
Simon Fredriksson
Original Assignee
Ulf Landegren
Simon Fredriksson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ulf Landegren, Simon Fredriksson filed Critical Ulf Landegren
Priority to SE0000538A priority Critical patent/SE516272C2/sv
Publication of SE0000538D0 publication Critical patent/SE0000538D0/xx
Priority to PCT/SE2001/000341 priority patent/WO2001061037A1/en
Priority to DE60134957T priority patent/DE60134957D1/de
Priority to CA002400384A priority patent/CA2400384A1/en
Priority to JP2001559873A priority patent/JP4804691B2/ja
Priority to AT01906476T priority patent/ATE402269T1/de
Priority to AU34300/01A priority patent/AU783644B2/en
Priority to EP01906476A priority patent/EP1255861B1/de
Publication of SE0000538L publication Critical patent/SE0000538L/xx
Publication of SE516272C2 publication Critical patent/SE516272C2/sv

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804Nucleic acid analysis using immunogens
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00Labels used in chemical analysis of biological material
    • G01N2458/10Oligonucleotides as tagging agents for labelling antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SE0000538A 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning SE516272C2 (sv)

Priority Applications (8)

Application Number Priority Date Filing Date Title
SE0000538A SE516272C2 (sv) 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning
PCT/SE2001/000341 WO2001061037A1 (en) 2000-02-18 2001-02-16 Methods and kits for proximity probing
DE60134957T DE60134957D1 (de) 2000-02-18 2001-02-16 Methoden und testsätze für annäherungstest
CA002400384A CA2400384A1 (en) 2000-02-18 2001-02-16 Methods and kits for proximity probing
JP2001559873A JP4804691B2 (ja) 2000-02-18 2001-02-16 近接プロービング方法およびキット
AT01906476T ATE402269T1 (de) 2000-02-18 2001-02-16 Methoden und testsätze für annäherungstest
AU34300/01A AU783644B2 (en) 2000-02-18 2001-02-16 Methods and kits for proximity probing
EP01906476A EP1255861B1 (de) 2000-02-18 2001-02-16 Methoden und testsätze für annäherungstest

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0000538A SE516272C2 (sv) 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning

Publications (3)

Publication Number Publication Date
SE0000538D0 SE0000538D0 (sv) 2000-02-18
SE0000538L SE0000538L (sv) 2001-08-19
SE516272C2 true SE516272C2 (sv) 2001-12-10

Family

ID=20278505

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0000538A SE516272C2 (sv) 2000-02-18 2000-02-18 Metoder och kit för analytdetektion mha proximitets-probning

Country Status (8)

Country Link
EP (1) EP1255861B1 (de)
JP (1) JP4804691B2 (de)
AT (1) ATE402269T1 (de)
AU (1) AU783644B2 (de)
CA (1) CA2400384A1 (de)
DE (1) DE60134957D1 (de)
SE (1) SE516272C2 (de)
WO (1) WO2001061037A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US20070166741A1 (en) 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
WO2002088733A1 (fr) * 2001-04-23 2002-11-07 Eiken Kagaku Kabushiki Kaisha Methode d'analyse faisant intervenir une interaction intermoleculaire par rapporteur (marqueur)
DE60220804D1 (de) * 2001-08-20 2007-08-02 Regenesis Bioremediation Produ Biosensor für kleinmolekulare analyten
CA2462625A1 (en) * 2001-10-03 2003-04-10 Iseao Technologies Limited Methods for detection of target molecules and molecular interactions
GB0212544D0 (en) * 2002-05-30 2002-07-10 Microsens Biophage Ltd Methods for detection of target molecules and molecular interactions
EP1451356A1 (de) * 2001-11-23 2004-09-01 Simon Fredriksson Verfahren und kit zur proximitätssondierung mit mehrwertigen proximitätssonden
US7553619B2 (en) 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
US7977048B2 (en) 2004-01-13 2011-07-12 Pathogenetix, Inc. Detection and quantification of analytes in solution using polymers
US7595160B2 (en) 2004-01-13 2009-09-29 U.S. Genomics, Inc. Analyte detection using barcoded polymers
EP1709203A2 (de) * 2004-01-23 2006-10-11 Lingvitae AS Verbesserung von polynukleotid-ligationsreaktionen
WO2005123963A2 (en) 2004-06-14 2005-12-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for use in analyte detection using proximity probes
ATE480643T1 (de) * 2004-11-03 2010-09-15 Iris Molecular Diagnostics Inc Homogener nachweis von analyten
US20090011955A1 (en) * 2005-07-06 2009-01-08 Forskarpatent L Uppsala Ab Method for Localization of Nucleic Acid Associated Molecules and Modifications
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
EP1945813A4 (de) * 2005-10-11 2010-04-21 Stratagene California Binäre signalnachweistests
WO2007054515A1 (en) * 2005-11-14 2007-05-18 Boehringer Ingelheim Vetmedica Gmbh Method for detecting microorganisms
ES2538038T3 (es) * 2006-01-17 2015-06-16 Somalogic, Inc. Análisis multiplexado de muestras de ensayo
GB0605584D0 (en) * 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
WO2007117444A2 (en) * 2006-03-31 2007-10-18 Yinghe Hu Protein detection by aptamers
EP2049688B1 (de) * 2006-08-01 2018-01-24 Applied Biosystems, LLC Nachweis von analyten und nukleinsäuren
US8778846B2 (en) * 2006-12-04 2014-07-15 General Electric Company Composition, device and associated method
US8975026B2 (en) 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US20110136099A1 (en) 2007-01-16 2011-06-09 Somalogic, Inc. Multiplexed Analyses of Test Samples
GB0918712D0 (en) * 2009-10-26 2009-12-09 Axis Shield Diagnostics Ltd An assay
GB201004292D0 (en) 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
US20120004132A1 (en) * 2010-07-02 2012-01-05 Affymetrix, Inc. Detection of Nucleic Acids and Proteins
GB201011971D0 (en) 2010-07-15 2010-09-01 Olink Ab Methods and product
WO2012049316A1 (en) 2010-10-15 2012-04-19 Olink Ab Dynamic range methods
US20130323729A1 (en) * 2010-10-29 2013-12-05 Olink Ab Proximity Ligation Technology for Western Blot Applications
EP2466310A1 (de) 2010-12-17 2012-06-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Mittel und Verfahren für den Nachweis von mehrstrangigen Brüchen
EP3567121B1 (de) 2011-01-17 2023-08-30 Life Technologies Corporation Arbeitsablauf zum nachweis von liganden mit nukleinsäuren
EP2665815B1 (de) 2011-01-17 2017-08-09 Life Technologies Corporation Enzymatische ligation von nukleinsäuren
US11560585B2 (en) 2011-01-31 2023-01-24 Roche Sequencing Solutions, Inc. Methods of identifying multiple epitopes in cells
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
ES2687761T3 (es) 2011-01-31 2018-10-29 F. Hoffmann-La Roche Ag Métodos de identificación de múltiples epítopos en células
GB201107863D0 (en) 2011-05-11 2011-06-22 Olink Ab Method and product
US10597701B2 (en) 2011-05-11 2020-03-24 Navinci Diagnostics Ab Unfolding proximity probes and methods for the use thereof
GB201108678D0 (en) 2011-05-24 2011-07-06 Olink Ab Multiplexed proximity ligation assay
US9029086B2 (en) * 2012-01-26 2015-05-12 Masood Kamali Moghaddam Detection of single and multimodal analytes
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
WO2014076214A1 (en) 2012-11-14 2014-05-22 Olink Ab Rca reporter probes and their use in detecting nucleic acid molecules
EP2920324B1 (de) 2012-11-14 2017-12-27 Olink Bioscience AB Lokalisiertes rca-basiertes verstärkungsverfahren
GB201320145D0 (en) 2013-11-14 2014-01-01 Olink Ab Localised RCA-based amplification method using a padlock-probe
GB201321123D0 (en) 2013-11-29 2014-01-15 Linea Ab Q Amplification of circular molecules
