SE306735B - - Google Patents
Info
- Publication number
- SE306735B SE306735B SE1038362A SE1038362A SE306735B SE 306735 B SE306735 B SE 306735B SE 1038362 A SE1038362 A SE 1038362A SE 1038362 A SE1038362 A SE 1038362A SE 306735 B SE306735 B SE 306735B
- Authority
- SE
- Sweden
- Prior art keywords
- oxo
- steroids
- cyclomethylene
- specifications
- methyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Catalysts (AREA)
Abstract
6-Methyl-3-oxo-D 4,6-steroids having in rings A and B the structure: <FORM:0957222/C2/1> are prepared by contacting the corresponding 6-methylene-3-oxo-D 4-steroids with an activated palladium, platinum, rhodium, ruthenium, osmium, iridium or nickel catalyst in a solvent in the presence of a weakly basic buffering salt. The starting materials may be those 6-methyl-3-oxo-D 4,6-steroids described in Specifications 929,985 and 944,050. Examples are given. 16a , 17a -Cyclomethylene-6-methylenepregna-4, 6-diene-3, 20-dione is prepared by treating 16a , 17a -cyclomethylene-6-formyl-3-methoxy-pregna-3, 5-dien-20-one with sodium borohydride in methanol and tetrahydrofuran, heating the product in acetic acid and then treating the product of this reaction with chromium trioxide and pyridine. Specifications 870,286, 884,544, 886,619 and 929,983 also are referred to. Reference has been directed by the Comptroller to Specification 843,353.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3464061A GB957222A (en) | 1961-09-27 | 1961-09-27 | A process for the preparation of 6-methyl-3-oxo-í¸-steroids |
Publications (1)
Publication Number | Publication Date |
---|---|
SE306735B true SE306735B (en) | 1968-12-09 |
Family
ID=10368155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE1038362A SE306735B (en) | 1961-09-27 | 1962-09-27 |
Country Status (5)
Country | Link |
---|---|
CH (1) | CH429712A (en) |
DK (1) | DK104786C (en) |
FR (1) | FR1579454A (en) |
GB (1) | GB957222A (en) |
SE (1) | SE306735B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3402330A1 (en) * | 1984-01-20 | 1985-07-25 | Schering AG, 1000 Berlin und 4709 Bergkamen | 1 (ALPHA), 2 (ALPHA) -METHYLENE-6-METHYLENE AND 6 (ALPHA) -METHYL PREGNENE, METHOD FOR THE PRODUCTION THEREOF AND THEIR PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
-
1961
- 1961-09-27 GB GB3464061A patent/GB957222A/en not_active Expired
-
1962
- 1962-09-21 DK DK412062A patent/DK104786C/en active
- 1962-09-27 FR FR1579454D patent/FR1579454A/fr not_active Expired
- 1962-09-27 CH CH1140562A patent/CH429712A/en unknown
- 1962-09-27 SE SE1038362A patent/SE306735B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CH429712A (en) | 1967-02-15 |
FR1579454A (en) | 1969-08-29 |
GB957222A (en) | 1964-05-06 |
DK104786C (en) | 1966-07-04 |
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