SE383347B - Forfarande for framstellning av nya 4 h-benso (4,5)cyklohepta (1,2-b)tiofenderivat - Google Patents

Forfarande for framstellning av nya 4 h-benso (4,5)cyklohepta (1,2-b)tiofenderivat

Info

Publication number
SE383347B
SE383347B SE7300501A SE7300501A SE383347B SE 383347 B SE383347 B SE 383347B SE 7300501 A SE7300501 A SE 7300501A SE 7300501 A SE7300501 A SE 7300501A SE 383347 B SE383347 B SE 383347B
Authority
SE
Sweden
Prior art keywords
thiofene
cyclohepta
benzo
derivatives
procedure
Prior art date
Application number
SE7300501A
Other languages
English (en)
Swedish (sv)
Inventor
J-P Bourquin
G Schwarb
E Waldvogel
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH99272A external-priority patent/CH562244A5/de
Priority claimed from CH98872A external-priority patent/CH565172A5/de
Priority claimed from CH99072A external-priority patent/CH569006A5/de
Priority claimed from CH98672A external-priority patent/CH569012A5/de
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of SE383347B publication Critical patent/SE383347B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SE7300501A 1972-01-24 1973-01-15 Forfarande for framstellning av nya 4 h-benso (4,5)cyklohepta (1,2-b)tiofenderivat SE383347B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH99272A CH562244A5 (en) 1972-01-24 1972-01-24 4-piperidylidene benzocycloheptathiophenes - - antihistamines and serotonin and acetyl choline inhibitors
CH98872A CH565172A5 (en) 1972-01-24 1972-01-24 4-piperidylidene benzocycloheptathiophenes - - antihistamines and serotonin and acetyl choline inhibitors
CH99072A CH569006A5 (en) 1972-01-24 1972-01-24 4-piperidylidene benzocycloheptathiophenes - - antihistamines and serotonin and acetyl choline inhibitors
CH98672A CH569012A5 (en) 1972-01-24 1972-01-24 4-piperidylidene benzocycloheptathiophenes - - antihistamines and serotonin and acetyl choline inhibitors

Publications (1)

Publication Number Publication Date
SE383347B true SE383347B (sv) 1976-03-08

Family

ID=27428052

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7300501A SE383347B (sv) 1972-01-24 1973-01-15 Forfarande for framstellning av nya 4 h-benso (4,5)cyklohepta (1,2-b)tiofenderivat

Country Status (14)

Country Link
US (1) US3862156A (en, 2012)
JP (1) JPS5760351B2 (en, 2012)
BE (1) BE794377A (en, 2012)
CY (1) CY992A (en, 2012)
DD (1) DD102701A5 (en, 2012)
DE (1) DE2302944C2 (en, 2012)
FI (1) FI55843C (en, 2012)
FR (1) FR2183663B2 (en, 2012)
GB (1) GB1415591A (en, 2012)
HK (1) HK11279A (en, 2012)
HU (1) HU165130B (en, 2012)
MY (1) MY7900114A (en, 2012)
NL (1) NL7300796A (en, 2012)
SE (1) SE383347B (en, 2012)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI761607A7 (en, 2012) * 1975-06-16 1976-12-17 Sandoz Ag
GB1570500A (en) * 1976-01-02 1980-07-02 Sandoz Ltd Anti-9,10-dihydro-4-(1-methyl-4-piperidylidene)-4h-benzo(4,5) cyclohepta (1,2-b)thiophen-10(9h)-one oxime
US4132796A (en) * 1977-12-01 1979-01-02 Merck & Co., Inc. Antipsychotic 3-trifluoromethylsulfinyl analogs of cyproheptadine
US4356184A (en) * 1980-06-04 1982-10-26 G. D. Searle & Co. Anti-allergic or antihypertensive 1-piperidinylmethyl benzenamines
US4355036A (en) * 1980-06-19 1982-10-19 Schering Corporation Tricyclic-substituted piperidine antihistamines
JP5116928B2 (ja) * 1999-09-13 2013-01-09 ブリッジ ファーマ、インコーポレイテッド ケトチフェン及びその治療上有効な代謝産物の光学活性異性体
RU2266115C2 (ru) * 1999-09-13 2005-12-20 Бридж Фарма, Инк. Оптически активные изомеры кетотифена и их терапевтически активные метаболиты
DK2243778T3 (en) 2008-01-30 2014-11-17 Nippon Zoki Pharmaceutical Co piperidine
EP2727919B1 (en) * 2011-06-28 2019-05-08 Fujian Mindong Rejuvenation Pharmaceutical Co., Ltd. Benzocycloheptanethiophene derivatives for anti-allergic reactions
CN104031035B (zh) * 2014-06-26 2017-08-25 福建省闽东力捷迅药业有限公司 一种富马酸卢帕替芬混晶及其制备方法
CN104045633B (zh) * 2014-06-26 2017-07-21 福建省闽东力捷迅药业有限公司 一种富马酸卢帕替芬晶型a及其制备方法
CN113880801A (zh) * 2020-07-03 2022-01-04 合肥医工医药股份有限公司 一类三环化合物、其制备方法及其医药用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL137020C (en, 2012) * 1962-08-31
US3491103A (en) * 1963-12-19 1970-01-20 Sandoz Ag Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes
US3466291A (en) * 1966-02-16 1969-09-09 Sandoz Ag 4(2-dialkylaminoethoxy or 2-piperidinoethoxy) - 9,10 - dihydro benzo(4,5)cyclohepta(1,2-b)thiophene derivatives
CH504466A (de) * 1969-02-07 1971-03-15 Sandoz Ag Verfahren zur Herstellung von 4-(1-Methyl-4-piperidyliden-N-oxid)- -9,10-dihydro-4H-benzo(4,5)cycloheptal(1,2-b)thiophen
CH531000A (de) * 1970-03-11 1972-11-30 Sandoz Ag Verfahren zur Herstellung neuer Benzocycloheptathiophene

