SE0200979D0 - New compounds - Google Patents

New compounds

Info

Publication number
SE0200979D0
SE0200979D0 SE0200979A SE0200979A SE0200979D0 SE 0200979 D0 SE0200979 D0 SE 0200979D0 SE 0200979 A SE0200979 A SE 0200979A SE 0200979 A SE0200979 A SE 0200979A SE 0200979 D0 SE0200979 D0 SE 0200979D0
Authority
SE
Sweden
Prior art keywords
new compounds
active compounds
compounds
new
therapy
Prior art date
Application number
SE0200979A
Other languages
English (en)
Swedish (sv)
Inventor
Stefan Berg
Sven Hellberg
Martin Nyloef
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0200979A priority Critical patent/SE0200979D0/xx
Publication of SE0200979D0 publication Critical patent/SE0200979D0/xx
Priority to ARP030100931A priority patent/AR038996A1/es
Priority to TW092106042A priority patent/TWI330081B/zh
Priority to MYPI20031117A priority patent/MY144659A/en
Priority to SA03240054A priority patent/SA03240054B1/ar
Priority to UA20040806742A priority patent/UA79447C2/uk
Priority to UY27740A priority patent/UY27740A1/es
Priority to RU2004125146/04A priority patent/RU2338742C2/ru
Priority to US10/509,268 priority patent/US7399780B2/en
Priority to CNB038073897A priority patent/CN100519550C/zh
Priority to CNA2006101537141A priority patent/CN1923812A/zh
Priority to DK03745498T priority patent/DK1492785T3/da
Priority to DE60325032T priority patent/DE60325032D1/de
Priority to IL16389403A priority patent/IL163894A0/xx
Priority to AT03745498T priority patent/ATE416171T1/de
Priority to PL372966A priority patent/PL211096B1/pl
Priority to NZ534664A priority patent/NZ534664A/en
Priority to SI200331526T priority patent/SI1492785T1/sl
Priority to JP2003580319A priority patent/JP3989444B2/ja
Priority to EP03745498A priority patent/EP1492785B9/en
Priority to MXPA04009163A priority patent/MXPA04009163A/es
Priority to BR0308196-6A priority patent/BR0308196A/pt
Priority to ES03745498T priority patent/ES2316784T3/es
Priority to PCT/SE2003/000508 priority patent/WO2003082853A1/en
Priority to EP08157461A priority patent/EP1961748A3/en
Priority to KR1020047015389A priority patent/KR101014525B1/ko
Priority to PT03745498T priority patent/PT1492785E/pt
Priority to AU2003216026A priority patent/AU2003216026B2/en
Priority to CA2476343A priority patent/CA2476343C/en
Priority to IL163894A priority patent/IL163894A/en
Priority to ZA200407665A priority patent/ZA200407665B/en
Priority to IS7471A priority patent/IS7471A/is
Priority to NO20044432A priority patent/NO329884B1/no
Priority to HK05104104.0A priority patent/HK1071360A1/xx
Priority to JP2007155810A priority patent/JP2007224051A/ja
Priority to US12/140,510 priority patent/US20090149460A1/en
Priority to CY20091100196T priority patent/CY1108823T1/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16Masculine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • AIDS & HIV (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
SE0200979A 2002-03-28 2002-03-28 New compounds SE0200979D0 (sv)

Priority Applications (37)

