SE463541B - Granulaer produkt oeverdragen av en smaelta av sig sjaelv samt foerfarande foer dess framstaellning - Google Patents
Granulaer produkt oeverdragen av en smaelta av sig sjaelv samt foerfarande foer dess framstaellningInfo
- Publication number
- SE463541B SE463541B SE8703358A SE8703358A SE463541B SE 463541 B SE463541 B SE 463541B SE 8703358 A SE8703358 A SE 8703358A SE 8703358 A SE8703358 A SE 8703358A SE 463541 B SE463541 B SE 463541B
- Authority
- SE
- Sweden
- Prior art keywords
- melt
- solid
- itself
- product
- ratio
- Prior art date
Links
- 239000000155 melt Substances 0.000 title claims abstract description 19
- 238000000034 method Methods 0.000 title claims abstract description 5
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000000047 product Substances 0.000 claims abstract description 18
- 239000011248 coating agent Substances 0.000 claims abstract description 11
- 238000000576 coating method Methods 0.000 claims abstract description 11
- 239000012265 solid product Substances 0.000 claims abstract description 6
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 11
- 229960001680 ibuprofen Drugs 0.000 claims description 11
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 9
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 9
- 239000000811 xylitol Substances 0.000 claims description 9
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 9
- 235000010447 xylitol Nutrition 0.000 claims description 9
- 229960002675 xylitol Drugs 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 8
- 238000002844 melting Methods 0.000 claims description 6
- 230000008018 melting Effects 0.000 claims description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 3
- 239000004202 carbamide Substances 0.000 claims description 3
- 239000011343 solid material Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008187 granular material Substances 0.000 description 8
- 239000002245 particle Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 5
- 239000003826 tablet Substances 0.000 description 5
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 239000003595 mist Substances 0.000 description 2
- 239000011236 particulate material Substances 0.000 description 2
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- 229960004308 acetylcysteine Drugs 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229960002390 flurbiprofen Drugs 0.000 description 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
- 229960000991 ketoprofen Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000012768 molten material Substances 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- -1 phenoprofen Chemical compound 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- PIDSZXPFGCURGN-UHFFFAOYSA-N pirprofen Chemical compound ClC1=CC(C(C(O)=O)C)=CC=C1N1CC=CC1 PIDSZXPFGCURGN-UHFFFAOYSA-N 0.000 description 1
- 229960000851 pirprofen Drugs 0.000 description 1
- 239000012254 powdered material Substances 0.000 description 1
- 239000011164 primary particle Substances 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/003—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic followed by coating of the granules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/14—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic in rotating dishes or pans
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/30—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using agents to prevent the granules sticking together; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Glanulating (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Water Treatment By Sorption (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- General Preparation And Processing Of Foods (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Fertilizers (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8703358A SE463541B (sv) | 1987-08-31 | 1987-08-31 | Granulaer produkt oeverdragen av en smaelta av sig sjaelv samt foerfarande foer dess framstaellning |
| AT88850283T ATE64548T1 (de) | 1987-08-31 | 1988-08-26 | Granuliertes produkt. |
| ES88850283T ES2023509B3 (es) | 1987-08-31 | 1988-08-26 | Producto granular (i). |
| DE8888850283T DE3863328D1 (de) | 1987-08-31 | 1988-08-26 | Granuliertes produkt. |
| EP88850283A EP0305356B1 (de) | 1987-08-31 | 1988-08-26 | Granuliertes Produkt |
| CA000576020A CA1318482C (en) | 1987-08-31 | 1988-08-30 | Granular product (i) |
| US07/238,612 US4937080A (en) | 1987-08-31 | 1988-08-31 | Granular product (I) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8703358A SE463541B (sv) | 1987-08-31 | 1987-08-31 | Granulaer produkt oeverdragen av en smaelta av sig sjaelv samt foerfarande foer dess framstaellning |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8703358D0 SE8703358D0 (sv) | 1987-08-31 |
| SE8703358L SE8703358L (sv) | 1989-03-01 |
| SE463541B true SE463541B (sv) | 1990-12-10 |
Family
ID=20369425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8703358A SE463541B (sv) | 1987-08-31 | 1987-08-31 | Granulaer produkt oeverdragen av en smaelta av sig sjaelv samt foerfarande foer dess framstaellning |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4937080A (de) |
| EP (1) | EP0305356B1 (de) |
| AT (1) | ATE64548T1 (de) |
| CA (1) | CA1318482C (de) |
| DE (1) | DE3863328D1 (de) |
