SE0200979D0 - New compounds - Google Patents

New compounds

Info

Publication number
SE0200979D0
SE0200979D0 SE0200979A SE0200979A SE0200979D0 SE 0200979 D0 SE0200979 D0 SE 0200979D0 SE 0200979 A SE0200979 A SE 0200979A SE 0200979 A SE0200979 A SE 0200979A SE 0200979 D0 SE0200979 D0 SE 0200979D0
Authority
SE
Sweden
Prior art keywords
new compounds
active compounds
compounds
new
therapy
Prior art date
Application number
SE0200979A
Other languages
English (en)
Swedish (sv)
Inventor
Stefan Berg
Sven Hellberg
Martin Nyloef
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0200979A priority Critical patent/SE0200979D0/xx
Publication of SE0200979D0 publication Critical patent/SE0200979D0/xx
Priority to ARP030100931A priority patent/AR038996A1/es
Priority to TW092106042A priority patent/TWI330081B/zh
Priority to SA03240054A priority patent/SA03240054B1/ar
Priority to MYPI20031117A priority patent/MY144659A/en
Priority to PT03745498T priority patent/PT1492785E/pt
Priority to CA2476343A priority patent/CA2476343C/en
Priority to KR1020047015389A priority patent/KR101014525B1/ko
Priority to DK03745498T priority patent/DK1492785T3/da
Priority to RU2004125146/04A priority patent/RU2338742C2/ru
Priority to DE60325032T priority patent/DE60325032D1/de
Priority to PCT/SE2003/000508 priority patent/WO2003082853A1/en
Priority to EP08157461A priority patent/EP1961748A3/en
Priority to AU2003216026A priority patent/AU2003216026B2/en
Priority to NZ534664A priority patent/NZ534664A/en
Priority to EP03745498A priority patent/EP1492785B9/en
Priority to UY27740A priority patent/UY27740A1/es
Priority to AT03745498T priority patent/ATE416171T1/de
Priority to JP2003580319A priority patent/JP3989444B2/ja
Priority to IL16389403A priority patent/IL163894A0/xx
Priority to CNA2006101537141A priority patent/CN1923812A/zh
Priority to US10/509,268 priority patent/US7399780B2/en
Priority to SI200331526T priority patent/SI1492785T1/sl
Priority to PL372966A priority patent/PL211096B1/pl
Priority to UA20040806742A priority patent/UA79447C2/uk
Priority to BR0308196-6A priority patent/BR0308196A/pt
Priority to ES03745498T priority patent/ES2316784T3/es
Priority to CNB038073897A priority patent/CN100519550C/zh
Priority to MXPA04009163A priority patent/MXPA04009163A/es
Priority to IL163894A priority patent/IL163894A/en
Priority to ZA200407665A priority patent/ZA200407665B/en
Priority to IS7471A priority patent/IS7471A/is
Priority to NO20044432A priority patent/NO329884B1/no
Priority to HK05104104.0A priority patent/HK1071360A1/xx
Priority to JP2007155810A priority patent/JP2007224051A/ja
Priority to US12/140,510 priority patent/US20090149460A1/en
Priority to CY20091100196T priority patent/CY1108823T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • AIDS & HIV (AREA)
SE0200979A 2002-03-28 2002-03-28 New compounds SE0200979D0 (sv)

Priority Applications (37)

