SA520411575B1 - نظام موائع جزيئية وطريقة لاستعادة الجسيمات - Google Patents
نظام موائع جزيئية وطريقة لاستعادة الجسيماتInfo
- Publication number
- SA520411575B1 SA520411575B1 SA520411575A SA520411575A SA520411575B1 SA 520411575 B1 SA520411575 B1 SA 520411575B1 SA 520411575 A SA520411575 A SA 520411575A SA 520411575 A SA520411575 A SA 520411575A SA 520411575 B1 SA520411575 B1 SA 520411575B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- particles
- outlet
- recovery
- fluid
- microfluidic system
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 2
- 238000011084 recovery Methods 0.000 title abstract 2
- 239000012530 fluid Substances 0.000 abstract 3
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0663—Whole sensors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0424—Dielectrophoretic forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
- B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
- B01L2400/0451—Thermophoresis; Thermodiffusion; Soret-effect
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1028—Sorting particles
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Fluid Mechanics (AREA)
- Physics & Mathematics (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Extraction Or Liquid Replacement (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
يتعلق الاختراع الحالي بطريقة method ونظام موائع جزيئية microfluidic system (1) لاستعادة الجسيمات recovery of particles ؛ يشتمل النظام (1) system على حجرة ثابتة واحدة على الأقل (3) standing chamber, ومخرج outlet واحد على الأقل (4), ومدخل inlet واحد على الأقل (5) وتجميعة متحركة (6) moving assembly, مهيأة لتحريك الجسيمات particles (2', 2)؛ تتم تغذية مائع fluid من المدخل (5) inlet إلى المخرج (4) outlet من أجل توليد تدفق مائع fluid مستمر إلى حد كبير؛ يتم نقل جسيم معين given particle (2') من مجموعة (8) من الجسيمات (2) particles موضوع في حجرة التجميع collecting chamber بشكل انتقائي بالنسبة لباقي جسيمات (2) particles التجميعة إلى منطقة إطلاق (9) release area, حيث تعمل قوة سحب ناشئة عن تدفق المائع fluid flow على تحريك الجسيم (2') particle تجاه المخرج (4) outlet. الشكل 1
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102017000105948A IT201700105948A1 (it) | 2017-09-21 | 2017-09-21 | Metodo e sistema microfluidico per il recupero di particelle |
Publications (1)
Publication Number | Publication Date |
---|---|
SA520411575B1 true SA520411575B1 (ar) | 2023-10-22 |
Family
ID=61024881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SA520411575A SA520411575B1 (ar) | 2017-09-21 | 2020-03-19 | نظام موائع جزيئية وطريقة لاستعادة الجسيمات |
Country Status (18)
Country | Link |
---|---|
US (1) | US11292001B2 (ar) |
EP (1) | EP3684509B1 (ar) |
JP (1) | JP7220707B2 (ar) |
KR (1) | KR102676275B1 (ar) |
CN (2) | CN111132766A (ar) |
AU (1) | AU2018335606B2 (ar) |
CA (1) | CA3074954A1 (ar) |
DK (1) | DK3684509T3 (ar) |
ES (1) | ES2892315T3 (ar) |
HU (1) | HUE056185T2 (ar) |
IL (1) | IL273447B2 (ar) |
IT (1) | IT201700105948A1 (ar) |
PL (1) | PL3684509T3 (ar) |
PT (1) | PT3684509T (ar) |
SA (1) | SA520411575B1 (ar) |
SG (1) | SG11202001962WA (ar) |
SI (1) | SI3684509T1 (ar) |
WO (1) | WO2019058326A1 (ar) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US9725710B2 (en) | 2014-01-08 | 2017-08-08 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
WO2018183744A1 (en) | 2017-03-29 | 2018-10-04 | The Research Foundation For The State University Of New York | Microfluidic device and methods |
KR102439221B1 (ko) | 2017-12-14 | 2022-09-01 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6062392A (en) * | 1998-11-13 | 2000-05-16 | Mesosystems Technology, Inc. | Micromachined virtual impactor |
IT1309430B1 (it) | 1999-05-18 | 2002-01-23 | Guerrieri Roberto | Metodo ed apparato per la manipolazione di particelle per mezzo delladielettroforesi |
JP2004000144A (ja) * | 2002-03-29 | 2004-01-08 | Aisin Seiki Co Ltd | 細胞分離選別装置、細胞整列用基板 |
CN100475317C (zh) * | 2003-09-04 | 2009-04-08 | 阿尔利克斯公司 | 利用激光操纵进行基于多层流的颗粒和细胞分离 |
US20050178700A1 (en) * | 2004-01-21 | 2005-08-18 | David Tyvoll | Sorting particles in parallel |
US8158410B2 (en) * | 2005-01-18 | 2012-04-17 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
