SE306735B - - Google Patents

Info

Publication number
SE306735B
SE306735B SE1038362A SE1038362A SE306735B SE 306735 B SE306735 B SE 306735B SE 1038362 A SE1038362 A SE 1038362A SE 1038362 A SE1038362 A SE 1038362A SE 306735 B SE306735 B SE 306735B
Authority
SE
Sweden
Prior art keywords
oxo
steroids
cyclomethylene
specifications
methyl
Prior art date
Application number
SE1038362A
Inventor
V Petrow
Original Assignee
British Drug Houses Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Drug Houses Ltd filed Critical British Drug Houses Ltd
Publication of SE306735B publication Critical patent/SE306735B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Catalysts (AREA)

Abstract

6-Methyl-3-oxo-D 4,6-steroids having in rings A and B the structure: <FORM:0957222/C2/1> are prepared by contacting the corresponding 6-methylene-3-oxo-D 4-steroids with an activated palladium, platinum, rhodium, ruthenium, osmium, iridium or nickel catalyst in a solvent in the presence of a weakly basic buffering salt. The starting materials may be those 6-methyl-3-oxo-D 4,6-steroids described in Specifications 929,985 and 944,050. Examples are given. 16a , 17a -Cyclomethylene-6-methylenepregna-4, 6-diene-3, 20-dione is prepared by treating 16a , 17a -cyclomethylene-6-formyl-3-methoxy-pregna-3, 5-dien-20-one with sodium borohydride in methanol and tetrahydrofuran, heating the product in acetic acid and then treating the product of this reaction with chromium trioxide and pyridine. Specifications 870,286, 884,544, 886,619 and 929,983 also are referred to. Reference has been directed by the Comptroller to Specification 843,353.
SE1038362A 1961-09-27 1962-09-27 SE306735B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3464061A GB957222A (en) 1961-09-27 1961-09-27 A process for the preparation of 6-methyl-3-oxo-í¸-steroids

Publications (1)

Publication Number Publication Date
SE306735B true SE306735B (en) 1968-12-09

Family

ID=10368155

Family Applications (1)

Application Number Title Priority Date Filing Date
SE1038362A SE306735B (en) 1961-09-27 1962-09-27

Country Status (5)

Country Link
CH (1) CH429712A (en)
DK (1) DK104786C (en)
FR (1) FR1579454A (en)
GB (1) GB957222A (en)
SE (1) SE306735B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3402330A1 (en) * 1984-01-20 1985-07-25 Schering AG, 1000 Berlin und 4709 Bergkamen 1 (ALPHA), 2 (ALPHA) -METHYLENE-6-METHYLENE AND 6 (ALPHA) -METHYL PREGNENE, METHOD FOR THE PRODUCTION THEREOF AND THEIR PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Also Published As

Publication number Publication date
CH429712A (en) 1967-02-15
FR1579454A (en) 1969-08-29
GB957222A (en) 1964-05-06
DK104786C (en) 1966-07-04

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