SE440360B - Bis-(2-ammonium-2-hydroximetyl-1,3-propandiol)-(2r-cis)-(3-metyloxiranyl)-fosfanat, sett att framstella denna forening och farmaceutisk komposition innehallande foreningen - Google Patents
Bis-(2-ammonium-2-hydroximetyl-1,3-propandiol)-(2r-cis)-(3-metyloxiranyl)-fosfanat, sett att framstella denna forening och farmaceutisk komposition innehallande foreningenInfo
- Publication number
- SE440360B SE440360B SE7906172A SE7906172A SE440360B SE 440360 B SE440360 B SE 440360B SE 7906172 A SE7906172 A SE 7906172A SE 7906172 A SE7906172 A SE 7906172A SE 440360 B SE440360 B SE 440360B
- Authority
- SE
- Sweden
- Prior art keywords
- cis
- methyloxiranyl
- bis
- ammonium
- pharmaceutical composition
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 239000000126 substance Substances 0.000 title 1
- YMDXZJFXQJVXBF-STHAYSLISA-N fosfomycin Chemical compound C[C@@H]1O[C@@H]1P(O)(O)=O YMDXZJFXQJVXBF-STHAYSLISA-N 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- DYASJGUMFFSTDH-UHFFFAOYSA-N CC1OC1OP(O)=O Chemical compound CC1OC1OP(O)=O DYASJGUMFFSTDH-UHFFFAOYSA-N 0.000 claims 1
- DYASJGUMFFSTDH-STHAYSLISA-N C[C@@H]1O[C@@H]1OP(O)=O Chemical compound C[C@@H]1O[C@@H]1OP(O)=O DYASJGUMFFSTDH-STHAYSLISA-N 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 159000000007 calcium salts Chemical class 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
- C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
- C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT25853/78A IT1112282B (it) | 1978-07-19 | 1978-07-19 | Bis-(2-ammonio-2-idrossimetil-1,3-propandiolo)(2r-cis)-(3-metilossiranil)fosfonato |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7906172L SE7906172L (ja) | 1980-01-20 |
| SE440360B true SE440360B (sv) | 1985-07-29 |
Family
ID=11217928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7906172A SE440360B (sv) | 1978-07-19 | 1979-07-18 | Bis-(2-ammonium-2-hydroximetyl-1,3-propandiol)-(2r-cis)-(3-metyloxiranyl)-fosfanat, sett att framstella denna forening och farmaceutisk komposition innehallande foreningen |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4727065A (ja) |
| JP (1) | JPS5517381A (ja) |
| AT (1) | AT371823B (ja) |
| AU (1) | AU526464B2 (ja) |
| BE (1) | BE877286A (ja) |
| CA (1) | CA1108631A (ja) |
| CH (1) | CH640823A5 (ja) |
| DE (1) | DE2926847A1 (ja) |
| DK (1) | DK148023C (ja) |
| ES (1) | ES482268A1 (ja) |
| FR (1) | FR2431506A1 (ja) |
| GB (1) | GB2025975B (ja) |
| GR (1) | GR75071B (ja) |
| IE (1) | IE48781B1 (ja) |
| IL (1) | IL57680A (ja) |
| IT (1) | IT1112282B (ja) |
| LU (1) | LU81500A1 (ja) |
| NL (1) | NL190488C (ja) |
| SE (1) | SE440360B (ja) |
| YU (1) | YU41411B (ja) |
| ZA (1) | ZA793354B (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1124610B (it) * | 1979-10-18 | 1986-05-07 | Zambo Spa | Mono(2-ammonio-2-idrossimetil-1,3-propandiolo) (2r-cis)-(o-metilossiranil)fosfonato |
| IT1136652B (it) * | 1981-06-04 | 1986-09-03 | Crinos Industria Farmaco | Compesizione farmaceutica di fosfomicina in compresse da succhiare |
| DE3203937C2 (de) * | 1982-02-05 | 1985-10-03 | Luc Dr. 4150 Krefeld Barrut | Verfahren und Vorrichtung zum maschinellen Sanieren oder Korrigieren mindestens eines Zahnes oder zum maschinellen Vorbereiten mindestens eines Zahnes für eine festsitzende prothetische Restaurierung und zum maschinellen Herstellen der festsitzenden prothetischen Restaurierung |
| CH660306A5 (de) * | 1984-10-05 | 1987-04-15 | Schering Spa | Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren. |
| CH660305A5 (de) * | 1984-10-05 | 1987-04-15 | Schering Spa | Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren. |