Application Number Priority Date Filing Date Title
SE0200979A SE0200979D0 (sv) 2002-03-28 2002-03-28 New compounds
ARP030100931A AR038996A1 (es) 2002-03-28 2003-03-17 Compuestos con efecto inhibidor sobre la gsk3, formulaciones farmaceuticas que los contienen y proceso de preparacion de los mismos
TW092106042A TWI330081B (en) 2002-03-28 2003-03-19 New compounds, their preparations and their use in treatment and/or prevention of disease associated with glycogen synthase kinase-3
MYPI20031117A MY144659A (en) 2002-03-28 2003-03-26 2-hydroxy-3-heteroarylindole derivatives as gsk3 inhibitors
SA03240054A SA03240054B1 (ar) 2002-03-28 2003-03-26 مشتقات 2-هيدروكسي- 3-يترواريل اندول كمثبطات لـ gsk3
CA2476343A CA2476343C (en) 2002-03-28 2003-03-28 2-hydroxy-3-heteroarylindole derivatives as gsk3 inhibitors
NZ534664A NZ534664A (en) 2002-03-28 2003-03-28 GSK-3 inhibiting compounds
MXPA04009163A MXPA04009163A (es) 2002-03-28 2003-03-28 Nuevos compuestos.
RU2004125146/04A RU2338742C2 (ru) 2002-03-28 2003-03-28 Производные индола, способ их получения (варианты), промежуточные соединения, используемые для их получения, фармацевтическая композиция содержащая их и их применение для лечения состояний, связанных с гликоген-синтазой-киназой-3
US10/509,268 US7399780B2 (en) 2002-03-28 2003-03-28 3-Heterocyclyl-indole inhibitors of glycogen synthase kinase-3
CNB038073897A CN100519550C (zh) 2002-03-28 2003-03-28 具有抑制糖原合成酶激酶3受体作用的2-氧代吲哚化合物
CNA2006101537141A CN1923812A (zh) 2002-03-28 2003-03-28 新化合物
DK03745498T DK1492785T3 (da) 2002-03-28 2003-03-28 2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
DE60325032T DE60325032D1 (de) 2002-03-28 2003-03-28 2-hydroxy-3-heteroarylindole derivate als gsk3 inhibitoren
IL16389403A IL163894A0 (en) 2002-03-28 2003-03-28 New compounds
AT03745498T ATE416171T1 (de) 2002-03-28 2003-03-28 2-hydroxy-3-heteroarylindole derivate als gsk3 inhibitoren
PL372966A PL211096B1 (pl) 2002-03-28 2003-03-28 Pochodne indolu, środek farmaceutyczny, zastosowanie pochodnych indolu i związki pośrednie
UA20040806742A UA79447C2 (en) 2002-03-28 2003-03-28 Indole derivates, pharmaceutical composition based thereon, process for their preparation (variants), intermediate compound
SI200331526T SI1492785T1 (sl) 2002-03-28 2003-03-28 2-hidroksi-3-heteroarilindolni derivati kot inhibitorji GSK3
JP2003580319A JP3989444B2 (ja) 2002-03-28 2003-03-28 新規な化合物
EP03745498A EP1492785B9 (en) 2002-03-28 2003-03-28 2-hydroxy-3-heteroarylindole derivatives as gsk3 inhibitors
UY27740A UY27740A1 (es) 2002-03-28 2003-03-28 Nuevos compuestos
BR0308196-6A BR0308196A (pt) 2002-03-28 2003-03-28 Composto, formulação farmacêutica, uso de um composto, métodos de prevenção e/ou tratamento de condições associadas com a glicogênio sintase cinase-3, e de doenças, e, processo para a preparação de um composto
ES03745498T ES2316784T3 (es) 2002-03-28 2003-03-28 Derivados de 2-hidroxi-3-heteroarilindol como inhibidores de gsk3.
PCT/SE2003/000508 WO2003082853A1 (en) 2002-03-28 2003-03-28 New compounds
EP08157461A EP1961748A3 (en) 2002-03-28 2003-03-28 2-Hydroxy-3-heteroarylindole derivatives as GSK3 inhibitors
KR1020047015389A KR101014525B1 (ko) 2002-03-28 2003-03-28 신규 화합물
PT03745498T PT1492785E (pt) 2002-03-28 2003-03-28 Derivados de 2-hidroxi-3-heteroarilindole como inibidores de gsk3
AU2003216026A AU2003216026B2 (en) 2002-03-28 2003-03-28 New compounds
IL163894A IL163894A (en) 2002-03-28 2004-09-02 2-hydroxy-3-heteroarylindole derivatives, pharmaceutical compositions comprising them and their uses in the preparation of medicaments
ZA200407665A ZA200407665B (en) 2002-03-28 2004-09-22 New compounds.
IS7471A IS7471A (is) 2002-03-28 2004-09-27 Ný efnasambönd
NO20044432A NO329884B1 (no) 2002-03-28 2004-10-19 Indolderivater, farmasoytisk formulering, anvendelse av forbindelsene, fremgangsmate for fremstilling derav samt mellomprodukter for anvendelse i fremgangsmaten
HK05104104.0A HK1071360A1 (en) 2002-03-28 2005-05-17 2-hydroxy-3-heteroarylindole derivatives as gsk3 inhibitors
JP2007155810A JP2007224051A (ja) 2002-03-28 2007-06-13 新規な化合物
US12/140,510 US20090149460A1 (en) 2002-03-28 2008-06-17 New Compounds
CY20091100196T CY1108823T1 (el) 2002-03-28 2009-02-19 Παραγωγα 2-υδροξυ-3-ετεροαρυλινδολης ως αναστολεις της gsk3