Application Number Priority Date Filing Date Title
SE0200979A SE0200979D0 (sv) 2002-03-28 2002-03-28 New compounds
ARP030100931A AR038996A1 (es) 2002-03-28 2003-03-17 Compuestos con efecto inhibidor sobre la gsk3, formulaciones farmaceuticas que los contienen y proceso de preparacion de los mismos
TW092106042A TWI330081B (en) 2002-03-28 2003-03-19 New compounds, their preparations and their use in treatment and/or prevention of disease associated with glycogen synthase kinase-3
SA03240054A SA03240054B1 (ar) 2002-03-28 2003-03-26 مشتقات 2-هيدروكسي- 3-يترواريل اندول كمثبطات لـ gsk3
MYPI20031117A MY144659A (en) 2002-03-28 2003-03-26 2-hydroxy-3-heteroarylindole derivatives as gsk3 inhibitors
MXPA04009163A MXPA04009163A (es) 2002-03-28 2003-03-28 Nuevos compuestos.
UY27740A UY27740A1 (es) 2002-03-28 2003-03-28 Nuevos compuestos
CNA2006101537141A CN1923812A (zh) 2002-03-28 2003-03-28 新化合物
KR1020047015389A KR101014525B1 (ko) 2002-03-28 2003-03-28 신규 화합물
DK03745498T DK1492785T3 (da) 2002-03-28 2003-03-28 2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
RU2004125146/04A RU2338742C2 (ru) 2002-03-28 2003-03-28 Производные индола, способ их получения (варианты), промежуточные соединения, используемые для их получения, фармацевтическая композиция содержащая их и их применение для лечения состояний, связанных с гликоген-синтазой-киназой-3
DE60325032T DE60325032D1 (de) 2002-03-28 2003-03-28 2-hydroxy-3-heteroarylindole derivate als gsk3 inhibitoren
PCT/SE2003/000508 WO2003082853A1 (en) 2002-03-28 2003-03-28 New compounds
EP08157461A EP1961748A3 (en) 2002-03-28 2003-03-28 2-Hydroxy-3-heteroarylindole derivatives as GSK3 inhibitors
AU2003216026A AU2003216026B2 (en) 2002-03-28 2003-03-28 New compounds
NZ534664A NZ534664A (en) 2002-03-28 2003-03-28 GSK-3 inhibiting compounds
EP03745498A EP1492785B9 (en) 2002-03-28 2003-03-28 2-hydroxy-3-heteroarylindole derivatives as gsk3 inhibitors
PT03745498T PT1492785E (pt) 2002-03-28 2003-03-28 Derivados de 2-hidroxi-3-heteroarilindole como inibidores de gsk3
AT03745498T ATE416171T1 (de) 2002-03-28 2003-03-28 2-hydroxy-3-heteroarylindole derivate als gsk3 inhibitoren
JP2003580319A JP3989444B2 (ja) 2002-03-28 2003-03-28 新規な化合物
IL16389403A IL163894A0 (en) 2002-03-28 2003-03-28 New compounds
CA2476343A CA2476343C (en) 2002-03-28 2003-03-28 2-hydroxy-3-heteroarylindole derivatives as gsk3 inhibitors
US10/509,268 US7399780B2 (en) 2002-03-28 2003-03-28 3-Heterocyclyl-indole inhibitors of glycogen synthase kinase-3
SI200331526T SI1492785T1 (sl) 2002-03-28 2003-03-28 2-hidroksi-3-heteroarilindolni derivati kot inhibitorji GSK3
PL372966A PL211096B1 (pl) 2002-03-28 2003-03-28 Pochodne indolu, środek farmaceutyczny, zastosowanie pochodnych indolu i związki pośrednie
UA20040806742A UA79447C2 (en) 2002-03-28 2003-03-28 Indole derivates, pharmaceutical composition based thereon, process for their preparation (variants), intermediate compound
BR0308196-6A BR0308196A (pt) 2002-03-28 2003-03-28 Composto, formulação farmacêutica, uso de um composto, métodos de prevenção e/ou tratamento de condições associadas com a glicogênio sintase cinase-3, e de doenças, e, processo para a preparação de um composto
ES03745498T ES2316784T3 (es) 2002-03-28 2003-03-28 Derivados de 2-hidroxi-3-heteroarilindol como inhibidores de gsk3.
CNB038073897A CN100519550C (zh) 2002-03-28 2003-03-28 具有抑制糖原合成酶激酶3受体作用的2-氧代吲哚化合物
IL163894A IL163894A (en) 2002-03-28 2004-09-02 2-hydroxy-3-heteroarylindole derivatives, pharmaceutical compositions comprising them and their uses in the preparation of medicaments
ZA200407665A ZA200407665B (en) 2002-03-28 2004-09-22 New compounds.
IS7471A IS7471A (is) 2002-03-28 2004-09-27 Ný efnasambönd
NO20044432A NO329884B1 (no) 2002-03-28 2004-10-19 Indolderivater, farmasoytisk formulering, anvendelse av forbindelsene, fremgangsmate for fremstilling derav samt mellomprodukter for anvendelse i fremgangsmaten
HK05104104.0A HK1071360A1 (en) 2002-03-28 2005-05-17 2-hydroxy-3-heteroarylindole derivatives as gsk3 inhibitors
JP2007155810A JP2007224051A (ja) 2002-03-28 2007-06-13 新規な化合物
US12/140,510 US20090149460A1 (en) 2002-03-28 2008-06-17 New Compounds
CY20091100196T CY1108823T1 (el) 2002-03-28 2009-02-19 Παραγωγα 2-υδροξυ-3-ετεροαρυλινδολης ως αναστολεις της gsk3

