SA520411575B1 - نظام موائع جزيئية وطريقة لاستعادة الجسيمات - Google Patents

نظام موائع جزيئية وطريقة لاستعادة الجسيمات

Info

Publication number
SA520411575B1
SA520411575B1 SA520411575A SA520411575A SA520411575B1 SA 520411575 B1 SA520411575 B1 SA 520411575B1 SA 520411575 A SA520411575 A SA 520411575A SA 520411575 A SA520411575 A SA 520411575A SA 520411575 B1 SA520411575 B1 SA 520411575B1
Authority
SA
Saudi Arabia
Prior art keywords
particles
outlet
recovery
fluid
microfluidic system
Prior art date
Application number
SA520411575A
Other languages
English (en)
Inventor
ميدورو جياني
كالانكا إليكس
Original Assignee
ميناريني سيليكون بيوسيستمـز اس. بي. ايه.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ميناريني سيليكون بيوسيستمـز اس. بي. ايه. filed Critical ميناريني سيليكون بيوسيستمـز اس. بي. ايه.
Publication of SA520411575B1 publication Critical patent/SA520411575B1/ar

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0621Control of the sequence of chambers filled or emptied
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668Trapping microscopic beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0663Whole sensors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0424Dielectrophoretic forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0436Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B01L2400/0451Thermophoresis; Thermodiffusion; Soret-effect
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1028Sorting particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Fluid Mechanics (AREA)
  • Physics & Mathematics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

يتعلق الاختراع الحالي بطريقة method ونظام موائع جزيئية microfluidic system (1) لاستعادة الجسيمات recovery of particles ؛ يشتمل النظام (1) system على حجرة ثابتة واحدة على الأقل (3) standing chamber, ومخرج outlet واحد على الأقل (4), ومدخل inlet واحد على الأقل (5) وتجميعة متحركة (6) moving assembly, مهيأة لتحريك الجسيمات particles (2', 2)؛ تتم تغذية مائع fluid من المدخل (5) inlet إلى المخرج (4) outlet من أجل توليد تدفق مائع fluid مستمر إلى حد كبير؛ يتم نقل جسيم معين given particle (2') من مجموعة (8) من الجسيمات (2) particles موضوع في حجرة التجميع collecting chamber بشكل انتقائي بالنسبة لباقي جسيمات (2) particles التجميعة إلى منطقة إطلاق (9) release area, حيث تعمل قوة سحب ناشئة عن تدفق المائع fluid flow على تحريك الجسيم (2') particle تجاه المخرج (4) outlet. الشكل 1
SA520411575A 2017-09-21 2020-03-19 نظام موائع جزيئية وطريقة لاستعادة الجسيمات SA520411575B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102017000105948A IT201700105948A1 (it) 2017-09-21 2017-09-21 Metodo e sistema microfluidico per il recupero di particelle

Publications (1)

Publication Number Publication Date
SA520411575B1 true SA520411575B1 (ar) 2023-10-22

Family

ID=61024881

Family Applications (1)

Application Number Title Priority Date Filing Date
SA520411575A SA520411575B1 (ar) 2017-09-21 2020-03-19 نظام موائع جزيئية وطريقة لاستعادة الجسيمات

Country Status (18)

Country Link
US (1) US11292001B2 (ar)
EP (1) EP3684509B1 (ar)
JP (1) JP7220707B2 (ar)
KR (1) KR102676275B1 (ar)
CN (2) CN111132766A (ar)
AU (1) AU2018335606B2 (ar)
CA (1) CA3074954A1 (ar)
DK (1) DK3684509T3 (ar)
ES (1) ES2892315T3 (ar)
HU (1) HUE056185T2 (ar)
IL (1) IL273447B2 (ar)
IT (1) IT201700105948A1 (ar)
PL (1) PL3684509T3 (ar)
PT (1) PT3684509T (ar)
SA (1) SA520411575B1 (ar)
SG (1) SG11202001962WA (ar)
SI (1) SI3684509T1 (ar)
WO (1) WO2019058326A1 (ar)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9725710B2 (en) 2014-01-08 2017-08-08 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
WO2018183744A1 (en) 2017-03-29 2018-10-04 The Research Foundation For The State University Of New York Microfluidic device and methods
KR102439221B1 (ko) 2017-12-14 2022-09-01 프로디자인 소닉스, 인크. 음향 트랜스듀서 구동기 및 제어기

