SE428472B - Analogiforfarande for framstellning av kvaternera n-beta-substituerade bensilsyra-n-alkyl-nortropinestrar - Google Patents

Analogiforfarande for framstellning av kvaternera n-beta-substituerade bensilsyra-n-alkyl-nortropinestrar

Info

Publication number
SE428472B
SE428472B SE7610070A SE7610070A SE428472B SE 428472 B SE428472 B SE 428472B SE 7610070 A SE7610070 A SE 7610070A SE 7610070 A SE7610070 A SE 7610070A SE 428472 B SE428472 B SE 428472B
Authority
SE
Sweden
Prior art keywords
quaterane
nortropin
beta
esters
alkyl
Prior art date
Application number
SE7610070A
Other languages
English (en)
Swedish (sv)
Other versions
SE7610070L (sv
Inventor
R Banholzer
R Bauer
A Heusner
W Schulz
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of SE7610070L publication Critical patent/SE7610070L/xx
Publication of SE428472B publication Critical patent/SE428472B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE7610070A 1975-09-12 1976-09-10 Analogiforfarande for framstellning av kvaternera n-beta-substituerade bensilsyra-n-alkyl-nortropinestrar SE428472B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752540633 DE2540633A1 (de) 1975-09-12 1975-09-12 Neue quartaere n-beta-substituierte benzilsaeure-n-alkyl-nortropinester und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
SE7610070L SE7610070L (sv) 1977-03-13
SE428472B true SE428472B (sv) 1983-07-04

Family

ID=5956267

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7610070A SE428472B (sv) 1975-09-12 1976-09-10 Analogiforfarande for framstellning av kvaternera n-beta-substituerade bensilsyra-n-alkyl-nortropinestrar

Country Status (22)

Country Link
US (1) US4042700A (nl)
JP (2) JPS5236693A (nl)
AT (1) AT353428B (nl)
AU (1) AU506286B2 (nl)
BE (1) BE846104A (nl)
CA (1) CA1079733A (nl)
CH (1) CH621349A5 (nl)
DE (1) DE2540633A1 (nl)
DK (1) DK142988C (nl)
ES (1) ES451467A1 (nl)
FI (1) FI62083C (nl)
FR (1) FR2323387A1 (nl)
GB (1) GB1517086A (nl)
IE (1) IE44166B1 (nl)
LU (1) LU75781A1 (nl)
MX (1) MX4053E (nl)
NL (1) NL187210C (nl)
NO (1) NO145199C (nl)
NZ (1) NZ182011A (nl)
PT (1) PT65571B (nl)
SE (1) SE428472B (nl)
ZA (1) ZA765426B (nl)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU174431B (hu) * 1976-12-08 1980-01-28 Egyt Gyogyszervegyeszeti Gyar Sposob poluchenija novykh proizvodnykh nortropin-carbazata
DE3320138A1 (de) * 1983-06-03 1984-12-06 Boehringer Ingelheim KG, 6507 Ingelheim Neues nortropinderivat, verfahren zu seiner herstellung und seine verwendung
DE4108393A1 (de) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
JPH0558911A (ja) * 1991-08-27 1993-03-09 N D Shinyaku Kaihatsu Kenkyusho:Kk 鎮咳去痰剤
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions
EE200200602A (et) * 2000-04-27 2004-04-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pikatoimelised beetamimeetikumid, meetod nende valmistamiseks ja nende kasutamine ravimitena
CN1210017C (zh) * 2000-10-12 2005-07-13 贝林格尔英格海姆法玛两合公司 含噻托品鎓的新颖可吸入粉末
US6908928B2 (en) 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
US6706726B2 (en) * 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
DE10050995A1 (de) * 2000-10-14 2002-04-18 Boehringer Ingelheim Pharma Neue Anticholinergika, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US6852728B2 (en) 2000-10-14 2005-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
DE10062712A1 (de) * 2000-12-15 2002-06-20 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020151541A1 (en) * 2000-10-31 2002-10-17 Michel Pairet Pharmaceutical compositions containing tiotropium salts and antihistamines and their use
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
US20100310477A1 (en) * 2000-11-28 2010-12-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg. Pharmaceutical compositions based on anticholingerics and additional active ingredients
US20030013675A1 (en) * 2001-05-25 2003-01-16 Boehringer Ingelheim Pharma Kg Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US20030018019A1 (en) * 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US6790856B2 (en) * 2002-01-31 2004-09-14 Boehringer Ingelheim Pharma Kg Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
US7405224B2 (en) * 2002-01-31 2008-07-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
US20030229227A1 (en) * 2002-03-16 2003-12-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
US7244415B2 (en) * 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7311894B2 (en) * 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
DE60308497T2 (de) * 2002-04-04 2007-02-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverzubereitungen zur inhalation
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US7084153B2 (en) * 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
DE10216427A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Arzneimittelkompositionen enthaltend heterocyclische Verbindungen und ein neues Anticholinergikum
US7417051B2 (en) * 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US7094788B2 (en) * 2002-04-13 2006-08-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
TWI274641B (en) * 2005-08-30 2007-03-01 Rexon Ind Corp Ltd Cutting machine
USD831375S1 (en) 2017-01-20 2018-10-23 The Gillette Company Llc Shaving razor stand
EP3351138B1 (en) 2017-01-20 2020-09-09 The Gillette Company LLC Personal care product docking system

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3505337A (en) * 1967-12-22 1970-04-07 Boehringer Sohn Ingelheim N - hydrocarbyl-substituted noratropinium,haloalkylates and o-acyl derivatives thereof

Also Published As

Publication number Publication date
FI762590A (nl) 1977-03-13
GB1517086A (en) 1978-07-12
BE846104A (fr) 1977-03-10
DK142988C (da) 1981-10-12
PT65571B (de) 1978-07-04
NL187210B (nl) 1991-02-01
JPS6233232B2 (nl) 1987-07-20
NL7610063A (nl) 1977-03-15
LU75781A1 (nl) 1978-05-12
IE44166B1 (en) 1981-08-26
CA1079733A (en) 1980-06-17
DE2540633A1 (de) 1977-04-28
DK142988B (da) 1981-03-09
IE44166L (en) 1977-03-12
FR2323387B1 (nl) 1980-10-10
NZ182011A (en) 1978-09-25
AU506286B2 (en) 1979-12-20
AU1762976A (en) 1978-03-16
NL187210C (nl) 1991-07-01
AT353428B (de) 1979-11-12
NO763109L (nl) 1977-03-15
SE7610070L (sv) 1977-03-13
ZA765426B (en) 1978-05-30
JPS6152155B2 (nl) 1986-11-12
ATA618676A (de) 1979-04-15
US4042700A (en) 1977-08-16
PT65571A (de) 1976-10-01
ES451467A1 (es) 1977-11-01
FI62083C (fi) 1982-11-10
DE2540633C2 (nl) 1989-01-19
JPS5236693A (en) 1977-03-22
MX4053E (es) 1981-11-24
FI62083B (fi) 1982-07-30
NO145199B (no) 1981-10-26
FR2323387A1 (fr) 1977-04-08
CH621349A5 (nl) 1981-01-30
NO145199C (no) 1982-02-03
DK411576A (da) 1977-03-13
JPS625983A (ja) 1987-01-12

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