SE429655B - Forfarande for framstellning av 4'-deoxidauromycin hydroklorid - Google Patents

Forfarande for framstellning av 4'-deoxidauromycin hydroklorid

Info

Publication number
SE429655B
SE429655B SE7610564A SE7610564A SE429655B SE 429655 B SE429655 B SE 429655B SE 7610564 A SE7610564 A SE 7610564A SE 7610564 A SE7610564 A SE 7610564A SE 429655 B SE429655 B SE 429655B
Authority
SE
Sweden
Prior art keywords
deoxidauromycine
hydrochloride
preparing
procedure
deoxidauromycine hydrochloride
Prior art date
Application number
SE7610564A
Other languages
English (en)
Swedish (sv)
Other versions
SE7610564L (sv
Inventor
S Penco
F Arcamone
Marco A Di
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of SE7610564L publication Critical patent/SE7610564L/xx
Publication of SE429655B publication Critical patent/SE429655B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
SE7610564A 1975-09-26 1976-09-23 Forfarande for framstellning av 4'-deoxidauromycin hydroklorid SE429655B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB39471/75A GB1511559A (en) 1975-09-26 1975-09-26 Anthracycline glycosides

Publications (2)

Publication Number Publication Date
SE7610564L SE7610564L (sv) 1977-03-27
SE429655B true SE429655B (sv) 1983-09-19

Family

ID=10409731

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7610564A SE429655B (sv) 1975-09-26 1976-09-23 Forfarande for framstellning av 4'-deoxidauromycin hydroklorid
SE8001616A SE435514B (sv) 1975-09-26 1980-02-29 Forfarande for framstellning av 4'-deoxiadriamycin hydroklorid

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8001616A SE435514B (sv) 1975-09-26 1980-02-29 Forfarande for framstellning av 4'-deoxiadriamycin hydroklorid

Country Status (16)