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0200979A SE0200979D0 (sv) 2002-03-28 2002-03-28 New compounds

Publications (1)

Publication Number Publication Date
SE0200979D0 true SE0200979D0 (sv) 2002-03-28

Family

ID=20287447

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0200979A SE0200979D0 (sv) 2002-03-28 2002-03-28 New compounds

Country Status (32)

Country Link
US (2) US7399780B2 (ja)
EP (2) EP1492785B9 (ja)
JP (2) JP3989444B2 (ja)
KR (1) KR101014525B1 (ja)
CN (2) CN100519550C (ja)
AR (1) AR038996A1 (ja)
AT (1) ATE416171T1 (ja)
AU (1) AU2003216026B2 (ja)
BR (1) BR0308196A (ja)
CA (1) CA2476343C (ja)
CY (1) CY1108823T1 (ja)
DE (1) DE60325032D1 (ja)
DK (1) DK1492785T3 (ja)
ES (1) ES2316784T3 (ja)
HK (1) HK1071360A1 (ja)
IL (2) IL163894A0 (ja)
IS (1) IS7471A (ja)
MX (1) MXPA04009163A (ja)
MY (1) MY144659A (ja)
NO (1) NO329884B1 (ja)
NZ (1) NZ534664A (ja)
PL (1) PL211096B1 (ja)
PT (1) PT1492785E (ja)
RU (1) RU2338742C2 (ja)
SA (1) SA03240054B1 (ja)
SE (1) SE0200979D0 (ja)
SI (1) SI1492785T1 (ja)
TW (1) TWI330081B (ja)
UA (1) UA79447C2 (ja)
UY (1) UY27740A1 (ja)
WO (1) WO2003082853A1 (ja)
ZA (1) ZA200407665B (ja)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0302546D0 (sv) 2003-09-24 2003-09-24 Astrazeneca Ab New compounds
US20040067985A1 (en) * 2002-10-04 2004-04-08 Fortuna Haviv Method of inhibiting angiogenesis
EP1812439B2 (en) 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Kinase inhibitors
US8032389B2 (en) * 2005-06-10 2011-10-04 Pioneer Hi-Bred International, Inc. Method for use of environmental classification in product selection
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス,インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
CA2625153A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
SA07280004B1 (ar) * 2006-02-02 2011-10-29 استرازينيكا ايه بي ملح سترات من مركب 2- هيدروكسي –3- [5- (مورفولين –4- يل ميثيل) بيريدين –2- يل] 1h- إندول –5- كربونيتريل سترات
WO2007089193A1 (en) * 2006-02-02 2007-08-09 Astrazeneca Ab A process for preparing 2-hydroxy-3- [5- (morpholin-4-ylmethyl)pyridin-2-yl] lh-indole-5-carbonitrile as a free base or salts thereof
EP1981500A4 (en) * 2006-02-02 2010-08-25 Astrazeneca Ab PHARMACEUTICAL USE OF 2-HYDROXY-3- [5- (MORPHOLIN-4-YLMETHYL) PYRIDINE-2-YL] -1H-INDOL-5-CARBONITRIL AS FREE BASE OR SALT
US20120115865A1 (en) * 2006-02-28 2012-05-10 Anna-Lena Berg New Salts of an Indole Derivative and Their Use in Medicine
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007120102A1 (en) * 2006-04-19 2007-10-25 Astrazeneca Ab New substituted oxindole derivatives
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20080086340A1 (en) * 2006-10-04 2008-04-10 Pioneer Hi-Bred International, Inc. Crop quality insurance
JP2010505962A (ja) 2006-10-09 2010-02-25 武田薬品工業株式会社 キナーゼ阻害剤
RU2009119181A (ru) 2006-10-21 2010-11-27 Эбботт Гмбх Унд Ко.Кг (De) Гетероциклические соединения и их применение в качестве ингибиторов гликогенсинтаза-киназы-3
US8417534B2 (en) 2006-12-29 2013-04-09 Pioneer Hi-Bred International, Inc. Automated location-based information recall
BRPI0810216A2 (pt) 2007-04-18 2014-10-21 Astrazeneca Ab Processo para a preparação de composto, composto, e, método de tratamento de distúrbio bipolar
