RU95102323A - Производные 5,6,7,8-тетрагидро-имидазо [1,2-a]-пиридина, способ их получения, содержащая их композиция и способ ее получения - Google Patents

Производные 5,6,7,8-тетрагидро-имидазо [1,2-a]-пиридина, способ их получения, содержащая их композиция и способ ее получения

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Publication number
RU95102323A
RU95102323A RU95102323/04A RU95102323A RU95102323A RU 95102323 A RU95102323 A RU 95102323A RU 95102323/04 A RU95102323/04 A RU 95102323/04A RU 95102323 A RU95102323 A RU 95102323A RU 95102323 A RU95102323 A RU 95102323A
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Russia
Prior art keywords
preparation
derivatives
composition
tetrahydroimidazo
pyridine derivatives
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RU95102323/04A
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English (en)
Inventor
Юрашик Хорст
De]
Генте Йоахим
Вурцигер Ханнс
Бернотат-Данеловски Сабине
Мельцер Гвидо
At]
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Мерк Патент ГмбХ (DE)
Мерк Патент Гмбх
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Publication of RU95102323A publication Critical patent/RU95102323A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Соединения формулыа также соответствующие производные 5,6,7,8-тетрагидроимидазо[1,2-а] пиридина, их физиологически приемлемые соли и/или сольваты, подавляют связывание фибриногена с соответствующим рецептором и могут применяться для лечения тромбозов, остеопрозов, опухолевых заболеваний, апоплексии, инфаркта сердца, воспалений, артериосклероза и остеолитических заболеваний.

Claims (1)

  1. Соединения формулы
    Figure 00000001

    а также соответствующие производные 5,6,7,8-тетрагидроимидазо[1,2-а] пиридина, их физиологически приемлемые соли и/или сольваты, подавляют связывание фибриногена с соответствующим рецептором и могут применяться для лечения тромбозов, остеопрозов, опухолевых заболеваний, апоплексии, инфаркта сердца, воспалений, артериосклероза и остеолитических заболеваний.
RU95102323/04A 1994-02-19 1995-02-17 Производные 5,6,7,8-тетрагидро-имидазо [1,2-a]-пиридина, способ их получения, содержащая их композиция и способ ее получения RU95102323A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4405378A DE4405378A1 (de) 1994-02-19 1994-02-19 Adhäsionsrezeptor-Antagonisten
DEP4405378.9 1994-02-19

Publications (1)

Publication Number Publication Date
RU95102323A true RU95102323A (ru) 1997-03-20

Family

ID=6510687

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95102323/04A RU95102323A (ru) 1994-02-19 1995-02-17 Производные 5,6,7,8-тетрагидро-имидазо [1,2-a]-пиридина, способ их получения, содержащая их композиция и способ ее получения

Country Status (15)

Country Link
US (1) US5614531A (ru)
EP (1) EP0668278A1 (ru)
JP (1) JPH07252254A (ru)
KR (1) KR950032197A (ru)
CN (1) CN1111630A (ru)
AU (1) AU1230795A (ru)
CA (1) CA2142741A1 (ru)
CZ (1) CZ42495A3 (ru)
DE (1) DE4405378A1 (ru)
HU (1) HUT71806A (ru)
NO (1) NO950606L (ru)
PL (1) PL307328A1 (ru)
RU (1) RU95102323A (ru)
SK (1) SK22195A3 (ru)
ZA (1) ZA951345B (ru)

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KR20040084945A (ko) * 1996-07-25 2004-10-06 바이오겐 아이덱 엠에이 인코포레이티드 세포 유착 억제제
DE19653646A1 (de) * 1996-12-20 1998-06-25 Hoechst Ag Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung
AR011057A1 (es) * 1997-01-08 2000-08-02 Smithkline Beecham Corp Uso de bis-acridinas sustituidas y compuestos afines para la preparacion de medicamentos y dichos compuestos
US5902797A (en) * 1997-11-10 1999-05-11 Beth Israel Deaconess Medical Center Nutritional supplement for use in the treatment of attention deficit
EP1140194A2 (en) 1998-12-23 2001-10-10 G.D. SEARLE & CO. Use of cyclooxygenase-2 inhibitor, a matrix metallaproteinase inhibitor, an antineoplastic agent and optionally radiation as a combined treatment of neoplasia
DE10117183A1 (de) * 2001-04-05 2002-10-10 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]-pyridinverbindungen als Arzneimittel
DE10117184A1 (de) * 2001-04-05 2002-10-17 Gruenenthal Gmbh Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen
EP2484365B1 (en) 2004-06-04 2013-10-02 The Scripps Research Institute Compositions and method for treatment of neovascular diseases
KR20070101227A (ko) 2004-09-07 2007-10-16 아케믹스 코포레이션 폰 빌레브란트 인자에 대한 앱타머 및 이의 혈전증치료제로서의 용도
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
US20070066551A1 (en) * 2004-09-07 2007-03-22 Keefe Anthony D Aptamer medicinal chemistry
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US7919519B2 (en) * 2005-11-23 2011-04-05 Epix Pharmaceuticals Inc. S1P receptor modulating compounds and use thereof
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CL2007000742A1 (es) * 2006-03-21 2008-01-11 Epix Delaware Inc Compuestos derivados de 2-oxoimidazol, moduladores del recptor s1p (esfingosina-1-fosfato); composicion farmceutica que los contiene; y su uso para tratar condiciones tales como rechazo de trasplante, cancer, artritis reumatoide y diabetes.
WO2008027812A2 (en) * 2006-08-28 2008-03-06 Forest Laboratories Holdings Limited Imidazopyridine and imidazopyrimidine derivatives
EP1964840A1 (en) 2007-02-28 2008-09-03 sanofi-aventis Imidazo[1,2-a]pyridines and their use as pharmaceuticals
AU2007227278B2 (en) * 2007-03-21 2014-09-11 Epix Pharmaceuticals, Inc. SIP receptor modulating compounds and use thereof
US20090203766A1 (en) * 2007-06-01 2009-08-13 Archemix Corp. vWF aptamer formulations and methods for use
EP2188252B1 (en) * 2007-09-20 2011-04-13 Amgen Inc. 1-(4-(4-benzylbenzamido)-benzyl)azetidine-3-carboxylic acid derivatives and related compounds as s1p receptor modulators for the treatment of immune disorders
US7868001B2 (en) * 2007-11-02 2011-01-11 Hutchison Medipharma Enterprises Limited Cytokine inhibitors

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US4990506A (en) * 1986-02-05 1991-02-05 Synthelabo 3-(acylaminomethyl)imidazo[1,2-a]pyridine derivatives and their application in therapy
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Also Published As

Publication number Publication date
NO950606L (no) 1995-08-21
HUT71806A (en) 1996-02-28
AU1230795A (en) 1995-08-31
PL307328A1 (en) 1995-08-21
SK22195A3 (en) 1995-09-13
CZ42495A3 (en) 1995-10-18
JPH07252254A (ja) 1995-10-03
US5614531A (en) 1997-03-25
CA2142741A1 (en) 1995-08-20
KR950032197A (ko) 1995-12-20
DE4405378A1 (de) 1995-08-24
CN1111630A (zh) 1995-11-15
HU9500479D0 (en) 1995-04-28
ZA951345B (en) 1995-10-24
NO950606D0 (no) 1995-02-17
EP0668278A1 (de) 1995-08-23

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