RU2761476C2 - Макроциклические антибиотики широкого спектра действия - Google Patents

Макроциклические антибиотики широкого спектра действия Download PDF

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Publication number
RU2761476C2
RU2761476C2 RU2018122498A RU2018122498A RU2761476C2 RU 2761476 C2 RU2761476 C2 RU 2761476C2 RU 2018122498 A RU2018122498 A RU 2018122498A RU 2018122498 A RU2018122498 A RU 2018122498A RU 2761476 C2 RU2761476 C2 RU 2761476C2
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RU
Russia
Prior art keywords
alkyl
compound
formula
another embodiment
optionally substituted
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RU2018122498A
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English (en)
Russian (ru)
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RU2018122498A (ru
RU2018122498A3 (https=
Inventor
Юньшэнь ЧЭНЬ
Петер Эндрю Смит
Такер Карран Робертс
Роберт И. Хигучи
Прасуна Параселли
Майкл Ф.Т. КЕЛЕР
Джейкоб Бредли ШВАРЦ
Джеймс Джон Кроуфорд
Куонг Ц. ЛЮ
Хуайонг ХУ
Чжиоюн ЮЙ
Original Assignee
АрКьюИкс ФАРМАСЬЮТИКЭЛС, ИНК.
Дженетек, Инк.
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Publication of RU2018122498A publication Critical patent/RU2018122498A/ru
Publication of RU2018122498A3 publication Critical patent/RU2018122498A3/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
RU2018122498A 2015-11-20 2016-11-21 Макроциклические антибиотики широкого спектра действия RU2761476C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2015/095165 2015-11-20
CNPCT/CN2015/095165 2015-11-20
CNPCT/CN2016/105043 2016-11-08
CNPCT/CN2016/105043 2016-11-08
PCT/CN2016/106597 WO2017084629A1 (en) 2015-11-20 2016-11-21 Macrocyclic broad spectrum antibiotics

Publications (3)

Publication Number Publication Date
RU2018122498A RU2018122498A (ru) 2019-12-26
RU2018122498A3 RU2018122498A3 (https=) 2020-02-28
RU2761476C2 true RU2761476C2 (ru) 2021-12-08

Family

ID=58231314

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018122498A RU2761476C2 (ru) 2015-11-20 2016-11-21 Макроциклические антибиотики широкого спектра действия

Country Status (12)

Country Link
US (1) US11072635B2 (https=)
EP (1) EP3377474B1 (https=)
JP (1) JP6873993B2 (https=)
KR (1) KR20180109858A (https=)
CN (1) CN109219596B (https=)
AU (1) AU2016357926B2 (https=)
BR (1) BR112018010267A2 (https=)
CA (1) CA3005551A1 (https=)
IL (1) IL259429B (https=)
MX (1) MX387476B (https=)
RU (1) RU2761476C2 (https=)
WO (1) WO2017084629A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
BR112016027232A2 (pt) 2014-05-20 2018-06-26 Genentech Inc antibióticos macrocíclicos de amplo espectro
US11072635B2 (en) 2015-11-20 2021-07-27 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
UA126027C2 (uk) * 2017-02-15 2022-08-03 АрКьюЕкс ФАРМАСЬЮТІКЛС, ІНК. Макроциклічні антибіотики широкого спектра
JP2020536072A (ja) * 2017-09-29 2020-12-10 ジェネンテック， インコーポレイテッド ペプチド抗生物質複合体およびその使用方法
ES2961566T3 (es) * 2019-05-28 2024-03-12 Hoffmann La Roche Antibióticos macrocíclicos de amplio espectro

Citations (4)

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WO2012166665A2 (en) * 2011-05-27 2012-12-06 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
WO2013138187A1 (en) * 2012-03-14 2013-09-19 The Scripps Research Institute Broad spectrum antibiotic arylomycin analogs
RU2012142832A (ru) * 2010-03-09 2014-04-20 Мерк Шарп Энд Домэ Корп. Мостиковые липогликопептиды, усиливающие активность бета-лактамных антибактериальных агентов
WO2014081886A1 (en) * 2012-11-21 2014-05-30 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics

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BR112016027232A2 (pt) 2014-05-20 2018-06-26 Genentech Inc antibióticos macrocíclicos de amplo espectro
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UA126027C2 (uk) 2017-02-15 2022-08-03 АрКьюЕкс ФАРМАСЬЮТІКЛС, ІНК. Макроциклічні антибіотики широкого спектра
CN117777229A (zh) 2017-03-27 2024-03-29 豪夫迈·罗氏有限公司 用于制备阿龙霉素环类似物的方法
JP2020536072A (ja) 2017-09-29 2020-12-10 ジェネンテック， インコーポレイテッド ペプチド抗生物質複合体およびその使用方法
ES2961566T3 (es) 2019-05-28 2024-03-12 Hoffmann La Roche Antibióticos macrocíclicos de amplio espectro

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2012142832A (ru) * 2010-03-09 2014-04-20 Мерк Шарп Энд Домэ Корп. Мостиковые липогликопептиды, усиливающие активность бета-лактамных антибактериальных агентов
WO2012166665A2 (en) * 2011-05-27 2012-12-06 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
WO2013138187A1 (en) * 2012-03-14 2013-09-19 The Scripps Research Institute Broad spectrum antibiotic arylomycin analogs
WO2014081886A1 (en) * 2012-11-21 2014-05-30 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics

Also Published As

Publication number Publication date
MX387476B (es) 2025-03-18
CA3005551A1 (en) 2017-05-26
WO2017084629A1 (en) 2017-05-26
US20200239519A1 (en) 2020-07-30
IL259429B (en) 2021-12-01
KR20180109858A (ko) 2018-10-08
JP6873993B2 (ja) 2021-05-19
EP3377474B1 (en) 2023-08-16
JP2019501123A (ja) 2019-01-17
MX2018006199A (es) 2019-01-10
CN109219596A (zh) 2019-01-15
US11072635B2 (en) 2021-07-27
IL259429A (en) 2018-07-31
BR112018010267A2 (pt) 2018-11-27
RU2018122498A (ru) 2019-12-26
AU2016357926B2 (en) 2021-05-27
AU2016357926A1 (en) 2018-06-14
EP3377474C0 (en) 2023-08-16
CN109219596B (zh) 2022-04-19
RU2018122498A3 (https=) 2020-02-28
EP3377474A1 (en) 2018-09-26

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