Country Link
US (1) US4067969A (xx)
JP (1) JPS5242869A (xx)
AT (1) AT347582B (xx)
AU (1) AU504480B2 (xx)
BE (1) BE846548A (xx)
CA (1) CA1060002A (xx)
CH (1) CH606082A5 (xx)
DE (1) DE2642837C3 (xx)
DK (1) DK146626C (xx)
FR (1) FR2325659A1 (xx)
GB (1) GB1511559A (xx)
HK (1) HK1182A (xx)
NL (1) NL174015C (xx)
SE (2) SE429655B (xx)
SU (2) SU670226A3 (xx)
ZA (1) ZA765736B (xx)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives
GB1550879A (en) * 1976-12-22 1979-08-22 Farmaceutici Italia Antitumour glycosides
US4362720A (en) * 1977-04-14 1982-12-07 Chembiomed Ltd. Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals
GB1573037A (en) * 1977-05-05 1980-08-13 Farmaceutici Italia Anthracyclines
GB1573036A (en) * 1977-05-05 1980-08-13 Farmaceutici Italia Anthracyclines
US4201773A (en) * 1978-07-26 1980-05-06 The United States Of America As Represented By The Department Of Health, Education And Welfare 7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone
US4259476A (en) * 1979-04-02 1981-03-31 Kende Andrew S Novel heterocyclic anthracycline compounds
ATE1101T1 (de) * 1979-09-01 1982-06-15 Farmitalia Carlo Erba S.P.A. Anthracyclin-glycoside, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzung.
ZA814722B (en) * 1980-07-18 1982-07-28 Hoffmann La Roche Novel anthracycline glycosides
CA1174669A (en) * 1980-07-18 1984-09-18 Michael J. Broadhurst Anthracycline glycosides
US4345070A (en) * 1980-09-29 1982-08-17 Farmitalia Carlo Erba S.P.A. Process for the preparation of 4'-deoxy-daunorubicin and 4'-deoxy-doxorubicin
US4393052A (en) * 1980-11-01 1983-07-12 Farmitalia Carlo Erba S.P.A. Antitumor anthracycline glycosides, their preparation, intermediates therefor, and compositions and use thereof
ATE8401T1 (de) * 1980-11-01 1984-07-15 Farmitalia Carlo Erba S.P.A. Anthracyclin-glycoside, verfahren zu ihrer herstellung, zwischenprodukte und ihre herstellung und arzneimittel.
JPS57142981A (en) * 1981-01-21 1982-09-03 Erba Carlo Spa Anthracycline glycoside, manufacture and tumor generation inhibiting drug containing same
DE3200809C2 (de) * 1981-01-21 1986-08-28 Farmitalia Carlo Erba S.p.A., Mailand/Milano 4'-Desoxy-3'-epi-daunorubicin und -doxorubicin, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4325947A (en) * 1981-05-12 1982-04-20 Farmitalia Carlo Erba S.P.A. 4-Demethoxy-4'-deoxydoxorubicin
DE3317702A1 (de) * 1982-05-24 1983-11-24 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclinglykoside, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
US4562177A (en) * 1982-08-17 1985-12-31 The Ohio State University Research Foundation 3'-Amino-2' halo-anthracycline antibiotics
US4514561A (en) * 1983-04-15 1985-04-30 Research Corporation Process for preparing α-L N-acetyl daunosaminide
DE3500023A1 (de) * 1985-01-02 1986-07-10 Farmitalia Carlo Erba S.p.A., Mailand/Milano 4'-desoxyanthracyclinester
GB2169285A (en) * 1985-01-05 1986-07-09 Erba Farmitalia 4'-Deoxydoxorubicin-14-esters
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
GB8708927D0 (en) * 1987-04-14 1987-05-20 Erba Farmitalia Chiral synthesis of anthracyclines
NZ224252A (en) 1987-04-21 1991-09-25 Erba Carlo Spa An anthracycline glycoside and its preparation
GB2212154B (en) * 1987-11-10 1991-03-27 Erba Carlo Spa New 4-demethoxy anthracycline derivatives
JPH03502327A (ja) * 1988-01-19 1991-05-30 ボード・オブ・リージェンツ，ザ・ユニバーシティ・オブ・テキサス・システム ３’‐デアミノドキソルビシンのエステル体、そのリポソーム組成物およびその使用方法
GB8803076D0 (en) * 1988-02-10 1988-03-09 Erba Carlo Spa 3'-deamino-4'-deoxy-4'-amino anthracyclines
AU4752190A (en) * 1988-12-28 1990-08-01 Board Of Regents, The University Of Texas System 3'-deamino analogs of esorubicin and methods for their use
US5948896A (en) * 1997-08-13 1999-09-07 Gem Pharmaceuticals Processes for preparing 13-deoxy anthracycline derivatives
US5942605A (en) * 1998-03-03 1999-08-24 Gem Pharmaceuticals, Inc. 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
DE1792346C3 (de) * 1968-08-22 1980-10-23 Rotta Research Laboratorium S.P.A., San Fruttuoso Di Monza, Mailand (Italien) Pharmazeutisches Präparat für die Behandlung von degenerativen Gelenkerkrankungen
FR2183710A1 (en) * 1972-05-06 1973-12-21 Farmaceutici Italia Daunomycin (hydrochloride) prepn - by reaction of daunomycinone with daunosamines, useful as antitumour agent and anti-leucemic
US4020270A (en) * 1974-05-02 1977-04-26 Societa' Farmaceutici Italia S.P.A. L-lyxohex-1-enopyranose derivative

Also Published As

Publication number Publication date
AU504480B2 (en) 1979-10-18
DK146626C (da) 1984-04-30
SE8001616L (sv) 1980-02-29
SE7610564L (sv) 1977-03-27
GB1511559A (en) 1978-05-24
HK1182A (en) 1982-01-22
SU670226A3 (ru) 1979-06-25
DE2642837A1 (de) 1977-04-07
JPS6123189B2 (xx) 1986-06-04
AT347582B (de) 1979-01-10
CH606082A5 (xx) 1978-10-13
FR2325659B1 (xx) 1982-08-20
NL174015B (nl) 1983-11-16
ZA765736B (en) 1977-11-30
JPS5242869A (en) 1977-04-04
DK426076A (da) 1977-03-27
DE2642837B2 (de) 1982-01-07
DK146626B (da) 1983-11-21
FR2325659A1 (fr) 1977-04-22
NL174015C (nl) 1984-04-16
CA1060002A (en) 1979-08-07
SE435514B (sv) 1984-10-01
DE2642837C3 (de) 1982-08-12
AU1802576A (en) 1978-04-06
NL7610139A (nl) 1977-03-29
SU730310A3 (ru) 1980-04-25
US4067969A (en) 1978-01-10
ATA707276A (de) 1978-05-15
BE846548A (fr) 1977-03-24

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