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6062392A (en) * 1998-11-13 2000-05-16 Mesosystems Technology, Inc. Micromachined virtual impactor
IT1309430B1 (it) 1999-05-18 2002-01-23 Guerrieri Roberto Metodo ed apparato per la manipolazione di particelle per mezzo delladielettroforesi
JP2004000144A (ja) * 2002-03-29 2004-01-08 Aisin Seiki Co Ltd 細胞分離選別装置、細胞整列用基板
CN100475317C (zh) * 2003-09-04 2009-04-08 阿尔利克斯公司 利用激光操纵进行基于多层流的颗粒和细胞分离
US20050178700A1 (en) * 2004-01-21 2005-08-18 David Tyvoll Sorting particles in parallel
US8158410B2 (en) * 2005-01-18 2012-04-17 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
ITBO20050481A1 (it) 2005-07-19 2007-01-20 Silicon Biosystems S R L Metodo ed apparato per la manipolazione e/o l'individuazione di particelle
ITBO20050643A1 (it) 2005-10-24 2007-04-25 Si Bio S R L Metodo ed apparato per la manipolazione di particelle in soluzioni conduttive
CN100551550C (zh) * 2006-09-25 2009-10-21 瑞鼎科技股份有限公司 流体微粒分离装置
WO2009008925A2 (en) * 2007-04-05 2009-01-15 The Regents Of The University Of California A particle-based microfluidic device for providing high magnetic field gradients
US20110263044A1 (en) * 2008-07-31 2011-10-27 Eads Deutschland Gmbh Device and method for the automatic detection of biological particles
US9192943B2 (en) 2009-03-17 2015-11-24 Silicon Biosystems S.P.A. Microfluidic device for isolation of cells
ITBO20090155A1 (it) 2009-03-17 2010-09-18 Silicon Biosystems Spa Metodo per l'isolamento di particelle
ITBO20090154A1 (it) 2009-03-17 2010-09-18 Silicon Biosystems Spa Sistema microfluidico
IT1403518B1 (it) 2010-12-22 2013-10-31 Silicon Biosystems Spa Dispositivo microfluidico per la manipolazione di particelle
FR2984756B1 (fr) * 2011-12-27 2014-02-21 Commissariat Energie Atomique Dispositif nano et micro fluidique pour la separation et concentration de particules presentes dans un fluide
CA2894459C (en) * 2012-07-27 2020-07-07 Engender Technologies Limited Method and system for microfluidic particle orientation and/or sorting
WO2014138715A1 (en) * 2013-03-08 2014-09-12 Duke University Devices, systems, and methods for acoustically -enhanced magnetophoresis
US20150166956A1 (en) * 2013-12-16 2015-06-18 General Electric Company Devices for separation of particulates, associated methods and systems
SG10202103867PA (en) * 2016-10-18 2021-05-28 Menarini Silicon Biosystems Spa Microfluidic device, microfluidic system and method for the isolation of particles

Also Published As

Publication number Publication date
JP2020534141A (ja) 2020-11-26
US20200276585A1 (en) 2020-09-03
CA3074954A1 (en) 2019-03-28
IL273447B2 (en) 2024-06-01
DK3684509T3 (da) 2021-09-20
EP3684509A1 (en) 2020-07-29
PL3684509T3 (pl) 2022-01-03
HUE056185T2 (hu) 2022-01-28
KR20200067842A (ko) 2020-06-12
WO2019058326A1 (en) 2019-03-28
AU2018335606A1 (en) 2020-04-30
SI3684509T1 (sl) 2021-12-31
AU2018335606B2 (en) 2023-06-08
KR102676275B1 (ko) 2024-06-19
CN111132766A (zh) 2020-05-08
JP7220707B2 (ja) 2023-02-10
CN113058670A (zh) 2021-07-02
IT201700105948A1 (it) 2019-03-21
CN113058670B (zh) 2023-03-21
US11292001B2 (en) 2022-04-05
PT3684509T (pt) 2021-09-21
IL273447B1 (en) 2024-02-01
EP3684509B1 (en) 2021-09-08
SG11202001962WA (en) 2020-04-29
ES2892315T3 (es) 2022-02-03
IL273447A (en) 2020-05-31

Similar Documents

Publication Publication Date Title
SA520411575B1 (ar) نظام موائع جزيئية وطريقة لاستعادة الجسيمات
CL2020002499A1 (es) Sistema, método y aparato para flotación por espuma (divisional de la solicitud no. 201800544)
EP4215280A3 (en) Solids separation, washing and sampling system
AU2019268197A1 (en) Backflush methods and devices for chromatography
MX359348B (es) Método y sistema para la orientación y/o clasificación de partículas micro fluídicas.
WO2016176611A3 (en) Method and apparatus for conditioning fluids
MX2017014546A (es) Aparatos y metodos para eliminacion de gas intravenoso.
MX2013006645A (es) Sistema y metodo de control de flujo de fluido para el interior de pozos con resistencia al flujo dependiente de la direccion.
EP2562531A3 (en) Systems and methods for particle focusing in microchannels
MY182900A (en) Split flow pipe separator
WO2013142318A8 (en) Improved apparatus for detecting particles
MX2022013815A (es) Separacion de particulas solidas en la produccion de petroleo y/o gas.
MY196430A (en) Separation Device for Separating a Fluid
BR112014017427A2 (pt) sistema de filtro e método para filtrar líquido
WO2017108198A3 (de) Pulverbeschichtungsanlage zum beschichten von werkstücken mit beschichtungspulver
SA518390890B1 (ar) جـهاز استقـبال الطاقة الشمسية
EA201791440A1 (ru) Каталитический химический реактор с разделением частиц и сепаратор частиц
AU2018256585A1 (en) Modular pressure control and drilling waste management apparatus for subterranean borehole
MX2018015544A (es) Aparato de medicion de materia particulada.
NZ606676A (en) A barrage shaped so as to increase the fluid velocity past a turbine
MX2019015845A (es) Separador de hidrociclon.
WO2016025056A3 (en) Turbine engine and particle separators therefore
SA521430149B1 (ar) طريقة ونظام موائع دقيقة لعزل الجسيمات
EA201891310A1 (ru) Система, устройства и методы улучшения работы турбины с использованием электростатического осаждения
MX2017016615A (es) Disposicion de eyectores.