SE427659B - Forfarande for framstellning av terapeutiskt aktiva 1-(p-klorbensyl)-2-metyl-5-metoxi-3-indonylettiksyra-pyridylmetylestrar och derivat derav - Google Patents

Forfarande for framstellning av terapeutiskt aktiva 1-(p-klorbensyl)-2-metyl-5-metoxi-3-indonylettiksyra-pyridylmetylestrar och derivat derav

Info

Publication number
SE427659B
SE427659B SE7706976A SE7706976A SE427659B SE 427659 B SE427659 B SE 427659B SE 7706976 A SE7706976 A SE 7706976A SE 7706976 A SE7706976 A SE 7706976A SE 427659 B SE427659 B SE 427659B
Authority
SE
Sweden
Prior art keywords
indonylethytic
metoxy
chlorobenzyl
derivatives
methyl
Prior art date
Application number
SE7706976A
Other languages
English (en)
Other versions
SE7706976L (sv
Inventor
K Noda
A Nakagawa
S Miyata
Y Nakashima
H Ide
Original Assignee
Hisamitsu Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co filed Critical Hisamitsu Pharmaceutical Co
Publication of SE7706976L publication Critical patent/SE7706976L/sv
Publication of SE427659B publication Critical patent/SE427659B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE7706976A 1976-06-22 1977-06-16 Forfarande for framstellning av terapeutiskt aktiva 1-(p-klorbensyl)-2-metyl-5-metoxi-3-indonylettiksyra-pyridylmetylestrar och derivat derav SE427659B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7410476A JPS52156862A (en) 1976-06-22 1976-06-22 Novel indoleacetic acid ester derivatives

Publications (2)

Publication Number Publication Date
SE7706976L SE7706976L (sv) 1977-12-23
SE427659B true SE427659B (sv) 1983-04-25

Family

ID=13537537

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7706976A SE427659B (sv) 1976-06-22 1977-06-16 Forfarande for framstellning av terapeutiskt aktiva 1-(p-klorbensyl)-2-metyl-5-metoxi-3-indonylettiksyra-pyridylmetylestrar och derivat derav

Country Status (10)

Country Link
US (1) US4165428A (sv)
JP (1) JPS52156862A (sv)
AU (1) AU511662B2 (sv)
CA (1) CA1069889A (sv)
CH (1) CH623037A5 (sv)
DE (1) DE2727829A1 (sv)
FR (1) FR2355822A1 (sv)
GB (1) GB1588352A (sv)
NL (1) NL7706799A (sv)
SE (1) SE427659B (sv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2943125A1 (de) * 1979-10-25 1981-05-14 Troponwerke GmbH & Co KG, 5000 Köln Verfahren zur herstellung von 1-(4-chlorbenzoyl)-5-methoxy-2-methyl-3-indol acetoxyessigsaeure
DE2943127A1 (de) * 1979-10-25 1981-05-14 Troponwerke GmbH & Co KG, 5000 Köln (1-(4-chlorbenzoyl)-methoxy-2-methyl-3-indol) -acetoxyessigsaeuremonohydrat, verfahren zur herstellung sowie dessen verwendung in arzneimitteln
IT1133963B (it) * 1980-10-21 1986-07-24 D & D Srl Derivati piridossinici ad attivita' terapeutica,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4464379A (en) * 1981-06-01 1984-08-07 A. Nattermann & Cie Gmbh Indol acetic acid derivatives and anti-inflamatory and related uses thereof
US4428962A (en) 1981-10-30 1984-01-31 Schering Corporation Indoles in treatment of peptic ulcers
JPS58134077A (ja) * 1982-02-02 1983-08-10 Ss Pharmaceut Co Ltd 新規なインド−ル酢酸エステル誘導体及びその製造法
JPS59204172A (ja) * 1983-04-28 1984-11-19 Kowa Co アセメタシンの製造法
JPS6028957A (ja) * 1983-07-27 1985-02-14 Kaken Pharmaceut Co Ltd インドリル酢酸およびフエニル酢酸のエステル誘導体およびその製造法
DE3416895A1 (de) * 1984-05-08 1985-11-14 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von acemetacin
KR940007001A (ko) * 1992-09-16 1994-04-26 최승주 새로운 n-신나모일-2-메틸-5-메톡시-3-인돌 아세트산 에스테르, 그 제조방법 및 이를 함유하는 약학적 제제
MY186191A (en) * 2013-06-28 2021-06-30 Malaysian Palm Oil Board Isolation of novel bioactive compound obtained from oil palm base materials

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470203A (en) * 1964-02-01 1969-09-30 Merck & Co Inc Intermediates for preparing 1-aroylindole-3-alkanoic acids
US3271394A (en) * 1964-12-31 1966-09-06 Merck & Co Inc Alpha-indolyl-3-acetic acid esters
JPS4927190A (sv) * 1972-07-07 1974-03-11
DE2234651C3 (de) * 1972-07-14 1978-11-09 Troponwerke Gmbh & Co Kg, 5000 Koeln Eckige Klammer auf l-(p-Chlorbenzoyl)-5-methoxy-2-methyl-3-indol] -acetoxj essigsaure, ihre Salze mit Basen, Verfahren zu ihrer Herstellung sowie pharmakologische Zubereitungen
HU168745B (sv) * 1972-08-24 1976-07-28
DE2257867C2 (de) * 1972-11-25 1982-09-23 Troponwerke GmbH & Co KG, 5000 Köln Verfahren zur Herstellung von 1-Benzoylindol-Derivaten

Also Published As

Publication number Publication date
NL7706799A (nl) 1977-12-27
FR2355822B1 (sv) 1980-04-04
GB1588352A (en) 1981-04-23
US4165428A (en) 1979-08-21
CA1069889A (en) 1980-01-15
JPS6254106B2 (sv) 1987-11-13
JPS52156862A (en) 1977-12-27
AU2626877A (en) 1979-01-04
AU511662B2 (en) 1980-08-28
DE2727829A1 (de) 1978-01-05
SE7706976L (sv) 1977-12-23
CH623037A5 (sv) 1981-05-15
FR2355822A1 (fr) 1978-01-20

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