Also Published As

Publication number Publication date
JPS5760351B2 (en, 2012) 1982-12-18
HU165130B (en, 2012) 1974-06-28
FI55843B (fi) 1979-06-29
US3862156A (en) 1975-01-21
MY7900114A (en) 1979-12-31
GB1415591A (en) 1975-11-26
BE794377A (fr) 1973-07-23
JPS4885575A (en, 2012) 1973-11-13
DD102701A5 (en, 2012) 1973-12-20
HK11279A (en) 1979-03-16
DE2302944C2 (de) 1982-11-25
FR2183663B2 (en, 2012) 1976-07-02
CY992A (en) 1979-08-02
NL7300796A (en, 2012) 1973-07-26
FR2183663A2 (en, 2012) 1973-12-21
FI55843C (fi) 1979-10-10
DE2302944A1 (de) 1973-08-02

Similar Documents

Publication Publication Date Title
SE382059B (sv) Forfarande for framstellning av nya substituerade piperidinderivat
SE416203B (sv) Forfarande for framstellning av 4,5,6,7-tetrahydro-furo (respektive - tieno)-(3,2-c)pyridinderivat
SE382455B (sv) Forfarande for framstellning av nya olefiniska 4-substituerade piperidinderivat
SE7611410L (sv) Forfarande for framstellning av nya derivat av penam-3-karboxylsyra
SE420201B (sv) Forfarande for framstellning av nya 7alfa-metoxicefalosporinderivat
SE381047B (sv) Forfarande for framstellning av 3-substituerade 1,2-bensisoxazolderivat
SE383347B (sv) Forfarande for framstellning av nya 4 h-benso (4,5)cyklohepta (1,2-b)tiofenderivat
SE397530B (sv) Forfarande for framstellning av 1-pyrazolylalkyl-4-arylpiperazinderivat
SE419760B (sv) Analogiforfarande for framstellning av antivirala substituerade 1,3-dimetyl-1h-pyrazolo (3,4-b)kinoliner
SE424863B (sv) Analogiforfarande for framstellning av nya isokinolinderivat
SE385477B (sv) Forfarande for framstellning av nya isoindolinderivat
SE397088B (sv) Forfarande for framstellning av nya 2-propanolderivat
SE419443B (sv) Forfarande for framstellning av nya 2,4 diamino-5-bensylpyrimidinderivat
SE387344B (sv) Forfarande for framstellning av pyrazin-4-oxidderivat
SE419444B (sv) Forfarande for framstellning av nya 2,4-diamino-5-bensylpyrimidinderivat
SE384510B (sv) Forfarande for framstellning av nya isoindolinpiperazinderivat
SE384027B (sv) Forfarande for framstellning av nya alfa-alkylsulfobensylpenicilliner
SE404361B (sv) Forfarande for framstellning av nya 1-fenyl-3hydroxi-3-metyl-triazener
SE419980B (sv) Forfarande for framstellning av eventuellt substituerade 2-fenyl-bicyklo /2,2,2/okt-3-ylalkylaminer
SE419441B (sv) Forfarande for framstellning av butyrofenonderivat
SE7600275L (sv) Forfarande for framstellning av nya terapeutiskt verksamma 4h-benso(4,5)cyklohepta(1,2-b)tiofenderivat
SE384678B (sv) Forfarande for framstellning av nya 2-merkapto-pyrido (1,2-b)-1-2,4-tiadiazoliumsalter
SE418084B (sv) Forfarande for framstellning av 1,2,4-bensotiadiazin-derivat
SE402920B (sv) Forfarande for framstellning av nya 21-alkylerade 16alfa, 17alfa-alkylidendioxi-pregn-4-en-3,20-dioner
SE413025B (sv) Forfarande for framstellning av nya 6,7-bensomorfanderivat