GB201401885D0 (en) 2014-02-04 2014-03-19 Olink Ab Proximity assay with detection based on hybridisation chain reaction (HCR)
EP3234602B1 (de) * 2014-12-19 2021-08-25 F. Hoffmann-La Roche AG Verfahren zur identifizierung mehrerer epitope in ausgewählten subpopulationen von zellen
WO2016141040A1 (en) * 2015-03-02 2016-09-09 The Regents Of The University Of California Homogenous entropy-driven biomolecular assay (heba)
JP6822973B2 (ja) * 2015-04-17 2021-01-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 凝集の検出方法及びその方法を実施する際に使用する組成物
US11459598B2 (en) 2015-10-20 2022-10-04 Quateris Llc Multiplex DNA immuno-sandwich assay (MDISA)
GB201518655D0 (en) * 2015-10-21 2015-12-02 Olink Ab Method for generating proximity probes
EP3420110B1 (de) 2016-02-26 2021-09-22 The Board of Trustees of the Leland Stanford Junior University Multiplexierte einzelmolekül-rna-visualisierung mit einem zwei-sonden-proximitätsligationssystem
WO2017218881A1 (en) * 2016-06-17 2017-12-21 Proximity Biosciences, Llc Method for aptamer pair selection
GB201614023D0 (en) 2016-08-16 2016-09-28 Olink Bioscience Ab Double-stranded circle probes
NZ743812A (en) * 2016-10-21 2019-12-20 Zelda Therapeutics Operations Pty Ltd Prognostic method and kits useful in said method
GB201621514D0 (en) 2016-12-16 2017-02-01 Q-Linea Ab Padlock probe detection method
WO2019199579A1 (en) 2018-04-09 2019-10-17 The Board Of Trustees Of The Leland Stanford Junior University Method of in situ gene sequencing
CN111139285A (zh) * 2018-11-02 2020-05-12 深圳华大生命科学研究院 一种高通量检测多个待测样本中不同目的蛋白含量的方法及其专用试剂盒
WO2021034971A1 (en) * 2019-08-19 2021-02-25 Brickbio, Inc. Methods and compositions for analyte detection and quantification
WO2021113290A1 (en) 2019-12-03 2021-06-10 Alamar Biosciences, Inc. Nucleic acid linked immune-sandwich assay (nulisa)
GB201919032D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
GB201919029D0 (en) 2019-12-20 2020-02-05 Cartana Ab Method of detecting an analyte
GB202004469D0 (en) 2020-03-27 2020-05-13 Olink Proteomics Ab Controls for proximity detection assays
GB202004472D0 (en) 2020-03-27 2020-05-13 Olink Proteomics Ab Method for detecting analytes of varying abundance
BR112022019266A2 (pt) * 2020-03-27 2022-12-06 Olink Proteomics Ab Método para detectar analitos de abundância variável
JP2023545038A (ja) * 2020-10-06 2023-10-26 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 中和標的のシグナルオン検出のための方法、組成物、キット、およびシステム
GB202017873D0 (en) 2020-11-12 2020-12-30 Olso Unversitetssykehus Hf Method of determining DLBCL prognosis
GB202018503D0 (en) 2020-11-25 2021-01-06 Olink Proteomics Ab Analyte detection method employing concatamers
JP2024500447A (ja) * 2020-12-16 2024-01-09 コグネクスト ダイアグノスティックス エルエルシー アルツハイマー病及び他の神経障害の診断方法
CN113945720B (zh) * 2021-09-26 2024-08-16 瑞博奥(广州)生物科技股份有限公司 基于核酸适配体探针的pdgf-bb识别方法及检测pdgf-bb的试剂盒
US20250059592A1 (en) * 2021-12-23 2025-02-20 California Institute Of Technology Suppression of non-specific signals by exonucleases in fish experiment
GB202213930D0 (en) 2022-09-23 2022-11-09 Xu Bo Padlock blocking oligonucleotide
CN120187865A (zh) 2022-11-11 2025-06-20 欧邻科蛋白质组学公司 邻近探针文库和使用方法
EP4382534A1 (de) 2022-12-06 2024-06-12 Biomérieux Synthetisches peptid zur verwendung in einem immunmolekulartest
WO2025012398A1 (en) 2023-07-11 2025-01-16 Olink Proteomics Ab Dried reagents
WO2025012226A1 (en) 2023-07-12 2025-01-16 Olink Proteomics Ab Method, components and software for detecting a systematic error in a protein detection system
WO2025031642A1 (en) 2023-08-07 2025-02-13 Olink Proteomics Ab A method for determining run errors for an analysis-method for quantifying a plurality of analytes in a plurality of biological samples
CN119757755B (zh) * 2024-11-01 2025-08-29 上海伯杰医疗科技股份有限公司 一种环状连接超敏免疫检测方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
CA1323293C (en) * 1987-12-11 1993-10-19 Keith C. Backman Assay using template-dependent nucleic acid probe reorganization
ES2101116T3 (es) * 1991-09-13 1997-07-01 Cytocell Ltd Metodo de deteccion de una secuencia de acidos nucleicos.
US5846709A (en) * 1993-06-15 1998-12-08 Imclone Systems Incorporated Chemical process for amplifying and detecting nucleic acid sequences
SE504798C2 (sv) * 1995-06-16 1997-04-28 Ulf Landegren Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten
WO2001023894A1 (de) * 1999-09-28 2001-04-05 Evotec Oai Ag Quantitative analyse und typisierung subzellulärer partikel

Also Published As

Publication number Publication date
SE0000538D0 (sv) 2000-02-18
WO2001061037A1 (en) 2001-08-23
SE0000538L (sv) 2001-08-19
EP1255861A1 (de) 2002-11-13
JP4804691B2 (ja) 2011-11-02
CA2400384A1 (en) 2001-08-23
ATE402269T1 (de) 2008-08-15
AU783644B2 (en) 2005-11-17
AU3430001A (en) 2001-08-27
EP1255861B1 (de) 2008-07-23
DE60134957D1 (de) 2008-09-04
JP2003524419A (ja) 2003-08-19

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