SE307414B - - Google Patents

Info

Publication number
SE307414B
SE307414B SE1193160A SE1193160A SE307414B SE 307414 B SE307414 B SE 307414B SE 1193160 A SE1193160 A SE 1193160A SE 1193160 A SE1193160 A SE 1193160A SE 307414 B SE307414 B SE 307414B
Authority
SE
Sweden
Prior art keywords
complex
demethylchlortetracycline
solution
aqueous
urea
Prior art date
Application number
SE1193160A
Inventor
S Muller
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US44549A external-priority patent/US3053893A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of SE307414B publication Critical patent/SE307414B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to demethylchlortetracycline-urea-sulphate complex. The complex is prepared by a recovery process in which crude demethylchlortetracycline is contacted with an aqueous urea solution, an amount of a compound containing a sulphate ion e.g. sulphuric acid is added thereto which is such as to adjust the pH of the solution to a pH between 0.5 and 2.5 and the complex so formed is recovered or an aqueous slurry of the complex is further acidified to a pH of 0.1-1.0 to precipitate the corresponding demethylchlortetracycline acid addition salt e.g. the hydrochloride by acidifying with hydrochloric acid. An aqueous slurry of the complex is converted to demethylchlortetracycline in free base by adding an aqueous solution of a base e.g. ammonium hydroxide to a pH of 3 to 6.
SE1193160A 1959-12-09 1960-12-09 SE307414B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85833159A 1959-12-09 1959-12-09
US44549A US3053893A (en) 1960-07-22 1960-07-22 Recrystallization of demethylchlortetracycline

Publications (1)

Publication Number Publication Date
SE307414B true SE307414B (en) 1969-01-07

Family

ID=26721698

Family Applications (1)

Application Number Title Priority Date Filing Date
SE1193160A SE307414B (en) 1959-12-09 1960-12-09

Country Status (5)

Country Link
BE (1) BE597903A (en)
CH (1) CH385420A (en)
ES (1) ES263086A1 (en)
GB (1) GB917467A (en)
SE (1) SE307414B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108147976B (en) * 2016-12-06 2020-11-10 上海医药工业研究院 Extraction method of demethylated aureomycin

Also Published As

Publication number Publication date
GB917467A (en) 1963-02-06
BE597903A (en) 1961-06-07
ES263086A1 (en) 1961-03-01
CH385420A (en) 1964-12-15

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