| IT1231013B (it) * | 1989-07-27 | 1991-11-08 | Zambon Spa | Mono (2 ammonio 2 idrossimetil 1,3 propandiolo)(2r,cis) 1,2 epossipropil fosfonato avente migliorate caratteristiche di stabilita' e lavorabilita'. |
| US5191094A (en) * | 1989-07-27 | 1993-03-02 | Zambon Group S.P.A. | Mono (2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate with improved characteristics of stability and processing |
| ITMI20021725A1 (it) | 2002-08-01 | 2002-10-31 | Zambon Spa | Composizioni farmaceutiche ad attivita' antibiotica. |
| EP1762573A1 (en) | 2005-09-08 | 2007-03-14 | Interquim, S.A. De C.V. | A process for the preparation of fosfomycin salts |
| ES2385158B1 (es) * | 2010-12-24 | 2013-05-28 | Arafarma Group, S.A. | Composición farmacéutica de fosfomicina |
| CN102807586B (zh) | 2012-08-31 | 2015-05-13 | 东北制药集团股份有限公司 | 磷霉素氨盐的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3639590A (en) * | 1967-07-25 | 1972-02-01 | Merck & Co Inc | Antibacterial composition containing (-) (cis-1 2-epoxypropyl) phosphoric acid |
| US3641063A (en) * | 1968-01-22 | 1972-02-08 | Merck & Co Inc | Antibiotic purification process |
-
1978
- 1978-07-19 IT IT25853/78A patent/IT1112282B/it active
-
1979
- 1979-06-25 GB GB7922098A patent/GB2025975B/en not_active Expired
- 1979-06-26 BE BE0/195974A patent/BE877286A/xx not_active IP Right Cessation
- 1979-06-27 IL IL57680A patent/IL57680A/xx unknown
- 1979-06-27 CH CH601579A patent/CH640823A5/it not_active IP Right Cessation
- 1979-06-29 AU AU48552/79A patent/AU526464B2/en not_active Expired
- 1979-07-02 GR GR59481A patent/GR75071B/el unknown
- 1979-07-03 DE DE19792926847 patent/DE2926847A1/de active Granted
- 1979-07-05 ZA ZA793354A patent/ZA793354B/xx unknown
- 1979-07-05 YU YU1632/79A patent/YU41411B/xx unknown
- 1979-07-05 FR FR7917455A patent/FR2431506A1/fr active Granted
- 1979-07-06 ES ES482268A patent/ES482268A1/es not_active Expired
- 1979-07-11 AT AT0484079A patent/AT371823B/de not_active IP Right Cessation
- 1979-07-13 LU LU81500A patent/LU81500A1/xx unknown
- 1979-07-18 SE SE7906172A patent/SE440360B/sv unknown
- 1979-07-18 JP JP9046879A patent/JPS5517381A/ja active Granted
- 1979-07-18 DK DK302379A patent/DK148023C/da not_active IP Right Cessation
- 1979-07-19 NL NLAANVRAGE7905635,A patent/NL190488C/xx not_active IP Right Cessation
- 1979-07-19 CA CA332,193A patent/CA1108631A/en not_active Expired
- 1979-08-08 IE IE1366/79A patent/IE48781B1/en not_active IP Right Cessation
-
1986
- 1986-01-23 US US06/824,922 patent/US4727065A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GB2025975B (en) | 1983-02-02 |
| ATA484079A (de) | 1982-12-15 |
| DE2926847C2 (ja) | 1988-11-10 |
| NL7905635A (nl) | 1980-01-22 |
| IL57680A0 (en) | 1979-10-31 |
| IT1112282B (it) | 1986-01-13 |
| DK148023C (da) | 1985-07-08 |
| IT7825853A0 (it) | 1978-07-19 |
| NL190488C (nl) | 1994-03-16 |
| ZA793354B (en) | 1980-07-30 |
| LU81500A1 (fr) | 1979-10-31 |
| IE48781B1 (en) | 1985-05-15 |
| US4727065A (en) | 1988-02-23 |
| YU163279A (en) | 1983-02-28 |
| CA1108631A (en) | 1981-09-08 |
| NL190488B (nl) | 1993-10-18 |
| FR2431506B1 (ja) | 1984-11-23 |
| IE791366L (en) | 1980-01-19 |
| ES482268A1 (es) | 1980-04-16 |
| AT371823B (de) | 1983-08-10 |
| JPS6248678B2 (ja) | 1987-10-15 |
| FR2431506A1 (fr) | 1980-02-15 |
| DK302379A (da) | 1980-01-20 |
| CH640823A5 (it) | 1984-01-31 |
| JPS5517381A (en) | 1980-02-06 |
| AU526464B2 (en) | 1983-01-13 |
| YU41411B (en) | 1987-04-30 |
| GB2025975A (en) | 1980-01-30 |
| AU4855279A (en) | 1980-01-24 |
| GR75071B (ja) | 1984-07-13 |
| SE7906172L (ja) | 1980-01-20 |
| DK148023B (da) | 1985-02-04 |
| DE2926847A1 (de) | 1980-02-07 |
| BE877286A (fr) | 1979-12-27 |
| IL57680A (en) | 1986-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAL | Patent in force |
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