ITBO20050481A1 (it) | 2005-07-19 | 2007-01-20 | Silicon Biosystems S R L | Metodo ed apparato per la manipolazione e/o l'individuazione di particelle |
ITBO20050643A1 (it) | 2005-10-24 | 2007-04-25 | Si Bio S R L | Metodo ed apparato per la manipolazione di particelle in soluzioni conduttive |
CN100551550C (zh) * | 2006-09-25 | 2009-10-21 | 瑞鼎科技股份有限公司 | 流体微粒分离装置 |
WO2009008925A2 (en) * | 2007-04-05 | 2009-01-15 | The Regents Of The University Of California | A particle-based microfluidic device for providing high magnetic field gradients |
US20110263044A1 (en) * | 2008-07-31 | 2011-10-27 | Eads Deutschland Gmbh | Device and method for the automatic detection of biological particles |
US9192943B2 (en) | 2009-03-17 | 2015-11-24 | Silicon Biosystems S.P.A. | Microfluidic device for isolation of cells |
ITBO20090155A1 (it) | 2009-03-17 | 2010-09-18 | Silicon Biosystems Spa | Metodo per l'isolamento di particelle |
ITBO20090154A1 (it) | 2009-03-17 | 2010-09-18 | Silicon Biosystems Spa | Sistema microfluidico |
IT1403518B1 (it) | 2010-12-22 | 2013-10-31 | Silicon Biosystems Spa | Dispositivo microfluidico per la manipolazione di particelle |
FR2984756B1 (fr) * | 2011-12-27 | 2014-02-21 | Commissariat Energie Atomique | Dispositif nano et micro fluidique pour la separation et concentration de particules presentes dans un fluide |
CA2894459C (en) * | 2012-07-27 | 2020-07-07 | Engender Technologies Limited | Method and system for microfluidic particle orientation and/or sorting |
WO2014138715A1 (en) * | 2013-03-08 | 2014-09-12 | Duke University | Devices, systems, and methods for acoustically -enhanced magnetophoresis |
US20150166956A1 (en) * | 2013-12-16 | 2015-06-18 | General Electric Company | Devices for separation of particulates, associated methods and systems |
SG10202103867PA (en) * | 2016-10-18 | 2021-05-28 | Menarini Silicon Biosystems Spa | Microfluidic device, microfluidic system and method for the isolation of particles |
-
2017
- 2017-09-21 IT IT102017000105948A patent/IT201700105948A1/it unknown
-
2018
- 2018-09-21 CA CA3074954A patent/CA3074954A1/en active Pending
- 2018-09-21 CN CN201880061817.6A patent/CN111132766A/zh active Pending
- 2018-09-21 ES ES18789477T patent/ES2892315T3/es active Active
- 2018-09-21 DK DK18789477.9T patent/DK3684509T3/da active
- 2018-09-21 JP JP2020514690A patent/JP7220707B2/ja active Active
- 2018-09-21 WO PCT/IB2018/057312 patent/WO2019058326A1/en active Search and Examination
- 2018-09-21 KR KR1020207010235A patent/KR102676275B1/ko active IP Right Grant
- 2018-09-21 IL IL273447A patent/IL273447B2/en unknown
- 2018-09-21 PT PT187894779T patent/PT3684509T/pt unknown
- 2018-09-21 EP EP18789477.9A patent/EP3684509B1/en active Active
- 2018-09-21 SG SG11202001962WA patent/SG11202001962WA/en unknown
- 2018-09-21 US US16/648,646 patent/US11292001B2/en active Active
- 2018-09-21 HU HUE18789477A patent/HUE056185T2/hu unknown
- 2018-09-21 AU AU2018335606A patent/AU2018335606B2/en active Active
- 2018-09-21 CN CN202110396603.8A patent/CN113058670B/zh active Active
- 2018-09-21 PL PL18789477T patent/PL3684509T3/pl unknown
- 2018-09-21 SI SI201830410T patent/SI3684509T1/sl unknown
-
2020
- 2020-03-19 SA SA520411575A patent/SA520411575B1/ar unknown
Also Published As
Publication number | Publication date |
---|---|
JP2020534141A (ja) | 2020-11-26 |
US20200276585A1 (en) | 2020-09-03 |
CA3074954A1 (en) | 2019-03-28 |
IL273447B2 (en) | 2024-06-01 |
DK3684509T3 (da) | 2021-09-20 |
EP3684509A1 (en) | 2020-07-29 |
PL3684509T3 (pl) | 2022-01-03 |
HUE056185T2 (hu) | 2022-01-28 |
KR20200067842A (ko) | 2020-06-12 |
WO2019058326A1 (en) | 2019-03-28 |
AU2018335606A1 (en) | 2020-04-30 |
SI3684509T1 (sl) | 2021-12-31 |
AU2018335606B2 (en) | 2023-06-08 |
KR102676275B1 (ko) | 2024-06-19 |
CN111132766A (zh) | 2020-05-08 |
JP7220707B2 (ja) | 2023-02-10 |
CN113058670A (zh) | 2021-07-02 |
IT201700105948A1 (it) | 2019-03-21 |
CN113058670B (zh) | 2023-03-21 |
US11292001B2 (en) | 2022-04-05 |
PT3684509T (pt) | 2021-09-21 |
IL273447B1 (en) | 2024-02-01 |
EP3684509B1 (en) | 2021-09-08 |
SG11202001962WA (en) | 2020-04-29 |
ES2892315T3 (es) | 2022-02-03 |
IL273447A (en) | 2020-05-31 |
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