RU94046117A - Серусодержащие фосфонатные соединения, используемые для лечения аномального кальциевого и фосфатного обмена веществ, фармацевтические композиции - Google Patents
Серусодержащие фосфонатные соединения, используемые для лечения аномального кальциевого и фосфатного обмена веществ, фармацевтические композицииInfo
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- RU94046117A RU94046117A RU94046117/04A RU94046117A RU94046117A RU 94046117 A RU94046117 A RU 94046117A RU 94046117/04 A RU94046117/04 A RU 94046117/04A RU 94046117 A RU94046117 A RU 94046117A RU 94046117 A RU94046117 A RU 94046117A
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- Russia
- Prior art keywords
- treatment
- compounds
- effective amount
- relates
- human
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims abstract 9
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title claims abstract 5
- 239000011593 sulfur Substances 0.000 title claims abstract 5
- 229910052717 sulfur Inorganic materials 0.000 title claims abstract 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract 3
- 229910019142 PO4 Inorganic materials 0.000 title claims abstract 3
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title claims abstract 3
- 239000011575 calcium Substances 0.000 title claims abstract 3
- 229910052791 calcium Inorganic materials 0.000 title claims abstract 3
- 230000004060 metabolic process Effects 0.000 title claims abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title claims abstract 3
- 239000010452 phosphate Substances 0.000 title claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 11
- 206010003246 arthritis Diseases 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 4
- 239000000203 mixture Substances 0.000 claims abstract 3
- LQHYUUBBIJGBNR-UHFFFAOYSA-N OP(O)(=O)S(O)(=O)=O Chemical class OP(O)(=O)S(O)(=O)=O LQHYUUBBIJGBNR-UHFFFAOYSA-N 0.000 claims abstract 2
- 208000001132 Osteoporosis Diseases 0.000 claims abstract 2
- 150000002148 esters Chemical class 0.000 claims abstract 2
- 230000001575 pathological effect Effects 0.000 claims abstract 2
- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical class OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 241000124008 Mammalia Species 0.000 claims 4
- 241000282412 Homo Species 0.000 claims 2
- -1 bisphosphonates Chemical class 0.000 claims 2
- 229940122361 Bisphosphonate Drugs 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 150000004663 bisphosphonates Chemical class 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5532—Seven-(or more) membered rings
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/5765—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
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- C07F9/58—Pyridine rings
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
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- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Изобретение относится к новым серусодержащим фосфонатным соединениям и новым тиозамещенным соединениям, включающим бифосфонаты, фосфоноалкилфосфонаты, фосфонокарбоксилаты и фосфоносульфонаты и их фармацевтически приемлемым солям и эфирам, а также к фармацевтическим композициям, содержащим безопасное и эффективное количество соединения данного изобретения и фармацевтически приемлемые наполнители, к способам лечения и предотвращения патологических состояний, характеризующихся аномальным кальциевым и фосфатным метаболизмом у человека и других млекопитающих, включая лечение или предотвращение остеспороза и артрита, особенно ревматоидного артрита и остеоартрита. Этот способ состоит во введении человеку или другому млекопитающему, нуждающемуся в таком лечении, безопасного и эффективного количества соединения или композиции данного изобретения или соединения и композиции, раскрываемых на его основе. Новые серусодержащие соединения данного изобретения имеют общую структурную формулу I, приведенную в описании. Наконец, изобретение относится к лечению артрита у людей или других млекопитающих, нуждающихся в таком лечении, состоящему во введении человеку или другому млекопитающему безопасного и эффективного количества тиозамещенного фосфонатного соединения, имеющего структурную формулу III, приведенную в описании.
Claims (1)
- Изобретение относится к новым серусодержащим фосфонатным соединениям и новым тиозамещенным соединениям, включающим бифосфонаты, фосфоноалкилфосфонаты, фосфонокарбоксилаты и фосфоносульфонаты и их фармацевтически приемлемым солям и эфирам, а также к фармацевтическим композициям, содержащим безопасное и эффективное количество соединения данного изобретения и фармацевтически приемлемые наполнители, к способам лечения и предотвращения патологических состояний, характеризующихся аномальным кальциевым и фосфатным метаболизмом у человека и других млекопитающих, включая лечение или предотвращение остеспороза и артрита, особенно ревматоидного артрита и остеоартрита. Этот способ состоит во введении человеку или другому млекопитающему, нуждающемуся в таком лечении, безопасного и эффективного количества соединения или композиции данного изобретения или соединения и композиции, раскрываемых на его основе. Новые серусодержащие соединения данного изобретения имеют общую структурную формулу I, приведенную в описании. Наконец, изобретение относится к лечению артрита у людей или других млекопитающих, нуждающихся в таком лечении, состоящему во введении человеку или другому млекопитающему безопасного и эффективного количества тиозамещенного фосфонатного соединения, имеющего структурную формулу III, приведенную в описании.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89130992A | 1992-05-29 | 1992-05-29 | |
| US07/891309 | 1992-05-29 | ||
| US07/891.309 | 1992-05-29 | ||
| PCT/US1993/004977 WO1993024496A1 (en) | 1992-05-29 | 1993-05-26 | Sulfur-containing phosponate compounds for treating abnormal calcium and phosphate metabolism |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU94046117A true RU94046117A (ru) | 1996-09-27 |
| RU2136691C1 RU2136691C1 (ru) | 1999-09-10 |
Family
ID=25397954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94046117A RU2136691C1 (ru) | 1992-05-29 | 1993-05-26 | Серусодержащие фосфоновые кислоты или их фармацевтически приемлемые соли или эфиры и фармацевтическая композиция на их основе |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5824661A (ru) |
| EP (1) | EP0642519B1 (ru) |
| JP (1) | JPH07507315A (ru) |
| KR (1) | KR950701929A (ru) |
| CN (2) | CN1061049C (ru) |
| AT (1) | ATE195317T1 (ru) |
| AU (1) | AU669372B2 (ru) |
| CA (2) | CA2188066C (ru) |
| CZ (1) | CZ296794A3 (ru) |
| DE (1) | DE69329199D1 (ru) |
| DK (1) | DK0642519T3 (ru) |
| FI (1) | FI945593A0 (ru) |
| HK (1) | HK1014002A1 (ru) |
| HU (1) | HUT69699A (ru) |
| IL (2) | IL105834A (ru) |
| MX (1) | MX9303251A (ru) |
| MY (1) | MY109736A (ru) |
| NO (1) | NO305960B1 (ru) |
| NZ (1) | NZ253524A (ru) |
| PL (1) | PL175475B1 (ru) |
| RU (1) | RU2136691C1 (ru) |
| SG (1) | SG50518A1 (ru) |
| SK (1) | SK144494A3 (ru) |
| WO (1) | WO1993024496A1 (ru) |
| ZA (1) | ZA933759B (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ297094A3 (en) * | 1992-05-29 | 1995-12-13 | Procter & Gamble Pharma | Phosphate compounds containing quaternary nitrogen, their use and pharmaceutical compositions containing thereof |
| EP0642521A1 (en) * | 1992-05-29 | 1995-03-15 | Procter & Gamble Pharmaceuticals | Thio-substituted nitrogen-containing heterocyclic phosphonate compounds for treating abnormal calcium and phosphate metabolism |
| TW401276B (en) * | 1993-10-07 | 2000-08-11 | Zeneca Ltd | Novel compounds and a method of controlling growth of plants |
| US5728650A (en) * | 1993-10-07 | 1998-03-17 | Zeneca Limited | Herbicidal aza bisphosphonic acids and compositions containing the same |
| US5646134A (en) * | 1994-04-21 | 1997-07-08 | Merck & Co., Inc. | Alendronate therapy to prevent loosening of, or pain associated with, orthopedic implant devices |
| EP0944635A4 (en) * | 1996-10-09 | 2000-07-05 | Elizanor Biopharmaceuticals In | THERAPEUTIC DIPHOSPHONATE COMPOUNDS |
| US6121253A (en) * | 1998-11-20 | 2000-09-19 | Merck Frosst Canada & Co. | Prostaglandin conjugates for treating or preventing bone disease |
| FR2947266B1 (fr) * | 2009-06-26 | 2011-06-17 | Servier Lab | Nouveaux derives d'acide 2-mercaptocyclopentanecarboxylique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| TWI730039B (zh) * | 2016-01-29 | 2021-06-11 | 日商富士藥品股份有限公司 | 新穎雙膦酸化合物 |
| US11793452B2 (en) | 2019-10-03 | 2023-10-24 | Johnson & Johnson Consumer Inc. | Method of visualizing and quantifying remineralization |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3957858A (en) * | 1970-04-13 | 1976-05-18 | Monsanto Company | Substituted ethane diphosphonic acids and salts and esters thereof |
| US4208401A (en) * | 1977-08-19 | 1980-06-17 | Colgate-Palmolive Company | Quaternary ammonium alkylene diphosphonate anti-calculus agents |
| DE2745083C2 (de) * | 1977-10-07 | 1985-05-02 | Henkel KGaA, 4000 Düsseldorf | Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung |
| DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| FR2531088B1 (fr) * | 1982-07-29 | 1987-08-28 | Sanofi Sa | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
| EP0189405B1 (en) * | 1983-09-15 | 1989-02-22 | University Of Bath | Disinfection of contact lenses |
| FR2558837B1 (fr) * | 1984-01-26 | 1986-06-27 | Sanofi Sa | Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant |
| DE3428524A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4687768A (en) * | 1984-12-21 | 1987-08-18 | The Procter & Gamble Company | Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism |
| US5104863A (en) * | 1984-12-21 | 1992-04-14 | The Procter & Gamble Company | Certain bicycloalkane and azabicycloalkane-1,1-diphosphonic acid derivatives useful for treating diseases associated with abnormal calcium and phosphate metabolism |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| US4902679A (en) * | 1985-12-13 | 1990-02-20 | Norwich Eaton Pharmaceuticals, Inc. | Methods of treating diseases with certain geminal diphosphonates |
| IL84497A (en) * | 1986-11-21 | 1994-10-21 | Ciba Geigy Ag | History 2-) Imidazol-1-yl (ethane-1,1-diphosphonic acid, their preparation and pharmaceutical preparations containing them |
| DE3640938A1 (de) * | 1986-11-29 | 1988-06-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel |
| US5071840A (en) * | 1986-12-19 | 1991-12-10 | Norwich Eaton Pharmaceuticals, Inc. | Certain heterocyclic substituted diphosphonate compounds pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism |
| US4868164A (en) * | 1986-12-19 | 1989-09-19 | Norwich Eaton Pharmaceuticals, Inc. | Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| DE3881659D1 (en) * | 1987-12-11 | 1993-07-15 | Ciba Geigy Ag | Araliphatylaminoalkandiphosphonsaeuren. |
| US4933472A (en) * | 1988-04-08 | 1990-06-12 | Yamanouchi Pharmaceutical Co., Ltd. | Substituted aminomethylenebis(phosphonic acid) derivatives |
| TW198039B (ru) * | 1988-11-28 | 1993-01-11 | Ciba Geigy Ag | |
| CA2046905A1 (en) * | 1989-04-03 | 1990-10-04 | Colin John Dunn | Germinal bisphosphonic acids and derivatives as anti-arthritic agents |
| DE4011777A1 (de) * | 1989-04-14 | 1990-10-18 | Ciba Geigy Ag | N-trisubstituierte aminoalkandiphosphonsaeuren |
| US4922007A (en) * | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| EP0416689B1 (en) * | 1989-09-06 | 1995-11-29 | Merck & Co. Inc. | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors |
| AU7165791A (en) * | 1990-01-12 | 1991-08-05 | Rhone-Poulenc Rorer International (Holdings) Inc. | 1-azetidyl and 1-hexamethylenimine alkyl or aryl bisphosphonic acids and their use as pharmacological agents |
| JPH0826048B2 (ja) * | 1991-09-05 | 1996-03-13 | 東レ株式会社 | メタンジホスホン酸誘導体、その製造方法およびその医薬用途 |
-
1993
- 1993-05-26 CA CA002188066A patent/CA2188066C/en not_active Expired - Fee Related
- 1993-05-26 SG SG1996003361A patent/SG50518A1/en unknown
- 1993-05-26 WO PCT/US1993/004977 patent/WO1993024496A1/en not_active Application Discontinuation
- 1993-05-26 RU RU94046117A patent/RU2136691C1/ru active
- 1993-05-26 DE DE69329199T patent/DE69329199D1/de not_active Expired - Lifetime
- 1993-05-26 JP JP6500722A patent/JPH07507315A/ja active Pending
- 1993-05-26 AU AU43917/93A patent/AU669372B2/en not_active Ceased
- 1993-05-26 DK DK93914151T patent/DK0642519T3/da active
- 1993-05-26 CA CA002136818A patent/CA2136818C/en not_active Expired - Fee Related
- 1993-05-26 PL PL93306139A patent/PL175475B1/pl unknown
- 1993-05-26 NZ NZ253524A patent/NZ253524A/en unknown
- 1993-05-26 KR KR1019940704307A patent/KR950701929A/ko active IP Right Grant
- 1993-05-26 HU HU9403408A patent/HUT69699A/hu unknown
- 1993-05-26 AT AT93914151T patent/ATE195317T1/de not_active IP Right Cessation
- 1993-05-26 SK SK1444-94A patent/SK144494A3/sk unknown
- 1993-05-26 EP EP93914151A patent/EP0642519B1/en not_active Expired - Lifetime
- 1993-05-26 CZ CZ942967A patent/CZ296794A3/cs unknown
- 1993-05-28 IL IL10583493A patent/IL105834A/en not_active IP Right Cessation
- 1993-05-28 ZA ZA933759A patent/ZA933759B/xx unknown
- 1993-05-28 MY MYPI93001056A patent/MY109736A/en unknown
- 1993-05-29 CN CN93108419A patent/CN1061049C/zh not_active Expired - Fee Related
- 1993-05-31 MX MX9303251A patent/MX9303251A/es not_active IP Right Cessation
-
1994
- 1994-09-07 US US08/301,514 patent/US5824661A/en not_active Expired - Fee Related
- 1994-11-24 NO NO944499A patent/NO305960B1/no not_active IP Right Cessation
- 1994-11-28 FI FI945593A patent/FI945593A0/fi unknown
-
1996
- 1996-11-19 IL IL11964896A patent/IL119648A0/xx unknown
-
1998
- 1998-12-21 HK HK98114257A patent/HK1014002A1/xx not_active IP Right Cessation
-
1999
- 1999-12-23 CN CN99127416A patent/CN1288008A/zh active Pending
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