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0200979A SE0200979D0 (sv) 2002-03-28 2002-03-28 New compounds

Publications (1)

Publication Number Publication Date
SE0200979D0 true SE0200979D0 (sv) 2002-03-28

Family

ID=20287447

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0200979A SE0200979D0 (sv) 2002-03-28 2002-03-28 New compounds

Country Status (32)

Country Link
US (2) US7399780B2 (ja)
EP (2) EP1961748A3 (ja)
JP (2) JP3989444B2 (ja)
KR (1) KR101014525B1 (ja)
CN (2) CN100519550C (ja)
AR (1) AR038996A1 (ja)
AT (1) ATE416171T1 (ja)
AU (1) AU2003216026B2 (ja)
BR (1) BR0308196A (ja)
CA (1) CA2476343C (ja)
CY (1) CY1108823T1 (ja)
DE (1) DE60325032D1 (ja)
DK (1) DK1492785T3 (ja)
ES (1) ES2316784T3 (ja)
HK (1) HK1071360A1 (ja)
IL (2) IL163894A0 (ja)
IS (1) IS7471A (ja)
MX (1) MXPA04009163A (ja)
MY (1) MY144659A (ja)
NO (1) NO329884B1 (ja)
NZ (1) NZ534664A (ja)
PL (1) PL211096B1 (ja)
PT (1) PT1492785E (ja)
RU (1) RU2338742C2 (ja)
SA (1) SA03240054B1 (ja)
SE (1) SE0200979D0 (ja)
SI (1) SI1492785T1 (ja)
TW (1) TWI330081B (ja)
UA (1) UA79447C2 (ja)
UY (1) UY27740A1 (ja)
WO (1) WO2003082853A1 (ja)
ZA (1) ZA200407665B (ja)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0302546D0 (sv) * 2003-09-24 2003-09-24 Astrazeneca Ab New compounds
US20040067985A1 (en) * 2002-10-04 2004-04-08 Fortuna Haviv Method of inhibiting angiogenesis
DE602005023333D1 (de) 2004-10-15 2010-10-14 Takeda Pharmaceutical Kinaseinhibitoren
US20060282228A1 (en) * 2005-06-10 2006-12-14 Pioneer Hi-Bred International, Inc. Method and system for use of environmental classification in precision farming
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
WO2007089193A1 (en) * 2006-02-02 2007-08-09 Astrazeneca Ab A process for preparing 2-hydroxy-3- [5- (morpholin-4-ylmethyl)pyridin-2-yl] lh-indole-5-carbonitrile as a free base or salts thereof
SA07280004B1 (ar) * 2006-02-02 2011-10-29 استرازينيكا ايه بي ملح سترات من مركب 2- هيدروكسي –3- [5- (مورفولين –4- يل ميثيل) بيريدين –2- يل] 1h- إندول –5- كربونيتريل سترات
JP2009525325A (ja) * 2006-02-02 2009-07-09 アストラゼネカ・アクチエボラーグ ２−ヒドロキシ−３−［５−（モルホリン−４−イルメチル）ピリジン−２−イル］１ｈ−インドール−５−カルボニトリルの遊離塩基又は塩としての医薬用途
EP1991539A4 (en) * 2006-02-28 2010-08-25 Astrazeneca Ab NEW SALTS OF INDIGENOUS DERIVATIVES AND THEIR USE IN MEDICINE
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007120102A1 (en) * 2006-04-19 2007-10-25 Astrazeneca Ab New substituted oxindole derivatives
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20080086340A1 (en) * 2006-10-04 2008-04-10 Pioneer Hi-Bred International, Inc. Crop quality insurance
GEP20135728B (en) 2006-10-09 2013-01-25 Takeda Pharmaceuticals Co Kinase inhibitors
RU2009119181A (ru) 2006-10-21 2010-11-27 Эбботт Гмбх Унд Ко.Кг (De) Гетероциклические соединения и их применение в качестве ингибиторов гликогенсинтаза-киназы-3
WO2008083062A1 (en) 2006-12-29 2008-07-10 Pioneer Hi-Bred International, Inc. Automated location-based information recall
BRPI0810216A2 (pt) 2007-04-18 2014-10-21 Astrazeneca Ab Processo para a preparação de composto, composto, e, método de tratamento de distúrbio bipolar
