SA515360477B1 - مشتقات بيريدون كمثبطات إفراز حمض وعملية لتحضيرها - Google Patents

مشتقات بيريدون كمثبطات إفراز حمض وعملية لتحضيرها

Info

Publication number
SA515360477B1
SA515360477B1 SA515360477A SA515360477A SA515360477B1 SA 515360477 B1 SA515360477 B1 SA 515360477B1 SA 515360477 A SA515360477 A SA 515360477A SA 515360477 A SA515360477 A SA 515360477A SA 515360477 B1 SA515360477 B1 SA 515360477B1
Authority
SA
Saudi Arabia
Prior art keywords
preparation
hydrogen
acid secretion
secretion inhibitors
methyl
Prior art date
Application number
SA515360477A
Other languages
English (en)
Inventor
توكارام غاوضاري اشوك
باندورانج خالادكار توشار
سودارشان ميكاب جولاكتشاندرا
داجيسنج ماهالي راجندرا
ساتيش ميهتا ساميت
شانكار باوار سانجاي
كيشاف كالهابوري فيجاي
كيشاف جورجار موكوند
كومار تريباثي ناريندرا
Original Assignee
امكيور فارماسيوتيكالز ليمتد
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by امكيور فارماسيوتيكالز ليمتد filed Critical امكيور فارماسيوتيكالز ليمتد
Publication of SA515360477B1 publication Critical patent/SA515360477B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

يتعلق الاختراع الحالي بمشتقات داي كبريتيد بيريدين pyridine disulphide derivatives لها الصيغة (I) وتحضيرها، تركيبة صيدلانية. تتسم مشتقات داي كبريتيد بيريدين بأنها مفيدة في علاج الاضطرابات المَعِدية المعوية gastrointestinal disorders ، حيث، R1، R2 وR3 هي بشكل مستقل ألكيل alkyl ، ألكوكسي alkoxy ، هالوجين halogen ، ألكوكسي مهلجنة halogenated alkoxy ، ألكيل مهلجنة halogenated alkyl ، هيدروجين hydrogen ويمكن أن تكون متماثلة أو مختلفة وX هي CH أو N. R1 هي ميثيل methyl ، ميثوكسي methoxy ، فلور fluorine ، تراي فلورو ميثيل trifluoromefhyl ، داي فلورو ميثوكسي difluoromethoxy وهيدروجين، R2 هي ميثيل، ميثوكسي وهيدروجين، وR3 هي ميثيل وهيدروجين.
SA515360477A 2012-11-26 2015-05-25 مشتقات بيريدون كمثبطات إفراز حمض وعملية لتحضيرها SA515360477B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3360MU2012 2012-11-26
PCT/IN2013/000699 WO2014080422A2 (en) 2012-11-26 2013-11-18 Pyridone derivatives as acid secretion inhibitors and process for preparation thereof

Publications (1)

Publication Number Publication Date
SA515360477B1 true SA515360477B1 (ar) 2017-03-12

Family

ID=50776641

Family Applications (1)

Application Number Title Priority Date Filing Date
SA515360477A SA515360477B1 (ar) 2012-11-26 2015-05-25 مشتقات بيريدون كمثبطات إفراز حمض وعملية لتحضيرها

Country Status (17)

Country Link
US (2) US9447094B2 (ar)
EP (1) EP2922839B1 (ar)
JP (1) JP6322644B2 (ar)
KR (1) KR20150088301A (ar)
CN (2) CN108484643A (ar)
AU (1) AU2013349260B2 (ar)
BR (1) BR112015011925A2 (ar)
CA (1) CA2892620A1 (ar)
EA (1) EA028205B1 (ar)
ES (1) ES2660876T3 (ar)
IL (1) IL238625B (ar)
MX (1) MX2015006536A (ar)
PH (1) PH12015501087B1 (ar)
SA (1) SA515360477B1 (ar)
SG (1) SG11201503629PA (ar)
WO (1) WO2014080422A2 (ar)
ZA (1) ZA201503472B (ar)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8403179D0 (sv) 1984-06-13 1984-06-13 Haessle Ab New compounds
SE8405588D0 (sv) * 1984-11-08 1984-11-08 Haessle Ab New compounds
CA1276017C (en) 1986-02-13 1990-11-06 Takeda Chemical Industries, Ltd. Sulfenamide derivatives and their production
US5162317A (en) 1988-05-12 1992-11-10 Esai Co., Ltd. Pyridinium salt and pharmacological composition containing the same
JP3038064B2 (ja) * 1991-10-07 2000-05-08 日清製粉株式会社 インドール誘導体およびこれを有効成分とする抗潰瘍薬
CN101450939B (zh) * 2007-12-05 2013-06-19 沈阳药科大学 新型苯并咪唑类化合物
CN101486706B (zh) * 2009-03-09 2012-12-19 邓菊娟 一种奥美拉唑钠化合物及其合成方法

Also Published As

Publication number Publication date
IL238625A0 (en) 2015-06-30
IL238625B (en) 2018-05-31
US20160355529A1 (en) 2016-12-08
WO2014080422A3 (en) 2014-06-19
JP2016500097A (ja) 2016-01-07
BR112015011925A2 (pt) 2017-07-11
CA2892620A1 (en) 2014-05-30
SG11201503629PA (en) 2015-06-29
US9447094B2 (en) 2016-09-20
AU2013349260B2 (en) 2017-11-23
CN108484643A (zh) 2018-09-04
MX2015006536A (es) 2015-07-23
AU2013349260A1 (en) 2015-05-21
CN104797572A (zh) 2015-07-22
KR20150088301A (ko) 2015-07-31
US20150232467A1 (en) 2015-08-20
EP2922839A2 (en) 2015-09-30
PH12015501087A1 (en) 2015-08-03
WO2014080422A2 (en) 2014-05-30
EA201500571A1 (ru) 2016-03-31
EP2922839A4 (en) 2016-04-06
JP6322644B2 (ja) 2018-05-09
EP2922839B1 (en) 2017-10-04
ES2660876T3 (es) 2018-03-26
EA028205B1 (ru) 2017-10-31
ZA201503472B (en) 2016-11-30
US9522924B1 (en) 2016-12-20
PH12015501087B1 (en) 2015-08-03

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