WO2009017455A1 (en) * 2007-07-30 2009-02-05 Astrazeneca Ab A new combination of (a) an alpha-4-beta-2 -neuronal nicotinic agonist and (b) a gsk3 inhibitor
WO2009017453A1 (en) * 2007-07-30 2009-02-05 Astrazeneca Ab New therapeutic combination of an antipsychotic and a gsk3 inhibitor 958
JP2010535200A (ja) * 2007-07-30 2010-11-18 アストラゼネカ・アクチエボラーグ 2−ヒドロキシ−3−[5−(モルホリン−4−イルメチル)ピリジン−2−イル]−1h−インドール−5−カルボニトリル・クエン酸塩の新しい結晶形態
WO2009017454A1 (en) * 2007-07-30 2009-02-05 Astrazeneca Ab New therapeutic combination of a gsk3 inhibitor and an a7-nicotinic agonist 960
EP3037419B1 (en) * 2007-09-06 2019-09-04 Boston Biomedical, Inc. Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases
US20090291982A1 (en) * 2008-05-22 2009-11-26 Astrazeneca Ab New Substituted Oxindole Derivative 352
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
TW201040191A (en) * 2009-03-27 2010-11-16 Abbott Gmbh & Co Kg Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
WO2010143803A2 (en) * 2009-06-08 2010-12-16 Industry Foundation Of Chonnam National University New nicotinamide derivatives with anti-androgen effects, processes of preparing, and antiandrogens comprising the same
JP2011178752A (ja) * 2010-03-03 2011-09-15 Nagoya Univ 含窒素複素環化合物及びその製造方法
WO2012041814A1 (en) 2010-09-27 2012-04-05 Abbott Gmbh & Co. Kg Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
CA2819373A1 (en) 2010-12-09 2012-06-14 Amgen Inc. Bicyclic compounds as pim inhibitors
JP5980808B2 (ja) 2010-12-21 2016-08-31 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH トリアジニル−置換オキシインドール類を製造する方法
US9090592B2 (en) 2010-12-30 2015-07-28 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
JP2014510105A (ja) 2011-03-22 2014-04-24 アムジエン・インコーポレーテツド Pim阻害剤としてのアゾール化合物
SI2970890T1 (sl) 2013-03-14 2020-10-30 The Brigham And Women's Hospital, Inc. Sestavki in postopki za razmnoževanje in kultiviranje epitelijskih matičnih celic
EP3169337A1 (en) 2014-07-17 2017-05-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for treating neuromuscular junction-related diseases
EP3189134A1 (en) 2014-09-03 2017-07-12 The Brigham and Women's Hospital, Inc. Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
GB201519573D0 (en) 2015-11-05 2015-12-23 King S College London Combination
US11021687B2 (en) 2016-01-08 2021-06-01 The Brigham And Women's Hospital, Inc. Production of differentiated enteroendocrine cells and insulin producing cells
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
RU2648820C2 (ru) * 2016-04-14 2018-03-28 Общество с ограниченной ответственностью "Научно-исследовательский центр "Парк активных молекул" Средство, обладающее противоклоногенной активностью в отношении опухолевых клеток человека
SG10201910821XA (en) 2016-12-30 2020-01-30 Frequency Therapeutics Inc 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells
CN108440401A (zh) * 2018-04-13 2018-08-24 华东理工大学 5-[(4-乙基哌嗪-1-基)甲基]吡啶-2-胺的制备方法
WO2020037326A1 (en) 2018-08-17 2020-02-20 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by downregulating foxo
AU2019321641A1 (en) 2018-08-17 2021-04-15 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by upregulating Jag-1
WO2020163812A1 (en) 2019-02-08 2020-08-13 Frequency Therapeutics, Inc. Valproic acid compounds and wnt agonists for treating ear disorders