WO2009017453A1 (en) * 2007-07-30 2009-02-05 Astrazeneca Ab New therapeutic combination of an antipsychotic and a gsk3 inhibitor 958
WO2009017452A1 (en) * 2007-07-30 2009-02-05 Astrazeneca Ab New crystalline forms of 2 -hydroxy- 3- [5- (morpholin- 4- ylmethyl) pyridin-2-yl] ih- indole- 5 -carbonitrile citrate
WO2009017455A1 (en) * 2007-07-30 2009-02-05 Astrazeneca Ab A new combination of (a) an alpha-4-beta-2 -neuronal nicotinic agonist and (b) a gsk3 inhibitor
WO2009017454A1 (en) * 2007-07-30 2009-02-05 Astrazeneca Ab New therapeutic combination of a gsk3 inhibitor and an a7-nicotinic agonist 960
SI2197878T1 (sl) * 2007-09-06 2016-10-28 Boston Biomedical, Inc. Sestave za inhibitorje kinaze in njihova uporaba pri zdravljenju raka in drugih bolezni, povezanih s kinazami
US20090291982A1 (en) * 2008-05-22 2009-11-26 Astrazeneca Ab New Substituted Oxindole Derivative 352
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
TW201040191A (en) 2009-03-27 2010-11-16 Abbott Gmbh & Co Kg Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
WO2010143803A2 (en) * 2009-06-08 2010-12-16 Industry Foundation Of Chonnam National University New nicotinamide derivatives with anti-androgen effects, processes of preparing, and antiandrogens comprising the same
JP2011178752A (ja) * 2010-03-03 2011-09-15 Nagoya Univ 含窒素複素環化合物及びその製造方法
CN103119035B (zh) 2010-09-27 2015-09-30 雅培股份有限两合公司 杂环化合物和它们作为糖原合成酶激酶-3抑制剂的用途
EP2796456A1 (en) 2010-12-09 2014-10-29 Amgen Inc. Bicyclic compounds as Pim inhibitors
ES2571553T3 (es) 2010-12-21 2016-05-25 Bayer Ip Gmbh Procedimiento para la preparación de oxindoles sustituidos con triazinilo
US9090592B2 (en) 2010-12-30 2015-07-28 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
AU2012230890A1 (en) 2011-03-22 2013-09-26 Amgen Inc. Azole compounds as Pim inhibitors
NZ713219A (en) 2013-03-14 2017-04-28 Massachusetts Inst Technology Compositions and methods for epithelial stem cell expansion and culture
JP2017524739A (ja) 2014-07-17 2017-08-31 アンセルムＩｎｓｅｒｍ 神経筋接合部関連疾患の処置方法
KR102493376B1 (ko) 2014-09-03 2023-01-27 더 브리검 앤드 우먼즈 하스피털, 인크. 청력 손실의 치료를 위해 내이 털세포를 생성하기 위한 조성물, 시스템, 및 방법
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
GB201519573D0 (en) 2015-11-05 2015-12-23 King S College London Combination
CN108779437A (zh) 2016-01-08 2018-11-09 麻省理工学院 分化的肠内分泌细胞和胰岛素产生细胞的制备
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
RU2648820C2 (ru) * 2016-04-14 2018-03-28 Общество с ограниченной ответственностью "Научно-исследовательский центр "Парк активных молекул" Средство, обладающее противоклоногенной активностью в отношении опухолевых клеток человека
US11066419B2 (en) 2016-12-30 2021-07-20 Frequency Therapeutics, Inc. 1H-pyrrole-2,5-dione compounds and methods of using same
CN108440401A (zh) * 2018-04-13 2018-08-24 华东理工大学 5-[(4-乙基哌嗪-1-基)甲基]吡啶-2-胺的制备方法
AU2019321641A1 (en) 2018-08-17 2021-04-15 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by upregulating Jag-1
WO2020037326A1 (en) 2018-08-17 2020-02-20 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by downregulating foxo
AU2020218366A1 (en) 2019-02-08 2021-09-16 Frequency Therapeutics, Inc. Valproic acid compounds and Wnt agonists for treating ear disorders

