SE332178B - - Google Patents
Info
- Publication number
- SE332178B SE332178B SE09758/67A SE975867A SE332178B SE 332178 B SE332178 B SE 332178B SE 09758/67 A SE09758/67 A SE 09758/67A SE 975867 A SE975867 A SE 975867A SE 332178 B SE332178 B SE 332178B
- Authority
- SE
- Sweden
- Prior art keywords
- compounds
- nr3r4
- piperazino
- represent
- radical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
- C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
- C09K15/30—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing heterocyclic ring with at least one nitrogen atom as ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/30—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C07D333/80—Seven-membered rings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/38—Polymerisation using regulators, e.g. chain terminating agents, e.g. telomerisation
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
- C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
- C09K15/12—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing sulfur and oxygen
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
- C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
- C09K15/26—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing nitrogen and sulfur
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cartons (AREA)
Abstract
Novel compounds of the general formula <FORM:1084450/C2/1> (wherein R5 represents Cl, Br or a C1- 4 alkoxy radical, Z represents -CH = CH- or -CH2 CH2-, and either R1 and R2 are the same or different and each represent H or Me and R3 and R4 are the same or different and each represent a C1- 4 alkyl radical or -NR3R4 represents a pyrrolidino, piperidino, piperazino, 4-methylpiperazino or 4-(C2 or C3 hydroxyalkyl)-piperazino radical, or R4 represents a C1- 4 alkyl radical, R3 and R1 together represent -(CH2)2- or -(CH2)3- and R2 represents H, or R4 represents a C1- 4 alkyl radical, R3 and R2 together represent -(CH2)3- or -(CH2)4- and R1 represents H) are prepared as follows: (a) in all cases except where - NR3R4 is piperazino or 4-hydroxyalkylpiperazino, by dehydration, by the action of mineral acids, strong organic acids, acetic anhydride, SOCl2 or POCl3, of the corresponding 4-hydroxy compounds, themselves obtainable by a Grignard reaction from compounds of the general formula <FORM:1084450/C2/2> (b) when -NR3R4 is piperazino, by treating the corresponding 4-methylpiperazino compounds with a C1- 4 alkyl chloroformate and hydrolysing the resulting 4-alkoxycarbonylpiperazino compounds; (c) when -NR3R4 is 4-hydroxyalkylpiperazino, by treating the product of (b) with a hydroxyalkylating agent. The products may be converted into acid addition salts. Pharmaceutical compositions, e.g. tablets, dragees, injectable solutions and suppositories, having neuroleptic and sedative activity, comprise compounds (I) or their acid addition salts, together with a physiologically acceptable carrier.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1571263A CH448129A (en) | 1963-12-20 | 1963-12-20 | Process for the preparation of new thiophene derivatives |
| CH1320264A CH477471A (en) | 1964-10-12 | 1964-10-12 | Process for the preparation of new 4H-Benzo (4,5) cyclohepta (1,2-b) thiophene derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE332178B true SE332178B (en) | 1971-02-01 |
Family
ID=25711729
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE15369/64A SE323969B (en) | 1963-12-20 | 1964-12-18 | |