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ192948A (en) * 1979-03-09 1982-02-23 Ishihara Sangyo Kaisha Preparation of beta-trifuloromethyl-pyridine derivatives directly from beta-picoline
US5710158A (en) 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5565580A (en) * 1994-01-27 1996-10-15 Neurosearch A/S Glutamate Antagonists
CA2183655C (en) 1994-02-23 2001-03-06 Lee D. Arnold 4-polycyclic amino-substituted quinazoline derivatives
TW530047B (en) 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
GB9707800D0 (en) 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
DE69838172T2 (de) 1997-08-22 2008-04-10 Astrazeneca Ab Oxindolylchinazolinderivate als angiogenesehemmer
ES2237135T3 (es) 1998-08-20 2005-07-16 Sumitomo Pharmaceuticals Company, Limited Derivados de oxindol como liberadores de la hormona del crecimiento.
WO2000071129A1 (en) * 1999-05-21 2000-11-30 Bristol-Myers Squibb Company Pyrrolotriazine inhibitors of kinases
MXPA02003436A (es) 1999-10-07 2002-08-20 Amgen Inc Inhibidores de triazina cinasa.
US6455525B1 (en) * 1999-11-04 2002-09-24 Cephalon, Inc. Heterocyclic substituted pyrazolones
EP1136493A1 (en) 2000-03-23 2001-09-26 Sanofi-Synthelabo 2-(Thienopyridinyl)pyrimidone, 2-(furopyridinyl)pyrimidone 2-(isoquinolinyl)pyrimidone, 2-(pyridoindolyl)pyrimidone and 2-(benzofuropyridinyl)pyrimidone derivatives
CZ2003555A3 (en) 2000-07-27 2004-03-17 F. Hoffmann-La Roche Ag 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
US20020045566A1 (en) 2000-10-13 2002-04-18 Gribkoff Valentin K. Selective maxi-K potassium channel openers functional under conditions of high intracellular calcium concentration, methods and uses thereof
SE0104341D0 (sv) 2001-12-20 2001-12-20 Astrazeneca Ab New use
SE0104340D0 (sv) 2001-12-20 2001-12-20 Astrazeneca Ab New compounds
TW200301123A (en) 2001-12-21 2003-07-01 Astrazeneca Uk Ltd New use
AU2002359162A1 (en) 2001-12-21 2003-07-15 Astrazeneca Ab Use of oxindole derivatives in the treatment of dementia related diseases, alzheimer's disease and conditions associated with glycogen synthase kinase-3
SE0302546D0 (sv) * 2003-09-24 2003-09-24 Astrazeneca Ab New compounds
MXPA04012188A (es) * 2002-06-05 2005-07-25 Johnson & Johnson Derivados de bisindolil-maleimida como inhibidores de cinasa.

