RU2762596C2 - Введение множественных болюсов [6r]-mthf в химиотерапии на основе 5-фторурацила - Google Patents

Введение множественных болюсов [6r]-mthf в химиотерапии на основе 5-фторурацила Download PDF

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RU2762596C2
RU2762596C2 RU2020109122A RU2020109122A RU2762596C2 RU 2762596 C2 RU2762596 C2 RU 2762596C2 RU 2020109122 A RU2020109122 A RU 2020109122A RU 2020109122 A RU2020109122 A RU 2020109122A RU 2762596 C2 RU2762596 C2 RU 2762596C2
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methylenetetrahydrofolate
minutes
treatment
weeks
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Пер Леннарт ЛИНДБЕРГ
Гуннель Элисабет СУНДЕН
Бенгт ГУСТАВССОН
Андерс ВЕДИН
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Исофол Медикал Аб
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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RU2020109122A 2017-08-24 2018-01-05 Введение множественных болюсов [6r]-mthf в химиотерапии на основе 5-фторурацила RU2762596C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17187682.4 2017-08-24
EP17187682.4A EP3446703A1 (en) 2017-08-24 2017-08-24 6r]-mthf multiple bolus administration in 5-fluorouracil based chemotherapy
PCT/EP2018/050274 WO2019037899A1 (en) 2017-08-24 2018-01-05 ADMINISTRATION OF MULTIPLE [6R] -MTHF BOLUSES DURING CHEMOTHERAPY BASED ON 5-FLUORO-URACILE

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RU2020109122A RU2020109122A (ru) 2021-09-24
RU2020109122A3 RU2020109122A3 (enExample) 2021-09-24
RU2762596C2 true RU2762596C2 (ru) 2021-12-21

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EP (4) EP3446703A1 (enExample)
JP (3) JP2020531492A (enExample)
KR (1) KR102227451B1 (enExample)
CN (1) CN110214023A (enExample)
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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3446704A1 (en) 2017-08-24 2019-02-27 Isofol Medical AB [6r]-mthf - an efficient folate alternative in 5-fluorouracil based chemotherapy
WO2018150264A1 (en) 2017-02-14 2018-08-23 Isofol Medical Ab METHODS FOR INCREASING BLOOD PLASMA 2'-DEOXYURIDINE (dUrd) AND THYMIDYLATE SYNTHASE INHIBITION
WO2023046305A1 (en) * 2021-09-27 2023-03-30 Isofol Medical Ab [6r]-mthf in 5-fu based chemotherapy of left-sided colorectal cancer
WO2023046307A1 (en) * 2021-09-27 2023-03-30 Isofol Medical Ab [6r]-mthf in 5-fu based chemotherapy of right-sided colorectal cancer
WO2023046304A1 (en) * 2021-09-27 2023-03-30 Isofol Medical Ab [6r]-mthf in 5-fu based chemotherapy of braf- or kras-mutated colorectal cancer
US20240350495A1 (en) * 2023-04-20 2024-10-24 Isofol Medical Ab [6r]-mthf in b6 enhanced 5-fu based chemotherapy of carcinoma
EP4450071A1 (en) 2023-04-20 2024-10-23 Isofol Medical AB [6r]-mthf in b6 enhanced 5-fu based chemotherapy of pancreatic cancer
EP4534088A1 (en) 2023-10-04 2025-04-09 Isofol Medical AB Arfolitixorin for use in vitamin b6-enhanced, 5-fluorouracil-based chemotherapy of carcinomas

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WO2005097086A2 (en) * 2004-04-02 2005-10-20 Adventrx Pharmaceuticals, Inc. Use of 5,10-methylene tetrahydrofolate for the treatment of cancer
WO2007064968A2 (en) * 2005-12-02 2007-06-07 Adventrx Pharmaceuticals, Inc. Stable pharmaceutical compositions of 5,10 methylenetetrahydrofolate

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US5376658A (en) * 1990-05-11 1994-12-27 University Of Southern California 5,10-methylene-tetrahydrofolate as a modulator of a chemotherapeutic agent
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
CN1942189A (zh) * 2004-04-02 2007-04-04 阿德文特克斯药物有限公司 5,10－亚甲基四氢叶酸在癌症治疗中的用途
WO2008109349A1 (en) 2007-03-06 2008-09-12 Adventrx Pharmaceuticals, Inc. Improved regimen for treating cancer with 5-fluorouracil, 5,10-methylenetetrahydrofolate and capecitabine
EP2617421A1 (en) * 2012-01-20 2013-07-24 Isofol Medical AB Tetrahydrofolates in combination with EGFR-inhibitors in the use of treating cancer
EP2837631A1 (en) * 2013-08-14 2015-02-18 Merck & Cie New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid
EP3305318A1 (en) 2016-10-05 2018-04-11 Isofol Medical AB [6r]-5,10-methylenetetrahydrofolate in 5-fluorouracil based chemotherapy

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WO2005097086A2 (en) * 2004-04-02 2005-10-20 Adventrx Pharmaceuticals, Inc. Use of 5,10-methylene tetrahydrofolate for the treatment of cancer
WO2007064968A2 (en) * 2005-12-02 2007-06-07 Adventrx Pharmaceuticals, Inc. Stable pharmaceutical compositions of 5,10 methylenetetrahydrofolate

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NCT02244632, ClinicalTrials.gov archive, 08.03.2017. Peter V. Danenberg et al. Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action. Critical Reviews in Oncology/Hematology, 2016, Vol. 106, P. 118-131. *
NCT02244632, ClinicalTrials.gov archive, 08.03.2017. Peter V. Danenberg et al. Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action. Critical Reviews in Oncology/Hematology, 2016, Vol. 106, P. 118-131. Taflin H. et al. ISO-005; An open-label, multiple-site, dose cohort, phase I/II study in patients with stage IV colorectal cancer. Еuropean Journal of Cancer, january 2017, Vol.72, P. S71. *
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CN110214023A (zh) 2019-09-06
KR102227451B1 (ko) 2021-03-12
ES2889573T3 (es) 2022-01-12
IL272876B (en) 2021-12-01
DK3446706T3 (da) 2021-09-13
TW201912158A (zh) 2019-04-01
EP3854399A1 (en) 2021-07-28
CA2991361A1 (en) 2019-02-24
JP6734308B2 (ja) 2020-08-05
BR112020003604A2 (pt) 2020-09-01
RU2020109122A (ru) 2021-09-24
CA3073608A1 (en) 2019-02-28
EP3446706B1 (en) 2021-06-02
SG11202001371YA (en) 2020-03-30
MX2020002075A (es) 2020-08-13
WO2019037899A1 (en) 2019-02-28
TWI772354B (zh) 2022-08-01
CA3073608C (en) 2022-02-01
RU2020109122A3 (enExample) 2021-09-24
AU2018319671A1 (en) 2020-03-05
US20190212341A1 (en) 2019-07-11
HUE056275T2 (hu) 2022-02-28
EP3446703A1 (en) 2019-02-27
IL272876A (en) 2020-04-30
JP2019038796A (ja) 2019-03-14
JP2020531492A (ja) 2020-11-05
PL3446706T3 (pl) 2021-11-08
EP3672624A1 (en) 2020-07-01
SG10201800203SA (en) 2019-03-28
PT3446706T (pt) 2021-09-15
US20190060315A1 (en) 2019-02-28
KR20190022269A (ko) 2019-03-06
EP3446706A1 (en) 2019-02-27
JP2020169208A (ja) 2020-10-15
US10328079B2 (en) 2019-06-25

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