RU2768282C2 - Генетически модифицированные не принадлежащие к человеческому роду животные и способ их использования - Google Patents

Генетически модифицированные не принадлежащие к человеческому роду животные и способ их использования Download PDF

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RU2768282C2
RU2768282C2 RU2017145913A RU2017145913A RU2768282C2 RU 2768282 C2 RU2768282 C2 RU 2768282C2 RU 2017145913 A RU2017145913 A RU 2017145913A RU 2017145913 A RU2017145913 A RU 2017145913A RU 2768282 C2 RU2768282 C2 RU 2768282C2
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human
cells
csf
polypeptide
genetically modified
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RU2017145913A
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RU2017145913A (ru
RU2017145913A3 (OSRAM
Inventor
Ричард А. ФЛАВЕЛЛ
Маркус МАНЦ
Энтони РОНВО
Тил СТРОВИГ
Тим ВИЛЛИНДЖЕР
Эндрю Дж. МЁРФИ
Шон СТИВЕНС
Джордж ЯНКОПУЛОС
Original Assignee
Йель Юниверсити
Инститьют Фор Рисерч Ин Байомедсин (Ирб)
Ридженерон Фармасьютикалз, Инк.
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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RU2017145913A 2012-09-07 2013-09-06 Генетически модифицированные не принадлежащие к человеческому роду животные и способ их использования RU2768282C2 (ru)

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Application Number Priority Date Filing Date Title
US201261698002P 2012-09-07 2012-09-07
US61/698,002 2012-09-07
US201361775171P 2013-03-08 2013-03-08
US61/775,171 2013-03-08

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RU2015112607A Division RU2642319C2 (ru) 2012-09-07 2013-09-06 Генетически модифицированные, не принадлежащие к человеческому роду животные и способ их использования

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RU2017145913A RU2017145913A (ru) 2019-02-19
RU2017145913A3 RU2017145913A3 (OSRAM) 2021-08-16
RU2768282C2 true RU2768282C2 (ru) 2022-03-23

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RU2015112607A RU2642319C2 (ru) 2012-09-07 2013-09-06 Генетически модифицированные, не принадлежащие к человеческому роду животные и способ их использования

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US (6) US9820476B2 (OSRAM)
EP (3) EP2892330B1 (OSRAM)
JP (5) JP6283031B2 (OSRAM)
KR (7) KR102473555B1 (OSRAM)
CN (4) CN104955326B (OSRAM)
AU (3) AU2013312359B8 (OSRAM)
CA (1) CA2881468C (OSRAM)
DK (1) DK2892330T3 (OSRAM)
ES (2) ES3034290T3 (OSRAM)
FI (1) FI2892330T3 (OSRAM)
IL (4) IL307969B1 (OSRAM)
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RU (2) RU2768282C2 (OSRAM)
SG (2) SG10201701759VA (OSRAM)
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FI3850946T3 (fi) 2014-12-05 2023-12-28 Regeneron Pharma Ei-ihmiseläimiä, joilla on humanisoitu erilaistumisklusterin 47 geeni
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CA2969847A1 (en) 2014-12-10 2016-06-16 Regents Of The University Of Minnesota Genetically modified cells, tissues, and organs for treating disease
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RU2742354C2 (ru) 2016-02-04 2021-02-05 Регенерон Фармасьютикалз, Инк. Животные, отличные от человека, имеющие сконструированный ген angptl8
RU2749715C2 (ru) 2016-02-29 2021-06-16 Регенерон Фармасьютикалз, Инк. Грызуны, характеризующиеся гуманизированным геном tmprss
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JP7458185B2 (ja) * 2016-11-30 2024-03-29 ザ ジャクソン ラボラトリー 改善されたヒト自然免疫細胞の発生を有するヒト化マウスモデル
AU2018265887B2 (en) * 2017-05-12 2024-05-09 The Jackson Laboratory NSG mice lacking MHC class I and class II
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US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
CN111073907B (zh) * 2018-12-25 2025-07-29 百奥赛图江苏基因生物技术有限公司 人源化细胞因子csf1基因改造非人动物的构建方法及应用
CN111118019B (zh) * 2018-12-25 2021-03-16 百奥赛图江苏基因生物技术有限公司 人源化细胞因子il3基因改造非人动物的构建方法及应用
US20220354098A1 (en) * 2019-07-17 2022-11-10 Yale University Genetically Modified Non-Human Animals and Methods of Use Thereof
CN112779284B (zh) * 2019-11-01 2022-12-20 百奥赛图(北京)医药科技股份有限公司 Thpo基因人源化的非人动物的构建方法及应用
US11339279B2 (en) * 2020-04-01 2022-05-24 Chevron Phillips Chemical Company Lp Dual catalyst system for producing LLDPE and MDPE copolymers with long chain branching for film applications
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