Also Published As

Publication number Publication date
RU2004125146A (ru) 2005-06-27
CA2476343A1 (en) 2003-10-09
NO20044432L (no) 2004-10-19
EP1492785A1 (en) 2005-01-05
JP2005526814A (ja) 2005-09-08
CA2476343C (en) 2011-05-03
PL372966A1 (en) 2005-08-08
KR101014525B1 (ko) 2011-02-14
AU2003216026B2 (en) 2008-12-11
EP1961748A3 (en) 2009-10-07
HK1071360A1 (en) 2005-07-15
IL163894A0 (en) 2005-12-18
EP1492785B9 (en) 2009-10-21
ZA200407665B (en) 2005-08-29
ES2316784T3 (es) 2009-04-16
RU2338742C2 (ru) 2008-11-20
WO2003082853A1 (en) 2003-10-09
TWI330081B (en) 2010-09-11
NO329884B1 (no) 2011-01-17
ATE416171T1 (de) 2008-12-15
IS7471A (is) 2004-10-15
AR038996A1 (es) 2005-02-02
JP3989444B2 (ja) 2007-10-10
CY1108823T1 (el) 2014-04-09
PL211096B1 (pl) 2012-04-30
EP1492785B1 (en) 2008-12-03
CN1642938A (zh) 2005-07-20
SI1492785T1 (sl) 2009-06-30
US7399780B2 (en) 2008-07-15
US20050153987A1 (en) 2005-07-14
DE60325032D1 (de) 2009-01-15
UA79447C2 (en) 2007-06-25
BR0308196A (pt) 2005-01-11
MXPA04009163A (es) 2004-12-07
AU2003216026A1 (en) 2003-10-13
CN1923812A (zh) 2007-03-07
PT1492785E (pt) 2009-02-02
NZ534664A (en) 2007-06-29
EP1961748A2 (en) 2008-08-27
TW200306180A (en) 2003-11-16
UY27740A1 (es) 2003-10-31
DK1492785T3 (da) 2009-03-02
CN100519550C (zh) 2009-07-29
US20090149460A1 (en) 2009-06-11
SA03240054B1 (ar) 2009-04-04
KR20040094884A (ko) 2004-11-10
MY144659A (en) 2011-10-31
WO2003082853A8 (en) 2004-05-06
JP2007224051A (ja) 2007-09-06
IL163894A (en) 2010-11-30

Similar Documents

Publication Publication Date Title
SE0200979D0 (sv) New compounds
SE0100569D0 (sv) New compounds
TW200510375A (en) New compounds
TW200745111A (en) New compounds
TW200606164A (en) New compounds
EA200300776A1 (ru) Производные фенэтаноламина для лечения респираторных заболеваний
SE0102439D0 (sv) New compounds
PA8591701A1 (es) Derivados de pirrolopirimidina
ATE381537T1 (de) Formanilid-derivative als beta2-adrenorezeptor- agonisten
EA200501849A1 (ru) Производные пиразолохиназолина: способ получения и применение в качестве ингибиторов киназ
UY27368A1 (es) Nuevos compuestos
SE0400043D0 (sv) New compounds
CY1109366T1 (el) Υποκατεστημενες ενωσεις 1,4,8-τριαζασπειρο[4.5]δεκαν-2-ονης
TW200800984A (en) New compounds
MX2009010165A (es) Nuevas imidazo[4,5-b]piridina-7-carboxamidas 704.
TW200634001A (en) Novel compounds
SE0302546D0 (sv) New compounds
SE0102440D0 (sv) New compound
SE0102055D0 (sv) New Compounds
TW200640465A (en) New pharmaceutically active compounds for the treatment of respiratory diseases
SE0102057D0 (sv) New Salts I
IT1307786B1 (it) Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali.
SE0102058D0 (sv) New Salts II
SE0403118D0 (sv) New compounds 2
SE9900190D0 (sv) New compounds