| SE09758/67A SE332178B (en) | 1963-12-20 | 1967-06-29 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE15369/64A SE323969B (en) | 1963-12-20 | 1964-12-18 |
Country Status (14)
| Country | Link |
|---|---|
| AT (2) | AT246130B (en) |
| BE (2) | BE657367A (en) |
| DE (1) | DE1238923B (en) |
| DK (1) | DK107488C (en) |
| ES (3) | ES307273A1 (en) |
| FR (4) | FR1430945A (en) |
| GB (2) | GB1084450A (en) |
| IL (1) | IL22640A (en) |
| LU (1) | LU47609A1 (en) |
| MC (1) | MC510A1 (en) |
| NL (2) | NL6414603A (en) |
| NO (1) | NO115584B (en) |
| OA (1) | OA01345A (en) |
| SE (2) | SE323969B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3464983A (en) * | 1964-02-04 | 1969-09-02 | Sandoz Ag | 4h-benzo(4,5)cyclohepta(1,2-b)thiophenes |
| CH531000A (en) * | 1970-03-11 | 1972-11-30 | Sandoz Ag | Process for the preparation of new benzocycloheptathiophenes |
| US20040110802A1 (en) * | 2002-08-23 | 2004-06-10 | Atli Thorarensen | Antibacterial benzoic acid derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT202152B (en) * | 1956-12-28 | 1959-02-10 | American Cyanamid Co | Process for the preparation of new dimethylaminopropylidene thiaxanthenes. |
-
1964
- 1964-12-11 GB GB50551/64A patent/GB1084450A/en not_active Expired
- 1964-12-11 GB GB50476/64A patent/GB1084448A/en not_active Expired
- 1964-12-15 NL NL6414603A patent/NL6414603A/xx unknown
- 1964-12-15 NL NL6414607A patent/NL6414607A/xx unknown
- 1964-12-16 DE DES94650A patent/DE1238923B/en active Pending
- 1964-12-18 BE BE657367A patent/BE657367A/xx unknown
- 1964-12-18 FR FR999256A patent/FR1430945A/en not_active Expired
- 1964-12-18 AT AT1073564A patent/AT246130B/en active
- 1964-12-18 NO NO156055A patent/NO115584B/no unknown
- 1964-12-18 IL IL22640A patent/IL22640A/en unknown
- 1964-12-18 DK DK623764AA patent/DK107488C/en active
- 1964-12-18 LU LU47609D patent/LU47609A1/xx unknown
- 1964-12-18 AT AT1073664A patent/AT247315B/en active
- 1964-12-18 ES ES0307273A patent/ES307273A1/en not_active Expired
- 1964-12-18 FR FR999257A patent/FR1417838A/en not_active Expired
- 1964-12-18 BE BE657366A patent/BE657366A/xx unknown
- 1964-12-18 MC MC527A patent/MC510A1/en unknown
- 1964-12-18 SE SE15369/64A patent/SE323969B/xx unknown
- 1964-12-31 OA OA51795A patent/OA01345A/en unknown
-
1965
- 1965-03-17 FR FR9518A patent/FR4225M/fr not_active Expired
- 1965-03-17 FR FR9519A patent/FR4344M/fr not_active Expired
- 1965-03-30 ES ES0311201A patent/ES311201A1/en not_active Expired
- 1965-03-30 ES ES0311200A patent/ES311200A1/en not_active Expired
-
1967
- 1967-06-29 SE SE09758/67A patent/SE332178B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT246130B (en) | 1966-04-12 |
| OA01345A (en) | 1969-02-15 |
| FR1430945A (en) | 1966-03-11 |
| IL22640A (en) | 1968-08-22 |
| GB1084450A (en) | 1967-09-20 |
| ES307273A1 (en) | 1965-05-01 |
| FR4344M (en) | 1966-08-16 |
| DE1238923B (en) | 1967-04-20 |
| FR1417838A (en) | 1965-11-12 |
| ES311201A1 (en) | 1966-02-16 |
| NL6414607A (en) | 1965-06-21 |
| BE657366A (en) | 1965-06-18 |
| GB1084448A (en) | 1967-09-20 |
| SE323969B (en) | 1970-05-19 |
| ES311200A1 (en) | 1966-02-16 |
| NL6414603A (en) | 1965-06-21 |
| NO115584B (en) | 1968-10-28 |
| AT247315B (en) | 1966-06-10 |
| MC510A1 (en) | 1965-08-27 |
| DK107488C (en) | 1967-06-05 |
| BE657367A (en) | 1965-06-18 |
| LU47609A1 (en) | 1965-06-18 |
| FR4225M (en) | 1966-06-13 |
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