BR112015011925A2 - derivados de piridona como inibidores de secreção de ácido e processo para a preparação dos mesmos - Google Patents

derivados de piridona como inibidores de secreção de ácido e processo para a preparação dos mesmos

Info

Publication number
BR112015011925A2
BR112015011925A2 BR112015011925A BR112015011925A BR112015011925A2 BR 112015011925 A2 BR112015011925 A2 BR 112015011925A2 BR 112015011925 A BR112015011925 A BR 112015011925A BR 112015011925 A BR112015011925 A BR 112015011925A BR 112015011925 A2 BR112015011925 A2 BR 112015011925A2
Authority
BR
Brazil
Prior art keywords
hydrogen
preparation
acid secretion
derivatives
pyridone
Prior art date
Application number
BR112015011925A
Other languages
English (en)
Inventor
Tukaram Chaudhari Ashok
Sudarshan Maikap Golakchandra
Keshav Gurjar Mukund
Kumar Tripathy Narenda
Dagesing Mahale Rajendra
Satish Mehta Samit
Shankar Pawar Sanjay
Pandurang Khaladkar Tushar
Keshav Kalhapure Vijay
Original Assignee
Emcure Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emcure Pharmaceuticals Ltd filed Critical Emcure Pharmaceuticals Ltd
Publication of BR112015011925A2 publication Critical patent/BR112015011925A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

resumo “derivados de piridona como inibidores de secreção de ácido e processo para a preparação dos mesmos” a presente invenção refere-se à preparação de derivados estáveis de dissulfeto de piridona que têm fórmula geral (i) e seus estereoisômeros, que são úteis no tratamento de distúrbios gastrointestinais. derivados de dissulfeto de piridona (i) em que, r1, r2 e r3 são, independentemente, alquila, alcóxi, halogênio, alcóxi halogenado, alquila halogenada, hidrogênio e poderiam ser os mesmos ou diferentes e x é ch ou n. r1 é metila, metóxi, flúor, trifluorometila, difluorometóxi e hidrogênio, r2 é metila, metóxi e hidrogênio e r3 é metila e hidrogênio. 1/1
BR112015011925A 2012-11-26 2013-11-18 derivados de piridona como inibidores de secreção de ácido e processo para a preparação dos mesmos BR112015011925A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3360MU2012 2012-11-26
PCT/IN2013/000699 WO2014080422A2 (en) 2012-11-26 2013-11-18 Pyridone derivatives as acid secretion inhibitors and process for preparation thereof

Publications (1)

Publication Number Publication Date
BR112015011925A2 true BR112015011925A2 (pt) 2017-07-11

Family

ID=50776641

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015011925A BR112015011925A2 (pt) 2012-11-26 2013-11-18 derivados de piridona como inibidores de secreção de ácido e processo para a preparação dos mesmos

Country Status (17)

Country Link
US (2) US9447094B2 (pt)
EP (1) EP2922839B1 (pt)
JP (1) JP6322644B2 (pt)
KR (1) KR20150088301A (pt)
CN (2) CN108484643A (pt)
AU (1) AU2013349260B2 (pt)
BR (1) BR112015011925A2 (pt)
CA (1) CA2892620A1 (pt)
EA (1) EA028205B1 (pt)
ES (1) ES2660876T3 (pt)
IL (1) IL238625B (pt)
MX (1) MX2015006536A (pt)
PH (1) PH12015501087A1 (pt)
SA (1) SA515360477B1 (pt)
SG (1) SG11201503629PA (pt)
WO (1) WO2014080422A2 (pt)
ZA (1) ZA201503472B (pt)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8403179D0 (sv) 1984-06-13 1984-06-13 Haessle Ab New compounds
SE8405588D0 (sv) * 1984-11-08 1984-11-08 Haessle Ab New compounds
CA1276017C (en) 1986-02-13 1990-11-06 Takeda Chemical Industries, Ltd. Sulfenamide derivatives and their production
US5162317A (en) 1988-05-12 1992-11-10 Esai Co., Ltd. Pyridinium salt and pharmacological composition containing the same
JP3038064B2 (ja) * 1991-10-07 2000-05-08 日清製粉株式会社 インドール誘導体およびこれを有効成分とする抗潰瘍薬
CN101450939B (zh) * 2007-12-05 2013-06-19 沈阳药科大学 新型苯并咪唑类化合物
CN101486706B (zh) * 2009-03-09 2012-12-19 邓菊娟 一种奥美拉唑钠化合物及其合成方法

Also Published As

Publication number Publication date
IL238625A0 (en) 2015-06-30
US9447094B2 (en) 2016-09-20
PH12015501087B1 (en) 2015-08-03
SG11201503629PA (en) 2015-06-29
ES2660876T3 (es) 2018-03-26
US9522924B1 (en) 2016-12-20
EP2922839A4 (en) 2016-04-06
PH12015501087A1 (en) 2015-08-03
JP2016500097A (ja) 2016-01-07
US20160355529A1 (en) 2016-12-08
WO2014080422A2 (en) 2014-05-30
MX2015006536A (es) 2015-07-23
CN108484643A (zh) 2018-09-04
EP2922839A2 (en) 2015-09-30
EA201500571A1 (ru) 2016-03-31
AU2013349260B2 (en) 2017-11-23
CA2892620A1 (en) 2014-05-30
AU2013349260A1 (en) 2015-05-21
EP2922839B1 (en) 2017-10-04
JP6322644B2 (ja) 2018-05-09
US20150232467A1 (en) 2015-08-20
WO2014080422A3 (en) 2014-06-19
CN104797572A (zh) 2015-07-22
EA028205B1 (ru) 2017-10-31
ZA201503472B (en) 2016-11-30
KR20150088301A (ko) 2015-07-31
SA515360477B1 (ar) 2017-03-12
IL238625B (en) 2018-05-31

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements