RU92016224A - 4,13-дикосабицикло (8,2,1)-придеценон-производные, способ и промежуточные продукты для их получения и лекарственные средства, содержащие эти соединения - Google Patents

4,13-дикосабицикло (8,2,1)-придеценон-производные, способ и промежуточные продукты для их получения и лекарственные средства, содержащие эти соединения

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Publication number
RU92016224A
RU92016224A RU92016224/04A RU92016224A RU92016224A RU 92016224 A RU92016224 A RU 92016224A RU 92016224/04 A RU92016224/04 A RU 92016224/04A RU 92016224 A RU92016224 A RU 92016224A RU 92016224 A RU92016224 A RU 92016224A
Authority
RU
Russia
Prior art keywords
predecenon
dicosabiciclo
derivative
connections
production
Prior art date
Application number
RU92016224/04A
Other languages
English (en)
Other versions
RU2107070C1 (ru
Inventor
Хельтье Дагмар
Пройшофф Улф
Экхоут Кристиан
Original Assignee
Кали-Хеми Фарма ГмбХ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4200145A external-priority patent/DE4200145A1/de
Application filed by Кали-Хеми Фарма ГмбХ filed Critical Кали-Хеми Фарма ГмбХ
Publication of RU92016224A publication Critical patent/RU92016224A/ru
Application granted granted Critical
Publication of RU2107070C1 publication Critical patent/RU2107070C1/ru

Links

Claims (1)

  1. Описаны суженные в кольце N-дезметил-N-изопропил-эритромицин-А-производные с гастроинтестинально действующими мотилинагонистическими свойствами, способ их получения и лекарственные средства на их основе.
RU92016224A 1992-01-07 1992-12-30 Производные [2r,3r (2'r,3'r,), 6r,7s,8s,9r,10r] -3-(2',3'-дигидроксипент-2'-ил)-2,6,8,10,12-пентаметил -4,13-диоксабицикло [8,2,1]-тридец-12-ен-5-она, способ их получения, фармацевтическое средство RU2107070C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4200145A DE4200145A1 (de) 1992-01-07 1992-01-07 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DEP4200145,5 1992-01-07
DEP4200145.5 1992-01-07

Publications (2)

Publication Number Publication Date
RU92016224A true RU92016224A (ru) 1995-11-27
RU2107070C1 RU2107070C1 (ru) 1998-03-20

Family

ID=6449136

Family Applications (1)

Application Number Title Priority Date Filing Date
RU92016224A RU2107070C1 (ru) 1992-01-07 1992-12-30 Производные [2r,3r (2'r,3'r,), 6r,7s,8s,9r,10r] -3-(2',3'-дигидроксипент-2'-ил)-2,6,8,10,12-пентаметил -4,13-диоксабицикло [8,2,1]-тридец-12-ен-5-она, способ их получения, фармацевтическое средство

Country Status (28)

Country Link
US (1) US5418224A (ru)
EP (1) EP0550895B1 (ru)
JP (1) JP3300084B2 (ru)
KR (1) KR100273937B1 (ru)
CN (1) CN1033646C (ru)
AT (1) ATE155478T1 (ru)
AU (1) AU667699B2 (ru)
CA (1) CA2086811C (ru)
CZ (1) CZ281773B6 (ru)
DE (2) DE4200145A1 (ru)
DK (1) DK0550895T3 (ru)
DZ (1) DZ1652A1 (ru)
ES (1) ES2104808T3 (ru)
FI (1) FI106862B (ru)
GR (1) GR3024859T3 (ru)
HK (1) HK1014003A1 (ru)
HU (2) HU212272B (ru)
IL (1) IL104158A (ru)
LT (1) LT3015B (ru)
LV (1) LV10458B (ru)
MX (1) MX9300045A (ru)
NO (1) NO179586C (ru)
PH (1) PH30098A (ru)
RU (1) RU2107070C1 (ru)
SK (1) SK279251B6 (ru)
TW (1) TW238308B (ru)
UA (1) UA29393C2 (ru)
ZA (1) ZA9339B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100275A (en) * 1995-10-13 2000-08-08 Neurosearch A/S 8-azabicyclo[3.2.1.]oct-2-ene derivatives, their preparation and use
US6077943A (en) * 1996-03-01 2000-06-20 Takeda Chemical Industries, Ltd. Method of producing erythromycin derivative
CA2247929A1 (en) * 1996-03-01 1997-09-04 Miichiro Arita Processes for the preparation of erythromycin derivatives
DE19644195A1 (de) * 1996-10-24 1998-04-30 Solvay Pharm Gmbh 10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19805822B4 (de) * 1998-02-13 2009-02-05 Solvay Pharmaceuticals Gmbh 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6165985A (en) * 1998-02-13 2000-12-26 Solvay Pharmaceuticals Gmbh 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them
PT1489090E (pt) * 2000-08-17 2006-05-31 Kitasato Inst Novos derivados de pseudoeritromicina
ATE308537T1 (de) * 2001-05-10 2005-11-15 Solvay Pharm Gmbh Neue 1-amidomethylcarbonyl-piperidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US20040067896A1 (en) * 2002-07-25 2004-04-08 The Kitasato Institute Novel pseudoerythromycin derivatives
WO2004111077A1 (en) 2003-06-18 2004-12-23 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
BRPI0619556A2 (pt) * 2005-12-08 2011-10-04 Pfizer processo para desmetilação de grupo 3' -dimetil amino de compostos eritromicina
EP2431380A3 (en) 2006-09-11 2013-07-03 Tranzyme Pharma, Inc. Macrocyclic antagonist of the motilin receptor for treatment of gastrointestinal dysmotility disorders
RU2422453C2 (ru) * 2006-12-05 2011-06-27 Пфайзер Инк. Полиморфы мотилида
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
TWI662967B (zh) * 2013-03-25 2019-06-21 日商志瑞亞新藥工業股份有限公司 食後期之胃運動亢進劑

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725385A (en) * 1970-11-02 1973-04-03 Abbott Lab Process for the demethylation of 3-amino macrolides
CA1321581C (en) * 1987-05-26 1993-08-24 Herbert A. Kirst Ring-contracted macrolides
US5106961A (en) * 1987-05-26 1992-04-21 Eli Lilly And Company Erythromycin ring-contracted derivatives
US4920102A (en) * 1988-04-18 1990-04-24 Eli Lilly And Company Method for treating gastrointestinal disorders

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