| ES (1) | ES2023509B3 (de) |
| SE (1) | SE463541B (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3833446A1 (de) * | 1988-10-01 | 1990-04-05 | Hoechst Ag | Verfahren zur herstellung von arzneimittelwirkstoff-partikeln mit verbesserten fliess-, lager- und formulierungseigenschaften sowie arzneimittel, die diese arzneimittelwirkstoff-partikeln enthalten |
| EP0376331A3 (de) * | 1988-12-29 | 1991-03-13 | Asahi Kogaku Kogyo Kabushiki Kaisha | Granula zur langsamen Wirkstoffabgabe sowie Verfahren zu deren Herstellung |
| SE467525B (sv) * | 1990-10-09 | 1992-08-03 | Nemo Ivarson Ab | Foerfarande foer att oeverdraga fasta partiklar i pulverform med ett i rumstemperatur hoegviskoest eller fast material |
| US5204115A (en) * | 1990-12-12 | 1993-04-20 | Suomen Xyrofin Oy | Directly compressible xylitol and method |
| FR2670398B1 (fr) * | 1990-12-14 | 1995-02-17 | Roquette Freres | Composition pulverulente directement compressible et procede d'obtention. |
| GB2253164B (en) * | 1991-02-22 | 1994-10-05 | Hoechst Uk Ltd | Improvements in or relating to electrostatic coating of substrates of medicinal products |
| US5429825A (en) * | 1992-06-26 | 1995-07-04 | Mcneil-Ppc, Inc. | Rotomelt granulation |
| US5512300A (en) * | 1992-09-15 | 1996-04-30 | Warner-Lambert Company | Prevention of ibuprofen from forming low melting eutectics with other therapeutic agents in solid dosage forms |
| IT1272149B (it) * | 1993-03-26 | 1997-06-11 | Zambon Spa | Composizione farmeceutiche ad attivita' analgesica |
| DE4418837A1 (de) * | 1994-05-30 | 1995-12-07 | Bayer Ag | Thermisches Granulierverfahren |
| FI110095B (fi) | 1998-05-18 | 2002-11-29 | Xyrofin Oy | Ksylitolin kiteyttäminen, kiteinen ksylitolituote ja sen käyttö |
| DK1235558T3 (da) * | 1999-12-09 | 2006-10-09 | Reckitt Benckiser Healthcare | Sammenpresset tabletsammensætning, der omfatter et NSAID |
| GB0113839D0 (en) * | 2001-06-07 | 2001-08-01 | Boots Co Plc | Therapeutic agents |
| US6705028B2 (en) * | 2001-09-12 | 2004-03-16 | Honda Giken Kogyo Kabushiki Kaisha | Self-propelled snowplow vehicle |
| US20070048418A1 (en) * | 2002-07-23 | 2007-03-01 | Mars, Incorporated | Polyol coated food product |
| GB0217076D0 (en) * | 2002-07-23 | 2002-08-28 | Mars Inc | Foodstuff |
| US7338677B2 (en) * | 2002-08-14 | 2008-03-04 | Wm. Wrigley Jr. Company | Methods for manufacturing coated confectionary products |
| US7378118B2 (en) * | 2002-08-14 | 2008-05-27 | Wm. Wrigley Jr. Company | Methods for manufacturing coated confectionary products |
| US20060198924A1 (en) * | 2002-08-14 | 2006-09-07 | Joo Song | Methods for manufacturing coated confectionery products |
| US20070077297A1 (en) * | 2004-09-30 | 2007-04-05 | Scolr Pharma, Inc. | Modified release ibuprofen dosage form |
| DE102005037630A1 (de) | 2005-08-09 | 2007-02-15 | Glatt Gmbh | Verfahren zur Herstellung von Teilchen aus pharmazeutischen Substanzen, Teilchen aus pharmazeutischen Substanzen sowie deren Verwendung |
| US7749537B2 (en) * | 2006-12-04 | 2010-07-06 | Scolr Pharma, Inc. | Method of forming a tablet |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE556141A (de) * | 1956-03-27 | |||
| EP0015093A1 (de) * | 1979-02-21 | 1980-09-03 | Imperial Chemical Industries Plc | Verfahren und Vorrichtung zum Überziehen von Feststoffteilchen |
| SE421047B (sv) | 1979-04-05 | 1981-11-23 | Nemo Ivarson | Sett vid kontinuerlig blandning av vetska och pulver till en i huvudsak homogen blandning samt anordning for utforande av settet |
| US4439453A (en) * | 1980-12-22 | 1984-03-27 | Monsanto Company | Directly compressible acetaminophen granulation |
| US4465660A (en) * | 1981-04-01 | 1984-08-14 | Mead Johnson & Company | Sustained release tablet containing at least 95 percent theophylline |
| US4476248A (en) | 1983-02-28 | 1984-10-09 | The Upjohn Company | Crystallization of ibuprofen |
| DE3586600T2 (de) * | 1984-02-10 | 1993-02-18 | Benzon Pharma As | Dosierungsform eine vielzahl mit einer diffusionshuelle ueberzogener einheiten enthaltend. |
| SE455672B (sv) | 1985-02-04 | 1988-08-01 | Lejus Medical Ab | Forfarande for overdragning av fasta patiklar med en smelta |
| DE3523454A1 (de) * | 1985-07-01 | 1987-01-08 | Eberhard Prof Dr Nuernberg | Formkoerper |
-
1987
- 1987-08-31 SE SE8703358A patent/SE463541B/sv not_active IP Right Cessation
-
1988
- 1988-08-26 EP EP88850283A patent/EP0305356B1/de not_active Expired - Lifetime
- 1988-08-26 ES ES88850283T patent/ES2023509B3/es not_active Expired - Lifetime
- 1988-08-26 AT AT88850283T patent/ATE64548T1/de not_active IP Right Cessation
- 1988-08-26 DE DE8888850283T patent/DE3863328D1/de not_active Expired - Fee Related
- 1988-08-30 CA CA000576020A patent/CA1318482C/en not_active Expired - Fee Related
- 1988-08-31 US US07/238,612 patent/US4937080A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA1318482C (en) | 1993-06-01 |
| EP0305356B1 (de) | 1991-06-19 |
| SE8703358D0 (sv) | 1987-08-31 |
| ES2023509B3 (es) | 1992-01-16 |
| EP0305356A1 (de) | 1989-03-01 |
| ATE64548T1 (de) | 1991-07-15 |
| DE3863328D1 (de) | 1991-07-25 |
| US4937080A (en) | 1990-06-26 |
| SE8703358L (sv) | 1989-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAL | Patent in force |
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| NUG | Patent has lapsed |
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