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ192948A (en) * 1979-03-09 1982-02-23 Ishihara Sangyo Kaisha Preparation of beta-trifuloromethyl-pyridine derivatives directly from beta-picoline
US5710158A (en) 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5565580A (en) * 1994-01-27 1996-10-15 Neurosearch A/S Glutamate Antagonists
AU686843B2 (en) 1994-02-23 1998-02-12 Pfizer Inc. 4-heterocyclyl-substituted quinazoline derivatives, processes for their preparation and their use as anti-cancer agents
TW530047B (en) 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
GB9707800D0 (en) * 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
EP1005470B1 (en) * 1997-08-22 2007-08-01 AstraZeneca AB Oxindolylquinazoline derivatives as angiogenesis inhibitors
ES2237135T3 (es) 1998-08-20 2005-07-16 Sumitomo Pharmaceuticals Company, Limited Derivados de oxindol como liberadores de la hormona del crecimiento.
WO2000071129A1 (en) 1999-05-21 2000-11-30 Bristol-Myers Squibb Company Pyrrolotriazine inhibitors of kinases
ES2306671T3 (es) * 1999-10-07 2008-11-16 Amgen Inc. Inhibidores de triazina quinasa.
US6455525B1 (en) * 1999-11-04 2002-09-24 Cephalon, Inc. Heterocyclic substituted pyrazolones
EP1136493A1 (en) 2000-03-23 2001-09-26 Sanofi-Synthelabo 2-(Thienopyridinyl)pyrimidone, 2-(furopyridinyl)pyrimidone 2-(isoquinolinyl)pyrimidone, 2-(pyridoindolyl)pyrimidone and 2-(benzofuropyridinyl)pyrimidone derivatives
CZ2003555A3 (en) * 2000-07-27 2004-03-17 F. Hoffmann-La Roche Ag 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
US20020045566A1 (en) 2000-10-13 2002-04-18 Gribkoff Valentin K. Selective maxi-K potassium channel openers functional under conditions of high intracellular calcium concentration, methods and uses thereof
SE0104340D0 (sv) 2001-12-20 2001-12-20 Astrazeneca Ab New compounds
SE0104341D0 (sv) * 2001-12-20 2001-12-20 Astrazeneca Ab New use
TW200301123A (en) 2001-12-21 2003-07-01 Astrazeneca Uk Ltd New use
DE60221283T2 (de) * 2001-12-21 2008-03-20 Astrazeneca Ab Verwendung von oxindolderivaten zur behandlung von mit demenz in zusammenhang stehenden krankheiten, alzheimer-krankheit und mit glycogensynthasekinase-3 assoziierten leiden
SE0302546D0 (sv) * 2003-09-24 2003-09-24 Astrazeneca Ab New compounds
AU2003238874A1 (en) * 2002-06-05 2003-12-22 Janssen Pharmaceutica N.V. Bisindolyl-maleimid derivatives as kinase inhibitors

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